Chemotherapy

Delayed Administration Device for Pegfilgratim Safe, Effective in Preventing Grade 4 Neutropenia

Delayed Administration Device for Pegfilgratim Safe, Effective in Preventing Grade 4 Neutropenia

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In a comparison study, the Onpro® device was found to be a safe and effective alternative to manual injection of pegfilgrastim in patients receiving chemotherapy.

Estimating Quality of Life Based on Cumulative Drug Toxicity in Colorectal Cancer

Estimating Quality of Life Based on Cumulative Drug Toxicity in Colorectal Cancer

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Results of a study in which more than 100 patients with metastatic colorectal cancer completed EORTC-QLQ-C30 suggests an association between assessment of cumulative drug toxicities and predictions of quality of life for patients undergoing first-line chemotherapy for the disease.

Nedaplatin vs Cisplatin for Malignancy-Induced MPE: Noninferior, Less Toxicity

Nedaplatin vs Cisplatin for Malignancy-Induced MPE: Noninferior, Less Toxicity

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Researchers sought to determine if nedaplatin could effectively manage malignancy-induced MPE in patients with cancer with less toxicity than cisplatin.

Triplet Regimen Found Most Effective for Relapsed/Refractory Multiple Myeloma

Triplet Regimen Found Most Effective for Relapsed/Refractory Multiple Myeloma

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An updated network meta-analysis found that a triplet regimen consisting of lenalidomide and dexamethasone plus an immunotherapeutic agent had better efficacy in terms of NRR, TTP, PFS, and OS than other regimens.

New Formulations Improve Management of Chemotherapy-Induced Nausea and Vomiting

New Formulations Improve Management of Chemotherapy-Induced Nausea and Vomiting

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In a recent report, researchers evaluate the efficacy of newer 5HT3-RAs for the prevention of CINV in patients with cancer receiving moderately or highly emetogenic chemotherapy.

Too Much Physical Activity During Therapy for Pediatric ALL Decreases Cognitive Function

Too Much Physical Activity During Therapy for Pediatric ALL Decreases Cognitive Function

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Using a longitudinal parallel-process model, researchers evaluated the impact of physical activity on symptoms, physical activity, and cognitive function in children with ALL undergoing chemotherapy.

RiBVD Effective in the First-Line Setting for Mantle Cell Lymphoma

RiBVD Effective in the First-Line Setting for Mantle Cell Lymphoma

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Researchers sought to determine if the newly formed regimen RiBVD was effective and tolerable in patients older than 65 with mantle cell lymphoma.

Lenalidomide Plus R-CHOP Effective in High-Burden Follicular Lymphoma

Lenalidomide Plus R-CHOP Effective in High-Burden Follicular Lymphoma

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A phase 2 study was conducted to determine the effectiveness of adding lenalidomide to R-CHOP as a first-line treatment for high-burden follicular lymphoma.

Additional Mammography Between Regular Screenings May Improve Breast Cancer Detection

Additional Mammography Between Regular Screenings May Improve Breast Cancer Detection

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The MSP in Germany is designed to detect breast cancer during annually scheduled screenings and between the last negative and following screening among survivors.

Ibrutinib Compared With Chemotherapy in Treatment-Naive CLL

Ibrutinib Compared With Chemotherapy in Treatment-Naive CLL

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Ibrutinib monotherapy may reduce the need for chemotherapy for some treatment-naive patients with chronic CLL, research indicates.

Benefit of Chemotherapy for Breast Cancer Observed With Midrange Gene Assay Score

Benefit of Chemotherapy for Breast Cancer Observed With Midrange Gene Assay Score

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In a randomization of women with early-stage breast cancer, researchers explored the potential benefits of chemotherapy for women whose Oncotype DX RS was midrange.

Antioxidant Interaction With Cancer Therapy

Antioxidant Interaction With Cancer Therapy

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What is the concern with antioxidants and chemotherapy or radiation?

Oral Hydration Effectively Reduced Risk of Nephrotoxity After Cisplatin

Oral Hydration Effectively Reduced Risk of Nephrotoxity After Cisplatin

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A single-center retrospective study determined the safety of IV hydration before and oral hydration after cisplatin therapy to prevent nephrotoxicity in patients with lung cancer vs IV hydration both before and after therapy.

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers

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In an open-label study, researchers sought to determine the optimal amount of bed rest after intrathecal chemotherapy for patients with hematologic cancers.

Adding Bevacizumab to First-line Chemotherapy Benefits Selects Cases of Ovarian Cancer

Adding Bevacizumab to First-line Chemotherapy Benefits Selects Cases of Ovarian Cancer

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Researchers conducted a retrospective analysis to determine the impact of inflammatory responses in patients with ovarian cancer undergoing first-line chemotherapy with or without bevacizumab.

Intensive Chemotherapy May Not Be Effective in MDS or AML After MDS

Intensive Chemotherapy May Not Be Effective in MDS or AML After MDS

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Researchers sought to determine the impact of intensive chemotherapy on achieving complete remission and overall survival among patients with MDS or sAML.

Nurse-Led Program Improves Health, Financial Outcomes in Outpatient Chemotherapy

Nurse-Led Program Improves Health, Financial Outcomes in Outpatient Chemotherapy

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In a randomized study, researchers sought to determine the effect of a nurse-led care program on unscheduled hospital visits and admissions and cost for patients with breast cancer undergoing outpatient chemotherapy.

Involved-Field Radiotherapy Plus Chemotherapy Prolonged PFS in Follicular Lymphoma

Involved-Field Radiotherapy Plus Chemotherapy Prolonged PFS in Follicular Lymphoma

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Although involved-field radiotherapy (IFRT) has a high level of disease control in patients with follicular lymphoma, relapse frequently occurs; therefore, researchers sought to determine if adding chemotherapy would improve progression-free survival.

Remission Duration Predicts Long-Term Outcomes in Chronic Lymphocytic Leukemia

Remission Duration Predicts Long-Term Outcomes in Chronic Lymphocytic Leukemia

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A retrospective study sought to evaluate outcomes for patients with CLL who were treated with FCR, a highly effective treatment, and initially had refractory disease, experienced relapse early, or were unable to complete therapy due to toxicity.

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

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Three-drug regimen twice a week achieved good response and long-term outcomes in patients with newly diagnosed multiple myeloma; however, regimen has higher toxicity than once weekly dose.

Implementing an Ambulatory Adherence Program May Improve Oral Anticancer Medications Compliance

Implementing an Ambulatory Adherence Program May Improve Oral Anticancer Medications Compliance

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Adherence is a challenge for many patients receiving oral chemotherapy, new data suggests a potential solution.

R-THP-COP a New Therapeutic Alternative for Diffuse Large B Cell Lymphoma

R-THP-COP a New Therapeutic Alternative for Diffuse Large B Cell Lymphoma

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Results of a prospective phase 3 study demonstrated noninferiority of R-THP-COP for diffuse large B cell lymphoma to the standard of care, suggesting the regimen may be an alternative option for these patients.

Capecitabine Tolerance of EU vs US Patients

Capecitabine Tolerance of EU vs US Patients

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Why are European patients better able to tolerate high doses of capecitabine than US patients?

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

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In a retrospective study, researchers investigated the effect of primary prophylaxis on incidence of febrile neutropenia in patients with early stage breast cancer.

Dose-Dense Chemotherapy for Breast Cancer May Impair Lung Function

Dose-Dense Chemotherapy for Breast Cancer May Impair Lung Function

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Long-term analysis determined the effect of postadjuvant dose-dense chemotherapy on DLCO among women with breast cancer.

Novel Agents Plus Paclitaxel, Carboplatin, Does Not Improve Survival in Endometrial Cancer

Novel Agents Plus Paclitaxel, Carboplatin, Does Not Improve Survival in Endometrial Cancer

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A phase 2 study determined if adding bevacizumab or temsirolimus to PC, or an ixabepilone/carboplatin/bevacizumab combination will increase progression-free survival for women with advanced/recurrent endometrial cancer, compared with PC alone.

Patient Advocacy, Questioning 'Status Quo,' Improves Safety in Ambulatory Infusion Setting

Patient Advocacy, Questioning 'Status Quo,' Improves Safety in Ambulatory Infusion Setting

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In fielding reports of CNS-related adverse effects from patients in the ambulatory infusion room, nurses were able to prompt a pharmacy practice review. The outcomes of the resulting switch in premedication for HSR was presented at the 2018 ONS Annual Congress.

Nursing Practice Change Improved Chemo Administration, But Old Habits Die Hard

Nursing Practice Change Improved Chemo Administration, But Old Habits Die Hard

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A nursing staff worked together to identify and work a solution to a high rate of "near-misses" in chemotherapy administration, but further evaluation and additional interventions are needed to maintain the successful practice change, study findings presented at 2018 ONS Annual Congress have shown.

Simple Adjustment Key to Paclitaxel Infusion Protocol That Reduced Hypersensitivity Reactions

Simple Adjustment Key to Paclitaxel Infusion Protocol That Reduced Hypersensitivity Reactions

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A project presented at the 2018 ONS Annual Congress demonstrated the effectiveness of standardizing nursing practices for paclitaxel infusions.

Accurate Understanding of Capacity May Improve Workflow, Efficiency in Infusion Suite

Accurate Understanding of Capacity May Improve Workflow, Efficiency in Infusion Suite

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A nursing staff workflow and capacity study resulted in an overhaul of nurse scheduling in an infusion clinic. Results were presented at the 2018 ONS Annual Congress.

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