Chemotherapy

Including Quality Measures In Treatment Regimens Increases Survival in Stage IIIA Non-Small Cell Lung Cancer

Including Quality Measures In Treatment Regimens Increases Survival in Stage IIIA Non-Small Cell Lung Cancer

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When more quality measures are incorporated into patient care, survival rates for patients with stage IIIA non-small cell lung cancer (NSCLC) increase, but only 13% of eligible patients actually receive all 4 recommended quality measures.

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

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Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

Adding Two Inhibitors Enhances Effectiveness of Tamoxifen in ER-positive Breast Cancer

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Combining 2 existing chemotherapy drugs, a DNMT1 inhibitor and a histone deacetylase inhibitor, reduced the numbers of cancer stem cells and improved survival in a mouse model.

Radiation Therapy Better Than Chemotherapy for Stage IIA Testicular Cancer

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Patients with stage IIA testicular cancer gain a survival advantage from treatment with radiation therapy compared with chemotherapy.

Higher CAM Use Associated With Decreased Chemo Initiation

Higher CAM Use Associated With Decreased Chemo Initiation

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Researchers examined possible correlations between complementary and alternative medicine and delayed initiation of clinically indicated chemotherapy among patients with early-stage breast cancer.

Chemo-related Bloodstream Infection Predicted by Gut Microbes Before Treatment

Chemo-related Bloodstream Infection Predicted by Gut Microbes Before Treatment

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Bacteria present in the gut may predict a patient's risk for life-threatening blood infections after high-dose chemotherapy.

Survival in Head and Neck Cancer Increased With Nivolumab Over Chemotherapy

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The immunotherapy drug nivolumab conferred a survival benefit in patients with head and neck cancer over standard chemotherapy.

New Drug Combination Before Surgery May Improve Outcomes for Advanced HER2+ Breast Cancer

New Drug Combination Before Surgery May Improve Outcomes for Advanced HER2+ Breast Cancer

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Combining trastuzumab emtansine (T-DM1) and pertuzumab before surgery was more beneficial than the combination of paclitaxel plus trastuzumab for patients with HER2-positive invasive breast cancer.

Necitumumab With Chemotherapy Beneficial for Patients With EGFR-expressing NSCLC

Necitumumab With Chemotherapy Beneficial for Patients With EGFR-expressing NSCLC

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The most benefit from adding necitumumab to chemotherapy with gemcitabine and cisplatin occurred for patients whose advanced squamous NSCLC expressed EGFR.

Oral Chemotherapy Care Model Improves Safety, Quality Through Increased Collaboration

Oral Chemotherapy Care Model Improves Safety, Quality Through Increased Collaboration

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A nurse-facilitated oral chemotherapy care model has improved delivery times, patient satisfaction, and co-pay support at a Connecticut cancer hospital.

Follow-up Calls, Clinician Assessment May Identify Patients Who Need Adherence Support

Follow-up Calls, Clinician Assessment May Identify Patients Who Need Adherence Support

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Follow-up telephone calls and clinician assessment may be an effective strategy to identify early which patients require support with adhering to oral cancer therapy.

Inpatient Oral Chemotherapy Administration Process Developed to Comply With Safety Standards

Inpatient Oral Chemotherapy Administration Process Developed to Comply With Safety Standards

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Instituting a Chemotherapy Safety Committee and developing an administration process successfully standardized the inpatient oral chemotherapy administration process.

Formal Nursing Practice Promotes Patient Safety With Oral Chemotherapy

Formal Nursing Practice Promotes Patient Safety With Oral Chemotherapy

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A formal nursing practice was developed to promote patient safety and adherence with oral chemotherapy.

Central Venous Catheter Self-management Education Program Effective

Central Venous Catheter Self-management Education Program Effective

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A central venous catheter self-management education program is an effective nursing intervention to promote long-term self-management of a CVC for discharged patients with cancer.

Daily Chlorhexidine Gluconate Bathing Reduces CLABSI Rates

Daily Chlorhexidine Gluconate Bathing Reduces CLABSI Rates

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Daily chlorhexidine gluconate bathing on all patients with ports and tunneled catheters decreased the rates of CLABSI on an inpatient oncology unit.

Hygiene Practice Interventions Reduced CLABSI on an Inpatient Oncology Unit

Hygiene Practice Interventions Reduced CLABSI on an Inpatient Oncology Unit

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Formation of a multidisciplinary team and a focus on evidence-based interventions successfully reduced the rate of central line bloodstream infections (CLABSI) on an inpatient oncology unit.

PICC Claiming Antithrombogenic, Antimicrobial Properties Failed to Reduce Thromboses, Line Dysfunction

PICC Claiming Antithrombogenic, Antimicrobial Properties Failed to Reduce Thromboses, Line Dysfunction

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A PICC with preclinical data claiming antithrombogenic and antimicrobial properties failed to reduce the rate of CLABSI or catheter-related thromboses compared with a standard PICC.

Simulation-based Learning Improves Confidence, Competency in Treatment Administration

Simulation-based Learning Improves Confidence, Competency in Treatment Administration

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Simulation-based learning improved the confidence and skills of oncology nurses in chemotherapy-biotherapy administration.

Immune-stimulating Drug and Chemotherapy Show Early Promise for Pancreatic Cancer

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An experimental therapy looks to hold promise for tumor control treatment in pancreatic adenocarcinoma.

Patient Satisfaction Improves With Nurse-led Response to Patient Feedback

Patient Satisfaction Improves With Nurse-led Response to Patient Feedback

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A nurse-directed independent survey for patient feedback can inform measurable improvements in patient education and satisfaction survey scores.

Targeted Therapy Enhances Chemotherapy, Improves Outcomes in Retinoblastoma

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The effectiveness of chemotherapy was enhanced by targeting survivin, a protein that inhibits apoptosis or cell death, according to preclinical research in cells and mouse models of retinoblastoma.

Early Study Results Show Guadecitabine Effective for Metastatic Colorectal Cancer

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A small, phase I clinical trial indicates the experimental drug guadecitabine is safe in combination with the chemotherapy drug irinotecan, and it may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

Research Identifies Underlying Mechanism of Chemotherapy-Induced Peripheral Neuropathy

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A previously unidentified avenue exists for potential therapies for peripheral neuropathy induced by the chemotherapeutic agent paclitaxel.

Anthracycline Chemotherapy Not Associated With Cognitive Decline

Anthracycline Chemotherapy Not Associated With Cognitive Decline

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Anthracycline chemotherapy, such as doxorubicin and daunorubicin, is not associated with lasting cognitive decline among breast cancer survivors.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

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The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

Breast Cancer Therapy and Cardiotoxicity Risk in Older Women

Breast Cancer Therapy and Cardiotoxicity Risk in Older Women

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A study examined the relation between various forms of breast cancer therapies and risk of congestive heart failure.

Adding Aflibercept to First-line mFOLFOX6 Does Not Improve PFS in mCRC

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Adding aflibercept to first-line mFOLFOX6 did not improve progression-free survival compared with mFOLFOX6 alone in patients with mCRC, and the combination was associated with higher toxicity.

Progression-free and Overall Survival Better With Mutations Affecting DNA Repair Genes in Ovarian Cancer

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Women with advanced ovarian cancer who had mutations affecting DNA repair genes had longer progression-free and overall survival than women without the mutations.

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

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A multigene test can identify patients with early stage breast cancer who do not need chemotherapy and who will be alive 5 years after diagnosis.

Anxiety and Depressive Symptoms Are Increased in Pediatric Survivors of Acute Lymphoblastic Leukemia

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Emotional distress during and after undergoing chemotherapy for ALL affects a significant percentage of children with the disease.

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