Chemotherapy

Perioperative chemotherapy increases bladder cancer survival

Perioperative chemotherapy increases bladder cancer survival

Study shows low utilization of bladder cancer perioperative chemotherapy is associated with a survival benefit in the general population.

Nail care tips for patients undergoing chemotherapy

Nail care tips for patients undergoing chemotherapy

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Are there any evidence-based practices for managing changes to nails during chemotherapy?

Conventional chemotherapy may improve advanced NSCLC survival

Conventional chemotherapy may improve advanced NSCLC survival

For patients with non-small-cell lung cancer and wild-type EGFR mutations, conventional chemotherapy improves progression-free survival better than first-generation EGFR tyrosine kinase inhibitors.

Chemotherapy-free treatment a possibility for leukemia/lymphoma

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Patients with terminal forms of leukemia and lymphoma who have run out of treatment options could soon benefit from a new drug, which not only puts an end to chemotherapy and has virtually no side effects.

Palliative chemotherapy may overshadow patients' wishes for end-of-life care

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Terminal cancer patients who receive chemotherapy in the last months of their lives are less likely to die where they want and are more likely to undergo invasive medical procedures than those who do not.

Epigenetic imprint of chemotherapy linked to inflammation in breast cancer survivors

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Chemotherapy, one of the major treatments for breast cancer, can leave a long-lasting epigenetic imprint in the DNA of the blood cells of breast cancer patients, according to new research.

Diagnosis of radiation recall hampered by delayed occurrence

Diagnosis of radiation recall hampered by delayed occurrence

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Although uncommon, this side effect of radiation with adjuvant drug therapy is unpredictable, sometimes delayed, and can occur with administration of antibiotics and other drugs as well as chemotherapy.

Protocols for concomitant infusions in the same IV line

Protocols for concomitant infusions in the same IV line

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What is the protocol for using the same intravenous line for concomitant infusions of IV chemotherapy drugs with other IV medications?

Metal implants may reduce chemotherapy side effects

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The chemical composition of commonly used chemotherapy drugs can be altered so that they only become active when they come into contact with palladium, and cancer patients could one day experience fewer side effects from chemotherapy since this discovery opens the door for more targeted treatments.

Delivery order in IV/IP chemotherapy administration

Delivery order in IV/IP chemotherapy administration

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Oncology nurses are taught to always administer platinums before taxanes for IV chemotherapy regimens; does this still hold true when the taxane is ordered IV, and the platinum is ordered IP?

Adding chemotherapy after radiation improves survival for adults with low-grade gliomas

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Receiving a chemotherapy regimen following the completion of radiation therapy resulted in longer survival in adults with low-grade gliomas compared with those who received radiation therapy alone.

'Weeding the garden' technique extends effectiveness of crizotinib for NSCLC

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Patients taking crizotinib for ALK-positive non-small cell lung cancer may safely and durably use up to three courses of targeted radiation therapy to eradicate pockets of drug-resistant disease.

Using methotrexate in children

Using methotrexate in children

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Why do children with Down syndrome who are being treated for acute lymphocytic leukemia sometimes require oral leucovorin after intrathecal methotrexate administration?

Chemotherapy after radiation does not improve survival of rectal cancer

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Long-term results of an EORTC trial show that 5- fluorouracil (FU)-based adjuvant chemotherapy after preoperative chemoradiotherapy for patients with cT3-resectable T4 M0 rectal cancer does not improve survival or disease-free survival.

Doxorubicin cardiotoxicity is associated with mitochondria-accumulating iron

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Doxorubicin accumulates within the mitochondria of cardiomyocytes and this accumulation promotes mitochondrial production of reactive oxygen species (ROS) and the accumulation of iron.

Nanoparticles deliver one-two punch to targeted areas of cancer cells

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Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and then delivers those drugs to separate parts of the cancer cell where they will be most effective.

High-dose cytarabine improves outcomes in acute myeloid leukemia

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High-dose cytarabine in induction treatment improves the outcomes of adult patients with acute myeloid leukemia (AML).

Surgery beats chemotherapy for tongue cancer

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Patients with tongue cancer who started their treatment with a course of chemotherapy fared significantly worse than patients who received surgery first, according to a new study.

Anti-CD20 antibody plus chemo aids CLL with comorbidity

Anti-CD20 antibody plus chemo aids CLL with comorbidity

For patients with previously untreated chronic lymphocytic leukemia and coexisting conditions, combining an anti-CD20 antibody with chemotherapy is associated with improved outcomes, according to a study.

Surgery and radiation after chemotherapy not beneficial for patients with metastatic breast cancer

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After a response to initial chemotherapy, treatment with radiotherapy and surgical removal of the breast tumor and nearby lymph nodes do not provide any additional benefit to patients with metastatic breast cancer.

Highly effective treatment options identified for HER2-positive breast cancer

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Combining the chemotherapy drugs docetaxel and carboplatin with the HER2-targeted therapy trastuzumab was identified to be an ideal postsurgery treatment option for patients with HER2-positive breast cancer.

PIK3CA gene mutations make some breast cancers resistant to treatment

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Women with breast cancer characterized by high levels of the protein HER2 and hormone receptors gained much less benefit from presurgery treatment with chemotherapy and HER2-targeted therapies if their cancer had one or more mutations in the PIK3CA gene. These results were presented at the 2013 San Antonio Breast Cancer Symposium.

Adding carboplatin to chemotherapy is promising for triple-negative breast cancer

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In a study of women with triple-negative breast cancer, adding carboplatin or Avastin to standard chemotherapy drugs brought a sharp increase in the number of patients whose tumors shrank away completely. This was reported at the 2013 San Antonio Breast Cancer Symposium.

New presurgery combination therapy promising for triple-negative breast cancer

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I-SPY 2 has yielded positive results with the first drug to complete testing during the trial. Adding carboplatin and veliparib to standard presurgery chemotherapy improved outcomes for women with triple-negative breast cancer, according to results presented at the 2013 San Antonio Breast Cancer Symposium.

Changing chemotherapy not beneficial for metastatic breast cancer with elevated CTCs

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For women with metastatic breast cancer who had elevated amounts of CTCs in their blood after a first line of chemotherapy, switching immediately to a different chemotherapy did not improve overall survival or time to progression. These phase 3 clinical trial results were presented at the 2013 San Antonio Breast Cancer Symposium.

Targeted treatment reduces relapse in children with AML

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Combining the monoclonal antibody gemtuzumab with standard chemotherapy significantly reduced the risk of relapse and increased rates of disease-free survival in pediatric patients with AML. Posttreatment relapse rates are a major indicator of potential for long-term survival in children with the disease.

Understanding current and emerging therapies for HNC

Understanding current and emerging therapies for HNC

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Head and neck cancer treatments have high morbidity rates. Newer options reduce morbidities and offer patients better quality of life after treatment.

Chemotherapy drug shortages common to oncologists

Chemotherapy drug shortages common to oncologists

More than 80 percent of oncologists report being unable to prescribe preferred drug at least once in past six months.

Less painful drug delivery is safe and effective for pediatric leukemia patients

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Children with acute lymphoblastic leukemia (ALL), the most common form of pediatric cancer, can safely receive intravenous infusions of a reformulated mainstay of chemotherapy that has been delivered via painful IM injection for more than 40 years, research suggests.

SABCS: Chemo combo aids triple-negative breast cancer

SABCS: Chemo combo aids triple-negative breast cancer

Two studies show increase in pathologic complete response with pre-op chemotherapy combinations.

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