Chemotherapy

Nivolumab Provides Better Long-Term Efficacy Compared With Docetaxel in NSCLC

Nivolumab Provides Better Long-Term Efficacy Compared With Docetaxel in NSCLC

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Two phase 3 studies reveal the clinical benefit, safety profile, and overall survival of nivolumab and docetaxel for patients with squamous and nonsquamous NSCLC.

Pursuing Aggressive Treatment Impacts Breast Cancer Patients' Employment

Pursuing Aggressive Treatment Impacts Breast Cancer Patients' Employment

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Investigators surveyed more than 3000 patients with breast cancer and found that disruptions to employment and work stoppage were greater in those who underwent more aggressive treatment options.

Nurse Survey Identifies Adverse Events Related to Handling Chemotherapy

Nurse Survey Identifies Adverse Events Related to Handling Chemotherapy

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Using a 4-question survey, investigators determined oncology nurses' perception of their risks in handling and administering cytotoxic chemotherapy to patients.

Radiation Prior to Chemotherapy Prolongs Progression-Free Survival in NSCLC

Radiation Prior to Chemotherapy Prolongs Progression-Free Survival in NSCLC

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Researchers present findings of a phase 2 study that compared PFS when SBRT is administered prior to maintenance chemotherapy in patients with limited metastatic NSCLC vs chemotherapy alone. Data was presented at ASTRO 59th Annual Meeting.

Progression-Free Survival in CLL Prolonged With Maintenance Lenalidomide

Progression-Free Survival in CLL Prolonged With Maintenance Lenalidomide

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Lenalidomide reduced the relative risk of disease progression in a clinical trial of patients with chronic lymphocytic leukemia who did not achieve MRD negative disease state after first-line chemoimmunotherapy.

Progression-Free, Overall Survival in Liposarcoma Improved With Eribulin vs Dacarbazine

Progression-Free, Overall Survival in Liposarcoma Improved With Eribulin vs Dacarbazine

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Comparison study shows significantly improved overall survival and progression-free survival in patients with advanced LPS treated with eribulin vs dacarbazine.

Frozen Gloves Reduced Chemotherapy-Induced PN, Improved Quality of Life

Frozen Gloves Reduced Chemotherapy-Induced PN, Improved Quality of Life

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Quality of life for patients with CIPN was improved by wearing frozen gloves during treatment. Researchers reported in an oral presentation at ESMO 2017 Congress that the gloves reduced symptoms even though long-term differences in neuropathy were not observed.

Daratumumab Infusion-Related Reactions Managed by Pre/Postinfusion Medications

Daratumumab Infusion-Related Reactions Managed by Pre/Postinfusion Medications

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Patients with multiple myeloma treated with daratumumab who experience IRRs may easily be managed by administering pre-infusion and postinfusion medications, investigators reported in a presentation at ESMO 2017 Congress.

Niraparib Maintains Quality of Life in Recurrent Ovarian Cancer

Niraparib Maintains Quality of Life in Recurrent Ovarian Cancer

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Administering niraparib to patients with recurrent ovarian cancer after CR or PR to platinum-based chemotherapy may allow patients to continuously maintain QOL during treatment, reported researchers in presentation at ESMO 2017 Congress.

Carfilzomib Improves Overall Survival in Relapsed/Refractory Multiple Myeloma

Carfilzomib Improves Overall Survival in Relapsed/Refractory Multiple Myeloma

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The first interim analysis of the ENDEAVOR trial reported superiority of carfilzomib in some outcomes; however, data on overall survival were not available. This second interim analysis reports on overall survival with carfilzomib for patients with relapsed/refractory multiple myeloma.

Breast Conservation Improves Survival vs Mastectomy in Breast Cancer

Breast Conservation Improves Survival vs Mastectomy in Breast Cancer

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Results of a recent study demonstrated overall survival was better among women who underwent breast-conserving surgery vs mastectomy. Furthermore, best overall survival was achieved with adjuvant radiotherapy in the former group and systemic therapy in the latter group.

Value of Type and Crossmatch Prior to Daratumumab Administration

Value of Type and Crossmatch Prior to Daratumumab Administration

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If type and crossmatch is obtained before initiating treatment with daratumumab, what good would that do if a transfusion is required a month later?

Induction Regimens for Untreated Multiple Myeloma Compared for ORR, OS, PFS

Induction Regimens for Untreated Multiple Myeloma Compared for ORR, OS, PFS

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Comparison study demonstrates early response and survival benefits of VTD, VTDC, and TAD regimens in transplant-eligible patients with newly diagnosed multiple myeloma.

Palonosetron Prevents Delayed Nausea and Vomiting After CHOP in Non-Hodgkin Lymphoma

Palonosetron Prevents Delayed Nausea and Vomiting After CHOP in Non-Hodgkin Lymphoma

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Palonosetron effectively prevents and manages delayed CINV in patients with non-Hodgkin lymphoma.

ASCO Updates Guidelines for Antiemetic Therapy in Adult, Pediatric Patients Receiving Chemotherapy

ASCO Updates Guidelines for Antiemetic Therapy in Adult, Pediatric Patients Receiving Chemotherapy

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The American Society of Clinical Oncology (ASCO) convened a panel of experts to update its clinical guidelines for antiemetic therapy in patients receiving chemotherapy. A notable change is the addition of olanzapine in emetic regimens for adult patients.

Decitabine Improves Overall Survival, Overall Response Rate in Chronic Myelomonocytic Leukemia

Decitabine Improves Overall Survival, Overall Response Rate in Chronic Myelomonocytic Leukemia

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Patients with high-risk chronic myelomonocytic leukemia (CMML), a MDS/myeloproliferative neoplasm, may experience prolonged overall survival and increased overall response rate from treatment with decitabine.

Cabazitaxel Does Not Prolong Overall Survival vs Docetaxel in Metastatic Prostate Cancer

Cabazitaxel Does Not Prolong Overall Survival vs Docetaxel in Metastatic Prostate Cancer

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Cabazitaxel does not prolong OS in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer compared with the first-line chemotherapy agent docetaxel.

Chemotherapy-associated Paronychia Treated With 2% Povidone-iodine: A Series of Cases

Chemotherapy-associated Paronychia Treated With 2% Povidone-iodine: A Series of Cases

[Cancer Management and Research] This research examines cases of chemotherapy-induced nail changes in individuals treated with taxanes and EGFR inhibitors.

Oropharyngeal Mucositis Pain Effectively Relieved With Indomethacin Oral Spray

Oropharyngeal Mucositis Pain Effectively Relieved With Indomethacin Oral Spray

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Indomethacin oral spray (IM-OS) is proven to be a safe and effective treatment for oropharyngeal mucositis pain in patients with cancer.

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

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In this review, investigators discuss current and emerging treatments for acute lymphocytic leukemia and acute myeloid leukemia in pediatric patients.

Dexamethasone-Induced Hiccups in Chemotherapy May be Prevented by Rotating to Methylprednisolone

Dexamethasone-Induced Hiccups in Chemotherapy May be Prevented by Rotating to Methylprednisolone

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Rotating dexamethasone and methylprednisolone can help to alleviate dexamethasone-induced hiccups (DIH) without the loss of antiemetic effects in patients undergoing chemotherapy.

FDA Expands Clearance for Cooling Cap Use With Chemotherapy for Solid Tumors

FDA Expands Clearance for Cooling Cap Use With Chemotherapy for Solid Tumors

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The US FDA has granted expanded clearance for the DigniCap Cooling System to include use in patients undergoing chemotherapy for solid tumors in other areas of the body besides the breast.

Recommendations for Vaccine Administration During Chemotherapy

Recommendations for Vaccine Administration During Chemotherapy

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Which vaccines should be avoided in patients receiving chemotherapy?

Midostaurin Improves Survival in Acute Myeloid Leukemia With FLT3 Mutation

Midostaurin Improves Survival in Acute Myeloid Leukemia With FLT3 Mutation

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Adding midostaurin, a multitargeted kinase inhibitor, to standard chemotherapy provides significant survival benefit for patients with AML and a FLT3 mutation.

QOL, Adverse Effects Better With Capecitabine After Adjuvant Epirubicin for Breast Cancer

QOL, Adverse Effects Better With Capecitabine After Adjuvant Epirubicin for Breast Cancer

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Women with breast cancer who received capecitabine after adjuvant epirubicin had better quality of life (QOL) compared with those who received CMF after adjuvant therapy.

Taxane-based Chemotherapy May Diminish Balance, Gait in Breast Cancer Survivors

Taxane-based Chemotherapy May Diminish Balance, Gait in Breast Cancer Survivors

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Breast cancer survivors who received taxane-based chemotherapy for their disease are at increased risk for falls due to CIPN and treatment-associated effects on balance and gait.

Wait Times From Cancer Diagnosis to First Treatment Longer, Negative Impact on Survival

Wait Times From Cancer Diagnosis to First Treatment Longer, Negative Impact on Survival

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Data from the National Cancer Database are indicating that wait times from cancer diagnosis to initial treatment were substantially longer over a 5-year period.

Pembrolizumab Use With CRT Safe in Locally Advanced HNSCC

Pembrolizumab Use With CRT Safe in Locally Advanced HNSCC

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Small study also showed that pembrolizumab does not significant impair radiation or chemotherapy dosing.

Ovarian Function Recovery May Increase Risk of Breast Cancer Recurrence

Ovarian Function Recovery May Increase Risk of Breast Cancer Recurrence

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Ovarian function recovery (OFR) in women with chemotherapy-induced ovarian function failure decreases residual 5-year disease-free and overall survival.

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

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Five-year survival rate found similar to observation despite a significant improvement in disease-free interval.

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