Chemotherapy

Breast Conservation Improves Survival vs Mastectomy in Breast Cancer

Breast Conservation Improves Survival vs Mastectomy in Breast Cancer

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Results of a recent study demonstrated overall survival was better among women who underwent breast-conserving surgery vs mastectomy. Furthermore, best overall survival was achieved with adjuvant radiotherapy in the former group and systemic therapy in the latter group.

Value of Type and Crossmatch Prior to Daratumumab Administration

Value of Type and Crossmatch Prior to Daratumumab Administration

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If type and crossmatch is obtained before initiating treatment with daratumumab, what good would that do if a transfusion is required a month later?

Induction Regimens for Untreated Multiple Myeloma Compared for ORR, OS, PFS

Induction Regimens for Untreated Multiple Myeloma Compared for ORR, OS, PFS

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Comparison study demonstrates early response and survival benefits of VTD, VTDC, and TAD regimens in transplant-eligible patients with newly diagnosed multiple myeloma.

Palonosetron Prevents Delayed Nausea and Vomiting After CHOP in Non-Hodgkin Lymphoma

Palonosetron Prevents Delayed Nausea and Vomiting After CHOP in Non-Hodgkin Lymphoma

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Palonosetron effectively prevents and manages delayed CINV in patients with non-Hodgkin lymphoma.

ASCO Updates Guidelines for Antiemetic Therapy in Adult, Pediatric Patients Receiving Chemotherapy

ASCO Updates Guidelines for Antiemetic Therapy in Adult, Pediatric Patients Receiving Chemotherapy

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The American Society of Clinical Oncology (ASCO) convened a panel of experts to update its clinical guidelines for antiemetic therapy in patients receiving chemotherapy. A notable change is the addition of olanzapine in emetic regimens for adult patients.

Decitabine Improves Overall Survival, Overall Response Rate in Chronic Myelomonocytic Leukemia

Decitabine Improves Overall Survival, Overall Response Rate in Chronic Myelomonocytic Leukemia

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Patients with high-risk chronic myelomonocytic leukemia (CMML), a MDS/myeloproliferative neoplasm, may experience prolonged overall survival and increased overall response rate from treatment with decitabine.

Cabazitaxel Does Not Prolong Overall Survival vs Docetaxel in Metastatic Prostate Cancer

Cabazitaxel Does Not Prolong Overall Survival vs Docetaxel in Metastatic Prostate Cancer

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Cabazitaxel does not prolong OS in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer compared with the first-line chemotherapy agent docetaxel.

Chemotherapy-associated Paronychia Treated With 2% Povidone-iodine: A Series of Cases

Chemotherapy-associated Paronychia Treated With 2% Povidone-iodine: A Series of Cases

[Cancer Management and Research] This research examines cases of chemotherapy-induced nail changes in individuals treated with taxanes and EGFR inhibitors.

Oropharyngeal Mucositis Pain Effectively Relieved With Indomethacin Oral Spray

Oropharyngeal Mucositis Pain Effectively Relieved With Indomethacin Oral Spray

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Indomethacin oral spray (IM-OS) is proven to be a safe and effective treatment for oropharyngeal mucositis pain in patients with cancer.

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

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In this review, investigators discuss current and emerging treatments for acute lymphocytic leukemia and acute myeloid leukemia in pediatric patients.

Dexamethasone-Induced Hiccups in Chemotherapy May be Prevented by Rotating to Methylprednisolone

Dexamethasone-Induced Hiccups in Chemotherapy May be Prevented by Rotating to Methylprednisolone

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Rotating dexamethasone and methylprednisolone can help to alleviate dexamethasone-induced hiccups (DIH) without the loss of antiemetic effects in patients undergoing chemotherapy.

FDA Expands Clearance for Cooling Cap Use With Chemotherapy for Solid Tumors

FDA Expands Clearance for Cooling Cap Use With Chemotherapy for Solid Tumors

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The US FDA has granted expanded clearance for the DigniCap Cooling System to include use in patients undergoing chemotherapy for solid tumors in other areas of the body besides the breast.

Recommendations for Vaccine Administration During Chemotherapy

Recommendations for Vaccine Administration During Chemotherapy

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Which vaccines should be avoided in patients receiving chemotherapy?

Midostaurin Improves Survival in Acute Myeloid Leukemia With FLT3 Mutation

Midostaurin Improves Survival in Acute Myeloid Leukemia With FLT3 Mutation

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Adding midostaurin, a multitargeted kinase inhibitor, to standard chemotherapy provides significant survival benefit for patients with AML and a FLT3 mutation.

QOL, Adverse Effects Better With Capecitabine After Adjuvant Epirubicin for Breast Cancer

QOL, Adverse Effects Better With Capecitabine After Adjuvant Epirubicin for Breast Cancer

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Women with breast cancer who received capecitabine after adjuvant epirubicin had better quality of life (QOL) compared with those who received CMF after adjuvant therapy.

Taxane-based Chemotherapy May Diminish Balance, Gait in Breast Cancer Survivors

Taxane-based Chemotherapy May Diminish Balance, Gait in Breast Cancer Survivors

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Breast cancer survivors who received taxane-based chemotherapy for their disease are at increased risk for falls due to CIPN and treatment-associated effects on balance and gait.

Wait Times From Cancer Diagnosis to First Treatment Longer, Negative Impact on Survival

Wait Times From Cancer Diagnosis to First Treatment Longer, Negative Impact on Survival

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Data from the National Cancer Database are indicating that wait times from cancer diagnosis to initial treatment were substantially longer over a 5-year period.

Pembrolizumab Use With CRT Safe in Locally Advanced HNSCC

Pembrolizumab Use With CRT Safe in Locally Advanced HNSCC

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Small study also showed that pembrolizumab does not significant impair radiation or chemotherapy dosing.

Ovarian Function Recovery May Increase Risk of Breast Cancer Recurrence

Ovarian Function Recovery May Increase Risk of Breast Cancer Recurrence

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Ovarian function recovery (OFR) in women with chemotherapy-induced ovarian function failure decreases residual 5-year disease-free and overall survival.

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

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Five-year survival rate found similar to observation despite a significant improvement in disease-free interval.

Lanreotide Eases Carcinoid Syndrome Symptoms in All Patients

Lanreotide Eases Carcinoid Syndrome Symptoms in All Patients

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Lanreotide decreased the proportion of days patients had flushing and diarrhea compared with placebo, even in patients previously responsive to rescue therapy with octreotide.

Mobile App May Improve Oral Chemotherapy Adherence

Mobile App May Improve Oral Chemotherapy Adherence

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Patients with adherence problems were more likely to take their pills compared with those who received standard care.

ESW Technique Improves Nanoparticle Drug Delivery to Solid Tumors with Restricted Blood Flow

ESW Technique Improves Nanoparticle Drug Delivery to Solid Tumors with Restricted Blood Flow

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Combining extracorporeal shock wave (ESW) technique with nanoparticle delivery improves treatment of difficult-to-treat solid tumors, such as anaplastic thyroid cancer.

Risk of Bladder Recurrence Reduced With Chemotherapy Flush After Tumor Resection

Risk of Bladder Recurrence Reduced With Chemotherapy Flush After Tumor Resection

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Flushing the bladder with a chemotherapeutic agent after tumor resection significantly reduced recurrence rates of bladder cancer.

No Improvement in KRAS-Mutation Lung Cancer With MEK Inhibitor Plus Chemotherapy

No Improvement in KRAS-Mutation Lung Cancer With MEK Inhibitor Plus Chemotherapy

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A combination treatment of mitogen-activated protein kinase MEK inhibitor and chemotherapy did not improve progression-free survival in patients with advanced lung cancer caused by a KRAS gene mutation.

Significant Reductions in CLABSIs Achieved With Daily Chlorhexidine Bathing in Oncology Population

Significant Reductions in CLABSIs Achieved With Daily Chlorhexidine Bathing in Oncology Population

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Daily CHG bathing can safely reduce CLABSIs in oncology patients with central lines, with small variations in efficacy of the practice due to differences in patient population, work processes, and team engagement.

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

Cisplatin Plus Standard-of-Care Regimen Reduced Tumors in Advanced Pancreatic Cancer

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Cisplatin plus standard-of-care gemcitabine/nab-paclitaxel improved tumor shrinkage in patients with metastatic pancreatic cancer, according to a study by the HonorHealth Research Institute and the Translational Genomics Research Institute.

Research Shows Temozolomide Has Potential to Increase Depression

Research Shows Temozolomide Has Potential to Increase Depression

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Temozolomide, an antimitotic chemotherapy used to treat brain cancer, demonstrated the potential to increase depression in a mouse model.

Standardized Assessment Tool Prevents Chemotherapy-Induced Neurotoxicity

Standardized Assessment Tool Prevents Chemotherapy-Induced Neurotoxicity

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Standardized tool improved efficiency and thoroughness of patient assessment and documentation of neurotoxicity caused by high-dose cytarabine.

Education and Coaching Are Necessary to Treat Oropharyngeal Cancers After Chemoradiotherapy

Education and Coaching Are Necessary to Treat Oropharyngeal Cancers After Chemoradiotherapy

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A literature review noted improvements in quality of life after patients were coached and educated following radiotherapy for HPV-associated oropharyngeal cancers.

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