Chemotherapy

Role of Chemotherapy and Mechanisms of Resistance to Chemotherapy in Metastatic Castration-Resistant Prostate Cancer

Role of Chemotherapy and Mechanisms of Resistance to Chemotherapy in Metastatic Castration-Resistant Prostate Cancer

[Clinical Medicine Insights: Oncology] This research examines the various mechanisms of resistance to chemotherapy in metastatic CRPC and the potential role of emerging regimens and agents in varying clinical phases of development.

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

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The benefits of primary cytoreductive surgery relative to neoadjuvant chemotherapy remain uncertain; therefore, researchers performed a retrospective data analysis to compare overall survival of surgery with that of neoadjuvant chemotherapy in advanced-stage epithelial ovarian cancer.

'Just Bag It' Campaign Aims to Promote Safe Vincristine Handling

'Just Bag It' Campaign Aims to Promote Safe Vincristine Handling

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The NCCN campaign was developed to ensure the proper administration of vincristine and to render it impossible to accidentally administer the medication into the spinal fluid.

How We Developed a New Protocol for Treatment of Urethral Carcinoma

How We Developed a New Protocol for Treatment of Urethral Carcinoma

Faced with a harsh treatment option, a patient with genitourinary cancer helps create a treatment plan that preserves his self-image.

PD-1 Inhibitors Ideal for First-Line Therapy in Treatment-Naïve Advanced Melanoma

PD-1 Inhibitors Ideal for First-Line Therapy in Treatment-Naïve Advanced Melanoma

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Atlhough survival for patients with advanced melanoma is similar with both targeted therapies and immunotherapies, a review of the literature reveals why one of them may be a better choice as first-line therapy.

First-line Pembrolizumab + Chemo Could Be Effective for Non-squamous NSCLC

First-line Pembrolizumab + Chemo Could Be Effective for Non-squamous NSCLC

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The addition of pembrolizumab to carboplatin and pemetrexed improves overall response rate compared with chemotherapy alone and has a manageable safety profile in patients with newly diagnosed advanced nonsquamous NSCLC.

GERD Medications May Affect Absorption of Oral Chemotherapeutic Agents

GERD Medications May Affect Absorption of Oral Chemotherapeutic Agents

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What is the interaction between oral chemotherapy and GERD medicines?

Low-dose Dexamethasone Premedication May Be Preferred for Weekly Docetaxel Regimens

Low-dose Dexamethasone Premedication May Be Preferred for Weekly Docetaxel Regimens

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Low-dose dexamethasone may be preferred as a premedication protocol for patients receiving weekly docetaxel regimens due a significantly lower risk of infection compared with a higher dose regimen.

Pregnancy Screening Inconsistent in Female Adolescents Before Chemotherapy Exposure

Pregnancy Screening Inconsistent in Female Adolescents Before Chemotherapy Exposure

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Pregnancy screening rates before teratogenic exposures are low for female adolescent patients with acute leukemia and those with ER visits including abdominal/pelvic CT.

Neoadjuvant Chemotherapy Use on the Rise in Ovarian Cancer Treatment

Neoadjuvant Chemotherapy Use on the Rise in Ovarian Cancer Treatment

NeoadjuvantcChemotherapy (NACT) use went up from 2003 to 2012; linked to shorter overall survival in stage IIIC but not stage IV disease.

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

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Dexrazoxane has cardioprotective properties that can prevent long-term cardiotoxicity in pediatric patients receiving chemotherapy, according to a review of the medical literature on cardiotoxic effects of anthracycline treatment.

Chemotherapy-Induced Dormancy Improves Immunotherapy for Breast Cancer

Chemotherapy-Induced Dormancy Improves Immunotherapy for Breast Cancer

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Inducing quiescent dormancy with conventional chemotherapy makes cancer cells more susceptible to immunotherapy, thereby minimizing potential for tumor recurrence.

Adding Vandetanib to Platinum + Etoposide Not Effective for SCLC

Adding Vandetanib to Platinum + Etoposide Not Effective for SCLC

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The addition of vandetanib to a platinum agent and etoposide did not improve time to progression or overall survival in patients with newly diagnosed extensive-stage SCLC.

Recently Discovered microRNA Controls Response to Oxaliplatin in Colorectal Cancer

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Danish researchers identified a microRNA shown to predict whether a patient with colorectal cancer would be resistant to oxaliplatin treatment, a discovery that holds promise of improving both current treatment options and development of future treatment strategies.

Addition of Elotuzumab to Bortezomib/Dexamethasone Improves Survival in Relapsed/Refractory Multiple Myeloma

Addition of Elotuzumab to Bortezomib/Dexamethasone Improves Survival in Relapsed/Refractory Multiple Myeloma

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The addition of elotuzumab to bortezomib/dexamethasone appears to increase progression-free survival in relapsed/refractory multiple myeloma (RRMM).

Managing Toxicity Risks of Dose-Dense Chemotherapy in the Obese

Managing Toxicity Risks of Dose-Dense Chemotherapy in the Obese

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Risks for severe toxicities in obese patients receiving dose-dense chemotherapy are associated with measures used to determine dose, according to a retrospective evaluation of select participants in the GAIN study.

Hyper-CVAD + Ponatinib May Be Superior to Hyper-CVAD + Dasatinib in Ph+ ALL

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Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) plus ponatinib appears to be superior to hyper-CVAD plus dasatinib for the frontline treatment of patients with Philadelphia chromosome-positive ALL.

Administering Mannitol With Hydration and Premeds

Administering Mannitol With Hydration and Premeds

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At my current clinic, hydration and mannitol are administered before premedications on a cisplatin regimen; at previous clinic, premeds and hydration were administered before mannitol. Does it make a difference?

Cognitive Impairment Common With Adjuvant Therapy in Older Patients With Early Stage Breast Cancer

Cognitive Impairment Common With Adjuvant Therapy in Older Patients With Early Stage Breast Cancer

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Cognitive decline associated with adjuvant chemotherapy was more likely to occur in older patients, particularly those whose treatment included docetaxel.

Factors That Determine Sequence of Administration for Multiple Chemotherapeutic Agents

Factors That Determine Sequence of Administration for Multiple Chemotherapeutic Agents

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Chemotherapy agents are sometimes required to be administered in a specific sequence. What factors influence the need to follow a specific sequence?

Mimicking Fasting During Chemotherapy Enhances T Cell Activity in Preclinical Study

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Fasting during chemotherapy treatment may increase the presence of cancer-killing T cells, according to recent study data.

Understanding a Molecular Switch Modulating Tumor Metastasis and Chemotherapy Resistance

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Dab2 is an endocytic adaptor and tumor suppressor whose expression occurs during the epithelial-mesenchymal transition, which is mediated by TGF-beta. This study sought to understand how Dab2 regulates apoptosis.

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

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Telomere length is predictive for determining which children treated for AML are at highest risk for delayed recovery, a finding that may have significant implications for treatment-related morbidity and mortality.

Tango Dancing Improves Balance and Fall Risk in Cancer Patients With Peripheral Neuropathy

Tango Dancing Improves Balance and Fall Risk in Cancer Patients With Peripheral Neuropathy

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Balanced is improved and fall risk is reduced among cancer patients with peripheral neuropathy who participated in Argentine tango dancing as a form of therapy.

Triplet Regimen Followed by Maintenance Active in Triple-negative Breast Cancer

Triplet Regimen Followed by Maintenance Active in Triple-negative Breast Cancer

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A first-line triplet chemoimmunotherapy regimen comprised of paclitaxel, capecitabine, and bevacizumab followed by capecitabine and bevacizumab alone as maintenance therapy is highly active with a manageable safety profile in patients with triple-negative breast cancer.

PET-CT Can Inform Decision to Omit Bleomycin in Hodgkin Lymphoma Treatment to Reduce Toxicity

PET-CT Can Inform Decision to Omit Bleomycin in Hodgkin Lymphoma Treatment to Reduce Toxicity

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Omitting bleomycin from the treatment regimen for Hodgkin lymphoma in patients with negative findings on an interim PET scan led to a lower incidence of pulmonary toxic effects without significantly lowering treatment efficacy.

Flushing the Line Between Medications in IV Administrations of Multiple Agents

Flushing the Line Between Medications in IV Administrations of Multiple Agents

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What factors should be considered when calculating an adequate postmedication flush to deliver complete, accurate doses of small-volume IV medications to our patients?

Novel Nanoparticle Achieves Concomitant Tumor Cell Death and Resistance Suppression

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Resistance to therapy through adaptation poses a major hurdle for cancer therapy. Bioengineers addressed this by creating a single nanoparticle that comprises a synergistic drug pair that shuts down mechanisms of resistance to a degree that has not been previously achieved.

Chemotherapy Boosts Effectiveness of Immunotherapy in the Treatment of Ovarian Cancer

Chemotherapy Boosts Effectiveness of Immunotherapy in the Treatment of Ovarian Cancer

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Immunotherapy for advanced ovarian cancer more effectively treats tumors when administered immediately after chemotherapy. Sequential chemoimmunotherapy could improve disease control in stage IIIC/IV tubo-ovarian HGSC.

Assessment and Monitoring of Patients Receiving Chemotherapy for Multiple Myeloma: Strategies to Improve Outcomes

Assessment and Monitoring of Patients Receiving Chemotherapy for Multiple Myeloma: Strategies to Improve Outcomes

[Blood and Lymphatic Cancer: Targets and Therapy] This research reviews updates in the diagnosis and management of multiple myeloma, and provides for assessment and monitoring strategies for patients receiving chemotherapy for multiple myeloma.

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