Chemotherapy

Central Venous Catheter Self-management Education Program Effective

Central Venous Catheter Self-management Education Program Effective

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A central venous catheter self-management education program is an effective nursing intervention to promote long-term self-management of a CVC for discharged patients with cancer.

Daily Chlorhexidine Gluconate Bathing Reduces CLABSI Rates

Daily Chlorhexidine Gluconate Bathing Reduces CLABSI Rates

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Daily chlorhexidine gluconate bathing on all patients with ports and tunneled catheters decreased the rates of CLABSI on an inpatient oncology unit.

Hygiene Practice Interventions Reduced CLABSI on an Inpatient Oncology Unit

Hygiene Practice Interventions Reduced CLABSI on an Inpatient Oncology Unit

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Formation of a multidisciplinary team and a focus on evidence-based interventions successfully reduced the rate of central line bloodstream infections (CLABSI) on an inpatient oncology unit.

PICC Claiming Antithrombogenic, Antimicrobial Properties Failed to Reduce Thromboses, Line Dysfunction

PICC Claiming Antithrombogenic, Antimicrobial Properties Failed to Reduce Thromboses, Line Dysfunction

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A PICC with preclinical data claiming antithrombogenic and antimicrobial properties failed to reduce the rate of CLABSI or catheter-related thromboses compared with a standard PICC.

Simulation-based Learning Improves Confidence, Competency in Treatment Administration

Simulation-based Learning Improves Confidence, Competency in Treatment Administration

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Simulation-based learning improved the confidence and skills of oncology nurses in chemotherapy-biotherapy administration.

Immune-stimulating Drug and Chemotherapy Show Early Promise for Pancreatic Cancer

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An experimental therapy looks to hold promise for tumor control treatment in pancreatic adenocarcinoma.

Patient Satisfaction Improves With Nurse-led Response to Patient Feedback

Patient Satisfaction Improves With Nurse-led Response to Patient Feedback

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A nurse-directed independent survey for patient feedback can inform measurable improvements in patient education and satisfaction survey scores.

Targeted Therapy Enhances Chemotherapy, Improves Outcomes in Retinoblastoma

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The effectiveness of chemotherapy was enhanced by targeting survivin, a protein that inhibits apoptosis or cell death, according to preclinical research in cells and mouse models of retinoblastoma.

Early Study Results Show Guadecitabine Effective for Metastatic Colorectal Cancer

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A small, phase I clinical trial indicates the experimental drug guadecitabine is safe in combination with the chemotherapy drug irinotecan, and it may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

Research Identifies Underlying Mechanism of Chemotherapy-Induced Peripheral Neuropathy

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A previously unidentified avenue exists for potential therapies for peripheral neuropathy induced by the chemotherapeutic agent paclitaxel.

Anthracycline Chemotherapy Not Associated With Cognitive Decline

Anthracycline Chemotherapy Not Associated With Cognitive Decline

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Anthracycline chemotherapy, such as doxorubicin and daunorubicin, is not associated with lasting cognitive decline among breast cancer survivors.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

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The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

Breast Cancer Therapy and Cardiotoxicity Risk in Older Women

Breast Cancer Therapy and Cardiotoxicity Risk in Older Women

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A study examined the relation between various forms of breast cancer therapies and risk of congestive heart failure.

Adding Aflibercept to First-line mFOLFOX6 Does Not Improve PFS in mCRC

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Adding aflibercept to first-line mFOLFOX6 did not improve progression-free survival compared with mFOLFOX6 alone in patients with mCRC, and the combination was associated with higher toxicity.

Progression-free and Overall Survival Better With Mutations Affecting DNA Repair Genes in Ovarian Cancer

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Women with advanced ovarian cancer who had mutations affecting DNA repair genes had longer progression-free and overall survival than women without the mutations.

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

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A multigene test can identify patients with early stage breast cancer who do not need chemotherapy and who will be alive 5 years after diagnosis.

Anxiety and Depressive Symptoms Are Increased in Pediatric Survivors of Acute Lymphoblastic Leukemia

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Emotional distress during and after undergoing chemotherapy for ALL affects a significant percentage of children with the disease.

Advice for Patients With CML Traveling While On Oral Chemotherapy

Advice for Patients With CML Traveling While On Oral Chemotherapy

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As summer approaches, many patients with CML who are taking oral chemotherapy drugs have questions about taking their drugs while traveling. What advice can we give them regarding this?

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

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Use and clinical implications of a test commonly used to predict the aggressiveness of early stage ER-positive breast cancer is influenced by patient's race, insurance, and type of facility.

Neurofeedback Training Enables Cancer Survivors to Control Chemotherapy-Induced Peripheral Neuropathy

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Chronic pain was decreased and quality of life was increased through neurofeedback.

Presurgical Treatment in HER2-positive Breast Cancer Achieves Significant Reduction in Disease

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Treatment with lapatinib and trastuzumab before surgery and chemotherapy led to significant shrinkage or disappearance of the tumors in approximately 25% of women with HER2-positive breast cancer.

Survival Improved for Premenopausal Breast Cancer Patients Through Dose-Dense Chemo

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Dose-dense adjuvant chemotherapy (every 2 weeks) offers improved survival without increasing the risk of treatment-induced early menopause compared with the standard interval (every 3 weeks) chemotherapy for premenopausal women with breast cancer.

Expression Levels of SMARCA4/BRG1 Gene Indicates Response to Chemotherapy

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Significant sensitivity to cisplatin-based chemotherapy is signaled by the presence of low expression of SMARCA4/BRG1 in patients with earlier-stage NSCLC. Low expression of SMARCA4/BRG1 was also linked to a poor prognosis.

Temsirolimus Effective as Salvage Treatment in Patients With Relapsed/Refractory PCNSL

Temsirolimus Effective as Salvage Treatment in Patients With Relapsed/Refractory PCNSL

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A weekly dose of temsirolimus 75 mg was found to be active in patients with relapsed/refractory primary CNS lymphoma (PCNSL); however, only some patients achieved long-term control.

Novel Approach Harnesses Dendritic Cells to Treat Glioma

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A next-generation immunotherapy may offer hope for treating high-grade glioma, an aggressive form of brain cancer that is notoriously hard to treat.

Radiotherapy/Histone Deacetylase Inhibitor Combination Safe, Effective in High-grade Gliomas

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Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.

Adding Palbociclib to Fulvestrant Improves Progression-free Survival in Select Women With Metastatic Breast Cancer

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Progression-free survival was significantly and consistently improved when palbociclib was added to fulvestrant, compared with placebo and fulvestrant, for women with stage IV breast cancer that is hormone-receptor-positive and HER2-negative.

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

An analysis of test results can help women who won't benefit from additional treatment avoid potential side effects.

Adjuvant Chemotherapy More Effective in Reducing Distant Pancreatic Cancer Metastasis

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Adding radiotherapy to chemotherapy and surgery reduced the number of local disease recurrences but did not affect distant recurrences or survival.

Combination of Immune Checkpoint Blockers Shows Promise in Lung Cancer

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Combination therapy with durvalumab and tremelimumab demonstrated antitumor activity in 23% of 102 patients with lung cancer in a phase 1b trial, and toxicity was manageable.

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