Lack of CDX2 expression identified a subgroup of patients with high-risk stage II colon cancer who seemed to benefit from adjuvant chemotherapy.
Fosaprepitant may have a lower complete response rate than aprepitant when used in combination with a 5HT3 receptor antagonist.
Chemotherapy, with or without cranial irradiation, has been associated with improved survival versus surgery alone for patients with early-stage small-cell lung cancer (SCLC) undergoing resection.
Persistent Chemotherapy-induced Peripheral Neuropathy Symptoms Increase Risk of Falls and Altered GaitJanuary 20, 2016
Among women cancer survivors, 45% still experience symptoms of chemotherapy-induced peripheral neuropathy (CIPN) years after they have completed cancer treatment.
A study compared the effectiveness of volasertib versus chemotherapy for treatment of platinum-resistant or -refractory ovarian cancer.
A total of 40% of patients with mCRPC treated with docetaxel after abiraterone achieved at least a 50% reduction in PSA, according to a study presented at the 2016 Genitourinary Cancers Symposium.
Researchers observed significant changes in health-related quality of life (HRQoL), depression, and sexual function among patients with breast cancer receiving chemotherapy.
Progression-free and overall survival were prolonged with electromagnetic field and chemotherapy maintenance therapy in patients with a brain tumor.
Humanin analogue protects both male germ cells, essential to fertility, and white blood cells, the soldiers in the body's defense system, during chemotherapy.
Black women with breast cancer treated with early chemotherapy fare worse than women of other minority groups.
Anthracycline-based Chemotherapy More Likely to Produce Neurotoxic Effects on Cognition in Breast Cancer SurvivorsDecember 17, 2015
Anthracycline-based chemotherapy may have greater negative effects on some cognitive domains and brain network connections compared with nonanthracycline-based regimens.
Adding Carboplatin to Neoadjuvant Therapy for Triple-negative Early Breast Cancer Improves Disease-free SurvivalDecember 09, 2015
Carboplatin added to anthracycline/taxane-based neoadjuvant chemotherapy significantly improved pathological complete response rates in patients with triple-negative breast cancer in two large phase IIb studies: GeparSixto and CALGB 40603. Researchers reported on disease-free survival for GeparSixto after median 35 months of observation at the 2015 San Antonio Breast Cancer Symposium.
Premenopausal Patients With High-risk Luminal A Breast Cancer Get No Benefit From Adjuvant ChemotherapyDecember 09, 2015
Premenopausal women with luminal A subtype breast cancer had comparable 10-year disease-free survival rates regardless of whether they received adjuvant chemotherapy, according to data presented at the 2015 San Antonio Breast Cancer Symposium.
Although a fourth chemotherapy course may benefit younger patients with poor-risk acute myeloid leukemia, those with good and standard risk demonstrated little survival benefit from the additional course.
Single-agent clofarabine is was effective for older patients with newly diagnosed acute myeloid leukemia than standard therapy combined with daunorubicin and cytarabine.
Inotuzumab ozogamicin combined with low-intensity mini-hyper-CVD chemotherapy has demonstrated encouraging results in older patients with acute lymphoblastic leukemia, according to data from an ongoing study.
Scientists have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.
A novel immunotherapeutic approach improved outcomes for patients with advanced bladder cancer, according to a recent study.
Personalized Antinausea Regimens More Effective in Cancer Patients Receiving Emetogenic ChemotherapyNovember 23, 2015
A personalized approach to treating nausea and vomiting, the most expected side effects of chemotherapy, is far more effective than the existing one-size-fits-all guidelines.
TESARO Inc has announced that rolapitant (Varubi), a neurokinin-1 (NK-1) receptor antagonist, is now available in the United States.
Study findings may explain why chemotherapy drugs such as gemcitabine are not effective for many patients with pancreatic cancer, and perhaps point to new approaches to treatment including enhancing gemcitabine's ability to stop tumor growth.
The protein cytokeratin 5 (CK5), known to be a marker of poor prognosis in patients with breast cancer, also marks ovarian cancers likely to be resistant to the common chemotherapy cisplatin.
Gene Expression Test Can Lead to More Effective Treatment Decisions In Patients With Invasive Lobular Carcinoma (ILC) Breast CancerNovember 06, 2015
Most patients with invasive lobular carcinoma (ILC) breast cancer could be treated with hormones alone and not with chemotherapy.
Ramosetron plus dexamethasone and aprepitant is as effective and tolerable as ondansetron.
An analysis of an international, cooperative-led trial of patients with locally advanced NSCLC has shown that those who received IMRT had less severe lung toxicity and were able to better tolerate their chemotherapy, compared with patients who received 3-D CRT.
High-Dose Chemo and Stem Cell Transplantation Results in Long-Term Survival for Patients With AmyloidosisOctober 27, 2015
Patients with light-chain amyloidosis who are treated with high-dose chemotherapy and autologous stem cell transplantation have the greatest success for long-term survival.
Surviving neuroblastoma as a child can come with just as many challenges as the cancer itself. But a team of surgeons is in the nascent stages of developing a more targeted method for delivering chemotherapy, with lower toxicity.
Remarkable early results were reported from a phase 1 trial of a novel agent, rovalpituzumab tesirine (Rova-T, or S16LD6.5), in 79 patients with SCLC who had progressed after first- or second-line therapy.
Young women undergoing chemotherapy for breast cancer may be more likely to remain fertile if they also receive hormonal treatment, according to new research presented at ECC2015.
How can accidental exposure/leaks when handling chemotherapy drugs that incompatible with the closed system device (CSD) be prevented?
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