Chemotherapy

Outcomes in nonsquamous lung cancer comparable with docetaxel or pemetrexed

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The first direct comparison of treating nonsquamous lung cancer with either pemetrexed or docetaxel in addition to cisplatin has shown that the two combinations achieve similar progression-free survival.

Importance of sequence in chemotherapy administration

Importance of sequence in chemotherapy administration

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Is sequencing important when administering chemotherapy on the same day?

High-dose radiotherapy doesn't offer survival benefit in mesothelioma

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Treatnent with high-dose radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival, according to phase II trial data.

Cediranib added to chemotherapy improves progression-free survival in cervical cancer

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Addition of the experimental drug cediranib to standard chemotherapy improves tumor shrinkage and adds a modest improvement in progression-free survival for patients with cervical cancer that has recurred after treatment.

Afatinib improves progression-free survival in head and neck cancer

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After failure of platinum-based chemotherapy, the tyrosine kinase inhibitor (TKI) afatinib significantly improved progression-free survival in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

International team assessed the impact of cancer treatment on children of women pregnant at diagnosis or during treatment

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A number of oncologists hesitate to administer treatments to pregnant patients with cancer, due to concerns about the effect on the unborn.

FDA approves Akynzeo to prevent chemotherapy-induced nausea and vomiting

FDA approves Akynzeo to prevent chemotherapy-induced nausea and vomiting

Akynzeo approved for the treatment chemotherapy-induced nausea and vomiting (CINV) in patients with cancer.

Impact of vitamins, supplements, and diet on cancer treatment-related hair loss

Impact of vitamins, supplements, and diet on cancer treatment-related hair loss

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Can vitamins or supplements help address hair loss caused by cancer therapy?

Nivolumab shows signs of superior response rate compared with standard chemotherapy in advanced melanoma

Nivolumab shows signs of superior response rate compared with standard chemotherapy in advanced melanoma

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The monoclonal antibody nivolumab has demonstrated superior response and duration over standard chemotherapy in patients whose melanoma has progressed after ipilimumab treatment.

Good news for young patients with a leukemia subtype with poor prognosis

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For younger patients with an acute lymphoblastic leukemia (ALL) subtype, modifying treatment based on chemotherapy response can make a vital difference.

Exercise boosts tumor-fighting ability of chemotherapy

Exercise boosts tumor-fighting ability of chemotherapy

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A combination of exercise with chemotherapy shrunk tumors more than employing chemotherapy alone, according to research performed with a melanoma model.

Combination treatment for melanoma achieves significant progression-free survival and response rates

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Combination therapy with both BRAF inhibitor vemurafenib and MEK inhibitor cobimetinib achieved superior results over vemurafenib plus placebo for BRAF-mutation positive melanoma.

Increased toxicity seen in many newly approved anticancer drugs

Increased toxicity seen in many newly approved anticancer drugs

Managing toxicity costs are higher for treatment with less-specific targeted agents and chemotherapies.

Nighttime dim light exposure may increase breast cancer resistance to doxorubicin

Nighttime dim light exposure may increase breast cancer resistance to doxorubicin

Exposure to dim light at night may make breast tumors resistant to chemotherapy

Adding drugs to standard chemotherapy improves response in triple-negative breast cancer

Adding drugs to standard chemotherapy improves response in triple-negative breast cancer

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Adding carboplatin and/or bevacizumab to the standard treatment regimen significantly improved pathologic complete response rates in patients with triple-negative breast cancer, according to a new phase 2 study.

Concurrent radiation and chemotherapy after surgery effective in high-risk endometrial cancer

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Radiation therapy with concurrent paclitaxel chemotherapy after surgery can be effective to treat patients with high-risk endometrial cancer, according to new research.

Wild berry may up chemotherapy effectiveness for pancreatic cancer

Wild berry may up chemotherapy effectiveness for pancreatic cancer

Chokeberry extract enhances cytotoxicity of gemcitabine on a single cancer cell line, according to research.

Chest radiation may be useful for combating advanced lung cancers

Chest radiation may be useful for combating advanced lung cancers

The addition of chest radiation reduces recurrence rate and, improves survival when added to chemo in extensive stage small-cell lung cancer.

Efficacy of half-strength chemotherapy

Efficacy of half-strength chemotherapy

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Is there any benefit to half-strength chemotherapy given to patients experiencing side effects from the drug or due to decreased functional status?

Management of chemotherapy-induced nausea and vomiting (CINV)

Management of chemotherapy-induced nausea and vomiting (CINV)

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Could a medication indicated for nausea and vomiting in pregnancy resolve the same symptoms in patients undergoing chemotherapy?

Herpes zoster vaccine effective with chemotherapy

Herpes zoster vaccine effective with chemotherapy

Vaccine is effective even among older adults who subsequently undergo chemotherapy.

Shingles vaccine found to be safe and effective after chemotherapy

Shingles vaccine found to be safe and effective after chemotherapy

The herpes zoster vaccine continues to be effective in protecting older adults against shingles, even after they undergo chemotherapy, according to a recent study.

Overall survival in advanced NSCLC increased with less toxic chemotherapy

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A 10-year study shows that increased availability of better systemic chemotherapies and targeted therapies for patients with advanced non-small cell lung cancer coincides with increased usage of these therapies.

Managing follicular lymphoma

Managing follicular lymphoma

Changes in how follicular lymphoma is managed have led to substantial improvement in prognosis and over all survival for patients with the disease.

DNA origami can deliver targeted cancer drugs

DNA origami can deliver targeted cancer drugs

Scientists have shown that DNA origami can be used for the targeted delivery of cancer drugs to tumor cells in mice.

Everolimus does not affect survival rate for advanced liver cancer

Everolimus does not affect survival rate for advanced liver cancer

No considerable survival difference found between patients receiving everolimus and those receiving a placebo.

Combination treatment improves recurrence and survival in ovarian cancer

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A new combination of medications for treatment of recurrent ovarian cancer showed improved response rates, increased the rate of tumor shrinkage, and prolonged the time until cancers recurred

Benefits of trastuzumab outweigh the risk of harm in advanced breast cancer

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A new systematic review shows that treatment with the breast cancer drug trastuzumab is associated with prolonged survival in women with advanced breast cancer, but the risk of developing heart problems also increases.

Neuroendocrine cancer halted by chemo-radionuclide therapy

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Advanced cancer of the neuroendocrine system can lead to dismal prognoses, but a novel therapy is packing a punch by uniting powerful radionuclide treatment and chemotherapy drugs.

Study Compares Outcomes for Treatments of Uncommon Eye Cancer

Study Compares Outcomes for Treatments of Uncommon Eye Cancer

Treatment with selumetinib resulted in improved progression-free survival time and tumor response rate compared with chemotherapy, but no improvement was seen in overall survival. Furthermore, the modest improvement in clinical outcomes was accompanied by a high rate of adverse effects.

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