Chemotherapy

Involved-Field Radiotherapy Plus Chemotherapy Prolonged PFS in Follicular Lymphoma

Involved-Field Radiotherapy Plus Chemotherapy Prolonged PFS in Follicular Lymphoma

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Although involved-field radiotherapy (IFRT) has a high level of disease control in patients with follicular lymphoma, relapse frequently occurs; therefore, researchers sought to determine if adding chemotherapy would improve progression-free survival.

Remission Duration Predicts Long-Term Outcomes in Chronic Lymphocytic Leukemia

Remission Duration Predicts Long-Term Outcomes in Chronic Lymphocytic Leukemia

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A retrospective study sought to evaluate outcomes for patients with CLL who were treated with FCR, a highly effective treatment, and initially had refractory disease, experienced relapse early, or were unable to complete therapy due to toxicity.

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

Ixazomib, Lenalidomide, Dexamethasone Effective But Increases Toxicity in Multiple Myeloma

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Three-drug regimen twice a week achieved good response and long-term outcomes in patients with newly diagnosed multiple myeloma; however, regimen has higher toxicity than once weekly dose.

Implementing an Ambulatory Adherence Program May Improve Oral Anticancer Medications Compliance

Implementing an Ambulatory Adherence Program May Improve Oral Anticancer Medications Compliance

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Adherence is a challenge for many patients receiving oral chemotherapy, new data suggests a potential solution.

R-THP-COP a New Therapeutic Alternative for Diffuse Large B Cell Lymphoma

R-THP-COP a New Therapeutic Alternative for Diffuse Large B Cell Lymphoma

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Results of a prospective phase 3 study demonstrated noninferiority of R-THP-COP for diffuse large B cell lymphoma to the standard of care, suggesting the regimen may be an alternative option for these patients.

Capecitabine Tolerance of EU vs US Patients

Capecitabine Tolerance of EU vs US Patients

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Why are European patients better able to tolerate high doses of capecitabine than US patients?

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

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In a retrospective study, researchers investigated the effect of primary prophylaxis on incidence of febrile neutropenia in patients with early stage breast cancer.

Dose-Dense Chemotherapy for Breast Cancer May Impair Lung Function

Dose-Dense Chemotherapy for Breast Cancer May Impair Lung Function

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Long-term analysis determined the effect of postadjuvant dose-dense chemotherapy on DLCO among women with breast cancer.

Novel Agents Plus Paclitaxel, Carboplatin, Does Not Improve Survival in Endometrial Cancer

Novel Agents Plus Paclitaxel, Carboplatin, Does Not Improve Survival in Endometrial Cancer

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A phase 2 study determined if adding bevacizumab or temsirolimus to PC, or an ixabepilone/carboplatin/bevacizumab combination will increase progression-free survival for women with advanced/recurrent endometrial cancer, compared with PC alone.

Patient Advocacy, Questioning 'Status Quo,' Improves Safety in Ambulatory Infusion Setting

Patient Advocacy, Questioning 'Status Quo,' Improves Safety in Ambulatory Infusion Setting

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In fielding reports of CNS-related adverse effects from patients in the ambulatory infusion room, nurses were able to prompt a pharmacy practice review. The outcomes of the resulting switch in premedication for HSR was presented at the 2018 ONS Annual Congress.

Nursing Practice Change Improved Chemo Administration, But Old Habits Die Hard

Nursing Practice Change Improved Chemo Administration, But Old Habits Die Hard

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A nursing staff worked together to identify and work a solution to a high rate of "near-misses" in chemotherapy administration, but further evaluation and additional interventions are needed to maintain the successful practice change, study findings presented at 2018 ONS Annual Congress have shown.

Simple Adjustment Key to Paclitaxel Infusion Protocol That Reduced Hypersensitivity Reactions

Simple Adjustment Key to Paclitaxel Infusion Protocol That Reduced Hypersensitivity Reactions

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A project presented at the 2018 ONS Annual Congress demonstrated the effectiveness of standardizing nursing practices for paclitaxel infusions.

Accurate Understanding of Capacity May Improve Workflow, Efficiency in Infusion Suite

Accurate Understanding of Capacity May Improve Workflow, Efficiency in Infusion Suite

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A nursing staff workflow and capacity study resulted in an overhaul of nurse scheduling in an infusion clinic. Results were presented at the 2018 ONS Annual Congress.

Symptoms, Quality of Life May Improve During Hospitalization for Acute Leukemia

Symptoms, Quality of Life May Improve During Hospitalization for Acute Leukemia

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Results of a prospective, longitudinal study presented at 2018 ONS Congress demonstrate improvement from baseline to discharge patients with acute leukemia who receive induction chemotherapy in hospital.

Electronic Self-Report Assessment-Cancer May Preserve Physical Function in Chemotherapy-Induced Peripheral Neuropathy

Electronic Self-Report Assessment-Cancer May Preserve Physical Function in Chemotherapy-Induced Peripheral Neuropathy

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Research presented at the 2018 ONS Congress reported on the effectiveness of ESRA-C, a web-based assessment and self-care intervention program, in the management of CIPN in patients receiving platinum and/or taxane-based chemotherapy.

Class Preps Patients With AML for Successful At-Home Symptom Management and Self-Care

Class Preps Patients With AML for Successful At-Home Symptom Management and Self-Care

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A presentation at 2018 ONS Congress described the success of a class focused on preparing patients and their families to management their care after discharge.

New Pharmacy Regulations

New Pharmacy Regulations

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What impact do the new pharmacy regulations (USP) have on nursing staff?

RVD-Lite Has Comparable Efficacy, Improved Toxicity in Transplant-Ineligible MM

RVD-Lite Has Comparable Efficacy, Improved Toxicity in Transplant-Ineligible MM

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In a single-arm phase 2 study, researchers explored the effectiveness of a modified lenalidomide, bortezomib, and dexamethasone (RVD-lite) regimen in transplant-ineligible patients with multiple myeloma.

Cervical Cancer Outcomes Comparable With Adjuvant Chemotherapy, Chemoradiotherapy

Cervical Cancer Outcomes Comparable With Adjuvant Chemotherapy, Chemoradiotherapy

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Researchers compared the efficacy of chemotherapy alone vs concurrent chemoradiotherapy (CCRT) for use after radical hysterectomy among patients with early-stage cervical cancer with risk factors,

Mitomycin Extravasation Protocol

Mitomycin Extravasation Protocol

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What is the protocol for extravasation of Mitomycin C?

Venetoclax Found Effective in Relapsed/Refractory Chronic Lymphocytic Leukemia

Venetoclax Found Effective in Relapsed/Refractory Chronic Lymphocytic Leukemia

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A group of Australian researchers report study findings that demonstrate a significant improvement in PFS in patients with relapsed/refractory CLL treated with venetoclax plus rituximab compared with the standard care.

Evidence-Based Practices, No CLABSIs Achieved Through Quality Improvement

Evidence-Based Practices, No CLABSIs Achieved Through Quality Improvement

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Faced with an increasing CLABSI rate on their oncology unit, nurse leaders at this rural Northwest hospital surveyed their staff to identify the changes they needed to make. Implementing those changes resulted in a dramatic improvement in patient care outcomes.

Moderately Emetogenic Chemotherapy Drug Demonstrates High Emetogenic Potential

Moderately Emetogenic Chemotherapy Drug Demonstrates High Emetogenic Potential

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Based on results of a prospective and retrospective study evaluating emetogenic potential of 50 chemotherapeutic regimens, researchers suggest changing the classification of irinotecan.

Lenalidomide Alone or With Dexamethasone Effective in Relapsed Multiple Myeloma

Lenalidomide Alone or With Dexamethasone Effective in Relapsed Multiple Myeloma

A study of 133 patients with multiple myeloma who experienced a first relapse compared the efficacy of long-term therapy lenalidomide alone vs with dexamethasone.

Spotlight on Triptorelin in the Treatment of Premenopausal Women with Early-Stage Breast Cancer

Spotlight on Triptorelin in the Treatment of Premenopausal Women with Early-Stage Breast Cancer

[Breast Cancer: Targets and Therapy] Researchers present a review of the LHRH agonist triptorelin and the use of this agent to induce chemical castration in estrogen-sensitive breast cancer tumors in younger women.

Evolving Role of Radiation Therapy in the Treatment of Mesothelioma

Evolving Role of Radiation Therapy in the Treatment of Mesothelioma

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Research into the potential of radiation therapy in the management of mesothelioma may improve the prognosis, and possibly extend progression-free survival, for patients with this incurable cancer.

Elderly Patients Are Underrepresented in Trials For Soft Tissue Sarcoma

Elderly Patients Are Underrepresented in Trials For Soft Tissue Sarcoma

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With median age of participants in clinical trials for soft-tissue sarcoma younger than most patients who develop the disease, these researchers sought to determine the prevalence of including persons older than 65 in clinical trials and the efficacy of first-line chemotherapy for STS in older patients.

Progression-Free Survival Extended With PANEX Protocol in R/R Multiple Myeloma

Progression-Free Survival Extended With PANEX Protocol in R/R Multiple Myeloma

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This treatment-expansion study evaluated the tolerability and safety of the PANEX (panobinostat plus bortezomib with dexamethasone) protocol in heavily treated patients with R/R multiple myeloma.

National Cancer Drug Shortages Unknown to Many Patients

National Cancer Drug Shortages Unknown to Many Patients

A majority of study respondents reported wanting to be informed about the differences in a drug substitution's efficacy or side effects.

Taxane Acute Pain Syndrome in Cancer Therapy: Occurrence, Impact on Quality of Life

Taxane Acute Pain Syndrome in Cancer Therapy: Occurrence, Impact on Quality of Life

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Results of a prospective study of patients with breast or prostate cancer demonstrate the impact of taxane-based chemotherapy on quality of life.

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