Chemoradiotherapy

Adjuvant CRT Feasible for High-risk Endometrial Cancer

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Adjuvant chemotherapy administered during and after radiotherapy is feasible for the treatment of patients with high-risk endometrial cancer despite an increased risk of toxicities compared with radiotherapy alone.

No Benefit for Chemoradiotherapy vs Chemotherapy After Resectable Gastric Cancer

No Benefit for Chemoradiotherapy vs Chemotherapy After Resectable Gastric Cancer

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First results from the phase 3 CRITICS study found no significant difference in overall survival between postoperative chemotherapy and chemoradiotherapy in patients with resectable gastric cancer, according to a study presented at the ASCO 2016 Annual Meeting.

Concurrent Chemoradiotherapy Remains Standard of Care in Locally Advanced SCCHN

Concurrent Chemoradiotherapy Remains Standard of Care in Locally Advanced SCCHN

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A phase 3 noninferiority study has found that in patients with nonoperable locally advanced squamous cell cancer of the head and neck, concurrent chemoradiotherapy remains the standard treatment, according to results presented at the ASCO 2016 Annual Meeting.

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

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Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

Adjuvant Chemotherapy More Effective in Reducing Distant Pancreatic Cancer Metastasis

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Adding radiotherapy to chemotherapy and surgery reduced the number of local disease recurrences but did not affect distant recurrences or survival.

No Survival Advantage Seen With Induction Chemotherapy vs Chemoradiation in Head and Neck Cancer

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Survival rates are not increased and the likelihood of receiving a full course of radiation is decreased for patients with locally advanced head and neck cancer who receive IC rather than the standard treatment of CRT.

Elderly Patients With Head and Neck Cancer Benefit From Chemoradiation

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Adding chemotherapy to radiation therapy improves survival among elderly patients—age 71 to 79 years—with head and neck cancers, low comorbidity scores, and advanced-stage disease.

Data Analysis Shows 8-week Chemoradiotherapy-to-Surgery Timeline Achieves Optimal Tumor Response

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Overall survival was best and resection of residual locally advanced rectal tumors most successful when surgery occurred at precisely 8 weeks, or 56 days, after completion of chemoradiotherapy.

Reduced Toxicity, Similar Efficacy Achieved With Novel Regimen for Advanced Rectal Cancer

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No difference in local efficacy was found between two treatment regimens for colorectal cancer: short-course (5-day) radiation followed by consolidation chemotherapy before surgery and standard 5-week chemoradiation.

Concurrent Chemoradiotherapy Using Paclitaxel Plus Cisplatin in the Treatment of Elderly Patients With Esophageal Cancer

Concurrent Chemoradiotherapy Using Paclitaxel Plus Cisplatin in the Treatment of Elderly Patients With Esophageal Cancer

The purpose of this research was to examine both efficiency and safety of concurrent chemoradiotherapy (CCRT) using paclitaxel combined with cisplatin in elderly esophageal cancer patients.

Chemoradiotherapy May Be Best Option for Elderly With Lung Cancer

Chemoradiotherapy May Be Best Option for Elderly With Lung Cancer

Increased survival for chemoradiotherapy versus chemotherapy in limited-stage, small-cell lung cancer was observed in a recent study.

Breast cancer and chemobrain: Stress of diagnosis can impair cognitive function before chemotherapy is started

Breast cancer and chemobrain: Stress of diagnosis can impair cognitive function before chemotherapy is started

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Milder cognitive defects displayed by breast cancer patient even before the initiation of chemotherapy may be attributable to disease-related posttraumatic stress, new study data indicates.

Capecitabine-induced leukocytoclastic vasculitis under neoadjuvant chemotherapy for locally advanced colorectal cancer

Capecitabine-induced leukocytoclastic vasculitis under neoadjuvant chemotherapy for locally advanced colorectal cancer

[Journal of Gastrointestinal Oncology] The article examines a case of capecitabine-induced leukocytoclastic vasculitis in a patient with locally advanced rectal cancer under curative neoadjuvant concurrent chemoradiation using capecitabine.

Concurrent chemoradiation treatment at high-volume facilities improves survival for NSCLC

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Patients treated with definitive concurrent chemotherapy and radiation therapy for stage III non-small cell lung cancer (NSCLC) showed better overall survival when treated at experienced facilities.

Concurrent radiation and chemotherapy after surgery effective in high-risk endometrial cancer

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Radiation therapy with concurrent paclitaxel chemotherapy after surgery can be effective to treat patients with high-risk endometrial cancer, according to new research.

Combination therapy improves response in glioblastoma recurrence

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Results from a clinical trial of a new treatment for glioblastoma suggest that researchers may have found a new approach to treating this aggressive brain tumor.

Locally advanced pancreatic cancer responds to FOLFIRINOX

FOLFIRINOX chemotherapy plus chemoradiation helped make resection possible in locally advanced pancreatic cancer.

Chemotherapy agents and radiosensitivity

Chemotherapy agents and radiosensitivity

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How do certain chemotherapy agents make tumors more radiosensitive?

Erlotinib doesn't hurt but doesn't help standard head-and-neck therapy

Adding erlotinib did not increase treatment toxicity in squamous cell carcinoma of the head and neck, but it also did not improve survival.

Combining chemotherapy and radiation improves survival for some with rare brain cancer

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Long-term follow-up results from two clinical trials have confirmed substantially longer survival for certain patients with anaplastic oligodendrogliomas if they are treated with a combination of chemotherapy and radiation therapy instead of radiation alone.

FDA Update - July/August 2012

News about pertuzumab injection (Perjeta); ondansetron (Zofran); carfilzomib (Kyprolis); Therascreen KRAS RGQ PCR Kit; Prostate Health Index (phi); and Prepopik

"Inoperable" pancreatic cancer may be treatable after all

"Inoperable" pancreatic cancer may be treatable after all

Oncologists at M.D. Anderson Cancer Center found the key to screening for pancreatic cancer lies in the interpretation of preoperative CT scans.

Adding Radiation Aids Pediatric Nonmetastatic Medulloblastoma

Adding Radiation Aids Pediatric Nonmetastatic Medulloblastoma

Induction chemotherapy plus conformal radiation therapy improves event-free survival.

Induction chemo beneficial in locally advanced pancreatic CA

Induction chemo beneficial in locally advanced pancreatic CA

Gemcitabine/oxaliplatin induction followed by chemoradiotherapy improves survival, resectability.

Chemoradiotherapy prolongs life for older patients with lung cancer

Survival improved for elderly patients with non-small cell lung cancer who had combined chemotherapy and radiotherapy rather than radiotherapy alone.

Pre-op chemoradiotherapy ups survival in esophageal cancer

Pre-op chemoradiotherapy ups survival in esophageal cancer

Significantly better overall survival exists for patients with esophageal, esophagogastric-junction cancer.

Fewer cycles of higher-dose chemotherapy best in advanced Hodgkin lymphoma

Six cycles of higher-dose chemotherapy, not the standard eight cycles or a lower-dose variant, should be the treatment of choice for advanced Hodgkin.

A creative approach to teaching safe chemotherapy handling techniques delivers the message

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An interactive educational event demonstrated the importance of safe-handling technique of chemotherapy drugs in an approach that bridged generational learning differences.

No link between BMI and surgical outcome in esophageal cancer

BMI appears to have no bearing on surgical complications or survival after esophagectomy following neoadjuvant chemoradiotherapy for adenocarcinoma.

Chemoradiotherapy combo ups bladder cancer control

Chemoradiotherapy combo ups bladder cancer control

Locoregional control of muscle-invasive bladder cancer improved without additional toxicity.

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