Cancer Immunotherapy

The Renaissance of Cancer Immunotherapy

The Renaissance of Cancer Immunotherapy

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The journal Science named cancer immunotherapy as "the breakthrough of the year"; but challenges still remain to overcome tumor immune suppression and genomic instability.

Protein complex linked to cancer growth may also help fight tumors

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A gene expression signature has been discovered that may lead to new immune therapies for patients with lung cancer.

Immunotherapy triggers antitumor responses in advanced ovarian cancer

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A two-step personalized immunotherapy therapy treatment, which involved a dendritic cell vaccine using the patient's own tumor followed by adoptive T-cell therapy, triggered antitumor immune responses in four of six patients.

Dual-antigen recognition could improve cancer immunotherapy

Creating T cells that recognize two different antigens on a tumor cell rather than just one could lead to more precisely targeted immunotherapy.

Gene variant may serve as target for bladder cancer therapy

A newfound predictor of prostate stem cell antigen (PCSA) expression in bladder cancer could improve treatment efficacy in this disease.

Ibrutinib appears safe, effective against chronic lymphocytic leukemia

Ibrutinib, which targets the Bruton's tyrosine kinase to combat chronic lymphocytic leukemia, showed promising results in two phase II studies.

Engineered immune cells produce complete response in aggressive pediatric leukemia

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By reprogramming a 7-year-old girl's own immune cells to attack an aggressive form of childhood leukemia, a pediatric oncologist has achieved a complete response in his patient.

HF/CM risks in breast chemotherapy

HF/CM risks in breast chemotherapy

Earlier study findings that anthracycline- or trastuzumab-based treatment for breast cancer raises the risk for heart failure and cardiomyopathy can be extended to a more general population of women.

Persistent headache plagues an immunocompromised patient

Persistent headache plagues an immunocompromised patient

Imaging studies and laboratory tests were negative, but lumbar puncture revealed the cause of this patient's unexplained neurologic symptoms.

Heart drugs turn cancer cells into anticancer vaccines

Plant-based drugs primarily used in the treatment of heart failure and arrhythmias have now been found to exert anticancer effects.

Kidney transplant drug boosts immune activity in breast cancer

Daclizumab, which prevents organ rejection after renal transplant, improved survival in persons with breast cancer receiving a therapeutic vaccine.

Breast cancer vaccine works better with letrozole than with tamoxifen

A vaccine significantly increased survival in mice with breast cancer when given with the hormonal therapy letrozole, but not with tamoxifen.

Survival improves for youths with leukemia

The 5-year survival rate for children and adolescents with acute lymphoblastic leukemia rose from 83.7% for 1990-1994 to 90.4% for 2000-2005.

Abscopal effect strengthens combination therapy in a melanoma patient

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Combination therapy may be a promising treatment approach for patients with advanced melanoma who experience the abscopal effect.

New drugs change treatment landscape for advanced prostate cancer

Several newly approved drugs plus more in the pipeline present the real possibility of prolonging survival in men with advanced prostate cancer.

Vaccine used in early breast cancer shows good immunity response

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Many women with early breast cancer experienced a sustained immune response after immunization with a vaccine that fights HER2, and this may reduce their risk for more invasive cancer.

Therapeutic vaccine for brain cancer being studied

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A vaccine for people newly diagnosed with glioblastoma multiforme—the most aggressive and highest-grade malignant glioma—is being tested at 20 sites nationwide in a phase II trial.

What You Need to Know About Breast Cancer: A Guide for Newly Diagnosed African American Women

What You Need to Know About Breast Cancer: A Guide for Newly Diagnosed African American Women

Learning you have breast cancer doesn't stop your life. This guide helps provide more information to African American women about what to do once a cancer diagnosis is made and what the next steps should be.

FDA Update: December 2011

In November and December 2011, the FDA approved a number of new cancer drugs. Highlights include cetuximab for head and neck cancer, Hemacord, and asparaginase Erwinia chrysanthemi for ALL.

Arginine may combat immunosuppression in glioblastoma

A common amino acid may help restore function to cancer-fighting T-cells in persons with glioblastoma, say researchers.

HPV vaccine protects men from anal cancer

A quadrivalent human papillomavirus (HPV) vaccine to prevent anal cancer was shown to be safe and effective in a trial of healthy men who have sex with men.

Vaccine may enhance NSCLC treatment

Recent study results suggest that a targeted immunotherapy based on a poxvirus may make chemotherapy for advanced non-small cell lung cancer more effective and slow disease progression.

Keep checking on thyroid during use of antineoplastic agents

People with cancer who are being treated with antineoplastic agents should undergo routine testing for thyroid abnormalities.

Frailty undermines outcomes in melanoma

In persons with stage III melanoma, frailty—not age—was associated with decreased disease-free survival and distant disease-free survival, and with more surgical complications.

New monoclonal antibody is a "source of hope" for patients with metastatic melanoma

New monoclonal antibody is a "source of hope" for patients with metastatic melanoma

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A recently FDA-approved treatment and an experimental BRAF inhibitor offer hope to patients with metastatic melanoma.

Autoimmune vitiligo may help fight melanoma

Inducing vitiligo in persons with melanoma might enhance the natural immune response of these patients, according to data yielded by a recent study.

Fish oil may intensify effects of tamoxifen

Omega-3 fatty acids could be a safe booster for tamoxifen, helping to produce a greater expression of genes that indicate lower cancer severity than seen with corn oil in an animal model.

Recombinant human protein fights a common form of leukemia

A newly identified protein is reportedly the first CD19-specific recombinant human protein with potent anti-leukemic activity against B-lineage acute lymphoblastic leukemia (ALL).

Small target for melanoma eradication gets big results

Immune cells targeting just two cancer-related proteins in melanoma cells largely shrunk the tumors and kept the melanoma at bay for more than 36 weeks post-injection.

Infusion reactions and immunotherapy for prostate cancer

Infusion reactions and immunotherapy for prostate cancer

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This month's questions: retreating with rituximab after an allergic reaction and administering the new prostate cancer immunotherapy.

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