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CALAN SR
Hypertension
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Drug Name:

CALAN SR Rx

Generic Name and Formulations:
Verapamil HCl 120mg, 180mg+, 240mg+; sust-rel caplets; +scored.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for CALAN SR:

Hypertension.

Adult:

Take with food. Initially 180mg in the AM; may titrate to max 480mg/day in divided doses. Elderly or small patients: initially 120mg in the AM.

Children:

<18yrs: not recommended.

Contraindications:

Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract.

Warnings/Precautions:

Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid ivabradine, disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, phenobarbital), rifampin. Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium.

See Also:

CALAN

Pharmacological Class:

Calcium channel blocker (CCB) (diphenylalkylamine).

Adverse Reactions:

Constipation, dizziness, nausea, hypotension, headache, edema, CHF, fatigue, dyspnea, bradycardia, AV block, rash, flushing, elevated hepatic enzymes, paralytic ileus.

How Supplied:

Calan 40mg—100; 80mg—100, 500, 1000; 120mg—100, 1000; SR 120mg, 180mg—100; SR 240mg—100, 500

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