Breast Cancer

Patients With HER2-enriched Subtype Benefit Most from Dual HER2 Blockade

Patients With HER2-enriched Subtype Benefit Most from Dual HER2 Blockade

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HER-2 enriched subtype predicts for HER2 blockade benefit with lapatinib and trastuzumab

Scalp Cooling Reduces Risk of Chemotherapy-Induced Alopecia

Scalp Cooling Reduces Risk of Chemotherapy-Induced Alopecia

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Risk of chemotherapy-induced hair loss common to breast cancer therapy may be reduced with the use of scalp-cooling device.

1 Year of Adjuvant Trastuzumab Improves Long-Term DFS in Early Breast Cancer

1 Year of Adjuvant Trastuzumab Improves Long-Term DFS in Early Breast Cancer

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Adjuvant trastuzumab following chemotherapy significantly improves long-term disease-free survival in women with HER2-positive early breast cancer, according to study data.

Myalgia-arthralgia Syndrome Associated With Taxanes in Patients with Breast Cancer

Myalgia-arthralgia Syndrome Associated With Taxanes in Patients with Breast Cancer

[Breast Cancer: Targets and Therapy] This research examines predisposing factors, prevention, and therapy of myalgia-arthralgia syndrome (M-AS).

Women Treated for DCIS Have Slightly Lower Risk for All-Cause Mortality

Women Treated for DCIS Have Slightly Lower Risk for All-Cause Mortality

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Risk for all-cause mortality is lower among older women treated for DCIS.

Mammographic Breast Density Correlates With Risk of Primary, Contralateral Breast Cancer

Mammographic Breast Density Correlates With Risk of Primary, Contralateral Breast Cancer

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High mammographic breast density is a risk factor for primary breast cancer. In this study, a potential correlation with contralateral breast cancer was investigated.

Cholesterol-Lowering Drugs May Prevent Breast Cancer Recurrence

Cholesterol-Lowering Drugs May Prevent Breast Cancer Recurrence

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In this study, the impact of cholesterol-lowering medications on breast cancer recurrence in women receiving adjuvant endocrine therapy was investigated.

Racial Disparities in BRCA-Related Management Strategies

Racial Disparities in BRCA-Related Management Strategies

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Fewer black BRCA carriers undergo salpingo-oophorectomy to reduce their risk for breast cancer than their Hispanic and non-Hispanic white counterparts.

False Positive Mammograms More Likely to Delay Subsequent Screening

False Positive Mammograms More Likely to Delay Subsequent Screening

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Women who experience a false positive mammogram were more likely to delay their subsequent screening, potentially increasing the risk of having late stage breast cancer at diagnosis.

Some Early Breast Cancer Patients Should Have Breast Conservation Instead of Mastectomy

Some Early Breast Cancer Patients Should Have Breast Conservation Instead of Mastectomy

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Investigators from the Netherlands present their research findings on survival in women with early stage breast cancer who underwent breast-conserving therapy vs mastectomy at the 2017 European Cancer Congress.

Might a Chemical from Celery and Broccoli One Day Yield a New Drug to Prevent Breast Cancer Metastasis?

Might a Chemical from Celery and Broccoli One Day Yield a New Drug to Prevent Breast Cancer Metastasis?

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Investigators report on their findings from preclinical studies of luteolin injections to prevent lung metastases of triple-negative breast cancer.

Inflammatory Cytokine Levels Increase Breast Tissue Density, Cancer Risk

Inflammatory Cytokine Levels Increase Breast Tissue Density, Cancer Risk

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Discovered link between inflammation and overexpression of CCL2 hints at potential of anti-inflammatory medications as a breast cancer preventive in women with dense-tissue breasts.

Soy Consumption Influences Tamoxifen Efficacy Against Breast Tumor Recurrence

Soy Consumption Influences Tamoxifen Efficacy Against Breast Tumor Recurrence

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Lifelong soy consumption improves tamoxifen response in women with breast cancer; however, adding soy to diet after initiating tamoxifen therapy may not provide the same benefits.

Gastric and Colon Metastasis From Breast Cancer: Case Report, Review of the Literature, and Possible Underlying Mechanisms

Gastric and Colon Metastasis From Breast Cancer: Case Report, Review of the Literature, and Possible Underlying Mechanisms

[Breast Cancer: Targets and Therapy] This research presents a case report of patient with gastrointestinal metastases from breast cancer.

Underuse, Misuse of Adjuvant Endocrine Therapy for Breast Cancer Has Decreased

Underuse, Misuse of Adjuvant Endocrine Therapy for Breast Cancer Has Decreased

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Although significant variation in care persists, underuse and misuse of adjuvant endocrine therapy for breast cancer has decreased since 2004.

Neoadjuvant Chemotherapy May Benefit African-American Women with Breast Cancer

Neoadjuvant Chemotherapy May Benefit African-American Women with Breast Cancer

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Administering chemotherapy to African-American women with breast cancer prior to surgery may help improve their survival.

A Call for Better Efforts to Treat and Prevent Breast Cancer Treatment-Related Toxicities

A Call for Better Efforts to Treat and Prevent Breast Cancer Treatment-Related Toxicities

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Researchers report that clinicians may want to start collecting toxicity data routinely and offering early interventions to patients with breast cancer.

Letrozole Not Superior to Anastrazole for HR+, Node+ Early Breast Cancer

Letrozole Not Superior to Anastrazole for HR+, Node+ Early Breast Cancer

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Letrozole was not superior to anastrazole with respect to efficacy or safety in postmenopausal women with HR-positive, node-positive early breast cancer.

Zoledronic Acid Every 12 Weeks Noninferior to Every 4 Weeks

Zoledronic Acid Every 12 Weeks Noninferior to Every 4 Weeks

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Researchers sought to determine the noninferiority of continuing zoledronic acid for an additional year every 12 weeks vs zoledronic acid every 4 weeks in patients receiving monthly intravenous zoledronic acid and/or pamidronate disodium for 1 year or longer.

New Understanding of Mechanisms Revealed in Development of Breast Cancer and Resistance to Treatment

New Understanding of Mechanisms Revealed in Development of Breast Cancer and Resistance to Treatment

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Researchers explore the biologic influences of breast cancer development and resistance to treatment.

Women With Early-Stage Breast Cancer Report Substantial Treatment-Related Toxicities

Women With Early-Stage Breast Cancer Report Substantial Treatment-Related Toxicities

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In this study, researchers quantified the frequency, severity, and burden of treatment-associated toxicities in patients with early-stage invasive breast cancer using patient surveys.

New Use of an Old Drug Could Address Cancer Metastasis

New Use of an Old Drug Could Address Cancer Metastasis

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CDK 4/6 inhibitors, currently approved for the treatment of estrogen-positive breast cancer, were found to inhibit metastasis in triple-negative breast

Intervention Reduces Fear of Recurrence for Breast Cancer Survivors

Intervention Reduces Fear of Recurrence for Breast Cancer Survivors

The Attention and Interpretation Modification for Fear of Breast Cancer Recurrence (AIM-FBCR) intervention helped reduce health worries for survivors of breast cancer.

Screening for Breast Cancer Correlates with Significant Overdiagnosis

Screening for Breast Cancer Correlates with Significant Overdiagnosis

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A review of data from 2 Danish cancer registries revealed the incidence of overdiagnosis of tumors not likely to affect a patient's health during her lifetime and diagnosis of advanced tumors in a program offering biennial mammography for women aged 50 to 69 years.

Menopause-specific QoL Changes Associated With Chemoprevention Nonadherence

Menopause-specific QoL Changes Associated With Chemoprevention Nonadherence

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A cohort of participants in the MAP.3 trial completed the MENQOL questionnaire, and the findings shed light on the influence of changes in menopause-specific quality of life on aromatase inhibitor adherence in women at high risk for breast cancer.

Perceived Breast Density May Influence Single Read Suitability

Perceived Breast Density May Influence Single Read Suitability

Features mainly linked to mammographic breast density are key in influencing a classification of normal.

Longer Dosing Interval of Zoledronic Acid May Be Acceptable for Bone Metastases

Longer Dosing Interval of Zoledronic Acid May Be Acceptable for Bone Metastases

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Results from a phase 3 trial comparing a 12-week dosing interval with the standard 4-week dosing interval of zoledronic acid to reduce the incidence of skeletal-related events and pain in patients with bone metastases.

Serum IL-12 May Predict for Chemotherapy-Related Fatigue in Early-Stage Breast Cancer

Serum IL-12 May Predict for Chemotherapy-Related Fatigue in Early-Stage Breast Cancer

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In this study, researchers sought to identify physical, neurocognitive, and serologic markers that may correlate with self-reported fatigue before and after (neo)adjuvant chemotherapy for patients with early-stage breast cancer.

Patients With Breast Cancer Report More Cognitive Difficulties After Chemotherapy

Patients With Breast Cancer Report More Cognitive Difficulties After Chemotherapy

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Researchers sought to evaluate the incidence of cancer-related cognitive impairment in patients with breast cancer in a large prospective, longitudinal, nationwide study. These findings address limitations in previous research.

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

Drug-Drug Interaction Between Capecitabine and PPIs Reduces Survival in GI Cancers

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Drug-drug interaction between capecitabine and common heartburn medications has a negative effect on progression-free survival and overall survival in patients with GI cancer.

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