The US FDA approved pertuzumab in combination with trastuzumab and chemotherapy for adjuvant treatment of HER2-positive early breast cancer, and converted accelerated to full approval for the regimen as neoadjuvant therapy in certain breast cancers.
In a retrospective study of SEER-Medicare data, researchers determined the survival outcomes of women with breast cancer and comorbid mental illness vs those without mental illness.
Two studies evaluate use of deep learning algorithm; one for breast cancer, the other for diabetic retinopathy
Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study
[Cancer Management and Research] Researchers determined the effect of breast cancer and its treatment on quality of life relative to foot health issues.
Postmenopausal women with weight gain had increased risk of triple-negative breast cancer, research indicates.
Trial investigates which of 3 maintenance regimens of nab-paclitaxel has the most ideal impact on quality of life in patients with metastatic breast cancer. Results were presented at SABCS 2017.
A study from French researchers identified which people are the most likely to influence a breast cancer patient's decision whether to undergo breast reconstruction. These findings were presented at SABCS 2017.
A team from Methodist Hospital Cancer Center discuss an app developed at the facility that helps breast cancer survivors with nutrition and physical activity at SABCS 2017.
A single-center analysis demonstrates likelihood that mastalgia indicates presence of breast cancer and extensiveness of common work-up for the complaint. These findings were presented at SABCS 2017.
A team from Dana-Farber Cancer Institute describe EMBRACE, their comprehensive care program for patients with metastatic breast cancer at SABCS 2017.
Results of a study evaluating the effectiveness of bioimpedance spectroscopy in reducing incidence of chronic breast cancer-related lymphedema (BCRL) in high-risk patients with breast cancer were presented at SABCS 2017.
Researchers presented an update of findings in the GeparSepto trial, which seeks to determine whether improvements in pathologic complete response can be translated to a survival benefit, at SABCS 2017.
Novel weight reduction plan helps breast cancer survivors achieve and maintain a healthy weight and glucose level, according to a presentation at SABCS 2017.
An approach for incorporating palliative care into oncologic care early after diagnosis is explained in an education session at the 2017 SABCS.
Ogivri was granted FDA approval to treat HER2 breast and gastric or gastroesophageal junction adenocarcinoma cancers.
A comparison study presented at the 2017 SABCS sought to determine the effectiveness of bisphosphonates with denosumab for skeletal-related events in women with breast cancer metastases to bone.
Choosing the optimal adjuvant therapy option for a patient with early-stage HR-positive breast cancer should be a continuous discussion with the patient, according to a presentation at SABCS 2017.
Using a mouse model of HER2+ breast cancer, researchers tested the efficiency of combined epigenetic modulation and checkpoint inhibition using the histone deacetylase inhibitor ENT and antibodies for 2 checkpoint inhibitor proteins. These findings were presented at the 2017 SABCS.
A comparison of adjuvant endocrine therapies showed one option provided greater reduction in disease recurrence among premenopausal women with ER+ breast cancer.
Researchers seeking to determine whether breast cancer metastases to the brain would respond to abemaciclib presented the results of a phase 2 Simon 2-stage trial at SABCS 2017.
A phase 2, randomized study investigated the effectiveness of oral curcumin, a component of turmeric, in reducing radiation dermatitis severity in patients undergoing radiation therapy for breast cancer.
Breast cancer was previously thought to not be immunogenic in nature, but a subset of patients with breast cancer, primarily with triple negative disease, have exhibited robust levels of tumor infiltrating leukocytes.
This fact sheet examines possible correlations between cancer risk and factors such as pregnancy and breast feeding.
Researchers conducted a review of more than 400 patients with hormone receptor-positive breast cancer to determine if high Oncotype DX RS is associated with a greater likelihood the cancer is hereditary.
Biomarker analysis revealed markers for cardiotoxicity enabling early initiation of heart failure therapy in patients with breast cancer who were treated with chemotherapy.
Results of an open-label study demonstrated the effectiveness of loratadine in the management of bone pain in patients with breast cancer undergoing chemotherapy and receiving supportive therapy with pegfilgrastim.
Research presented at SABCS 2017 demonstrated the effect of refining the linear predictor for determining which patients with breast cancer would potentially benefit from adjuvant chemotherapy.
A retrospective analysis presented at 2017 SABCS reveals the factors that indicate a higher risk of developing brain metastases for women with HER2+ breast cancer.
Study findings presented at SABCS 2017 demonstrate that intermediate Oncotype DX scores are prognostic of overall survival for patients with early-stage breast cancer, particularly in younger women with the disease.
Patients with early-stage breast cancer treated with aromatase inhibitors often experience adverse events that lead to discontinuation. In this phase 3 study, researchers sought to determine if duloxetine could manage these symptoms.
Researchers investigated the incidence of lymphedema on patients with breast cancer treated with TAC after axillary lymph node dissection (ALND), with or without radiotherapy, and its impact on quality of life for patients.
Follow-up of a 2-year analysis of the ExteNET phase 3 study demonstrates the influence of 1-year extended adjuvant therapy with neratinib on relapse in patients with breast cancer 5.2 years after treatment.
Women with ER-positive BC who stop therapy after 5 years have steady recurrence rate up to 20 years afterward.
The 70-GS was linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay.
The recommendation of an HCP is a key factor in the decision to employ selective estrogen receptor modulators (SERMs) for patients at higher risk for breast cancer.
From 2009 to 2014, increases for all age groups, especially for women aged 65 years and older
When her search for a realistic nipple to complete her breast reconstruction alluded Michelle Kolath-Arbel, a breast cancer survivor, she decided to make one herself.
The transition from active treatment to survivorship for patients with breast cancer can be as complex as the disease. An oncology social worker discusses the challenges of this "new unknown" in the continuum of care.
Investigators surveyed more than 3000 patients with breast cancer and found that disruptions to employment and work stoppage were greater in those who underwent more aggressive treatment options.
This study explored the potential for pregnancy and breastfeeding among women who survived breast cancer, particularly those with ER-positive disease, and the impact of pregnancy on disease recurrence.
Patients with breast cancer experiencing fatigue need to be encouraged to exercise. In this study, investigators measured the impact of enhancing oncologist recommendations with a yoga-based DVD.
This fact sheet examines methods of breast reconstruction for patients with breast cancer and treatment implications after surgery.
Researchers report that adjuvant HFRT and adjuvant CFRT offer similar benefits to women with high-risk breast cancer after mastectomy in an oral presentation at the 59th Annual Meeting of ASTRO.
Retrospective analysis of data from more than 19,000 women revealed that all-cause mortality rates are higher in women with breast cancer who have a prior diagnosis of a mental illness.
[Cancer Control] This research reviews the evidence regarding breast density as a risk factor for the development of breast cancer and presents a management strategy for screening women with dense breasts.
Researchers examined popular breast cancer screening recommendations and their varying impact on patient mortality.
Oncological Safety and Cosmetic Outcomes in Oncoplastic Breast Conservation Surgery, a Review of the Best Level of Evidence Literature
[Breast Cancer: Targets and Therapy] This review examines oncological safety in oncoplastic breast conservation surgery, local recurrence and patient outcome, postoperative complications, and cosmetic outcomes.
Women should be encouraged to optimize lifestyle and should not generally be treated with hormone therapy following breast cancer.
Blocking the beta-adrenergic and COX-2 pathways in the perioperative period may inhibit cellular and molecular pathways associated with metastasis and disease recurrence in patients with early stage breast cancer.
A majority of patients with early-stage breast cancer consider undergoing contralateral prophylactic mastectomy.
An analysis of the 3 most adhered to protocols for screening mammography for breast cancer revealed that the greatest benefit is achieved with annual screening beginning at age 40 years.
Results of a recent study demonstrated overall survival was better among women who underwent breast-conserving surgery vs mastectomy. Furthermore, best overall survival was achieved with adjuvant radiotherapy in the former group and systemic therapy in the latter group.
A study on a cohort of women enrolled in the WHI-OS shows that those with a history of periodontal disease had a higher risk for developing some cancers.
A study finds that report that overall outcomes and prognosis have significantly improved over time for women aged 40 years and younger with breast cancer who undergo breast conserving surgery, and the procedure should be recommended to these patients.
Partial-breast and reduced-dose radiotherapy was found to be noninferior in preventing local relapse compared with whole-breast radiation therapy in patients with early stage breast cancer with a lower-than-average risk of relapse.
[OncoTargets and Therapy] This research reviews available data on the role of the HER2 pathway in breast cancer and on the different targeted agents for the treatment of patients with early-stage HER2-positive disease, with a particular focus on neratinib.
A Systematic Literature Review Exploring the Prevalence of Post-traumatic Stress Disorder and the Role Played by Stress and Traumatic Stress in Breast Cancer Diagnosis and Trajectory
[Breast Cancer: Targets and Therapy] This research examines literature regarding the prevalence of PTSD in breast cancer patients and reviews mechanisms by which stress impacts cancer risk.
Moderate-to-vigorous physical activity was found to improve working memory and executive function in survivors of breast cancer.
Use of antiperspirant or deodorant does not adversely affect potential for dermal toxicity or surface concentrations of aluminum in the axilla in women undergoing radiation therapy for breast cancer.
Many women with breast cancer with genetic variants of uncertain significance (VUS) undergo testing and bilateral mastectomy without receiving genetic counseling.
Disease-Free Survival After Breast Cancer Comparable With Exemestane, Sequential Tamoxifen/Exemestane
A 10-year follow-up study finds disease-free survival (DFS) comparable with exemestane and sequential tamoxifen/exemestane in patients with HR-positive breast cancer.
Supplementation with vitamin D3 in premenopausal women does not have a significant effect on breast density percentage, nor does it reduce breast cancer risk.
CDK4/6 inhibitors, which block the activity of regulatory enzymes, are tolerated fairly well in patients with cancer; however, oncology nurses should be aware of some strategies that minimize their adverse effects.
Although a strong correlation between breast cancer diagnosis and stress has been noted — particularly in the form of posttraumatic stress disorder (PTSD) — there is no demonstrable evidence to suggest a direct causal relationship between them.
Many women with breast cancer with genetic VUS undergo testing and bilateral mastectomy (BLM) without ever receiving genetic counseling.
Fat grafting provides benefits to women with breast cancer considering their options for postmastectomy breast reconstruction, even though this study shows that patient-reported outcomes are similar among women who did and did not undergo the procedure.
A report on adherence to NCCN Guidelines found that, contrary to guideline recommendations, many asymptomatic patients with stage I/II breast cancer undergo chest CT for pulmonary nodules.
Two recent studies examined the benefits of using a 3D bioabsorbable marker to indicate the tumor bed in women with breast cancer who underwent breast conserving surgery (BCS).
Risk assessment study for carriers of the BRCA1/2 mutation identified the factors that influence their risk of developing breast cancer, ovarian cancer, or contralateral breast cancer.
Screening mammography programs increased early detection of tumors, improving outcomes for those women; however, these programs also increased detection of tumors that would never pose a clinical problem.
Regular aspirin use is associated with a lower risk of breast cancer among women with diabetes, a recent study from Taiwan has shown.
Ethnic Differences, Cultural Barriers Negatively Impact Mammography Follow-up Among Asian Ethnic Groups
Follow-up after abnormal results on mammography is more likely to be delayed among Asian American women compared with white women, and varies between different Asian ethnicities.
Changes in Pulmonary Function Tests in Breast Carcinoma Patients Treated With Locoregional Post-mastectomy Radiotherapy: Results of a Pilot Study
[Breast Cancer: Targets and Therapy] The goal of this research was to evaluate the acute changes in PFTs in breast carcinoma patients who received adjuvant chemotherapy and were treated with PMRT including SC regions.
Women with breast cancer who received capecitabine after adjuvant epirubicin had better quality of life (QOL) compared with those who received CMF after adjuvant therapy.
Breast cancer survivors who received taxane-based chemotherapy for their disease are at increased risk for falls due to CIPN and treatment-associated effects on balance and gait.
Community-based, interventionist-guided weight loss program was efficacious for early-stage survivors.
Adding a second HER2-blocker to standard care therapy after surgery for HER2-positive breast cancer may be modestly beneficial for some women.
A patient survey was designed to examine patient views of their initial breast cancer diagnosis process and care management.
Participants with high risk of depression reported lower mood disturbance, anxiety, depression following intervention.
Ovarian function recovery (OFR) in women with chemotherapy-induced ovarian function failure decreases residual 5-year disease-free and overall survival.
A questionnaire added to intake forms at a breast cancer imaging center identified women with BRCA mutations who might otherwise have been missed.
A tool called iCanDecide prepares patients for making decision about treatment better than static online information, study finds.
Male breast cancer patients are less likely than their female counterparts to receive adjuvant hormone therapy and postlumpectomy radiation.
Biosimilars and originator trastuzumab neoadjuvant therapy had a comparable effect on pathologic complete response rates.
'Conquer Fear' decreased fear among survivors of breast and colorectal cancer and melanoma compared with relaxation techniques.
Tai chi is as effective as cognitive behavioral therapy for insomnia (CBT-I) for the treatment of insomnia in breast cancer survivors.
Even a small glass of wine each day can increase the odds of both premenopausal and postmenopausal breast cancer, evidence suggests.
An educational counseling intervention delivered by nurses directly to spouses of women with breast cancer improved marital communications and patients' appraisal of their spouse's interpersonal support.
Trends in caregiver involvement in home-based patient care are introducing new avenues for symptom management and improved health-related quality of life for patients undergoing chemotherapy for advanced breast cancer.
Weekly journaling with oncology nurse review ensures adherence to skin self-care in women undergoing radiation therapy for breast cancer.
Canadian investigators sought to understand the factors that influence the treatment choices of women with early-stage breast cancer.
High Levels of Negative Emotions in Breast Cancer Survivors Motivates Exercise, Increases Cortisol Levels
Negative emotions were shown to motivate breast cancer survivors to engage in moderate-to-vigorous exercise, and can increase their daytime levels of cortisol.
Seven interdisciplinary cancer and bone societies released a position statement updating recommendations for limiting bone loss and fracture risk in patients with early-stage breast cancer undergoing treatment with AIs.
A texture analysis technique improved classification of different types of breast tissue imaged with optical coherence microscopy.
Women with triple-negative or HER2-positive breast cancer who achieve a pathologic complete response from neoadjuvant chemotherapy may be able to avoid follow-up breast or lymph node surgery.
Researchers manipulated triple-negative breast cancer cells to make them susceptible to conventional antiestrogen therapy for breast cancer.
New Criteria for Appropriate Use of Bone Scintigraphy to Diagnose and Manage Prostate and Breast Cancer
Several clinical societies came together to create appropriate use criteria for the use of bone scintigraphy in patients with prostate and breast cancer.
Given recent guideline changes and lack of consistency in guidelines, a survey sought to highlight how primary care physicians recommend breast cancer screening to their patients.
Low Acculturated Latina Women Reported Breast Cancer Treatment Experience Differently Than Other Groups
Researchers found that low acculturated Latina women were moderately less satisfied with surgeon and oncology communication compared with other racial and ethnic groups.
Researchers compared cost data and complications between mastectomy with reconstruction and other guideline-based treatments for patients with early-stage breast cancer.
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- Incidence of Post-traumatic Stress Disorder High Among Patients With Cancer
- Long-Term Night Shift Work Associated With Cancer Risk in Women
- Distress, Neuroticism Predict Long-term Emotional Distress After Cancer Diagnosis
- Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy
- FDA Grants Breakthrough Therapy Designation to Lenvatinib Plus Pembrolizumab for RCC
- Bacteria in Probiotics Carry Potential Risks for Immunocompromised Patients
- Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers
- Artificial Sweeteners and Cancer Risk (Fact Sheet)
- Blueberry Extract May Boost Efficacy of Radiotherapy for Cervical Cancer
- Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma
- Identifying the Psychosocial Needs of Young Adults With Metastatic Cancer
- BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC
- Patient Satisfaction Ratings Can Be Negatively Impacted by Nurse Staffing Ratio
- Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy
- Comparison of Survival Outcomes Between Radical Hysterectomy and Definitive Radiochemotherapy in Stage IB1 and IIA1 Cervical Cancer
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