Radiotherapy Outcomes Improved When Breast Cancer CTCs Detectable

Radiotherapy Outcomes Improved When Breast Cancer CTCs Detectable 

Researchers explored connections between overall survival and adjuvant radiotherapy when factoring in CTC status.

Personalized Therapy Shows Promise in Metastatic Breast Cancer

Personalized Therapy Shows Promise in Metastatic Breast Cancer

A personalized therapy can mediate complete durable cancer regression, according to study results.

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

In a retrospective study, researchers investigated the effect of primary prophylaxis on incidence of febrile neutropenia in patients with early stage breast cancer.

Radiation-Induced Esophagitis: A Common, Debilitating Clinical Challenge in Thoracic Radiotherapy

Radiation-Induced Esophagitis: A Common, Debilitating Clinical Challenge in Thoracic Radiotherapy

A review of current options and ongoing trials for managing ARIE, a common esophageal adverse effect caused by radiotherapy to the thoracic region for lung, breast, or head and neck cancers, or lymphoma.

Ado-trastuzumab Emtansine Effective in HER2 Amplified Non-breast, Non-gastric Cancers

Ado-trastuzumab Emtansine Effective in HER2 Amplified Non-breast, Non-gastric Cancers

Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.

Walking Program Improved Physical Function, But Not Fatigue, After RT for Breast Cancer

Walking Program Improved Physical Function, But Not Fatigue, After RT for Breast Cancer

In a multicenter phase 2 study, the Walk With Ease program was evaluated for its effectiveness in reducing radiotherapy-associated fatigue vs usual care in older patients with breast cancer. Results were presented at 2018 ASCO Annual Meeting.

Sarcopenia, Adiposity Help Determine Management Strategies for Nonmetastatic Breast Cancer

Sarcopenia, Adiposity Help Determine Management Strategies for Nonmetastatic Breast Cancer

Sarcopenia and adiposity measures may help clinicians steer management strategies for some patients with breast cancer.

Dose-Dense Chemotherapy for Breast Cancer May Impair Lung Function

Dose-Dense Chemotherapy for Breast Cancer May Impair Lung Function

Long-term analysis determined the effect of postadjuvant dose-dense chemotherapy on DLCO among women with breast cancer.

Patient-Provider Conversations Regarding Financial Impact of Cancer Therapy Lacking

Patient-Provider Conversations Regarding Financial Impact of Cancer Therapy Lacking

Survey results presented at the 2018 ASCO Annual Meeting demonstrated the effects of financial toxicity on patients with early stage breast cancer.

Low-fat Diet May Improve Overall Survival in Newly Diagnosed Breast Cancer

Low-fat Diet May Improve Overall Survival in Newly Diagnosed Breast Cancer

In a follow-up to the Women's Health Initiative study, researchers determined the effect of a low-fat diet on overall survival after a breast cancer diagnosis.

Computer analysis is not better than human clinical evaluation when it comes to measuring breast density

1. Similar associations were observed with clinical BI-RADS and automated BI-RADS with respect to interval and screen-detected cancer. 2. Both automated and clinical BI-RADS showed similar discriminatory accuracy and mammography accuracy. Evidence Rating Level: 2 (Good) Study Rundown: In the United States, the standard for monitoring breast density is through the Breast Imaging Reporting and []

Evolution of HER2-Positive Breast Cancer: Yesterday, Today, and Tomorrow

Evolution of HER2-Positive Breast Cancer: Yesterday, Today, and Tomorrow

A review of HER2-positive breast cancer, including etiology, diagnosis, and treatments.

Relative Survival for AYAs Comparable to General Population After 7 Years

Relative Survival for AYAs Comparable to General Population After 7 Years

Survivorship plans for adolescent and young adult survivors need to consider the relative long-term survival for AYAs with certain cancers. Those with certain cancers may have excess long-term mortality.

Poor Prognosis for Interval Breast Cancer Following Negative Mammography

Poor Prognosis for Interval Breast Cancer Following Negative Mammography

Researchers discovered that the likelihood of a poor prognosis was increased for cases of cancer diagnosed after screening mammography with negative results versus those diagnosed after mammography with positive results.

Various Factors Effect Risk for Interval Invasive Second Breast Cancers

Various Factors Effect Risk for Interval Invasive Second Breast Cancers

A review of surveillance mammography demonstrated the potential value of these images in post primary therapy treatment of women with breast cancer.

Following False-Positive Results, Patients More Likely to Have Future Cancer Screenings

Following False-Positive Results, Patients More Likely to Have Future Cancer Screenings

The researchers found that the choice to undergo future screenings appeared to be influenced by previous false-positive results for both men and women.

Cancer Screening Follow-up: Enabling Timely Diagnosis, Treatment

Cancer Screening Follow-up: Enabling Timely Diagnosis, Treatment

A review of the literature on follow-up after positive screening results led researchers to a consensus opinion on timing of diagnostic tests for 4 cancers: breast, cervical, colorectal, and lung.

Intervention Improves Body Image-Related Distress in Survivors of Breast Cancer

Intervention Improves Body Image-Related Distress in Survivors of Breast Cancer

A randomized study assessed the effectiveness of an Internet-based psychological intervention in helping women survivors of breast cancer cope with the changes brought by their disease and treatment.

Breast Cancer Treatment-Related Financial Burden Greater for Black vs White Women

Breast Cancer Treatment-Related Financial Burden Greater for Black vs White Women

In a study that evaluated outcomes for younger, working age women with breast cancer, researchers identified differences in cancer-related financial adverse events in black women vs white women.

False-Positive Cancer Screening Results May Increase Likelihood of Future Screenings

False-Positive Cancer Screening Results May Increase Likelihood of Future Screenings

A logistic regression analysis determined the effect receiving a false-positive result had on future participation in cancer screenings.

Spotlight on Triptorelin in the Treatment of Premenopausal Women with Early-Stage Breast Cancer

Spotlight on Triptorelin in the Treatment of Premenopausal Women with Early-Stage Breast Cancer

[Breast Cancer: Targets and Therapy] Researchers present a review of the LHRH agonist triptorelin and the use of this agent to induce chemical castration in estrogen-sensitive breast cancer tumors in younger women.

Combination Effective as First-Line Therapy in Advanced ER-Positive HER2-Negative Breast Cancer

Combination Effective as First-Line Therapy in Advanced ER-Positive HER2-Negative Breast Cancer

In this open label phase 2 BOLERO-4 study, researchers evaluated the effect of everolimus plus endocrine therapy on progression-free survival.

In Older Women With Breast Cancer QoL May Predict 10-Year Mortality

In Older Women With Breast Cancer QoL May Predict 10-Year Mortality

A model that incorporates HRQOL was found to outperform a model that only employs traditional prognostic variables.

Factoring in Breast Density Improves Long-Term Risk Models for Breast Cancer

Factoring in Breast Density Improves Long-Term Risk Models for Breast Cancer

A study using a cohort of women from Kaiser Permanente Washington evaluated the accuracy of risk assessment models for breast cancer that included classic risk factors with and without breast density as an additional factor during more than 10 years of follow-up.

Heart-Specific Mortality Not Higher Among Breast Cancer Survivors

Heart-Specific Mortality Not Higher Among Breast Cancer Survivors

A retrospective cohort study of data from the SEER database assessed the potential risk of cardiac-related mortality in patients with breast cancer, treated with chemotherapy or radiotherapy, vs the general population.

Palpable Cancers Detected at Smaller Size in Breasts With Implants

Palpable Cancers Detected at Smaller Size in Breasts With Implants

Researchers reviewed 48 cases of patients with prior breast augmentation undergoing breast cancer treatment to determine detection rate and treatment choices.

Benefit of Lymph Node Biopsies May Be Limited in Microinvasive Breast Cancer

Benefit of Lymph Node Biopsies May Be Limited in Microinvasive Breast Cancer

Researchers sought to determine the benefit of managing microinvasive breast cancer similarly to invasive tumors in a retrospective study.

Does Better Breast Imaging Lead to Improved Outcomes or Increased Overdiagnosis?

Does Better Breast Imaging Lead to Improved Outcomes or Increased Overdiagnosis?

Advances in breast imaging such as DBT offer better, clearer images of breast tissue that can identify even low-grade DCIS tumors. But will more sensitive imaging lead to improved outcomes or increased overtreatment?

Spousal, Partner Perception of Coping Affects Adjustments in Breast Cancer

Spousal, Partner Perception of Coping Affects Adjustments in Breast Cancer

Male spouse or partner perspectives on a female patient's ability to cope was found to have a positive effect on her ability to cope and adjust to her disease. Unfortunately, this effect remains rarely researched and poorly understood among patients with breast cancer in same sex relationships.

Taxane Acute Pain Syndrome in Cancer Therapy: Occurrence, Impact on Quality of Life

Taxane Acute Pain Syndrome in Cancer Therapy: Occurrence, Impact on Quality of Life

Results of a prospective study of patients with breast or prostate cancer demonstrate the impact of taxane-based chemotherapy on quality of life.

Choosing Wisely After Publication of Level I Evidence in Breast Cancer Radiotherapy

Choosing Wisely After Publication of Level I Evidence in Breast Cancer Radiotherapy

[Breast Cancer: Targets and Therapy] In this retrospective analysis of medical records and estimated costs of treatment, investigators demonstrated that rapid change based on level I evidence is feasible.

Increases in CVD Risk Factors Associated With Worse Survival in Breast Cancer

Increases in CVD Risk Factors Associated With Worse Survival in Breast Cancer

Researchers assessed outcomes of elderly patients with breast cancer to identify the correlation between cardiovascular disease risk factors and overall survival in survivors older than 66.

Women With Schizophrenia May Be at Greater Risk for Breast Cancer

Women With Schizophrenia May Be at Greater Risk for Breast Cancer

Pooled analysis indicated that schizophrenia was associated with a significantly increased risk of breast cancer incidence in women, but researchers had some reservations with the results.

Direct-to-Consumer Genetic Test for Select BRCA Mutations Gets FDA Nod

Direct-to-Consumer Genetic Test for Select BRCA Mutations Gets FDA Nod

The US FDA has approved a consumer test that may indicate increased breast and ovarian cancer risk in some individuals.

Intervention Improves Breast Cancer Survivors' Memory Contentment

Intervention Improves Breast Cancer Survivors' Memory Contentment

Results of a prospective study demonstrated the effectiveness of a 1-hour psychoeducational intervention designed to help survivors of breast cancer manage their chemotherapy-related cognitive dysfunction and improve their memory contentment.

Breast Cancer Screening Recommendations Not Completely Reflective of Race, Age

Breast Cancer Screening Recommendations Not Completely Reflective of Race, Age

An analysis of SEER data sought to examine the appropriateness of age- and race-specific breast cancer screening recommendations for white vs nonwhite women in the United States.

Cost vs Benefits: The Controversy Over Proton Beam Radiotherapy

Cost vs Benefits: The Controversy Over Proton Beam Radiotherapy

At $225 million per system, the precision of proton beam radiotherapy is not necessarily overshadowing its high costs. Yet ongoing studies seek to determine how this technology fits into current treatment regimens for prostate, breast, and other cancers.

Patient Expectations at Odds With Actual Outcomes for Radiotherapy in Breast Cancer

Patient Expectations at Odds With Actual Outcomes for Radiotherapy in Breast Cancer

Researchers present the results of a survey of patients with breast cancer who underwent radiation therapy to assess the difference between their pretreatment expectations and their actual experience.

Calcitriol May Improve Hormone-Therapy Induced Osteoporosis in Breast Cancer Survivors

Calcitriol May Improve Hormone-Therapy Induced Osteoporosis in Breast Cancer Survivors

In this study, researchers determined the efficacy of calcitriol, weight-bearing exercise, both, or daily multivitamins on bone formation and resorption in breast cancer survivors actively maintained on hormone therapy.

Profile of Buparlisib and its Potential in the Treatment of Breast Cancer: Evidence to Date

Profile of Buparlisib and its Potential in the Treatment of Breast Cancer: Evidence to Date

[Breast Cancer: Targets and Therapy] A review of studies investigating the efficacy of buparlisib monotherapy and in combination with various other anticancer agents in the treatment of breast cancer and other solid tumors.

Breast cancer screening using MRI versus mammography associated with more biopsies but lower cancer yield

1. In women both with and without personal history of breast cancer (PHBC), screening MRI was associated with higher biopsy rates compared to mammography. 2. Screening MRI was also associated with lower rates of ductal carcinoma in situ (DCIS) and invasive cancer findings when compared to mammography. Evidence Rating Level: 2 (Good) Study Rundown: Screening []

Factors Affecting Employment Participation in Early-stage Breast Cancer

Factors Affecting Employment Participation in Early-stage Breast Cancer

Researchers conducted a multivariate analysis to determine the factors that contribute to employment participation among women with early-stage breast cancer.

Induced Pluripotent Stem Cell Vaccine May Help Prevent Tumor Growth

Induced Pluripotent Stem Cell Vaccine May Help Prevent Tumor Growth

iPSC vaccine prevented tumor growth in syngeneic murine breast CA, mesothelioma, melanoma models

Chemotherapy-Related Fatigue Linked to Levothyroxine Use in Breast Cancer

Chemotherapy-Related Fatigue Linked to Levothyroxine Use in Breast Cancer

In a secondary analysis of the BEATE and INVEST study, researchers followed a link between levothyroxine use, exercise, and fatigue in women with breast cancer undergoing chemotherapy.

Self-Predictions for Well-Being Influence Satisfaction After Mastectomy, Breast Reconstruction

Self-Predictions for Well-Being Influence Satisfaction After Mastectomy, Breast Reconstruction

Observational study assessed the influence of patients' self-predictions for well-being after undergoing mastectomy for breast cancer with or without immediate breast reconstruction.

Anticancer Properties of Omega-3 Fatty Acids: Plant-Based vs Marine-Based

Anticancer Properties of Omega-3 Fatty Acids: Plant-Based vs Marine-Based

Researchers compared the association between diets high in plant-based omega-3 polyunsaturated fatty acids (PUFAs) vs those high in marine-based PUFAs and the risk for breast cancer.

Breast Cancer Therapies Associated With Increased Risk for Cardiovascular Disease

Breast Cancer Therapies Associated With Increased Risk for Cardiovascular Disease

Advances in breast cancer treatment are improving outcomes for patients with the disease; however, treatments are increasing these patients' risk for cardiovascular diseases.

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

Retrospective study examines the association between risk of cardiotoxicity and race in women with breast cancer receiving chemotherapy and at least 1 year of HER2-targeted therapy.

Breast Cancer Recurrence and CV Risks Down With Exercise in Survivors

Breast Cancer Recurrence and CV Risks Down With Exercise in Survivors

Exercise intervention was associated with improved z-score and serum biomarkers in obese survivors of breast cancer.

Acupuncture Benefits Aromatase Inhibitor-Related Joint Pain

Acupuncture Benefits Aromatase Inhibitor-Related Joint Pain

Acupuncture may represent an effective adjuvant therapy in the management of joint pain associated with aromatase inhibitor treatment in postmenopausal women with breast cancer.

cfDNA Profiling Prognostic for Survival in Metastatic Triple-Negative Breast Cancer

cfDNA Profiling Prognostic for Survival in Metastatic Triple-Negative Breast Cancer

Despite other clinicopathologic factors, patients with a tumor fraction of 10% or greater were more than twice as likely to pass away as those with a fraction of less than 10%.

Body Image, Quality of Life for Breast Cancer Survivors Improved by Intervention

Body Image, Quality of Life for Breast Cancer Survivors Improved by Intervention

A randomized prospective study determined the effectiveness of the Restoring Body Image after Cancer (ReBIC) intervention in women breast cancer survivors who reported struggling with body image issues and sexual functioning.

Resolving Vaginal Dryness in Women With a History of Breast Cancer

Resolving Vaginal Dryness in Women With a History of Breast Cancer

What are some nonhormonal treatments that can improve vaginal dryness in women with a history of breast cancer?

Breast Cancer Deaths Decrease Sharply Since 2000

Breast Cancer Deaths Decrease Sharply Since 2000

Improved therapies and better screening has led to a plunge in breast cancer deaths over the last two decades.

BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC

BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC

Results from the POSH breast cancer study may influence decisions regarding treatments intended to reduce the incidence of second primary cancers in patients with BRCA-positive triple-negative breast cancer.

Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy

Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy

A metabolomics study of the effect of palbociclib/letrozole combination on cancer cells discovered that consumption of foods with certain xenoestrogens has a negative effect on the treatment.

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

Melatonin and its analogues, in addition to their ability to regulate circadian rhythms, may exhibit cytotoxic activity via various cellular mechanisms.

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

A longitudinal study assessed psychological status of postoperative patients with breast cancer between adjuvant chemotherapy for anxiety and depression.

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

The safety of breast implants has not been confirmed despite widespread use.

Effect of Statins on Breast Cancer Recurrence and Mortality: A Review

Effect of Statins on Breast Cancer Recurrence and Mortality: A Review

[Breast Cancer: Targets and Therapy] Researchers present a review of study findings on the effect of statins on clinical outcomes for patients with breast cancer.

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

FDA grants Breakthrough Therapy designation for ribociclib as an initial endocrine-based therapy for HR+/HER2- breast cancer in premenopausal or perimenopausal women.

Exercise Reduces Sleep Problems Experienced by Breast Cancer Survivors

Exercise Reduces Sleep Problems Experienced by Breast Cancer Survivors

Researchers examined the impact of BEAT Cancer intervention on sleep for breast cancer survivors.

Bridging the Gap in Genetic Cancer Research Data on Minority Populations

Bridging the Gap in Genetic Cancer Research Data on Minority Populations

Investigators sought to determine why so few biospecimens were available for research from minority populations of women with breast cancer.

Male Occult Triple-negative Breast Cancer With Dermatomyositis: A Case Report and Review of the Literature

Male Occult Triple-negative Breast Cancer With Dermatomyositis: A Case Report and Review of the Literature

[OncoTargets and Therapy] In this case report, a patient with male breast cancer developed dermatomyositis.

Aromatase Inhibitor Use Does Not Increase Risk of Colorectal Cancer

Aromatase Inhibitor Use Does Not Increase Risk of Colorectal Cancer

No additional risk of colorectal cancer was noted among women treated with aromatase inhibitors (AIs) following a median follow-up of 2.4 and 2.9 years.

Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers

Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers

The US FDA approved pertuzumab in combination with trastuzumab and chemotherapy for adjuvant treatment of HER2-positive early breast cancer, and converted accelerated to full approval for the regimen as neoadjuvant therapy in certain breast cancers.

Breast Cancer Risk Higher Among Women Who Used Hormonal Contraception

Breast Cancer Risk Higher Among Women Who Used Hormonal Contraception

Recent use of hormonal contraception was associated with a higher risk of breast cancer than seen in women who had never used hormonal contraceptives, researchers found.

Mortality Higher in Women With Breast Cancer and Comorbid Mental Illness

Mortality Higher in Women With Breast Cancer and Comorbid Mental Illness

In a retrospective study of SEER-Medicare data, researchers determined the survival outcomes of women with breast cancer and comorbid mental illness vs those without mental illness.

Artificial Intelligence Promising for Breast Cancer Metastases Detection

Artificial Intelligence Promising for Breast Cancer Metastases Detection

Two studies evaluate use of deep learning algorithm; one for breast cancer, the other for diabetic retinopathy

Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study

Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study

[Cancer Management and Research] Researchers determined the effect of breast cancer and its treatment on quality of life relative to foot health issues.

SABCS: Modest Weight Loss Cuts Postmenopause Breast Cancer Risk

SABCS: Modest Weight Loss Cuts Postmenopause Breast Cancer Risk

Postmenopausal women with weight gain had increased risk of triple-negative breast cancer, research indicates.

Quality of Life During Maintenance Therapy Better With Lower Dose, More Often

Quality of Life During Maintenance Therapy Better With Lower Dose, More Often

Trial investigates which of 3 maintenance regimens of nab-paclitaxel has the most ideal impact on quality of life in patients with metastatic breast cancer. Results were presented at SABCS 2017.

Most Influential in Breast Reconstruction Decision: Surgeon, Spouse, GP

Most Influential in Breast Reconstruction Decision: Surgeon, Spouse, GP

A study from French researchers identified which people are the most likely to influence a breast cancer patient's decision whether to undergo breast reconstruction. These findings were presented at SABCS 2017.

MOCHA App Helps Breast Cancer Survivors Achieve Weight-Loss Goals

MOCHA App Helps Breast Cancer Survivors Achieve Weight-Loss Goals

A team from Methodist Hospital Cancer Center discuss an app developed at the facility that helps breast cancer survivors with nutrition and physical activity at SABCS 2017.

Physical Examination Sufficient Work-up for Complaints of Breast Pain

Physical Examination Sufficient Work-up for Complaints of Breast Pain

A single-center analysis demonstrates likelihood that mastalgia indicates presence of breast cancer and extensiveness of common work-up for the complaint. These findings were presented at SABCS 2017.

EMBRACE at Dana-Farber Improves Care in Metastatic Breast Cancer

EMBRACE at Dana-Farber Improves Care in Metastatic Breast Cancer

A team from Dana-Farber Cancer Institute describe EMBRACE, their comprehensive care program for patients with metastatic breast cancer at SABCS 2017.

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

Results of a study evaluating the effectiveness of bioimpedance spectroscopy in reducing incidence of chronic breast cancer-related lymphedema (BCRL) in high-risk patients with breast cancer were presented at SABCS 2017.

Current Findings in Trial Evaluating Paclitaxel Substitution in Invasive Breast Cancer

Current Findings in Trial Evaluating Paclitaxel Substitution in Invasive Breast Cancer

Researchers presented an update of findings in the GeparSepto trial, which seeks to determine whether improvements in pathologic complete response can be translated to a survival benefit, at SABCS 2017.

Bio-individualized Diet Helps Breast Cancer Survivors Stabilize Weight, Glucose

Bio-individualized Diet Helps Breast Cancer Survivors Stabilize Weight, Glucose

Novel weight reduction plan helps breast cancer survivors achieve and maintain a healthy weight and glucose level, according to a presentation at SABCS 2017.

Balancing Early Palliative Care With Active Treatment in Advanced Breast Cancer

Balancing Early Palliative Care With Active Treatment in Advanced Breast Cancer

An approach for incorporating palliative care into oncologic care early after diagnosis is explained in an education session at the 2017 SABCS.

FDA Approves Biosimilar Trastuzumab-dkst for Breast and Stomach Cancers

FDA Approves Biosimilar Trastuzumab-dkst for Breast and Stomach Cancers

Ogivri was granted FDA approval to treat HER2 breast and gastric or gastroesophageal junction adenocarcinoma cancers.

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

A comparison study presented at the 2017 SABCS sought to determine the effectiveness of bisphosphonates with denosumab for skeletal-related events in women with breast cancer metastases to bone.

Adjuvant Therapy Duration a Continuous Discussion in HR+ Breast Cancer

Adjuvant Therapy Duration a Continuous Discussion in HR+ Breast Cancer

Choosing the optimal adjuvant therapy option for a patient with early-stage HR-positive breast cancer should be a continuous discussion with the patient, according to a presentation at SABCS 2017.

Epigenetic Modulation, Checkpoint Inhibition Showed Potential in HER2 Breast Cancer

Epigenetic Modulation, Checkpoint Inhibition Showed Potential in HER2 Breast Cancer

Using a mouse model of HER2+ breast cancer, researchers tested the efficiency of combined epigenetic modulation and checkpoint inhibition using the histone deacetylase inhibitor ENT and antibodies for 2 checkpoint inhibitor proteins. These findings were presented at the 2017 SABCS.

Adjuvant Endocrine Therapy Benefits Younger Women With ER+ Breast Cancer

Adjuvant Endocrine Therapy Benefits Younger Women With ER+ Breast Cancer

A comparison of adjuvant endocrine therapies showed one option provided greater reduction in disease recurrence among premenopausal women with ER+ breast cancer.

Partial Response Reported With Abemaciclib for Breast Cancer Metastases to Brain

Partial Response Reported With Abemaciclib for Breast Cancer Metastases to Brain

Researchers seeking to determine whether breast cancer metastases to the brain would respond to abemaciclib presented the results of a phase 2 Simon 2-stage trial at SABCS 2017.

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

A phase 2, randomized study investigated the effectiveness of oral curcumin, a component of turmeric, in reducing radiation dermatitis severity in patients undergoing radiation therapy for breast cancer.

Examining the Role of Anti-PD-1 Immunotherapy in Advanced Triple-negative Breast Cancer

Examining the Role of Anti-PD-1 Immunotherapy in Advanced Triple-negative Breast Cancer

Breast cancer was previously thought to not be immunogenic in nature, but a subset of patients with breast cancer, primarily with triple negative disease, have exhibited robust levels of tumor infiltrating leukocytes.

Reproductive History and Cancer Risk (Fact Sheet)

Reproductive History and Cancer Risk (Fact Sheet)

This fact sheet examines possible correlations between cancer risk and factors such as pregnancy and breast feeding.

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

Researchers conducted a review of more than 400 patients with hormone receptor-positive breast cancer to determine if high Oncotype DX RS is associated with a greater likelihood the cancer is hereditary.

Markers Identified for Cardiotoxicity Due to Chemotherapy for Breast Cancer

Markers Identified for Cardiotoxicity Due to Chemotherapy for Breast Cancer

Biomarker analysis revealed markers for cardiotoxicity enabling early initiation of heart failure therapy in patients with breast cancer who were treated with chemotherapy.

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

Results of an open-label study demonstrated the effectiveness of loratadine in the management of bone pain in patients with breast cancer undergoing chemotherapy and receiving supportive therapy with pegfilgrastim.

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

Research presented at SABCS 2017 demonstrated the effect of refining the linear predictor for determining which patients with breast cancer would potentially benefit from adjuvant chemotherapy.

Risk Factors for Brain Metastases in HER2+ Breast Cancer Identified in Analysis

Risk Factors for Brain Metastases in HER2+ Breast Cancer Identified in Analysis

A retrospective analysis presented at 2017 SABCS reveals the factors that indicate a higher risk of developing brain metastases for women with HER2+ breast cancer.

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

Study findings presented at SABCS 2017 demonstrate that intermediate Oncotype DX scores are prognostic of overall survival for patients with early-stage breast cancer, particularly in younger women with the disease.

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

Patients with early-stage breast cancer treated with aromatase inhibitors often experience adverse events that lead to discontinuation. In this phase 3 study, researchers sought to determine if duloxetine could manage these symptoms.

Axillary Lymph Node Dissection Predictive for Lymphedema in Breast Cancer

Axillary Lymph Node Dissection Predictive for Lymphedema in Breast Cancer

Researchers investigated the incidence of lymphedema on patients with breast cancer treated with TAC after axillary lymph node dissection (ALND), with or without radiotherapy, and its impact on quality of life for patients.

Extended Adjuvant Therapy for Breast Cancer Improves 5-Year Disease-free Survival

Extended Adjuvant Therapy for Breast Cancer Improves 5-Year Disease-free Survival

Follow-up of a 2-year analysis of the ExteNET phase 3 study demonstrates the influence of 1-year extended adjuvant therapy with neratinib on relapse in patients with breast cancer 5.2 years after treatment.

Breast Cancer Recurrences Steady Following Therapy Cessation

Breast Cancer Recurrences Steady Following Therapy Cessation

Women with ER-positive BC who stop therapy after 5 years have steady recurrence rate up to 20 years afterward.

70-Gene Signature Assay Impacts Treatment Decisions in Breast Cancer

70-Gene Signature Assay Impacts Treatment Decisions in Breast Cancer

The 70-GS was linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay.

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