Researchers explored connections between overall survival and adjuvant radiotherapy when factoring in CTC status.
A personalized therapy can mediate complete durable cancer regression, according to study results.
In a retrospective study, researchers investigated the effect of primary prophylaxis on incidence of febrile neutropenia in patients with early stage breast cancer.
A review of current options and ongoing trials for managing ARIE, a common esophageal adverse effect caused by radiotherapy to the thoracic region for lung, breast, or head and neck cancers, or lymphoma.
Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.
In a multicenter phase 2 study, the Walk With Ease program was evaluated for its effectiveness in reducing radiotherapy-associated fatigue vs usual care in older patients with breast cancer. Results were presented at 2018 ASCO Annual Meeting.
Sarcopenia and adiposity measures may help clinicians steer management strategies for some patients with breast cancer.
Long-term analysis determined the effect of postadjuvant dose-dense chemotherapy on DLCO among women with breast cancer.
Survey results presented at the 2018 ASCO Annual Meeting demonstrated the effects of financial toxicity on patients with early stage breast cancer.
In a follow-up to the Women's Health Initiative study, researchers determined the effect of a low-fat diet on overall survival after a breast cancer diagnosis.
Computer analysis is not better than human clinical evaluation when it comes to measuring breast density
1. Similar associations were observed with clinical BI-RADS and automated BI-RADS with respect to interval and screen-detected cancer. 2. Both automated and clinical BI-RADS showed similar discriminatory accuracy and mammography accuracy. Evidence Rating Level: 2 (Good) Study Rundown: In the United States, the standard for monitoring breast density is through the Breast Imaging Reporting and 
A review of HER2-positive breast cancer, including etiology, diagnosis, and treatments.
Survivorship plans for adolescent and young adult survivors need to consider the relative long-term survival for AYAs with certain cancers. Those with certain cancers may have excess long-term mortality.
Researchers discovered that the likelihood of a poor prognosis was increased for cases of cancer diagnosed after screening mammography with negative results versus those diagnosed after mammography with positive results.
A review of surveillance mammography demonstrated the potential value of these images in post primary therapy treatment of women with breast cancer.
The researchers found that the choice to undergo future screenings appeared to be influenced by previous false-positive results for both men and women.
A review of the literature on follow-up after positive screening results led researchers to a consensus opinion on timing of diagnostic tests for 4 cancers: breast, cervical, colorectal, and lung.
A randomized study assessed the effectiveness of an Internet-based psychological intervention in helping women survivors of breast cancer cope with the changes brought by their disease and treatment.
In a study that evaluated outcomes for younger, working age women with breast cancer, researchers identified differences in cancer-related financial adverse events in black women vs white women.
A logistic regression analysis determined the effect receiving a false-positive result had on future participation in cancer screenings.
[Breast Cancer: Targets and Therapy] Researchers present a review of the LHRH agonist triptorelin and the use of this agent to induce chemical castration in estrogen-sensitive breast cancer tumors in younger women.
In this open label phase 2 BOLERO-4 study, researchers evaluated the effect of everolimus plus endocrine therapy on progression-free survival.
A model that incorporates HRQOL was found to outperform a model that only employs traditional prognostic variables.
A study using a cohort of women from Kaiser Permanente Washington evaluated the accuracy of risk assessment models for breast cancer that included classic risk factors with and without breast density as an additional factor during more than 10 years of follow-up.
A retrospective cohort study of data from the SEER database assessed the potential risk of cardiac-related mortality in patients with breast cancer, treated with chemotherapy or radiotherapy, vs the general population.
Researchers reviewed 48 cases of patients with prior breast augmentation undergoing breast cancer treatment to determine detection rate and treatment choices.
Researchers sought to determine the benefit of managing microinvasive breast cancer similarly to invasive tumors in a retrospective study.
Advances in breast imaging such as DBT offer better, clearer images of breast tissue that can identify even low-grade DCIS tumors. But will more sensitive imaging lead to improved outcomes or increased overtreatment?
Male spouse or partner perspectives on a female patient's ability to cope was found to have a positive effect on her ability to cope and adjust to her disease. Unfortunately, this effect remains rarely researched and poorly understood among patients with breast cancer in same sex relationships.
Results of a prospective study of patients with breast or prostate cancer demonstrate the impact of taxane-based chemotherapy on quality of life.
[Breast Cancer: Targets and Therapy] In this retrospective analysis of medical records and estimated costs of treatment, investigators demonstrated that rapid change based on level I evidence is feasible.
Researchers assessed outcomes of elderly patients with breast cancer to identify the correlation between cardiovascular disease risk factors and overall survival in survivors older than 66.
Pooled analysis indicated that schizophrenia was associated with a significantly increased risk of breast cancer incidence in women, but researchers had some reservations with the results.
The US FDA has approved a consumer test that may indicate increased breast and ovarian cancer risk in some individuals.
Results of a prospective study demonstrated the effectiveness of a 1-hour psychoeducational intervention designed to help survivors of breast cancer manage their chemotherapy-related cognitive dysfunction and improve their memory contentment.
An analysis of SEER data sought to examine the appropriateness of age- and race-specific breast cancer screening recommendations for white vs nonwhite women in the United States.
At $225 million per system, the precision of proton beam radiotherapy is not necessarily overshadowing its high costs. Yet ongoing studies seek to determine how this technology fits into current treatment regimens for prostate, breast, and other cancers.
Researchers present the results of a survey of patients with breast cancer who underwent radiation therapy to assess the difference between their pretreatment expectations and their actual experience.
In this study, researchers determined the efficacy of calcitriol, weight-bearing exercise, both, or daily multivitamins on bone formation and resorption in breast cancer survivors actively maintained on hormone therapy.
[Breast Cancer: Targets and Therapy] A review of studies investigating the efficacy of buparlisib monotherapy and in combination with various other anticancer agents in the treatment of breast cancer and other solid tumors.
Breast cancer screening using MRI versus mammography associated with more biopsies but lower cancer yield
1. In women both with and without personal history of breast cancer (PHBC), screening MRI was associated with higher biopsy rates compared to mammography. 2. Screening MRI was also associated with lower rates of ductal carcinoma in situ (DCIS) and invasive cancer findings when compared to mammography. Evidence Rating Level: 2 (Good) Study Rundown: Screening 
Researchers conducted a multivariate analysis to determine the factors that contribute to employment participation among women with early-stage breast cancer.
iPSC vaccine prevented tumor growth in syngeneic murine breast CA, mesothelioma, melanoma models
In a secondary analysis of the BEATE and INVEST study, researchers followed a link between levothyroxine use, exercise, and fatigue in women with breast cancer undergoing chemotherapy.
Observational study assessed the influence of patients' self-predictions for well-being after undergoing mastectomy for breast cancer with or without immediate breast reconstruction.
Researchers compared the association between diets high in plant-based omega-3 polyunsaturated fatty acids (PUFAs) vs those high in marine-based PUFAs and the risk for breast cancer.
Advances in breast cancer treatment are improving outcomes for patients with the disease; however, treatments are increasing these patients' risk for cardiovascular diseases.
Retrospective study examines the association between risk of cardiotoxicity and race in women with breast cancer receiving chemotherapy and at least 1 year of HER2-targeted therapy.
Exercise intervention was associated with improved z-score and serum biomarkers in obese survivors of breast cancer.
Acupuncture may represent an effective adjuvant therapy in the management of joint pain associated with aromatase inhibitor treatment in postmenopausal women with breast cancer.
Despite other clinicopathologic factors, patients with a tumor fraction of 10% or greater were more than twice as likely to pass away as those with a fraction of less than 10%.
A randomized prospective study determined the effectiveness of the Restoring Body Image after Cancer (ReBIC) intervention in women breast cancer survivors who reported struggling with body image issues and sexual functioning.
What are some nonhormonal treatments that can improve vaginal dryness in women with a history of breast cancer?
Improved therapies and better screening has led to a plunge in breast cancer deaths over the last two decades.
Results from the POSH breast cancer study may influence decisions regarding treatments intended to reduce the incidence of second primary cancers in patients with BRCA-positive triple-negative breast cancer.
A metabolomics study of the effect of palbociclib/letrozole combination on cancer cells discovered that consumption of foods with certain xenoestrogens has a negative effect on the treatment.
Melatonin and its analogues, in addition to their ability to regulate circadian rhythms, may exhibit cytotoxic activity via various cellular mechanisms.
A longitudinal study assessed psychological status of postoperative patients with breast cancer between adjuvant chemotherapy for anxiety and depression.
The safety of breast implants has not been confirmed despite widespread use.
[Breast Cancer: Targets and Therapy] Researchers present a review of study findings on the effect of statins on clinical outcomes for patients with breast cancer.
FDA grants Breakthrough Therapy designation for ribociclib as an initial endocrine-based therapy for HR+/HER2- breast cancer in premenopausal or perimenopausal women.
Researchers examined the impact of BEAT Cancer intervention on sleep for breast cancer survivors.
Investigators sought to determine why so few biospecimens were available for research from minority populations of women with breast cancer.
Male Occult Triple-negative Breast Cancer With Dermatomyositis: A Case Report and Review of the Literature
[OncoTargets and Therapy] In this case report, a patient with male breast cancer developed dermatomyositis.
No additional risk of colorectal cancer was noted among women treated with aromatase inhibitors (AIs) following a median follow-up of 2.4 and 2.9 years.
The US FDA approved pertuzumab in combination with trastuzumab and chemotherapy for adjuvant treatment of HER2-positive early breast cancer, and converted accelerated to full approval for the regimen as neoadjuvant therapy in certain breast cancers.
Recent use of hormonal contraception was associated with a higher risk of breast cancer than seen in women who had never used hormonal contraceptives, researchers found.
In a retrospective study of SEER-Medicare data, researchers determined the survival outcomes of women with breast cancer and comorbid mental illness vs those without mental illness.
Two studies evaluate use of deep learning algorithm; one for breast cancer, the other for diabetic retinopathy
Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study
[Cancer Management and Research] Researchers determined the effect of breast cancer and its treatment on quality of life relative to foot health issues.
Postmenopausal women with weight gain had increased risk of triple-negative breast cancer, research indicates.
Trial investigates which of 3 maintenance regimens of nab-paclitaxel has the most ideal impact on quality of life in patients with metastatic breast cancer. Results were presented at SABCS 2017.
A study from French researchers identified which people are the most likely to influence a breast cancer patient's decision whether to undergo breast reconstruction. These findings were presented at SABCS 2017.
A team from Methodist Hospital Cancer Center discuss an app developed at the facility that helps breast cancer survivors with nutrition and physical activity at SABCS 2017.
A single-center analysis demonstrates likelihood that mastalgia indicates presence of breast cancer and extensiveness of common work-up for the complaint. These findings were presented at SABCS 2017.
A team from Dana-Farber Cancer Institute describe EMBRACE, their comprehensive care program for patients with metastatic breast cancer at SABCS 2017.
Results of a study evaluating the effectiveness of bioimpedance spectroscopy in reducing incidence of chronic breast cancer-related lymphedema (BCRL) in high-risk patients with breast cancer were presented at SABCS 2017.
Researchers presented an update of findings in the GeparSepto trial, which seeks to determine whether improvements in pathologic complete response can be translated to a survival benefit, at SABCS 2017.
Novel weight reduction plan helps breast cancer survivors achieve and maintain a healthy weight and glucose level, according to a presentation at SABCS 2017.
An approach for incorporating palliative care into oncologic care early after diagnosis is explained in an education session at the 2017 SABCS.
Ogivri was granted FDA approval to treat HER2 breast and gastric or gastroesophageal junction adenocarcinoma cancers.
A comparison study presented at the 2017 SABCS sought to determine the effectiveness of bisphosphonates with denosumab for skeletal-related events in women with breast cancer metastases to bone.
Choosing the optimal adjuvant therapy option for a patient with early-stage HR-positive breast cancer should be a continuous discussion with the patient, according to a presentation at SABCS 2017.
Using a mouse model of HER2+ breast cancer, researchers tested the efficiency of combined epigenetic modulation and checkpoint inhibition using the histone deacetylase inhibitor ENT and antibodies for 2 checkpoint inhibitor proteins. These findings were presented at the 2017 SABCS.
A comparison of adjuvant endocrine therapies showed one option provided greater reduction in disease recurrence among premenopausal women with ER+ breast cancer.
Researchers seeking to determine whether breast cancer metastases to the brain would respond to abemaciclib presented the results of a phase 2 Simon 2-stage trial at SABCS 2017.
A phase 2, randomized study investigated the effectiveness of oral curcumin, a component of turmeric, in reducing radiation dermatitis severity in patients undergoing radiation therapy for breast cancer.
Breast cancer was previously thought to not be immunogenic in nature, but a subset of patients with breast cancer, primarily with triple negative disease, have exhibited robust levels of tumor infiltrating leukocytes.
This fact sheet examines possible correlations between cancer risk and factors such as pregnancy and breast feeding.
Researchers conducted a review of more than 400 patients with hormone receptor-positive breast cancer to determine if high Oncotype DX RS is associated with a greater likelihood the cancer is hereditary.
Biomarker analysis revealed markers for cardiotoxicity enabling early initiation of heart failure therapy in patients with breast cancer who were treated with chemotherapy.
Results of an open-label study demonstrated the effectiveness of loratadine in the management of bone pain in patients with breast cancer undergoing chemotherapy and receiving supportive therapy with pegfilgrastim.
Research presented at SABCS 2017 demonstrated the effect of refining the linear predictor for determining which patients with breast cancer would potentially benefit from adjuvant chemotherapy.
A retrospective analysis presented at 2017 SABCS reveals the factors that indicate a higher risk of developing brain metastases for women with HER2+ breast cancer.
Study findings presented at SABCS 2017 demonstrate that intermediate Oncotype DX scores are prognostic of overall survival for patients with early-stage breast cancer, particularly in younger women with the disease.
Patients with early-stage breast cancer treated with aromatase inhibitors often experience adverse events that lead to discontinuation. In this phase 3 study, researchers sought to determine if duloxetine could manage these symptoms.
Researchers investigated the incidence of lymphedema on patients with breast cancer treated with TAC after axillary lymph node dissection (ALND), with or without radiotherapy, and its impact on quality of life for patients.
Follow-up of a 2-year analysis of the ExteNET phase 3 study demonstrates the influence of 1-year extended adjuvant therapy with neratinib on relapse in patients with breast cancer 5.2 years after treatment.
Women with ER-positive BC who stop therapy after 5 years have steady recurrence rate up to 20 years afterward.
The 70-GS was linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay.
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