Choosing Wisely After Publication of Level I Evidence in Breast Cancer Radiotherapy

Choosing Wisely After Publication of Level I Evidence in Breast Cancer Radiotherapy

[Breast Cancer: Targets and Therapy] In this retrospective analysis of medical records and estimated costs of treatment, investigators demonstrated that rapid change based on level I evidence is feasible.

Increases in CVD Risk Factors Associated With Worse Survival in Breast Cancer

Increases in CVD Risk Factors Associated With Worse Survival in Breast Cancer

Researchers assessed outcomes of elderly patients with breast cancer to identify the correlation between cardiovascular disease risk factors and overall survival in survivors older than 66.

Women With Schizophrenia May Be at Greater Risk for Breast Cancer

Women With Schizophrenia May Be at Greater Risk for Breast Cancer

Pooled analysis indicated that schizophrenia was associated with a significantly increased risk of breast cancer incidence in women, but researchers had some reservations with the results.

Direct-to-Consumer Genetic Test for Select BRCA Mutations Gets FDA Nod

Direct-to-Consumer Genetic Test for Select BRCA Mutations Gets FDA Nod

The US FDA has approved a consumer test that may indicate increased breast and ovarian cancer risk in some individuals.

Intervention Improves Breast Cancer Survivors' Memory Contentment

Intervention Improves Breast Cancer Survivors' Memory Contentment

Results of a prospective study demonstrated the effectiveness of a 1-hour psychoeducational intervention designed to help survivors of breast cancer manage their chemotherapy-related cognitive dysfunction and improve their memory contentment.

Breast Cancer Screening Recommendations Not Completely Reflective of Race, Age

Breast Cancer Screening Recommendations Not Completely Reflective of Race, Age

An analysis of SEER data sought to examine the appropriateness of age- and race-specific breast cancer screening recommendations for white vs nonwhite women in the United States.

Cost vs Benefits: The Controversy Over Proton Beam Radiotherapy

Cost vs Benefits: The Controversy Over Proton Beam Radiotherapy

At $225 million per system, the precision of proton beam radiotherapy is not necessarily overshadowing its high costs. Yet ongoing studies seek to determine how this technology fits into current treatment regimens for prostate, breast, and other cancers.

Patient Expectations at Odds With Actual Outcomes for Radiotherapy in Breast Cancer

Patient Expectations at Odds With Actual Outcomes for Radiotherapy in Breast Cancer

Researchers present the results of a survey of patients with breast cancer who underwent radiation therapy to assess the difference between their pretreatment expectations and their actual experience.

Calcitriol May Improve Hormone-Therapy Induced Osteoporosis in Breast Cancer Survivors

Calcitriol May Improve Hormone-Therapy Induced Osteoporosis in Breast Cancer Survivors

In this study, researchers determined the efficacy of calcitriol, weight-bearing exercise, both, or daily multivitamins on bone formation and resorption in breast cancer survivors actively maintained on hormone therapy.

Profile of Buparlisib and its Potential in the Treatment of Breast Cancer: Evidence to Date

Profile of Buparlisib and its Potential in the Treatment of Breast Cancer: Evidence to Date

[Breast Cancer: Targets and Therapy] A review of studies investigating the efficacy of buparlisib monotherapy and in combination with various other anticancer agents in the treatment of breast cancer and other solid tumors.

Factors Affecting Employment Participation in Early-stage Breast Cancer

Factors Affecting Employment Participation in Early-stage Breast Cancer

Researchers conducted a multivariate analysis to determine the factors that contribute to employment participation among women with early-stage breast cancer.

Induced Pluripotent Stem Cell Vaccine May Help Prevent Tumor Growth

Induced Pluripotent Stem Cell Vaccine May Help Prevent Tumor Growth

iPSC vaccine prevented tumor growth in syngeneic murine breast CA, mesothelioma, melanoma models

Chemotherapy-Related Fatigue Linked to Levothyroxine Use in Breast Cancer

Chemotherapy-Related Fatigue Linked to Levothyroxine Use in Breast Cancer

In a secondary analysis of the BEATE and INVEST study, researchers followed a link between levothyroxine use, exercise, and fatigue in women with breast cancer undergoing chemotherapy.

Self-Predictions for Well-Being Influence Satisfaction After Mastectomy, Breast Reconstruction

Self-Predictions for Well-Being Influence Satisfaction After Mastectomy, Breast Reconstruction

Observational study assessed the influence of patients' self-predictions for well-being after undergoing mastectomy for breast cancer with or without immediate breast reconstruction.

Anticancer Properties of Omega-3 Fatty Acids: Plant-Based vs Marine-Based

Anticancer Properties of Omega-3 Fatty Acids: Plant-Based vs Marine-Based

Researchers compared the association between diets high in plant-based omega-3 polyunsaturated fatty acids (PUFAs) vs those high in marine-based PUFAs and the risk for breast cancer.

Breast Cancer Therapies Associated With Increased Risk for Cardiovascular Disease

Breast Cancer Therapies Associated With Increased Risk for Cardiovascular Disease

Advances in breast cancer treatment are improving outcomes for patients with the disease; however, treatments are increasing these patients' risk for cardiovascular diseases.

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

Retrospective study examines the association between risk of cardiotoxicity and race in women with breast cancer receiving chemotherapy and at least 1 year of HER2-targeted therapy.

Breast Cancer Recurrence and CV Risks Down With Exercise in Survivors

Breast Cancer Recurrence and CV Risks Down With Exercise in Survivors

Exercise intervention was associated with improved z-score and serum biomarkers in obese survivors of breast cancer.

Acupuncture Benefits Aromatase Inhibitor-Related Joint Pain

Acupuncture Benefits Aromatase Inhibitor-Related Joint Pain

Acupuncture may represent an effective adjuvant therapy in the management of joint pain associated with aromatase inhibitor treatment in postmenopausal women with breast cancer.

cfDNA Profiling Prognostic for Survival in Metastatic Triple-Negative Breast Cancer

cfDNA Profiling Prognostic for Survival in Metastatic Triple-Negative Breast Cancer

Despite other clinicopathologic factors, patients with a tumor fraction of 10% or greater were more than twice as likely to pass away as those with a fraction of less than 10%.

Body Image, Quality of Life for Breast Cancer Survivors Improved by Intervention

Body Image, Quality of Life for Breast Cancer Survivors Improved by Intervention

A randomized prospective study determined the effectiveness of the Restoring Body Image after Cancer (ReBIC) intervention in women breast cancer survivors who reported struggling with body image issues and sexual functioning.

Resolving Vaginal Dryness in Women With a History of Breast Cancer

Resolving Vaginal Dryness in Women With a History of Breast Cancer

What are some nonhormonal treatments that can improve vaginal dryness in women with a history of breast cancer?

Breast Cancer Deaths Decrease Sharply Since 2000

Breast Cancer Deaths Decrease Sharply Since 2000

Improved therapies and better screening has led to a plunge in breast cancer deaths over the last two decades.

BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC

BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC

Results from the POSH breast cancer study may influence decisions regarding treatments intended to reduce the incidence of second primary cancers in patients with BRCA-positive triple-negative breast cancer.

Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy

Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy

A metabolomics study of the effect of palbociclib/letrozole combination on cancer cells discovered that consumption of foods with certain xenoestrogens has a negative effect on the treatment.

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

Melatonin and its analogues, in addition to their ability to regulate circadian rhythms, may exhibit cytotoxic activity via various cellular mechanisms.

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

A longitudinal study assessed psychological status of postoperative patients with breast cancer between adjuvant chemotherapy for anxiety and depression.

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

The safety of breast implants has not been confirmed despite widespread use.

Effect of Statins on Breast Cancer Recurrence and Mortality: A Review

Effect of Statins on Breast Cancer Recurrence and Mortality: A Review

[Breast Cancer: Targets and Therapy] Researchers present a review of study findings on the effect of statins on clinical outcomes for patients with breast cancer.

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

FDA grants Breakthrough Therapy designation for ribociclib as an initial endocrine-based therapy for HR+/HER2- breast cancer in premenopausal or perimenopausal women.

Exercise Reduces Sleep Problems Experienced by Breast Cancer Survivors

Exercise Reduces Sleep Problems Experienced by Breast Cancer Survivors

Researchers examined the impact of BEAT Cancer intervention on sleep for breast cancer survivors.

Bridging the Gap in Genetic Cancer Research Data on Minority Populations

Bridging the Gap in Genetic Cancer Research Data on Minority Populations

Investigators sought to determine why so few biospecimens were available for research from minority populations of women with breast cancer.

Male Occult Triple-negative Breast Cancer With Dermatomyositis: A Case Report and Review of the Literature

Male Occult Triple-negative Breast Cancer With Dermatomyositis: A Case Report and Review of the Literature

[OncoTargets and Therapy] In this case report, a patient with male breast cancer developed dermatomyositis.

Aromatase Inhibitor Use Does Not Increase Risk of Colorectal Cancer

Aromatase Inhibitor Use Does Not Increase Risk of Colorectal Cancer

No additional risk of colorectal cancer was noted among women treated with aromatase inhibitors (AIs) following a median follow-up of 2.4 and 2.9 years.

Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers

Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers

The US FDA approved pertuzumab in combination with trastuzumab and chemotherapy for adjuvant treatment of HER2-positive early breast cancer, and converted accelerated to full approval for the regimen as neoadjuvant therapy in certain breast cancers.

Breast Cancer Risk Higher Among Women Who Used Hormonal Contraception

Breast Cancer Risk Higher Among Women Who Used Hormonal Contraception

Recent use of hormonal contraception was associated with a higher risk of breast cancer than seen in women who had never used hormonal contraceptives, researchers found.

Mortality Higher in Women With Breast Cancer and Comorbid Mental Illness

Mortality Higher in Women With Breast Cancer and Comorbid Mental Illness

In a retrospective study of SEER-Medicare data, researchers determined the survival outcomes of women with breast cancer and comorbid mental illness vs those without mental illness.

Artificial Intelligence Promising for Breast Cancer Metastases Detection

Artificial Intelligence Promising for Breast Cancer Metastases Detection

Two studies evaluate use of deep learning algorithm; one for breast cancer, the other for diabetic retinopathy

Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study

Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study

[Cancer Management and Research] Researchers determined the effect of breast cancer and its treatment on quality of life relative to foot health issues.

SABCS: Modest Weight Loss Cuts Postmenopause Breast Cancer Risk

SABCS: Modest Weight Loss Cuts Postmenopause Breast Cancer Risk

Postmenopausal women with weight gain had increased risk of triple-negative breast cancer, research indicates.

Quality of Life During Maintenance Therapy Better With Lower Dose, More Often

Quality of Life During Maintenance Therapy Better With Lower Dose, More Often

Trial investigates which of 3 maintenance regimens of nab-paclitaxel has the most ideal impact on quality of life in patients with metastatic breast cancer. Results were presented at SABCS 2017.

Most Influential in Breast Reconstruction Decision: Surgeon, Spouse, GP

Most Influential in Breast Reconstruction Decision: Surgeon, Spouse, GP

A study from French researchers identified which people are the most likely to influence a breast cancer patient's decision whether to undergo breast reconstruction. These findings were presented at SABCS 2017.

MOCHA App Helps Breast Cancer Survivors Achieve Weight-Loss Goals

MOCHA App Helps Breast Cancer Survivors Achieve Weight-Loss Goals

A team from Methodist Hospital Cancer Center discuss an app developed at the facility that helps breast cancer survivors with nutrition and physical activity at SABCS 2017.

Physical Examination Sufficient Work-up for Complaints of Breast Pain

Physical Examination Sufficient Work-up for Complaints of Breast Pain

A single-center analysis demonstrates likelihood that mastalgia indicates presence of breast cancer and extensiveness of common work-up for the complaint. These findings were presented at SABCS 2017.

EMBRACE at Dana-Farber Improves Care in Metastatic Breast Cancer

EMBRACE at Dana-Farber Improves Care in Metastatic Breast Cancer

A team from Dana-Farber Cancer Institute describe EMBRACE, their comprehensive care program for patients with metastatic breast cancer at SABCS 2017.

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

Results of a study evaluating the effectiveness of bioimpedance spectroscopy in reducing incidence of chronic breast cancer-related lymphedema (BCRL) in high-risk patients with breast cancer were presented at SABCS 2017.

Current Findings in Trial Evaluating Paclitaxel Substitution in Invasive Breast Cancer

Current Findings in Trial Evaluating Paclitaxel Substitution in Invasive Breast Cancer

Researchers presented an update of findings in the GeparSepto trial, which seeks to determine whether improvements in pathologic complete response can be translated to a survival benefit, at SABCS 2017.

Bio-individualized Diet Helps Breast Cancer Survivors Stabilize Weight, Glucose

Bio-individualized Diet Helps Breast Cancer Survivors Stabilize Weight, Glucose

Novel weight reduction plan helps breast cancer survivors achieve and maintain a healthy weight and glucose level, according to a presentation at SABCS 2017.

Balancing Early Palliative Care With Active Treatment in Advanced Breast Cancer

Balancing Early Palliative Care With Active Treatment in Advanced Breast Cancer

An approach for incorporating palliative care into oncologic care early after diagnosis is explained in an education session at the 2017 SABCS.

FDA Approves Biosimilar Trastuzumab-dkst for Breast and Stomach Cancers

FDA Approves Biosimilar Trastuzumab-dkst for Breast and Stomach Cancers

Ogivri was granted FDA approval to treat HER2 breast and gastric or gastroesophageal junction adenocarcinoma cancers.

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

A comparison study presented at the 2017 SABCS sought to determine the effectiveness of bisphosphonates with denosumab for skeletal-related events in women with breast cancer metastases to bone.

Adjuvant Therapy Duration a Continuous Discussion in HR+ Breast Cancer

Adjuvant Therapy Duration a Continuous Discussion in HR+ Breast Cancer

Choosing the optimal adjuvant therapy option for a patient with early-stage HR-positive breast cancer should be a continuous discussion with the patient, according to a presentation at SABCS 2017.

Epigenetic Modulation, Checkpoint Inhibition Showed Potential in HER2 Breast Cancer

Epigenetic Modulation, Checkpoint Inhibition Showed Potential in HER2 Breast Cancer

Using a mouse model of HER2+ breast cancer, researchers tested the efficiency of combined epigenetic modulation and checkpoint inhibition using the histone deacetylase inhibitor ENT and antibodies for 2 checkpoint inhibitor proteins. These findings were presented at the 2017 SABCS.

Adjuvant Endocrine Therapy Benefits Younger Women With ER+ Breast Cancer

Adjuvant Endocrine Therapy Benefits Younger Women With ER+ Breast Cancer

A comparison of adjuvant endocrine therapies showed one option provided greater reduction in disease recurrence among premenopausal women with ER+ breast cancer.

Partial Response Reported With Abemaciclib for Breast Cancer Metastases to Brain

Partial Response Reported With Abemaciclib for Breast Cancer Metastases to Brain

Researchers seeking to determine whether breast cancer metastases to the brain would respond to abemaciclib presented the results of a phase 2 Simon 2-stage trial at SABCS 2017.

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

A phase 2, randomized study investigated the effectiveness of oral curcumin, a component of turmeric, in reducing radiation dermatitis severity in patients undergoing radiation therapy for breast cancer.

Examining the Role of Anti-PD-1 Immunotherapy in Advanced Triple-negative Breast Cancer

Examining the Role of Anti-PD-1 Immunotherapy in Advanced Triple-negative Breast Cancer

Breast cancer was previously thought to not be immunogenic in nature, but a subset of patients with breast cancer, primarily with triple negative disease, have exhibited robust levels of tumor infiltrating leukocytes.

Reproductive History and Cancer Risk (Fact Sheet)

Reproductive History and Cancer Risk (Fact Sheet)

This fact sheet examines possible correlations between cancer risk and factors such as pregnancy and breast feeding.

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

Researchers conducted a review of more than 400 patients with hormone receptor-positive breast cancer to determine if high Oncotype DX RS is associated with a greater likelihood the cancer is hereditary.

Markers Identified for Cardiotoxicity Due to Chemotherapy for Breast Cancer

Markers Identified for Cardiotoxicity Due to Chemotherapy for Breast Cancer

Biomarker analysis revealed markers for cardiotoxicity enabling early initiation of heart failure therapy in patients with breast cancer who were treated with chemotherapy.

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

Results of an open-label study demonstrated the effectiveness of loratadine in the management of bone pain in patients with breast cancer undergoing chemotherapy and receiving supportive therapy with pegfilgrastim.

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

Research presented at SABCS 2017 demonstrated the effect of refining the linear predictor for determining which patients with breast cancer would potentially benefit from adjuvant chemotherapy.

Risk Factors for Brain Metastases in HER2+ Breast Cancer Identified in Analysis

Risk Factors for Brain Metastases in HER2+ Breast Cancer Identified in Analysis

A retrospective analysis presented at 2017 SABCS reveals the factors that indicate a higher risk of developing brain metastases for women with HER2+ breast cancer.

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

Study findings presented at SABCS 2017 demonstrate that intermediate Oncotype DX scores are prognostic of overall survival for patients with early-stage breast cancer, particularly in younger women with the disease.

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

Patients with early-stage breast cancer treated with aromatase inhibitors often experience adverse events that lead to discontinuation. In this phase 3 study, researchers sought to determine if duloxetine could manage these symptoms.

Axillary Lymph Node Dissection Predictive for Lymphedema in Breast Cancer

Axillary Lymph Node Dissection Predictive for Lymphedema in Breast Cancer

Researchers investigated the incidence of lymphedema on patients with breast cancer treated with TAC after axillary lymph node dissection (ALND), with or without radiotherapy, and its impact on quality of life for patients.

Extended Adjuvant Therapy for Breast Cancer Improves 5-Year Disease-free Survival

Extended Adjuvant Therapy for Breast Cancer Improves 5-Year Disease-free Survival

Follow-up of a 2-year analysis of the ExteNET phase 3 study demonstrates the influence of 1-year extended adjuvant therapy with neratinib on relapse in patients with breast cancer 5.2 years after treatment.

Breast Cancer Recurrences Steady Following Therapy Cessation

Breast Cancer Recurrences Steady Following Therapy Cessation

Women with ER-positive BC who stop therapy after 5 years have steady recurrence rate up to 20 years afterward.

70-Gene Signature Assay Impacts Treatment Decisions in Breast Cancer

70-Gene Signature Assay Impacts Treatment Decisions in Breast Cancer

The 70-GS was linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay.

Provider Advice Affects Breast Cancer Prevention Decisions

Provider Advice Affects Breast Cancer Prevention Decisions

The recommendation of an HCP is a key factor in the decision to employ selective estrogen receptor modulators (SERMs) for patients at higher risk for breast cancer.

Increase in Rate of Breast Reconstruction for Mastectomy

Increase in Rate of Breast Reconstruction for Mastectomy

From 2009 to 2014, increases for all age groups, especially for women aged 65 years and older

Prosthetic Nipple Crowns Survivor's Quest for Improved Breast Reconstruction

Prosthetic Nipple Crowns Survivor's Quest for Improved Breast Reconstruction

When her search for a realistic nipple to complete her breast reconstruction alluded Michelle Kolath-Arbel, a breast cancer survivor, she decided to make one herself.

Navigating the Transition From Treatment to Breast Cancer Survivor

Navigating the Transition From Treatment to Breast Cancer Survivor

The transition from active treatment to survivorship for patients with breast cancer can be as complex as the disease. An oncology social worker discusses the challenges of this "new unknown" in the continuum of care.

Pursuing Aggressive Treatment Impacts Breast Cancer Patients' Employment

Pursuing Aggressive Treatment Impacts Breast Cancer Patients' Employment

Investigators surveyed more than 3000 patients with breast cancer and found that disruptions to employment and work stoppage were greater in those who underwent more aggressive treatment options.

Breast Cancer Recurrence Not a Deterrent for Survivors Who Wish to Conceive

Breast Cancer Recurrence Not a Deterrent for Survivors Who Wish to Conceive

This study explored the potential for pregnancy and breastfeeding among women who survived breast cancer, particularly those with ER-positive disease, and the impact of pregnancy on disease recurrence.

DVD Motivated Patients to Exercise for Managing Fatigue in Breast Cancer

DVD Motivated Patients to Exercise for Managing Fatigue in Breast Cancer

Patients with breast cancer experiencing fatigue need to be encouraged to exercise. In this study, investigators measured the impact of enhancing oncologist recommendations with a yoga-based DVD.

Breast Reconstruction Following Mastectomy (Fact Sheet)

Breast Reconstruction Following Mastectomy (Fact Sheet)

This fact sheet examines methods of breast reconstruction for patients with breast cancer and treatment implications after surgery.

Outcomes Similar With Postmastectomy Hypofractionation, Standard Radiation

Outcomes Similar With Postmastectomy Hypofractionation, Standard Radiation

Researchers report that adjuvant HFRT and adjuvant CFRT offer similar benefits to women with high-risk breast cancer after mastectomy in an oral presentation at the 59th Annual Meeting of ASTRO.

Severe Mental Illness May Worsen Breast Cancer Survival Outcomes

Severe Mental Illness May Worsen Breast Cancer Survival Outcomes

Retrospective analysis of data from more than 19,000 women revealed that all-cause mortality rates are higher in women with breast cancer who have a prior diagnosis of a mental illness.

Imaging Management of Breast Density, a Controversial Risk Factor for Breast Cancer

Imaging Management of Breast Density, a Controversial Risk Factor for Breast Cancer

[Cancer Control] This research reviews the evidence regarding breast density as a risk factor for the development of breast cancer and presents a management strategy for screening women with dense breasts.

Beginning Regular Breast Screening Earlier May Produce Optimal Survival

Beginning Regular Breast Screening Earlier May Produce Optimal Survival

Researchers examined popular breast cancer screening recommendations and their varying impact on patient mortality.

Oncological Safety and Cosmetic Outcomes in Oncoplastic Breast Conservation Surgery, a Review of the Best Level of Evidence Literature

Oncological Safety and Cosmetic Outcomes in Oncoplastic Breast Conservation Surgery, a Review of the Best Level of Evidence Literature

[Breast Cancer: Targets and Therapy] This review examines oncological safety in oncoplastic breast conservation surgery, local recurrence and patient outcome, postoperative complications, and cosmetic outcomes.

Options Available for Estrogen Depletion After Breast Cancer

Options Available for Estrogen Depletion After Breast Cancer

Women should be encouraged to optimize lifestyle and should not generally be treated with hormone therapy following breast cancer.

Perioperative Blockade of Pathways May Improve Outcomes in Breast Cancer

Perioperative Blockade of Pathways May Improve Outcomes in Breast Cancer

Blocking the beta-adrenergic and COX-2 pathways in the perioperative period may inhibit cellular and molecular pathways associated with metastasis and disease recurrence in patients with early stage breast cancer.

One-Quarter of Patients With Early Breast Cancer Strongly Consider CPM

One-Quarter of Patients With Early Breast Cancer Strongly Consider CPM

A majority of patients with early-stage breast cancer consider undergoing contralateral prophylactic mastectomy.

Starting Screening Mammography at Age 40 Leads to Greatest Mortality Benefit

Starting Screening Mammography at Age 40 Leads to Greatest Mortality Benefit

An analysis of the 3 most adhered to protocols for screening mammography for breast cancer revealed that the greatest benefit is achieved with annual screening beginning at age 40 years.

Breast Conservation Improves Survival vs Mastectomy in Breast Cancer

Breast Conservation Improves Survival vs Mastectomy in Breast Cancer

Results of a recent study demonstrated overall survival was better among women who underwent breast-conserving surgery vs mastectomy. Furthermore, best overall survival was achieved with adjuvant radiotherapy in the former group and systemic therapy in the latter group.

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

A study on a cohort of women enrolled in the WHI-OS shows that those with a history of periodontal disease had a higher risk for developing some cancers.

Breast-Conserving Surgery Recommended For Younger Women With Breast Cancer

Breast-Conserving Surgery Recommended For Younger Women With Breast Cancer

A study finds that report that overall outcomes and prognosis have significantly improved over time for women aged 40 years and younger with breast cancer who undergo breast conserving surgery, and the procedure should be recommended to these patients.

Adjuvant Partial Breast Radiotherapy Noninferior in Preventing Relapse in Local Breast Cancer

Adjuvant Partial Breast Radiotherapy Noninferior in Preventing Relapse in Local Breast Cancer

Partial-breast and reduced-dose radiotherapy was found to be noninferior in preventing local relapse compared with whole-breast radiation therapy in patients with early stage breast cancer with a lower-than-average risk of relapse.

Emerging Treatments for HER2-positive Early-stage Breast Cancer: Focus on Neratinib

Emerging Treatments for HER2-positive Early-stage Breast Cancer: Focus on Neratinib

[OncoTargets and Therapy] This research reviews available data on the role of the HER2 pathway in breast cancer and on the different targeted agents for the treatment of patients with early-stage HER2-positive disease, with a particular focus on neratinib.

A Systematic Literature Review Exploring the Prevalence of Post-traumatic Stress Disorder and the Role Played by Stress and Traumatic Stress in Breast Cancer Diagnosis and Trajectory

A Systematic Literature Review Exploring the Prevalence of Post-traumatic Stress Disorder and the Role Played by Stress and Traumatic Stress in Breast Cancer Diagnosis and Trajectory

[Breast Cancer: Targets and Therapy] This research examines literature regarding the prevalence of PTSD in breast cancer patients and reviews mechanisms by which stress impacts cancer risk.

Physical Activity Improves Cognitive Function for Breast Cancer Survivors

Physical Activity Improves Cognitive Function for Breast Cancer Survivors

Moderate-to-vigorous physical activity was found to improve working memory and executive function in survivors of breast cancer.

Deodorant, Antiperspirant Use During Radiation Therapy for Breast Cancer Not Detrimental

Deodorant, Antiperspirant Use During Radiation Therapy for Breast Cancer Not Detrimental

Use of antiperspirant or deodorant does not adversely affect potential for dermal toxicity or surface concentrations of aluminum in the axilla in women undergoing radiation therapy for breast cancer.

Bilateral Mastectomy Without Proper Genetic Counseling

Bilateral Mastectomy Without Proper Genetic Counseling

Many women with breast cancer with genetic variants of uncertain significance (VUS) undergo testing and bilateral mastectomy without receiving genetic counseling.

Disease-Free Survival After Breast Cancer Comparable With Exemestane, Sequential Tamoxifen/Exemestane

Disease-Free Survival After Breast Cancer Comparable With Exemestane, Sequential Tamoxifen/Exemestane

A 10-year follow-up study finds disease-free survival (DFS) comparable with exemestane and sequential tamoxifen/exemestane in patients with HR-positive breast cancer.

Vitamin D3 Supplementation Has No Impact on Breast Density Percentage, Breast Cancer Risk

Vitamin D3 Supplementation Has No Impact on Breast Density Percentage, Breast Cancer Risk

Supplementation with vitamin D3 in premenopausal women does not have a significant effect on breast density percentage, nor does it reduce breast cancer risk.

A Review of CDK4/6 Toxicities and Interactions Management in Breast Cancer

A Review of CDK4/6 Toxicities and Interactions Management in Breast Cancer

CDK4/6 inhibitors, which block the activity of regulatory enzymes, are tolerated fairly well in patients with cancer; however, oncology nurses should be aware of some strategies that minimize their adverse effects.

Relationship Between Breast Cancer and Posttraumatic Stress Disorder Inconclusive

Relationship Between Breast Cancer and Posttraumatic Stress Disorder Inconclusive

Although a strong correlation between breast cancer diagnosis and stress has been noted — particularly in the form of posttraumatic stress disorder (PTSD) — there is no demonstrable evidence to suggest a direct causal relationship between them.

Counseling Regarding Genetic Testing in Breast Cancer Lacking, Yet Many Still Undergo BLM

Counseling Regarding Genetic Testing in Breast Cancer Lacking, Yet Many Still Undergo BLM

Many women with breast cancer with genetic VUS undergo testing and bilateral mastectomy (BLM) without ever receiving genetic counseling.

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