Genetic variants combined to improve breast cancer

An analysis of the genetic data from more than 67,000 women has helped establish a polygenic risk score, derived from many genetic factors, which can be used to identify women with a greater breast cancer risk.

Symptoms of Poor Sleep May Suggest Potential Sleep Disorders in Survivors of Breast Cancer

Symptoms of Poor Sleep May Suggest Potential Sleep Disorders in Survivors of Breast Cancer

ORLANDO, FL—A large percentage of survivors of breast cancer with sleep complaints have symptoms suggesting underlying sleep disorders that require referral to a sleep medicine specialist for further evaluation and treatment, according to preliminary study evidence presented at the ONS 40th Annual Congress.

Most women with early stage breast cancer avoid extensive lymph node removal

New research has found that in women with early stage breast cancer, surgeons no longer universally remove most of the lymph nodes in the underarm area when a biopsy of the nearby lymph nodes indicates cancer.

Teens with breast lumps may be able to avoid invasive biopsy

The use of breast ultrasound could eliminate the need for biopsy in many cases in adolescent girls, according to a recent study.

Biennial mammography optimal screening interval for average risk women

Biennial mammography optimal screening interval for average risk women

Biennial (once every two years) screening is preferable for women of age 50 through 74 that have an average risk of developing breast cancer.

Nighttime fasting may decrease breast cancer risk in women

Nighttime fasting may decrease breast cancer risk in women

An increase in overnight fasting decreases glucose levels and may lower the risk of breast cancer among women.

mHealth app assesses breast cancer risk and aids prevention

An evaluation of this mobile health app found easy to use for diverse, low-income women.

The switch that might tame the most aggressive of breast cancers

Researchers have learned more about breast cancer, including identification of a gene that drives the aggressive disease.

Most hospitalists not supportive of inpatient mammography

Most hospitalists not supportive of inpatient mammography

Most hospitalists would not order an inpatient mammography for breast cancer screening.

Breast cancer patients want, but may not get, genetic risk discussion

Breast cancer patients want, but may not get, genetic risk discussion

Although many patients with breast cancer are concerned about genetic risk for other cancer types, almost half don't have conversation with doctor about potential for future problems.

Low breast density in mammography worsens breast cancer prognosis

A low degree of mammographic breast density worsens the prognosis of breast cancer, according to a recent study.

Text message reminders boost breast cancer screening attendance

A text reminder can help increase breast cancer screening attendance, study data shows.

Specific mutated BRCA regions confer different risks of breast, ovarian cancers

Specific mutated BRCA regions confer different risks of breast, ovarian cancers

Specific BRCA mutations confer higher risks of breast cancer, while other BRCA mutations confer higher risks of ovarian cancer.

MRI can detect 90 percent of breast cancers

MRI can detect 90 percent of breast cancers

A recent study has determined that approximately 90 percent of breast cancers can be diagnosed via magnetic resonance imaging (MRI).

35 percent of patients with breast cancer worried about genetic risks to themselves, family members

35 percent of patients with breast cancer worried about genetic risks to themselves, family members

A third of women diagnosed with breast cancer are concerned about the genetic risk of a family member developing cancer.

Control of cell metabolism explains response to breast cancer drugs

A newly discovered mechanism that has helped researchers understand why some breast cancer tumors respond to specific chemotherapies and others do not.

Stress management improves long-term mood and quality of life in women with breast cancer

Enabling patients to manage stress early in their breast cancer treatment can improve their mood and quality of life many years later.

Racial and ethnic differences extend to how surgeons and hospitals for breast cancer care are selected

Black and Hispanic women with breast cancer were less likely to use reputation as a factor ins selecting their surgeon or hospital for treatment, when compared with white women.

Hormone-blocking drug prevents ovarian failure and improves fertility in breast cancer patients

Breast cancer patients given the hormone-blocking drug goserelin during chemotherapy experience less ovarian failure and are more likely to have successful pregnancies, according to study results.

Diabetes may predispose individuals to advanced breast cancer

Diabetes may predispose individuals to advanced breast cancer

Women with diabetes may have an increased risk of being diagnosed with advanced breast cancer, according to new study results.

Tamoxifen response in breast cancer predicted by protein marker

Tamoxifen response in breast cancer predicted by protein marker

An abnormally low amount of the protein TGFBR2 is associated with resistance to tamoxifen response in breast cancer treatment.

Study examined diagnostic accuracy of breast biopsy interpretations

A comparison of the diagnostic interpretation of breast biopsy slides by pathologists and that of an expert consensus panel yielded an overall agreement of 75%.

Risk of breast cancer in transgender persons studied in veterans

A study of breast cancer in transgender veterans has identified 10 new cases, increases the number of recorded cases in transgender individuals.

Risk of thyroid cancer increases after a breast cancer diagnosis

Risk of thyroid cancer increases after a breast cancer diagnosis

Breast cancer survivors have a higher risk of developing thyroid cancer, especially within 5 years of their breast cancer diagnosis, according to a national database analysis.

Fifteen new breast cancer genetic risk 'hot-spots' revealed

Fifteen new breast cancer genetic risk 'hot-spots' revealed

Researchers compared tiny variations in the genetic make-up of more than 120,000 women of European ancestry, with and without breast cancer, and identified 15 new genetic variations linked to a higher risk of the disease.

Chemotherapy before breast cancer surgery increases likelihood of breast-preserving procedure

Chemotherapy before breast cancer surgery increases likelihood of breast-preserving procedure

Patients with larger malignant tumors of the breast who undergo chemotherapy before breast cancer surgery are more likely to opt for a breast-preserving procedure, according to a new study.

Anesthetic technique could spare some women from chronic pain after breast cancer surgery

A regional anesthetic technique in combination with standard care could potentially spare a third of women undergoing a mastectomy chronic post-operative pain, according to study data.

Ultrasound lags behind MRI for supplemental breast cancer screening

Breast screening via ultrasound is unaffected by breast density, is not associated with ionizing radiation, and does not require IV contrast material, but acceptance of this modality has lagged.

Breast cancer more likely to be advanced stage disease at diagnosis in women with diabetes

Breast cancer more likely to be advanced stage disease at diagnosis in women with diabetes

Breast cancer in women with diabetes is more likely to be advanced stage at diagnosis.

Minority women less involved in breast cancer surgery decisions

Minority women less involved in breast cancer surgery decisions

Black and Hispanic women with breast cancer are less likely to select a surgeon or determine hospital based on reputation.

Inappropriate breast and prostate imaging of Medicare beneficiaries examined

An association of high rates of inappropriate imaging for prostate cancer and breast cancer found in a study of Medicare beneficiaries suggests that regional culture could contribute to inappropriate imaging.

US women's awareness of breast density varies

Disparities exist regarding the level of awareness and knowledge of breast density among US women, according to a study.

Disparities in adherence to breast cancer care linked to net worth

Household net worth can be linked to adherence to hormonal therapy among breast cancer patients and partially explains racial disparities in quality of care.

Newer breast implants could be safer for body

Newer breast implants could be safer for body

A newly developed surface for silicone breast implants could greatly increase the chance that they are properly assimilated by the body without rejection.

Text message reminders improve how women manage breast cancer screening

Text message reminders improve how women manage breast cancer screening

They found that women who received a reminder were 20% more likely to attend their breast cancer screening appointment.

Breast cancer metastasis may be tied to cell that regulates blood flow

Breast cancer metastasis may be tied to cell that regulates blood flow

Scientists believe that targeting blood vessel cells known as pericytes may offer a potential new therapeutic approach for breast and other cancers.

Family history of prostate cancer may indicate higher risk of breast cancer in women

A family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer, according to a new study.

Mental training program helps ease chemobrain in breast cancer

Mental training program helps ease chemobrain in breast cancer

A new program developed by UCLA researchers may ease post-treatment "chemo brain" in patients with breast cancer.

Magnetic resonance spectroscopy (MRS) shows precancerous breast changes in women with BRCA gene mutation

MRS that incorporates monitoring of biochemical changes in tissue could improve the management of women at risk of breast cancer, according to a new study.

Regional infrastructure tied to inappropriate breast, prostate cancer imaging

Regional infrastructure tied to inappropriate breast, prostate cancer imaging

Regional infrastructure could contribute to inappropriate imaging in patients at risk for prostate and breast cancer.

Therapeutic massage may ease fatigue in breast cancer

Therapeutic massage may ease fatigue in breast cancer

Researchers continue to examine the effects of massage therapy and how it may help to reduce fatigue in patients with breast cancer.

Education, not mandatory screening, best for women with dense breast tissue

Laws mandating notification of dense breasts may pose a risk of unnecessary procedures and false positives for women at low- and moderate-risk of breast cancer.

Sexual dysfunction in a breast cancer survivor: A case study

Sexual dysfunction in a breast cancer survivor: A case study

This case study examines a case of sex-related headaches in a breast cancer survivor after treatment for ductal carcinoma in situ (DCIS).

Goserelin reduces ovarian failure rate in breast cancer

Goserelin reduces ovarian failure rate in breast cancer

Use of the gonadotropin-releasing hormone agonist, goserelin, protects against ovarian failure, according to a study.

Mobile app helps to track breast cancer survivors' experiences

Mobile app helps to track breast cancer survivors' experiences

A new patient-centered mobile app entitled Share the Journey: Mind, Body and Wellness after Breast Cancer has launched.

History of prostate cancer in relatives may increase risk of breast cancer

History of prostate cancer in relatives may increase risk of breast cancer

Women with a family history of prostate cancer in first-degree relatives may have a higher risk of developing breast cancer.

Correlated spectroscopy pinpoints changes in BRCA1/2 carriers

Correlated spectroscopy pinpoints changes in BRCA1/2 carriers

Lipid and metabolite deregulation were seen in breast tissue of women carrying BRCA1/2 mutations.

Better informed women less likely to want to undergo mammography screening

Knowledge of the risk of over-detection and over-diagnosis associated with mammography screening can lower intentions to undergo breast screening, according to a new Lancet study.

Psychosocial challenges of pregnancy-associated breast cancer (PABC)

Psychosocial challenges of pregnancy-associated breast cancer (PABC)

Breast cancer during pregnancy presents additional psychosocial challenges as patients cope with a devastating diagnosis during a time of hope and promise for the future.

Breast cancer survivors may have increased risk of thyroid cancer

Breast cancer survivors may have increased risk of thyroid cancer

Female breast cancer survivors may be at an increased risk for developing thyroid cancer.

Inadequate pressure during manual breast examinations misses deep-tissue masses

Many physicians who tested their breast-examination skills on a new type of pressure-sensing breast model failed to detect masses deep in the breast because they were administering adequate pressure, a study has found.

Aluminum-containing deodorant safe for patients with breast cancer undergoing radiotherapy

Aluminum-containing deodorant safe for patients with breast cancer undergoing radiotherapy

Women undergoing radiotherapy for breast cancer can use deodorant without increasing risk of underarm skin reactions, pain, itching, or burning.

Major study links two new genetic variants to breast cancer

Major study links two new genetic variants to breast cancer

A worldwide study of the DNA of 100,000 women has discovered two new genetic variants associated with an increased risk of breast cancer.

New mechanism of acquired resistance to breast cancer drugs discovered

Researchers have discovered that ERBB4 (also known as HER4) is a driver protein in ERBB2-positive tumors that have developed resistance to first- or second-line treatments.

Crucial role of breast cancer tumor suppressor revealed

Cells that contain lower levels of protein profilin 1 in breast tumors have an increased capacity to metastasize and invade other tissues, according to research.

Women educated on overdiagnsosis are less likely to want mammogram

Women educated on overdiagnsosis are less likely to want mammogram

Risks and benefits of routine mammography continue to be debated, but educating women about the possibility of overdiagnosis from mammography screening may make some of them less likely to get the test.

New genetic anomalies linked to breast cancer in African American families

Newly discovered segments of DNA shared by African American family members who have breast cancer indicate there may still be undiscovered breast cancer genes that may be unique to African Americans.

Many patients with locally advanced breast cancer do not receive postmastectomy radiation

More than a third of women who should receive radiation subsequent to mastectomy are actually undergoing the recommended postmastectomy radiation therapy (PMRT), according to a new study.

Household net worth linked to hormonal therapy adherence among patients with breast cancer

Household net worth linked to hormonal therapy adherence among patients with breast cancer

Household net worth is a major factor in adherence to hormonal therapy among patients with breast cancer.

Epigenetic signatures differentiate triple negative breast cancers

Specific methylation patterns revealed in the primary biopsy breast cancer cells of breast cancer DNA methylome can indicate a better or worse prognosis.

Ultrasound helps determine which breast cancer patients need lymph nodes removed

Not all women with lymph node-positive breast cancer treated with chemotherapy before surgery need to have all underarm nodes removed, new research indicates.

California breast density law slow to have an impact

Half of primary care physicians are still unfamiliar with the California law mandating that clinicians notify women with dense breast tissue, and many do not feel comfortable answering breast density-related questions.

New model better predicts breast cancer risk in African American women

A new risk prediction model will allow for greater accuracy in predicting risk for breast cancer in African American women.

Women informed of over-detection risk less likely to want mammography

Women informed of over-detection risk less likely to want mammography

Women who are better informed about the risk of over-detection are less likely to have a breast cancer screening.

Some older patients with breast cancer can avoid postsurgery radiotherapy

Radiotherapy can be avoided by older women with breast cancer without a compromise to their safety, according to a recent study.

Smoking linked to breast and prostate cancer

Smoking linked to breast and prostate cancer

Smoking is associated with an increased risk of breast cancer, prostate cancer, and routine infections.

Eribulin effective in metastatic breast cancer

In treatment for metastatic breast cancer, eribulin is effective as a first-, second-, or third-line chemotherapy regimen.

Benefit of breast cancer prevention drug varies among at-risk women

Researchers examined the benefits and risks associated with taking drug tamoxifen for breast cancer prevention.

Factors identified for increased post-surgery weight gain among breast cancer survivors

Factors identified for increased post-surgery weight gain among breast cancer survivors

Average long-term weight gain among breast cancer survivors is small, but certain subgroups experience greater gain associated with adverse health.

Many patients with locally advanced breast cancer do not undergo recommended postmastectomy radiotherapy

Many patients with locally advanced breast cancer do not undergo recommended postmastectomy radiotherapy

Only 65% of patients with advanced breast cancer are receiving the postsurgical radiation therapy.

Ibrance now FDA-approved to treat advanced breast cancer

Ibrance now FDA-approved to treat advanced breast cancer

Ibrance (palbociclib) has been approved by the U.S. Food and Drug Administration (FDA) for postmenopausal women with ER, HER2-negative metastatic breast cancer.

Novel breast cancer risk prediction model is more accurate than current model

A new breast cancer risk model that combines histologic features of biopsied breast tissue from women with benign breast disease and individual patient demographic information more accurately classified breast cancer risk.

New imaging technique significantly improves detection of invasive breast cancers in dense breast tissue

A new breast imaging technique greatly increases the ability to detect invasive breast cancer in women with dense breast tissue, a number in which half of women of screening age are counted.

Potentially targetable signaling pathway generates chemotherapy-resistant cancer cells

Current research has identified a signaling pathway responsible for the generation of slowly proliferating cancer cells that are hard to eradicate via current treatments.

Poor metabolic health increases risk for postmenopausal breast cancer irrespective of BMI

Postmenopausal women who were metabolically unhealthy are at increased risk for breast cancer compared with their metabolically healthy counterparts, according to a recent study.

New sequencing technique reveals genetic clues to rare breast tumors

A recent study provides a comprehensive analysis of the molecular alterations at work in phyllodes tumors, a rare type of breast tumor.

FDA approval for novel breast cancer drug granted ahead of anticipated target date

FDA approval for novel breast cancer drug granted ahead of anticipated target date

The FDA granted accelerated approved for palbociclib (Ibrance) for the treatment of advanced breast cancer.

Many women with breast cancer have poor knowledge about their condition

Many women with breast cancer lack important knowledge about their illness, with minority patients less likely than white patients to know and report accurate information about their tumors' characteristics.

BMI and expression of estrogen receptor affect HER2 expression in luminal B breast cancer

Researchers continue to be fascinated and challenged by the multifactorial nature of breast cancer.

Maximum tolerated doses of gemcitabine

Maximum tolerated doses of gemcitabine

How much more toxicity and myelosuppression has been associated with gemcitabine (Gemzar) when it is infused over periods longer than 30 minutes?

Research promising for reducing risk of breast cancer spreading to the brain

New research seeks to better understand why breast cancer spreads to the brain, with the goal of developing a way to reduce the risk of this phenomenon.

Biopsies with DCIS diagnosis increase for women undergoing mammography

Biopsies with DCIS diagnosis increase for women undergoing mammography

Biopsy frequency went up after diagnostic, but not screening, mammographies.

Many breast cancer patients lack basic knowledge about their disease

Many breast cancer patients lack basic knowledge about their disease

Many women with breast cancer lack basic knowledge about their disease, and the problem is more pronounced among minority women.

Effectiveness of nanoparticle drugs was hindered by tumor microenvironment in triple-negative breast cancer

Nanoparticle drugs were considered to be a potential silver bullet against cancer, but they have not produced the anticipated improvement in overall survival rates.

Biological factors account for most of the variations in breast cancer survival rates

A study of approximately 375,000 U.S. women with invasive breast cancer showed differences in likelihood of diagnosis occurring at an early stage, and survival after stage I diagnosis, based on by race and ethnicity.

New model more accurately classifies breast cancer risk

New model more accurately classifies breast cancer risk

Histologic features of biopsied breast tissue from benign findings along with demographic data to more accurately determine risk.

Nutrition intervention leads to dietary behavior changes in Latina breast cancer survivors

Nutrition intervention leads to dietary behavior changes in Latina breast cancer survivors

An intervention aimed at an under-represented group of Latina breast cancer survivors helped encourage better eating habits and nutrition.

Nutrition education may help prevent breast cancer recurrence

Providing nutrition education to patients with breast cancer could be beneficial for patients and may help to prevent recurrence of their cancer, according to new research.

Mind body techniques added to aerobic exercise improve rehabilitation outcomes in breast cancer survivors

Mind body techniques added to aerobic exercise improve rehabilitation outcomes in breast cancer survivors

Researchers sought to determine the impact of aerobic exercise training and yoga on survivorship measures in breast cancer survivors.

Eribulin effective for earlier treatment of metastatic breast cancer

Eribulin effective for earlier treatment of metastatic breast cancer

Eribulin is active and well tolerated as first-, second-, or third-line therapy in patients with metastatic breast cancer.

Insulin resistance increases breast cancer risk

Insulin resistance increases breast cancer risk

Study of postmenopausal women suggests hormone levels matter more than excess weight, with regard to predicting breast cancer risk.

Combination therapy can reduce chance of recurrence from small HER2+ breast tumors

Women with stage 1 HER2-positive breast tumors who received a combination of lower-intensity chemotherapy and a targeted drug following surgery were unlikely to suffer cancer recurrence within 3 years of treatment.

Researchers map paths to cancer drug resistance

The researchers have mapped the steps used by cells of melanoma, breast cancer, and the blood cancer myelofibrosis to become resistant to drugs, allowing for better success in blocking these pathways and further enabling therapies.

Aerobic exercise reduces fatigue in women undergoing radiotherapy for breast cancer

Aerobic exercise reduces fatigue in women undergoing radiotherapy for breast cancer

Findings in a quasi-experimental study of Taiwanese women with early-stage breast cancer showed the potential for exercise to reduce fatigue in women undergoing radiotherapy.

Mindfulness-based intervention is helpful to younger breast cancer survivors

Mindfulness-based intervention is helpful to younger breast cancer survivors

Younger women with early stage breast cancer who had completed cancer treatment to a 6-week Mindful Awareness Practices (MAPS).

In breast cancer, febrile neutropenia-related admissions account for significant mortality

In breast cancer, febrile neutropenia-related admissions account for significant mortality

Febrile neutropenia-related hospitalizations still account for morbidity, and mortality among patients with breast cancer.

Breast cancer prognosis impacted by race and ethnicity

Breast cancer prognosis impacted by race and ethnicity

The odds of being early breast cancer development and survival chances vary greatly depending on race and ethnicity, according to a new study.

Women with atypical hyperplasia are at higher risk of breast cancer

A new study has better established the future risk of developing breast cancer for those with atypical hyperplasia of the breast.

Breast cancer data analyzed by race/ethnic groups to identify differences in diagnosis, prognosis

Breast cancer data analyzed by race/ethnic groups to identify differences in diagnosis, prognosis

Race and ethnicity may play a role in the timing of breast cancer diagnosis and the prognosis of the woman's disease.

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