Community Breast Navigation Program Improved Breast Screening Rates in Underserved African American and Latino Women

Community Breast Navigation Program Improved Breast Screening Rates in Underserved African American and Latino Women

A community breast navigation program successfully increased mammogram screening rates among African American and Latino women, according to a study presented at the 2016 San Antonio Breast Cancer Symposium (SABCS).

Live-streamed Videos Address End-of-Life Planning, Decision-making

Live-streamed Videos Address End-of-Life Planning, Decision-making

Live-streamed videos are a novel and forward-thinking approach for individuals to learn about end-of-life (EOL) planning and decision-making, according a study presented at the 2016 San Antonio Breast Cancer Symposium.

Metastatic Disease Linked to Patients Reporting Diminished QoL

Metastatic Disease Linked to Patients Reporting Diminished QoL

Patients with metastatic breast cancer have significantly diminished quality of life (QoL) compared with those without metastatic disease and those without breast cancer, a study presented at the 2016 San Antonio Breast Cancer Symposium.

History of Bilateral Salpingo-oophorectomy, Hormone Replacement Therapy Are Predictive of Breast Density at Cancer Diagnosis

History of Bilateral Salpingo-oophorectomy, Hormone Replacement Therapy Are Predictive of Breast Density at Cancer Diagnosis

A history of surgical menopause and were receiving hormone replacement therapy are a factor in breast density, according to a study presented at the 2016 San Antonio Breast Cancer Symposium (SABCS).

Mammographically Occult Contralateral Breast Cancer Detection is Effective With Preoperative MRI

Mammographically Occult Contralateral Breast Cancer Detection is Effective With Preoperative MRI

Study data presented at SABCS 2016 indicates that preoperative MRI is effective for detecting mammographically occult, early-stage, hormone receptor (HR)-positive contralateral breast cancer (CBC) in older patients.

Clinical Breast Examination Superior to MRI for Predicting pCR in HER2+ Breast Cancer

Clinical Breast Examination Superior to MRI for Predicting pCR in HER2+ Breast Cancer

Clinical breast examination (CBE) is superior to MRI for predicting pathologic complete response (pCR) in women with HER2-positive breast cancer, a study presented at the 2016 San Antonio Breast Cancer Symposium indicates.

Video Tool to Increase Breast Cancer Clinical Trial Participation Among Black Women

Video Tool to Increase Breast Cancer Clinical Trial Participation Among Black Women

A new tool may show promise for improving clinical trial participation among black women with breast cancer, according to a study presented at the 2016 San Antonio Breast Cancer Symposium (SABCS).

Genomic Features Predictive of Response to Trastuzumab-Containing Therapy

Genomic Features Predictive of Response to Trastuzumab-Containing Therapy

Research presented at SABCS 2016 identified biomarkers predictive of response to trastuzumab-containing therapies in patients with HER2-positive breast cancer.

No Difference Between RA Seed Localization and Wire Guided Localization

No Difference Between RA Seed Localization and Wire Guided Localization

Results of a comparison study of radioactive seed localization and wire guided localization in patients with nonpalpable invasive breast cancer or DCIS were presented at SABCS 2016.

BRD4 Inhibitor May Enhance Sensitivity to Endocrine Therapies

BRD4 Inhibitor May Enhance Sensitivity to Endocrine Therapies

A novel bromodomain-containing protein 4 inhibitor demonstrated antitumor activity in both endocrine-sensitive and endocrine-resistance breast cancer models, according to a study presented at SABCS 2016.

Dual HER2 Blockade With an AI Effective in Advanced Breast Cancer

Dual HER2 Blockade With an AI Effective in Advanced Breast Cancer

Patients with HER2-positive, HR-positive advanced breast cancer experience significantly improved progression-free survival when pertuzumab is added to first-line trastuzumab and an AI compared with trastuzumab and an AI alone, according to study findings presented at SABCS 2016.

Loperamide Regimen May Reduce Diarrhea in Neratinib-treated Patients

Loperamide Regimen May Reduce Diarrhea in Neratinib-treated Patients

Investigators report on the efficacy of a structured prophylactic regimen of loperamide for 2 cycles to reduce incidence and severity of neratinib-associated diarrhea in patients with HER2-positive early-stage breast cancer, at SABCS 2016.

PAM50 HER2-E Subtype Predicts pCR Following Lapatinib, Trastuzumab

PAM50 HER2-E Subtype Predicts pCR Following Lapatinib, Trastuzumab

In this presentation at SABCS 2016, researchers present an evaluation of the ability of the PAM50 HER2-enriched intrinsic subtype to predict pathologic complete response in the breast in patients who received 18 weeks of neoadjuvant dual HER2 blockade.

Arsenic Pretreatment May Protect Normal Tissue During Chemo in Breast Cancer

Arsenic Pretreatment May Protect Normal Tissue During Chemo in Breast Cancer

Researchers found that temporary pretreatment with LDA may protect normal breast tissue during chemotherapy for breast cancer in patients undergoing breast-conserving therapy, according to a study presented at SABCS 2016.

Netupitant/Palonosetron Efficacious for Prevention of N/V in Patients Receiving MEC or HEC

Netupitant/Palonosetron Efficacious for Prevention of N/V in Patients Receiving MEC or HEC

In a poster presentation at SABCS 2016, researchers reported on the efficacy and safety of netupitant/palonosetron (NEPA) for the prevention of CINV in patients receiving highly or moderately emetogenic chemotherapy.

Costs, Complications Higher for Women Who Undergo Second Surgery After BCS

Costs, Complications Higher for Women Who Undergo Second Surgery After BCS

A study presented at SABCS 2016 reports on the incidence of complications and costs in women who undergo breast-conserving surgery for breast carcinoma.

Omitting RT in Certain Older Women With Early Breast Cancer is Safe

Omitting RT in Certain Older Women With Early Breast Cancer is Safe

Researchers report their study findings on the safety of omitting radiotherapy after breast-conserving surgery, sentinel node biopsy, and adjuvant endocrine therapy in older patients with early breast cancer and favorable histopathology at SABCS 2016.

Fluorescent Nanoparticles Represent Novel Detection Method of HER2 Expression

Fluorescent Nanoparticles Represent Novel Detection Method of HER2 Expression

Researchers investigated the potential of PID fluorescent nanoparticles, a novel detection technique to visualize and quantify protein in clinical samples, for quantifying HER2 protein expression in breast cancer, according to a study presented at SABCS 2016.

Assessment of Stromal Features in DCIS Requires Robustness

Assessment of Stromal Features in DCIS Requires Robustness

Robustness of dichotomous assessment is important when evaluating stromal features of ductal carcinoma in situ (DCIS), according to a study presented at SABCS 2016.

RANKL Inhibition May Represent Promising Breast Cancer Prevention Strategy

RANKL Inhibition May Represent Promising Breast Cancer Prevention Strategy

Research presented at 2016 SABCS showed whether RANKL inhibition could reduce the risk for developing breast cancer in BRCA1 mutation carriers.

Bi-allelic Inactivation Common in BRCA1 and BRCA Breast Cancers

Bi-allelic Inactivation Common in BRCA1 and BRCA Breast Cancers

Bi-allelic inactivation of BRCA1 and BRCA2 are frequent events in BRCA1 breast cancers and BRCA2 breast cancers, respectively, according to a study presented at SABCS 2016.

In HER2+ Breast Cancer, Higher TIL Levels Associated With Improved OS

In HER2+ Breast Cancer, Higher TIL Levels Associated With Improved OS

In this study presented at SABCS 2016, investigators determined the association between higher TIL levels and overall survival in patients with advanced HER2-positive breast cancer treated with docetaxel plus trastuzumab in combination with pertuzumab or placebo.

High Immune Gene Expression Linked to Better Prognosis in TNBC

High Immune Gene Expression Linked to Better Prognosis in TNBC

Researchers assessed the relationship between immune gene expression and genomic complexity in TNBC in a study presented at SABCS 2016.

Extended Treatment With Letrozole Fails to Improve DFS in HR+ Breast Cancer

Extended Treatment With Letrozole Fails to Improve DFS in HR+ Breast Cancer

Today at SABCS 2016 investigators presented results of the NRG Oncology/NSABP B-42, a double-blind phase 3 trial to determine whether extended treatment with letrozole would improve disease-free survival in certain women with HR-positive breast cancer.

Study Identifies Patients Who May Derive More Benefit From Veliparib

Study Identifies Patients Who May Derive More Benefit From Veliparib

At SABCS 2016, researchers presented study findings demonstrating whether neoadjuvant treatment, PARPi-7, BRCAness, and MP1/2 predict response to veliparib plus carboplatin therapy in patients with high-risk breast cancer.

Latina Breast Cancer Survivors Experience Gaps in Survivorship Care

Latina Breast Cancer Survivors Experience Gaps in Survivorship Care

A study using focus groups identifies barriers that impact the quality of survivorship care for Latina women with breast cancer.

Biosimilar Promising for Treatment of ERBB2+ Breast Cancer

Biosimilar Promising for Treatment of ERBB2+ Breast Cancer

Equivalent response rate for women with ERBB2-positive metastatic breast cancer receiving taxanes

Acupuncture Improves Postoperative Symptoms in Women Undergoing Surgery for Breast Cancer

Acupuncture Improves Postoperative Symptoms in Women Undergoing Surgery for Breast Cancer

The effects of a 2-treatment course of acupuncture on pain, nausea, and anxiety and ability to cope among women undergoing mastectomy was compared with usual care.

Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling

Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling

Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, and the beta blocker bisoprolol protected against trastuzumab-related declines.

Resistance Training Improves Posttreatment Outcomes for Breast Cancer Survivors

Resistance Training Improves Posttreatment Outcomes for Breast Cancer Survivors

Loss of bone density related to chemotherapy and adjuvant therapy for breast cancer can lead to debilitating hip and vertebral fractures. This discussion discusses the impact of resistance training for these patients.

Depression May Contribute to Receipt of Inappropriate Breast Cancer Treatment

Depression May Contribute to Receipt of Inappropriate Breast Cancer Treatment

An analysis of data from Danish women with early-stage breast cancer assessed women's risk of receiving nonguideline treatment for their disease if they had a prior diagnosis of depression or prior treatment with antidepressants.

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

The feasibility of an estradiol-releasing vaginal ring vs intravaginal testosterone cream for women with HR-positive stage I to III breast cancer using aromatase inhibitors who reported vaginal dryness, decreased libido, or dyspareunia is evaluated in a phase 2 study.

Hospital Volume Linked to Odds of Appropriate Breast Cancer Locoregional Treatment

Hospital Volume Linked to Odds of Appropriate Breast Cancer Locoregional Treatment

Investigators examined the extent to which hospital volume explains variations in diagnosis and treatment of breast cancer.

Higher Protein Intake May Modestly Improve Breast Cancer Survival

Higher Protein Intake May Modestly Improve Breast Cancer Survival

An analysis of data from women with stage I to III breast cancer investigated the potential association between protein intake and survival.

Economic Burden Related to Chemotherapy-related Adverse Events in Patients with Metastatic Breast Cancer in an Integrated Health Care System

Economic Burden Related to Chemotherapy-related Adverse Events in Patients with Metastatic Breast Cancer in an Integrated Health Care System

[Breast Cancer: Targets and Therapy] This research evaluates costs related to chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care delivery system.

Telerehabilitation Program Improves Posttreatment Effects in Breast Cancer Survivors

Telerehabilitation Program Improves Posttreatment Effects in Breast Cancer Survivors

Study evaluates whether a web-based rehabilitation program can effectively improve pain, fatigue, strength, and quality of life for breast cancer survivors.

Both Older and Younger Women Benefit From Breast Reconstruction

Both Older and Younger Women Benefit From Breast Reconstruction

No greater risk of complications for older patients; benefited as much as younger breast cancer patients

Prolactin Expression May Indicate Better Prognosis for Patients With TNBC

Prolactin Expression May Indicate Better Prognosis for Patients With TNBC

Expression of this hormone receptor may indicate a less aggressive subtype of triple-negative breast cancer and better prognosis for patients with the disease.

Adherence to Tamoxifen, AIs Among Older Women is Low, Study Shows

Adherence to Tamoxifen, AIs Among Older Women is Low, Study Shows

A data analysis reveals the likelihood of older women with to ER-positive DCIS to initiate and adhere to adjuvant tamoxifen or aromatase inhibitors.

Nonadherence to Posttreatment Imaging Follow-up Common Among Breast Cancer Survivors

Nonadherence to Posttreatment Imaging Follow-up Common Among Breast Cancer Survivors

In this study, researchers assessed data on women who underwent breast cancer treatment to identify the factors associated with posttreatment imaging use.

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

The recurrence score assay stratifies early stage, estrogen receptor-positive breast cancer by recurrence risk. This study assessed how clinicians use the recurrence score to recommend adjuvant systemic therapy or patients' experiences with testing decision-making.

Short-Term Intervention May Have Long-term Diet Effect in Hispanic Breast Cancer Survivors

Short-Term Intervention May Have Long-term Diet Effect in Hispanic Breast Cancer Survivors

Researchers examined the long-term effects of a short-term culturally based dietary intervention on increasing the consumption of fruits and vegetables, decreasing fat, and changing biomarkers associated with recurrence in Hispanic breast cancer survivors.

How Physical Changes From Breast Cancer Affect Self-Image: Considerations for Clinicians

How Physical Changes From Breast Cancer Affect Self-Image: Considerations for Clinicians

Cancers that cause more readily noticeable physical changes can produce self-image challenges for patients. This discussion reviews what interventions can help validate patients' self-image concerns.

Costs of Breast Cancer Chemotherapy Vary Widely in the United States

Costs of Breast Cancer Chemotherapy Vary Widely in the United States

Researchers found wide variances in the cost of breast cancer chemotherapy, depending on the course of treatment selected.

Study Confirms Long-term Risk of VTE in Patients With Breast Cancer

Study Confirms Long-term Risk of VTE in Patients With Breast Cancer

Patients with breast cancer have more than 2 times the risk for developing a venous thromboembolism 5 years after diagnosis compared with the general population.

CDK4/6 Inhibitor Plus Aromatase Inhibitor Improves Progression-Free Survival in Metastatic Breast Cancer

CDK4/6 Inhibitor Plus Aromatase Inhibitor Improves Progression-Free Survival in Metastatic Breast Cancer

Adding ribociclib to letrozole significantly improves progression-free survival for postmenopausal women with metastatic hormone receptor (HR)-positive breast cancer, compared with hormone therapy alone.

Expectations of Chemotherapy Side Effects Influence Patients' Experiences During Breast Cancer Treatment

Expectations of Chemotherapy Side Effects Influence Patients' Experiences During Breast Cancer Treatment

Recent studies indicate that adverse side effects can result from factors unrelated to the pharmacologic agent, but rather from other factors.

Most Women Newly Diagnosed With Breast Cancer Perceive High PCP Quality

Most Women Newly Diagnosed With Breast Cancer Perceive High PCP Quality

Overall, 66.2 and 69.1 percent of women perceive high PCP engagement and communication

G-CSF May Only Modestly Prevent Neutropenia-related Hospitalization

G-CSF May Only Modestly Prevent Neutropenia-related Hospitalization

Primary prophylaxis with granulocyte colony-stimulating factor provided only a low-to-modest benefit in reducing neutropenia-related hospitalization in patients with breast cancer receiving low-to-intermediate risk chemotherapy regimens.

Monitoring Metastasis and Cachexia in a Patient with Breast Cancer: A Case Study

Monitoring Metastasis and Cachexia in a Patient with Breast Cancer: A Case Study

[Clinical Medicine Insights: Oncology] A case study of a 49-year-old premenopausal woman with metastatic invasive ductal breast carcinoma in the vertebral and iliac bones, which progressed with new metastases to her hips, thigh bones, and vertebrae.

Risk of Endometrial Abnormalities With Adjuvant Tamoxifen for Early Stage Breast Cancer Is Low

Risk of Endometrial Abnormalities With Adjuvant Tamoxifen for Early Stage Breast Cancer Is Low

For women receiving tamoxifen in the adjuvant setting for early stage breast cancer or as a preventive for high risk of breast cancer, the risk of developing endometrial pathology in those with negative uterine examination findings prior to treatment is very low.

Affordable Care Act Tied to Increased Breast Cancer Care Access for Hispanics

Affordable Care Act Tied to Increased Breast Cancer Care Access for Hispanics

Following the release of the Affordable Care Act (ACA) an increase in Hispanic women receiving breast cancer treatment and their related participation in clinical trials was observed.

Patients Receiving RT in APBI Facilities Despite Eligibility for Observation

Patients Receiving RT in APBI Facilities Despite Eligibility for Observation

Patients with early stage breast cancer who received breast-conserving surgery and were eligible for observation were more likely to undergo adjuvant radiotherapy in facilities performing APBI.

ASCO, ASTRO Issue Guideline Update for Postmastectomy RT

ASCO, ASTRO Issue Guideline Update for Postmastectomy RT

The American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology have issued a joint consensus guideline update for the use of radiotherapy following mastectomy in patients with breast cancer.

G-CSF Prophylaxis May Modestly Reduce Neutropenia-related Hospitalization

G-CSF Prophylaxis May Modestly Reduce Neutropenia-related Hospitalization

Primary prophylaxis with G-CSF may modestly reduce neutropenia-related hospitalization in patients with breast cancer receiving docetaxel and cyclophosphamide or docetaxel, carboplatin, and trastuzumab.

Bioimpedence Spectroscopy Improves Early Detection of Breast Cancer-Related Lymphedema in At-Risk Patients

Bioimpedance spectroscopy (BIS) effectively assesses for subclinical breast cancer-related lymphedema in patients at risk, and accurately assess patients for response to treatment.

Chemotherapy-Induced Dormancy Improves Immunotherapy for Breast Cancer

Chemotherapy-Induced Dormancy Improves Immunotherapy for Breast Cancer

Inducing quiescent dormancy with conventional chemotherapy makes cancer cells more susceptible to immunotherapy, thereby minimizing potential for tumor recurrence.

Artificial Intelligence Method Improves Mammography Readings

Artificial Intelligence Method Improves Mammography Readings

Natural language processing (NLP) software correlated key characteristics expressed verbally in mammography reports with pathologic findings, providing an accurate indication for biopsy referral.

Experimental Drug Improves Immunotherapy Activity in Triple-Negative Breast Cancer

Experimental Drug Improves Immunotherapy Activity in Triple-Negative Breast Cancer

An experimental drug, AMPI-109, shows promise as an immunotherapy that sensitizes triple-negative breast cancer cells, enhancing the effectiveness of the drug.

African American Breast Cancer Survivors Report Significant Problem Burden

African American Breast Cancer Survivors Report Significant Problem Burden

African American survivors of breast cancer experience significant problem burden during the first 5 years after diagnosis and treatment.

A Systematic Review and Meta-analysis of Harmonic Technology Compared With Conventional Techniques in Mastectomy and Breast-conserving Surgery With Lymphadenectomy for Breast Cancer

A Systematic Review and Meta-analysis of Harmonic Technology Compared With Conventional Techniques in Mastectomy and Breast-conserving Surgery With Lymphadenectomy for Breast Cancer

[Breast Cancer: Targets and Therapy] This research compares Harmonic technology and conventional techniques for a range of clinical outcomes and complications in both mastectomy and BCS patients, including axillary lymph node dissection.

Perceived Barriers Associated With Adherence to Aromatase Inhibitors

Perceived Barriers Associated With Adherence to Aromatase Inhibitors

Greater negative beliefs regarding the challenges of their aromatase inhibitor treatment more likely to lead to nonadherence.

Experienced Radiologists Can Detect Breast Cancer at First Glance

Experienced Radiologists Can Detect Breast Cancer at First Glance

Skilled radiologists see abnormalities immediately, and researchers want to learn how they do it.

Novel Radiotracer Is Near Perfect in Detecting Sentinel Lymph Node in Breast Cancer

Novel Radiotracer Is Near Perfect in Detecting Sentinel Lymph Node in Breast Cancer

A novel sentinel lymph node (SLN) radiotracer, 99mTC-rituximab, demonstrated nearly 100% detection/success rate in SLN and metastasis in breast cancer.

MammaPrint Helps to Identify Which Patients Require Adjuvant Chemotherapy

The 70-gene signature test, in combination with standard clinical-pathologic criteria, may help clinicians decide whether patients with early stage breast cancer who are at high clinical risk require adjuvant chemotherapy.

Adolescent Girls With Breast Cancer Family History Have Higher Self-esteem

Adolescent Girls With Breast Cancer Family History Have Higher Self-esteem

Adolescent girls from BRCA1/2 mutation-positive and breast cancer families have high self-esteem but greater breast-cancer specific-distress.

PMPS: A Common Late Effect of Surgery and Radiation for Breast Cancer

PMPS: A Common Late Effect of Surgery and Radiation for Breast Cancer

Postmastectomy pain syndrome (PMPS) is a debilitating late effect of surgery and radiation therapy for breast cancer.

Patient Expectations Linked to Clinical Outcome from Endocrine Treatment

Patient Expectations Linked to Clinical Outcome from Endocrine Treatment

Negative patient expectations are associated with an increased risk of adverse events in patients with breast cancer undergoing endocrine therapy.

Breast Cancer Tumors Often a Composite of Tumor Types, Enhancing Treatment Resistance

Breast Cancer Tumors Often a Composite of Tumor Types, Enhancing Treatment Resistance

Estrogen receptor (ER)-positive breast cancers are often not a single tumor but a composite of related tumors, referred to as sub-clones.

Hormone Receptor Test Results in DCIS Core Needle Biopsy Not Used, Not Needed

Hormone Receptor Test Results in DCIS Core Needle Biopsy Not Used, Not Needed

Routine testing for hormone receptors in tissue obtained in a first needle biopsy for ductal carcinoma in situ (DCIS).

Early Tumor Size Change May Predict OS in Metastatic Breast Cancer

Early Tumor Size Change May Predict OS in Metastatic Breast Cancer

Change in tumor size at week 8 may predict overall survival during first-line therapy in patients with metastatic breast cancer.

Physical Activity May Reduce Mortality by 44% in Patients With Breast Cancer

Physical Activity May Reduce Mortality by 44% in Patients With Breast Cancer

Participation in exercise may reduce mortality compared with nonparticipation in patients with breast cancer.

Weight Loss Through Diet Improves Risks for Cancer in Overweight/Obese Women

Weight Loss Through Diet Improves Risks for Cancer in Overweight/Obese Women

Losing weight through diet or diet and exercise improves risk for cancer in overweight or obese postmenopausal women. Although exercise alone can help maintain weight loss, it is not as effective as diet and exercise.

New Guidelines Establish Safe Surgery Margins for DCIS

New Guidelines Establish Safe Surgery Margins for DCIS

Consensus guideline states that a 2 mm margin is enough to guard against recurrences while reducing need for additional operations for women with DCIS who undergo breast-conserving surgery.

ESR1 Mutations Prevalent in ER+ Metastatic Breast Cancer

ESR1 Mutations Prevalent in ER+ Metastatic Breast Cancer

ESR1 mutations are more frequent in patients with estrogen receptor (ER)-positive metastatic breast cancer that are treated with aromatase inhibitors, according to recent study data.

Western Diet May Help Contribute to Dense Breasts

Western Diet May Help Contribute to Dense Breasts

Study data indicate that women who ate a Western diet also had 46 percent higher risk of breast cancer.

Sarcopenia Measures Associated With Toxicity Outcomes, Survival in Metastatic Breast Cancer

Sarcopenia Measures Associated With Toxicity Outcomes, Survival in Metastatic Breast Cancer

Measures of severe skeletal muscle loss, or sarcopenia, are associated with toxicity outcomes and survival in patients with metastatic breast cancer receiving first-line taxane-based chemotherapy.

Age-Related Prognosis in Breast Cancer Varies by Subtype

Age-Related Prognosis in Breast Cancer Varies by Subtype

Survival among women age 40 years and younger with breast cancer appears to vary according to breast cancer subtype, with age particularly prognostic for women with luminal type breast cancers.

Anti-HER2 Therapies Link With Heart Blood Vessel Development Explains Cardiovascular Side Effects of Trastuzumab

Anti-HER2 Therapies Link With Heart Blood Vessel Development Explains Cardiovascular Side Effects of Trastuzumab

Therapies targeting ErbB2 (HER2), such as trastuzumab (Herceptin), are often associated with cardiovascular side effects. ErbB2 was recently found to also be expressed by vascular endothelial cells, and is an example of how tissue growth and blood vessel patterning are integrated at the molecular level.

Cognitive Impairment Common With Adjuvant Therapy in Older Patients With Early Stage Breast Cancer

Cognitive Impairment Common With Adjuvant Therapy in Older Patients With Early Stage Breast Cancer

Cognitive decline associated with adjuvant chemotherapy was more likely to occur in older patients, particularly those whose treatment included docetaxel.

Acupressure Improves Fatigue, Sleep, and Quality of Life for Survivors of Breast Cancer

Acupressure Improves Fatigue, Sleep, and Quality of Life for Survivors of Breast Cancer

Acupressure reduced persistent fatigue in women who had been treated for breast cancer, improving both sleep and quality of life.

Trastuzumab Biosimilar Comparable the Monoclonal Antibody for Advanced HER2+ Breast Cancer

MYL-1401O is comparable in efficacy and safety to the anti-HER2 monoclonal antibody trastuzumab as frontline therapy in breast cancer.

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

Patients with kataegis, a recently discovered phenomenon in which multiple mutations cluster in a few hotspots in a genome, have less invasive tumors and better prognoses.

Helical APBI Delivers Targeted Dose of Adjuvant Radiation Treatment for Breast Cancer

Helical APBI Delivers Targeted Dose of Adjuvant Radiation Treatment for Breast Cancer

Preliminary results of a prospective, phase II trial show that once-daily accelerated partial breast irradiation (APBI) effectively prevented recurrence of cancer in the treated breast at a median 34 months after treatment.

A Systematic Review and Meta-analysis of the Risk of Diarrhea Associated With Vandetanib Treatment in Carcinoma Patients

A Systematic Review and Meta-analysis of the Risk of Diarrhea Associated With Vandetanib Treatment in Carcinoma Patients

[OncoTargets and Therapy] This research examines overall risks of all-grade and high-grade diarrhea during vandetanib treatment, to gain a better understanding of its prediction and management.

Chronic Pain Is More Likely for Women Who Undergo Armpit Lymph Node Surgery for Breast Cancer

Chronic Pain Is More Likely for Women Who Undergo Armpit Lymph Node Surgery for Breast Cancer

Risk factors for chronic pain after breast cancer surgery include axillary lymph node dissection, younger age, and radiation therapy. Only axillary lymph node dissection is a high-yield target for a modifiable risk factor to prevent the persistent pain after breast cancer surgery.

High-Fat Mediterranean Diet Can Protect Against Cancer

High-Fat Mediterranean Diet Can Protect Against Cancer

A Mediterranean-style diet can help protect against diabetes, cardiovascular disease, and breast cancer,research indicates.

Radiologists Vary Widely on the Definition of Dense Breasts

Radiologists Vary Widely on the Definition of Dense Breasts

The definition of dense breasts can range from 6.3 to 84.5 percent of patients, depending on radiologist.

Ratio of Biomarkers on Imaging Identifies Aggressiveness of DCIS

A new technique combines imaging and mathematics to identify aggressive forms of ductal carcinoma in situ (DCIS), or stage 0 breast cancer, from nonaggressive varieties.

Triplet Regimen Followed by Maintenance Active in Triple-negative Breast Cancer

Triplet Regimen Followed by Maintenance Active in Triple-negative Breast Cancer

A first-line triplet chemoimmunotherapy regimen comprised of paclitaxel, capecitabine, and bevacizumab followed by capecitabine and bevacizumab alone as maintenance therapy is highly active with a manageable safety profile in patients with triple-negative breast cancer.

Supine Position Better Informs Surgeons About Tumor Size and Location Before Lumpectomy for Breast Cancer

Considerable deformity of the breast and tumor position occur when placing patients in the prone (face down) position to obtain pre-operative MRI of the breast, compared with placing patients in the supine (face up) position.

Exercise Can Improve Memory in Breast Cancer Survivors

Exercise Can Improve Memory in Breast Cancer Survivors

Moderate physical activity can ease the stress that impairs memory among breast cancer survivors, research indicates.

Epigenetic Regulator of Tumorigenesis Suggests New Strategies Against Breast Cancer

The protein CBX8 uses a previously unknown mechanism to promote the origin of breast tumors, or tumorigenesis, in the most lethal forms of breast cancer, according to new research.

Moderate-to-Vigorous Exercise Improves Subjective Memory in Breast Cancer Survivors

Moderate-to-Vigorous Exercise Improves Subjective Memory in Breast Cancer Survivors

Memory problems in breast cancer survivors appear associated with the high stress load these patients experience rather than their treatment, and moderate-to-vigorous physical activity may help subjective memory in these patients.

Bacteria in Breast Tissue May Protect Against Breast Cancer

Bacteria in Breast Tissue May Protect Against Breast Cancer

Bacteria differ between healthy breasts and those with cancer, and beneficial bacteria may actually be protecting women against cancer; a finding that may lead to using probiotics to prevent breast cancer.

Photodynamic Cancer Therapy Holds Promise as an Noninvasive Option for Tumor Resection

A single dose and a beam of light can kill up to 95% of cancer cells in 2 hours, according to preclinical research on a novel approach to tumor resection. Photodynamic cancer therapy may be a treatment option for people whose tumors are inoperable or hard-to-reach.

Among Survivors, Relaxing Acupressure Improves Fatigue, Sleep Quality, QoL

Among Survivors, Relaxing Acupressure Improves Fatigue, Sleep Quality, QoL

Relaxing acupressure resulted in significant improvement in persistent fatigue, sleep quality, and quality of life among survivors of breast cancer, a recent study has shown.

POSTCARE Intervention May Improve QoL Among Cancer Survivors

POSTCARE Intervention May Improve QoL Among Cancer Survivors

The Patient-Owned Survivorship Transition Care for Activated, Empowered survivors (POSTCARE) intervention resulted in clinically meaningful improvements in 3 domains of quality of life (QoL) among survivors of breast cancers.

Surgery and Adjuvant Hormonal Therapy Less Effective for Older Patients With Breast Cancer

Surgery and Adjuvant Hormonal Therapy Less Effective for Older Patients With Breast Cancer

A group of researchers sought to examine the physical functioning of patients with breast cancer, in various age brackets, who were enrolled in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) phase III trial.

New Device Improves Breast Imaging With Less Radiation Exposure

New Device Improves Breast Imaging With Less Radiation Exposure

New screening device provides images with 6 times better contrast of breast tumors and approximately half the radiation dose of standard mammography.

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