Decisions about radiotherapy after breast-conserving surgery for ductal carcinoma in situ can be tailored on the basis of patient factors, tumor biology, and the prognostic score, according to research.
Moderate exercise intervention did not appear to improve physical functioning in women with advanced breast cancer to a significant degree, according to study data.
Chemotherapy for breast cancer can affect the body's ability to ward off common illnesses.
Smokers have good reason to quit the habit both before and after a breast cancer diagnosis.
Review found increased odds for developing thyroid or breast cancer as secondary malignancy after the other cancer type was diagnosed.
Replacing paclitaxel with nab-paclitaxel, followed by neoadjuvant epirubicin and cyclophosphamide, proved beneficial for patients with invasive breast cancer.
The accuracy of axillary staging and of pathologic evaluation of clinically node-positive breast cancer is improved by a new procedure, reducing the need for a more invasive procedure with debilitating complications.
Almost half of patients with metastatic HR-positive breast cancer treated with everolimus and exemestane required a dose reduction.
No increase in locoregional recurrence, systemic recurrence, or second breast cancer observed following breast lipofilling procedure.
An in-depth look at the issues associated with the care reveals a need to improve how clinicians can help these women sort through their options.
Listening to guided meditation significantly reduced biopsy pain during imaging-guided breast biopsy.
Higher dietary fiber intake during adolescence and early adulthood may reduce the risk for developing breast cancer.
Among persons 65 years or older with limited life expectancies of less than 10 years, an estimated 15.7% may have undergone nonrecommended screenings for prostate and breast cancers.
Dozens of new uses for existing drugs, new targets for drug discovery, and new drug combinations have been suggested by the largest analysis of breast cancer cell function to date.
Older Age, Quality of Life Associated With Deviations From Initial Treatment Decisions in Breast Cancer
Nonadherence to recommended adjuvant chemotherapy in patients with breast cancer is associated with poor quality of life (QoL).
Approximately two-thirds of women with stage 1 breast cancer who are 70 years or older are eligible to safely omit subsequent radiation therapy (RT).
Smoking before or after cancer diagnosis was associated with a higher mortality from breast cancer and several other causes.
The rate of non-recommended screening is 15.7 percent in those 65 years and older.
Breast density assessments can vary for as many as 19% of women, which can lead to inconsistent information regarding the need for additional clinical screenings.
The risk of radiation-induced breast cancer is higher for women with large breasts or breast implants because extra screening views often increase their radiation exposure.
[Breast Cancer: Targets and Therapy] This research examines the unique challenges faced by younger patients with breast cancer, such as the tendency for a more aggressive biology and consequently a poorer prognosis, as well as as related fertility and psychosocial issues.
The impact on quality of life for patients with breast cancer receiving adjuvant endocrine therapy (ET) should be given more attention, and clinicians should make better efforts to address patient-reported outcomes.
Age, surgery, and radiation were associated with the initiation of tamoxifen after ductal carcinoma in situ (DCIS).
Survivorship care plans led to improved outcomes in a randomized, controlled trial reported at the American Society of Clinical Oncology 2016 Cancer Survivorship Symposium.
Both black and white women age 75 to 84 years who underwent annual mammography had lower 10-year breast cancer mortality than corresponding women who underwent biennial or no/irregular mammographies.
Nurse-navigated treatment summaries and survivorship care plans (TSSCPs) may improve adherence.
[Breast Cancer: Basic and Clinical Research] This research examines previous recent research on the therapeutic effects and adversities of eribulin monotherapy and eribulin-based combination therapy for breast cancer treatment.
Highest rates of false-positive mammography results and additional imaging seen for women 40 to 49 years old.
Uptake of screening magnetic resonance imaging (MRI) of the breast into clinical practice has the potential to worsen population-based health disparities.
Palbociclib, a new oral treatment for certain types of breast cancer, demonstrates potential as a treatment for other types of cancer as well.
Excluding patients with renal insufficiency but good performance status from clinical trials due to concern of excessive hematologic toxicity or poor outcomes may not be necessary with appropriate dosing modifications.
Everolimus-induced stomatitis did not negatively affect progression-free survival in patients with various types of cancer, such as breast cancer and renal cell carcinoma.
Breast cancer survivors who are prescribed an adjuvant AI want ongoing communication with their oncology clinician about the potential for arthralgia and how these joint adverse effects can be managed.
Cancer-induced Weakness in Immune System May Be Key to HER2+ Breast Cancer Recurrence, and Prevention
T cells from patients whose breast cancer had recently recurred showed weak response to the HER2 receptor protein, according to a recent study. The study findings suggest that immune status monitoring may be used to gauge the risk of recurrence.
Travel distances continue to be a significant barrier to women undergoing breast reconstruction after mastectomy for breast cancer.
Ultrasound has comparable sensitivity in detecting breast cancer compared with mammography and should be considered when testing for the disease.
Follow-up of people whose screening examinations showed abnormal findings occurred faster for breast cancer than for colorectal and cervical cancers, according to a recent study involving more than 1 million people who underwent screening for these cancers.
Twins carry a significant excess familial risk for cancer overall and for specific types of cancer, including prostate, melanoma, breast, ovary, and uterus, according to a long-term follow-up study of twins in Nordic countries.
Nurse researchers examined the validity, sensitivity, and specificity of various symptoms indicative of breast cancer-related lymphedema. They also determined the best cutoff points for diagnosing lymphedema and risk of lymphedema in breast cancer survivors.
Data collected from Japanese and Korean participants in the global PALOMA3 trial provide evidence that combining palbociclib with fulvestrant is an effective strategy to overcome endocrine resistance in women with advanced HR+/HER2- breast cancer.
Discrepancies Exist Between Patient and Clinician Reports of Adjuvant Chemotherapy-related Adverse Effects
Patient self-reports of adjuvant chemotherapy-related adverse effects are consistently higher in frequency and greater in severity than physician reports, according to a recent study.
Postmenopausal women with periodontal disease are more likely to develop breast cancer than women who do not have the chronic inflammatory disease.
High amounts of dietary sugar, as is common in the typical Western diet, may increase the risk of breast cancer and metastasis to the lungs.
Researchers observed significant changes in health-related quality of life (HRQoL), depression, and sexual function among patients with breast cancer receiving chemotherapy.
Lymphedema related to breast cancer is one of the most distressing and feared late effects of breast cancer treatment. Given the improved survival following breast cancer, more and more survivors face lifetime risk of developing this late effect.
Concurrent administration of triptorelin and chemotherapy was associated with higher long-term probability of ovarian function compared with chemotherapy alone among premenopausal women with either HR-positive or HR-negative breast cancer.
Active surveillance could be a viable alternative to surgery and radiation for select patients with ductal carcinoma in situ (DCIS).
Findings from a recently published study point to the enzyme casein kinase 1δ (CK1δ), a critical regulator of growth, as a novel and highly vulnerable therapeutic target in hard-to-treat subtypes of breast cancer.
Tumor Location and Duration of Therapy Influence Palliative Effects of Radiation Therapy for Painful Bone Metastases
In a review of the Dutch Bone Metastasis Study results, stratified for primary tumor location, palliative radiation therapy was found to reduce pain and improve quality of life for some patients.
With long-term follow-up, letrozole can be safely administered concomitantly with adjuvant breast radiotherapy in postmenopausal patients with stage 1 to 2 breast cancer.
Economic burden is significantly higher for survivors of colorectal, breast, and prostate cancers compared with persons with no cancer history; however, excess economic burden attributable to cancer varies by cancer site and age.
Young patients with HER2+ breast cancer and no family history have low risk of carrying high risk genes
A recent study examined genetic susceptibility in younger patients diagnosed with HER2+ breast cancer.
Mindfulness-based Stress Reduction Reduces Cognitive Deficits in Survivors of Breast and Colorectal Cancers
Participation in an MBSR program yields robust and sustained improvement in cancer-related cognitive impairment.
American Cancer Society and American Society of Clinical Oncology publish their breast cancer survivorship care guideline, providing care guidance for the estimated 3.1 million female adult survivors of breast cancer in the United States.
[Breast Cancer: Targets and Therapy] This review examines clinical characteristics of male breast cancer and best practices for long-term care with a focus on surveillance, screening, and treatment-related symptom management.
A new analysis indicates that certain characteristics may indicate a higher risk of developing leukemia after chemotherapy and/or radiation for breast cancer survivors.
Screening for and treatment of ductal carcinoma in situ (DCIS) is found to prevent subsequent invasive cancer.
More than 3 months from surgery to chemotherapy and increasing delays from diagnosis to surgery in patients with breast cancer are associated with increased risk of death from the disease.
Black women with breast cancer treated with early chemotherapy fare worse than women of other minority groups.
Recent trial data indicate that axillary lymph node dissection (ALND) can be safely omitted in select patients, according to a research presented at the 2015 San Antonio Breast Cancer Symposium.
Adherence to cancer screening recommendations was not found to vary by race/ethnicity and body weight/obesity. In a focused look at the influence of body mass index (BMI) as a measure of obesity, some screening disparities may be decreasing.
Anthracycline-based Chemotherapy More Likely to Produce Neurotoxic Effects on Cognition in Breast Cancer Survivors
Anthracycline-based chemotherapy may have greater negative effects on some cognitive domains and brain network connections compared with nonanthracycline-based regimens.
Risk of death from all causes is 45% higher in women with breast cancer and a subsequent diagnosis of depression, according to a recent study. This finding could help identify those women most at risk for depression and in need of support.
Women with stage IV breast cancer are more likely to not only survive but survive for an increasingly longer period of time after diagnosis.
Laser ablation procedure shows promise on breast cancer tumors up to 2 cm in diameter, but more study is needed.
The use of sentinel lymph node biopsy (SLNB) alone for care for axillary management in breast cancer patients with negative nodes is on the increase, according to study data presented at the 2015 San Antonio Breast Cancer Symposium.
New study findings presented at SABCS 2015 suggest that BRCAT431 promotes tamoxifen resistance, thereby increasing the clinical risk of recurrence and metastases in breast cancer.
Research in mouse models has identified molecules that can bind to cancer cells and induce apoptosis.
A novel genetic driver analysis of matched breast cancer primary tumors and multiorgan metastases suggests that most genetic drivers in a single tumor are based on DNA copy number variants (CNV), are established early, and are maintained in metastases. These findings were presented at the 2015 San Antonio Breast Cancer Symposium.
Ten-year Overall Survival Is Higher After Breast-conserving Therapy Compared With Mastectomy in Early Stage Breast Cancer
Breast-conserving surgery with radiation therapy (BCT) demonstrated improved 10-year overall survival in patients with early stage breast cancer compared with mastectomy without radiation therapy, according to data presented at the 2015 San Antonio Breast Cancer Symposium.
EPclin Score Provides More Prognostic Information for Residual Distant Recurrence in ER+/HER2- Breast Cancer
EndoPredict (EP) provided superior information to the Oncotype DX recurrence score (RS) for distant recurrence (DR) in overall, N+, and N- patient populations, and also pinpointed a low-risk patient group who may not need chemotherapy.
There are benefits for breast and colorectal cancer survivors with mindfulness-based stress reduction, study data indicates.
The size of a surgically removed tumor is generally thought to relate to the risk of metastasis; however, tumor cells metastasize at different times therefore the rate of spread is difficult to assess. A mathematical model was developed to calculate the relationship between tumor size and the relative risk of recurrence after surgery.
Women who were taught how to manage stress early in their breast cancer treatment showed greater length of survival and longer time until disease recurrence over 8 to 15 years after their original diagnosis.
Synthetic 2D Mammography Is Cost Effective and Reduces X-ray Exposure in Breast Cancer Screening Mammography
Use of a synthetic 2D mammogram, instead of a standard 2d film, may offer breast cancer patients the benefits of 2D/3D screening combinations at a reduced radiation exposure level.
Adding Carboplatin to Neoadjuvant Therapy for Triple-negative Early Breast Cancer Improves Disease-free Survival
Carboplatin added to anthracycline/taxane-based neoadjuvant chemotherapy significantly improved pathological complete response rates in patients with triple-negative breast cancer in two large phase IIb studies: GeparSixto and CALGB 40603. Researchers reported on disease-free survival for GeparSixto after median 35 months of observation at the 2015 San Antonio Breast Cancer Symposium.
Premenopausal Patients With High-risk Luminal A Breast Cancer Get No Benefit From Adjuvant Chemotherapy
Premenopausal women with luminal A subtype breast cancer had comparable 10-year disease-free survival rates regardless of whether they received adjuvant chemotherapy, according to data presented at the 2015 San Antonio Breast Cancer Symposium.
Additional breast cancers found with MRI are sometimes larger and potentially more aggressive than those found on mammography, and in some cases, may necessitate a change in treatment plan.
Avelumab has an acceptable safety profile in patients with metastatic breast cancer and demonstrated signs of greater clinical activity in specific subsets of patients.
Prophylactic Heart Failure Pharmacotherapy Is Safe and Effective in Patients With HER2-overexpressing Breast Cancer
Prophylactic use of standard HF pharmacotherapy appears to be effective for patients with HER2-overexpressing breast cancer.
Nipple-sparing Mastectomy Offers Better Cosmetic and Psychological Outcomes for Patients With Breast Cancer
Nipple-sparing mastectomy and immediate breast reconstruction results in higher reported patient body image, when compared to skin-sparing partial mastectomy (SS-PM), and may lower risk of local recurrence.
Low-income women in Medicaid expansion states in the United States are more likely to undergo breast cancer screening than those in nonexpansion states, according to a study presented at RSNA 2015.
Researchers report that expansion of Medicaid coverage is improving access to mammograms in the United States.
Researchers developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting, and surfing the Web.
Women with a history of a false-positive mammogram result may have an increased risk for developing breast cancer.
Telephone counseling is similarly effective to in-person counseling for overweight breast cancer survivors.
Patients with breast cancer whose health insurance plans included prescription drug benefits were 10% more likely to start important hormonal therapy than patients who did not have prescription drug coverage.
Receipt of the 21-gene recurrence score assay (RS) impacts breast cancer treatment and health care costs.
Use of estrogen with progestin increases the risk of estrogen receptor (ER)-positive breast cancer in African American women.
New Model for Breast Cancer Risk in Hispanic Women Is the First to be Based Exclusively on Data From Hispanic Women
The first breast cancer risk-prediction model based entirely on data from Hispanic women, including whether a woman was born in or outside the United States, provides a more accurate assessment of Hispanic women's risk of developing breast cancer.
RNA test of blood platelets can detect, classify, and pinpoint the location of cancer by analyzing a sample equivalent to 1 drop of blood. Using this new method, researchers were able to identify cancer with 96% accuracy.
S-1 is just as effective in terms of overall survival as a taxane as first-line treatment for patients with metastatic breast cancer.
There are no racial disparities in Oncotype DX (ODX) testing for patients with node-negative early breast cancer for ODX testing.
Both in-person and telephone counseling were effective weight loss strategies in breast cancer survivors and resulted in favorable effects.
The use of anastrozole for the prevention of breast cancer was associated with a higher incidence of carpal tunnel syndrome (CTS).
Scientists developed a highly sensitive blood test that indicates when breast cancers become resistant to standard hormone treatment. In addition, the test results can be used to guide further treatment.
New and better drugs to treat diseases such as advanced breast cancer will have little effect on improving patient outcomes if a country does not have good health care structures in place.
International Experts Call for Investigations Into Long-Term Management Options for Select Patients With Advanced Breast Cancer
International experts have called for a clinical trial to investigate the best ways for identifying and treating a small but important group of patients with advanced breast cancer who can survive for long periods without their disease progressing.
Depression and antidepressant use may not be associated with increased risk of breast cancer.
Patients With Advanced Breast Cancer Address an International Conference About Misleading Disease-Specific Messages
Patients with advanced breast cancer spoke out about the damaging messages some organizations issue about advanced breast cancer. They need to be identified and educated to change the way they talk about the disease.
- Novel Procedure Improves Staging of Lymph Nodes in Patients With Breast Cancer
- Earlier and More Frequent Tanning Bed Use by Women Associated With Melanoma Incidence and Age at Diagnosis
- Nab-paclitaxel Increases Complete Response Rate in Invasive Breast Cancer
- Risk of Breast Cancer or Thyroid Cancer Higher Following a Diagnosis of the Other Cancer Type
- Satisfaction With Navigators Associated With Satisfaction With Cancer-related Care
- Understanding Drug Naming Nomenclature
- Low-income Breast Cancer Survivors Benefit From Personalized Survivorship Care Plans
- Inconclusive: The Pulmonary Nodules You Need to Follow
- Nurse Navigators Key to Seamless Transition From Pediatric to Adult Survivorship Care
- Novel Procedure Improves Staging of Lymph Nodes in Patients With Breast Cancer
- Tailoring Decisions on Radiation Therapy for DCIS
- Skeletal-related Events Linked With Worse Survival, Increased Costs
- Exercise Intervention Fails to Improve Physical Functioning in Advanced Breast Cancer
- PET Imaging Promising for Metastatic Prostate Cancer
- Families of Patients With Cancer Seek Information More Than Support on Internet
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