Obesity associated with increased breast cancer risk in postmenopausal women

Clinical trial data suggests that postmenopausal women of above-average weight have an increased risk of breast cancer.

Increasing percentages of patients undergoing breast-conserving therapy

The percentage of patients with early stage breast cancer undergoing breast-conserving therapy (BCT) increased from 54.3% in 1998 to 60.1% in 2011, according to a recent report. Notably, nonclinical factors including socioeconomic demographics, insurance, and the distance patients must travel to treatment facilities persist as key barriers to the treatment.

ALK1 protein may play a role in breast cancer metastasis

Breast cancer patients with high levels of the protein activin-like receptor kinase (ALK1) in the blood vessels of their tumors were more likely to develop metastatic disease, according to a new study. This makes inhibition of the ALK1 pathway a possible new target for the treatment of metastatic breast cancer.

Distinct triple-positive subtypes identified in breast cancer

CHICAGO, IL—Functional subtyping with a multigene classifier resulted in 1 in 5 tumors being reclassified compared with conventional immunohistochemistry/fluorescent in situ hybridization (IHC/FISH) analysis. This study was presented at the 2015 American Society for Clinical Oncology (ASCO) Annual Meeting.

10 percent urea cream superior to new ointment for hand-foot syndrome

10 percent urea cream superior to new ointment for hand-foot syndrome

10% urea cream is superior to a newly introduced ointment containing various antioxidants at preventing hand-foot syndrome.

Yoga and meditation can ease menopausal symptoms following breast cancer

Yoga and meditation can ease menopausal symptoms following breast cancer

Randomized trial shows beneficial effect for yoga combined with meditation in breast cancer survivors.

Racial differences in breast cancer survival

Racial differences in breast cancer survival

The links between demographic, treatment, and socioeconomic factors and breast cancer survival were examined in a recent study.

Partial versus entire breast radiation does not increase recurrence

Partial versus entire breast radiation does not increase recurrence

Women diagnosed with breast cancer and treated with a one-week regimen of partial breast radiation after tumor removal saw no increase in cancer recurrence or difference in cosmetic outcomes.

Lifestyle intervention trial produces posttreatment weight loss in patients with breast cancer

The presence of extra body fat causes increased risk of diabetes and heart disease, and also increases the chances for breast cancer recurrence.

Scientists identify key to preventing metastatic breast cancer

Scientists identify key to preventing metastatic breast cancer

The discovery of an enzyme that facilitates the spread of breast cancer may enable clinicians to prevent secondary cancer.

Embryo cryopreservation possible for women with breast cancer

Embryo cryopreservation possible for women with breast cancer

Embryo cryopreservation after aromatase inhibitor treatment and ovarian stimulation preserves fertility for patients with breast cancer, according to a study published online.

Smoking may have negative effect on breast cancer survival

Smoking may have negative effect on breast cancer survival

Premenopausal women with breast cancer are at increased risk of dying if they smoke.

Removing more breast tissue reduces the need for a second cancer surgery

Expanded surgical margins during a partial mastectomy could be beneficial for patients, preventing further surgery.

Majority of women with early-stage breast cancer undergoing imaging despite guidelines

Majority of women with early-stage breast cancer undergoing imaging despite guidelines

The majority of women with early-stage breast cancer undergo imaging for metastatic cancer despite guidelines.

Breast cancer false alarms have a negative impact on women's health

A false breast cancer diagnosis can have long-lasting psychological effects.

Breast-conserving therapy rates are slowly rising

Breast-conserving therapy rates are slowly rising

The number of patients that undergo breast-conserving therapy (BCT) has risen slowly in recent years, but many with early-stage disease still choose mastectomy.

Benefit of surgery for ductal carcinoma in-situ investigated

Breast surgery performed at or shortly after a diagnosis of low-grade ductal carcinoma in-situ (DCIS) was not found to significantly impact patients' survival rate.

Access to breast-conserving therapy still an issue for some patients

Access to breast-conserving therapy still an issue for some patients

Rates of breast-conserving therapy for early-stage breast cancer have increased.

Sleep quality impacts breast cancer survival

Sleep quality impacts breast cancer survival

Poor sleep and snoring before breast cancer diagnosis is tied to poor survival outcomes.

Misperceptions about impact of double mastectomy are common

Half of the women with breast cancer polled considered double mastectomy, but only a little more than a third knew the aggressive procedure doesn't up the chances of survival.

Attending breast cancer screening reduces risk of death from breast cancer by 40%

Attending breast cancer screening reduces risk of death from breast cancer by 40%

Women ages 50 to 69 years who attend mammography screening reduce their risk of dying from breast cancer by 40% compared with women who are not screened, according to the latest evidence.

Norwegian screening program reduces breast cancer-related death rates

Norwegian screening program reduces breast cancer-related death rates

A Norwegian breast cancer screening program has markedly reduced breast cancer mortality.

Male breast cancer added to list of obesity-associated cancers

Male breast cancer added to list of obesity-associated cancers

An increase in cases of male breast cancer to the growing list of cancers associated with rising obesity rates.

Obesity associated with increased postmenopausal invasive breast cancer risk

Obesity associated with increased postmenopausal invasive breast cancer risk

Obesity is associated with increased risk for invasive breast cancer in postmenopausal women.

Evidence for screening mammography for women in their 40s remains limited

Evidence for screening mammography for women in their 40s remains limited

A new research review indicates that breast screening in the 40s may not prevent breast cancer deaths, but the conclusion among researchers wasn't unanimous.

Prognosis for patients with breast cancer is not impeded by family history

A new study found that prognosis after treatment for women with breast cancer with a family history of the disease is no worse than it is for other women with breast cancer.

Surgery less likely if breast cancer diagnosed as an emergency

Surgery less likely if breast cancer diagnosed as an emergency

Breast cancer patients are much less likely to have potentially lifesaving surgery if diagnosed as an emergency rather than via urgent GP referral.

Increase in cancer screening may be result of ACA provision

Increase in cancer screening may be result of ACA provision

Affordable Care Act has removed financial barriers to preventive services, including breast and colorectal cancer screening.

ASCO: Palbociclib increases survival for HR+ metastatic breast cancer

ASCO: Palbociclib increases survival for HR+ metastatic breast cancer

Adding palbociclib to standard hormone therapy may be more beneficial than hormone therapy alone for HR+/HER2− breast cancer, according to a new study.

ASCO: Additional tissue removal reduces further breast cancer surgery

ASCO: Additional tissue removal reduces further breast cancer surgery

Removing extra tissue can halve the chances of requiring a second surgery in breast cancer.

Blood test detects breast cancer metastasis early

A blood test that involves examination of cell-free circulating DNA could be key to earlier detection of breast cancer metastases.

Breast surgery for low-grade ductal carcinoma may not improve survival

Breast surgery for low-grade ductal carcinoma may not improve survival

Breast surgery performed at or shortly after a diagnosis of low-grade ductal carcinoma in-situ (DCIS) experienced no difference in survival.

Cancer survivors have evolving information needs

Depending on the type of cancer faced, the needs of survivors can vary.

Enzalutamide May Represent Novel Therapeutic Option for Triple-Negative Breast Cancer

Enzalutamide May Represent Novel Therapeutic Option for Triple-Negative Breast Cancer

Enzalutamide may be a viable alternative therapy over cytotoxic chemotherapy for individuals with triple-negative breast cancer, according to a study presented at the 2015 American Society of Clinical Oncology annual meeting.

"Smarter" cancer screening advised for women with dense breasts

Not all women with dense breasts have a high enough breast cancer risk to justify additional imaging after a normal mammogram, according to a recent study.

Young Women with Breast Cancer on Ovarian Suppression Need Early Intervention to Mitigate Poor QOL

Young Women with Breast Cancer on Ovarian Suppression Need Early Intervention to Mitigate Poor QOL

Early intervention should be offered to young women with breast cancer on ovarian function suppression and tamoxifen, who experience poorer quality of life (QOL) in the early survivorship period, according to a study presented at the 2015 American Society of Clinical Oncology Annual Meeting.

Letrozole Significantly Reduces Late Invasive Events in HR+ Early Breast Cancer

Letrozole Significantly Reduces Late Invasive Events in HR+ Early Breast Cancer

Letrozole significantly reduced the rate of late invasive breast cancer events in postmenopausal women who had completed 4+ years of adjuvant endocrine therapy for HR+ breast cancer, the LATER trial concluded at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting.

Diagnostic Assay Improves Outcomes Prediction in Early Breast Cancer, Nixing Need for Chemo

Diagnostic Assay Improves Outcomes Prediction in Early Breast Cancer, Nixing Need for Chemo

Outcome prediction for postmenopausal patients with node-positive HR+ early breast cancer can be improved using a diagnostic assay, potentially negating the need for adjuvant chemotherapy, according to a study presented at ASCO 2015.

Breast cancer survivors can lose weight through modest lifestyle changes

Breast cancer survivors can lose weight through modest lifestyle changes

Female breast cancer survivors may be able to lose weight through modest lifestyle changes.

Men with high estrogen levels could be at greater risk of breast cancer

New research indicates that men with naturally high levels of the female hormone estrogen may have a greater risk of developing breast cancer.

A positive family history alone may not affect breast cancer outcomes

A positive family history alone may not affect breast cancer outcomes

No difference seen in distant disease-free intervals for those with versus those without a positive family history, say researchers.

Patients older than 60 years on hormone therapy for luminal A breast cancer may not need radiation

Women with luminal A subtype breast cancer, especially those older than 60 years, may not need radiation treatment if they are already taking hormone therapy.

False breast cancer alarm may still cause psychological strain

False breast cancer alarm may still cause psychological strain

A false breast cancer alarm may still result in severe psychological strain.

MRI shows potential to improve breast cancer prediction

Magnetic resonance imaging (MRI) can provide vital information for predicting the odds of breast cancer development.

Inconsistent Medicaid expansion would widen disparities in screenings for women's cancers

Low-income and women without insurance in states that are not expanding their Affordable Care Act (ACA) Medicaid coverage are less likely to receive breast and cervical cancer screenings.

Dense breasts do not always correlate to high risk of interval cancer

Dense breasts do not always correlate to high risk of interval cancer

Five-year risk plus breast density can best identify women at high risk for interval cancer.

Tomosynthesis detects more breast cancer in screening

Tomosynthesis detects 40% more breast cancers than traditional mammography does, according to a major screening study.

More detailed findings confirm that coffee protects against breast cancer recurrence

More detailed findings confirm that coffee protects against breast cancer recurrence

For women with breast cancer using the drug tamoxifen, coffee appears to both inhibit tumor growth and reduce recurrence.

Cancer detection rate in dense breast tissue dramatically improved with tomosynthesis

Digital breast tomosynthesis increases the rate of cancer detection in women with dense breast tissue by as much as 67%, according to research.

Prognosis for women with breast cancer not worse for those with family history

Prognosis for women with breast cancer not worse for those with family history

A family history of breast cancer does not influence prognosis for women with breast cancer.

Triple-negative breast cancer is distinctly different in African American women

Triple-negative breast cancer is distinctly different in African American women

A new study reveals specific genetic alterations that appear to impact the prognosis and survival rates of African American women.

Breast cancer survivors can benefit from weight lifting

Breast cancer survivors can benefit from weight lifting

Slowly progressive weight lifting can reduce incidence of physical function deterioration.

Unique goals for research and treatment of breast cancer in younger women are needed

Breast cancer that occurs in younger women is likely to be more aggressive and to require more intensive therapies, with increased risk of long-term side effects.

Most surgeons disregard US Preventive Services Task Force (USPSTF) breast screening recommendation

A majority of surgeon continue to recommend annual breast cancer screening for women in their forties, despite a 2009 US Preventive Services Task Force (USPSTF) recommendation that recommends otherwise.

New breast cancer gene strongly linked to onset of breast cancer in two populations

Researchers have identified gene mutations associated with breast cancer onset in populations of Polish and French-Canadian women.

Chemobrain is a real cognitive effect

Chemotherapy, which can cause an inability to concentrate, is measurable effect related to cancer treatment.

Many women choose mastectomy, despite being eligible for breast-conserving therapy

Nearly a third of women eligible for breast-conserving therapy instead opt for removal of an entire breast.

Weight lifting may reduce physical function deterioration among breast cancer survivors

Weight lifting may reduce physical function deterioration among breast cancer survivors

Slowly progressive weight lifting reduced the incidence of physical function deterioration among breast cancer survivors.

FDG PET/CT not useful in staging newly diagnosed stage III invasive lobular breast cancer

Although FDG PET/CT is appropriate for systemic staging of newly diagnosed stage III breast cancer, the technique may not be equally valuable for all breast cancer histologies, research indicates.

Oophorectomy may decrease in breast cancer death in women with cancer and BRCA1 mutation

Oophorectomy is linked to a 62% reduction in breast cancer death for women diagnosed with breast cancer that carry a BRCA1 gene mutation.

Many Americans not getting breast, cervical, colon cancer screenings

Many Americans not getting breast, cervical, colon cancer screenings

Many Americans are not getting recommended screening tests for breast, cervical, and colon cancers.

Simulation tool teaches clinical breast examination

Simulation tool teaches clinical breast examination

Sensor technology is used to illustrate the amount of pressure applied in breast palpation, helping clinicians refine their clinical skills for locating a breast mass.

South Asian women are more likely have later-stage breast cancer at diagnosis

South Asian women are more likely to have later stage breast cancer at diagnosis compared with the general population, research has shown.

Immediate zoledronic acid treatment better than delayed in women receiving letrozole

Immediate zoledronic acid treatment better than delayed in women receiving letrozole

Immediate treatment with zoledronic acid prevented bone loss compared with delayed treatment in breast cancer.

Survival mechanism in breast cancer cells is found to result in poorer outcomes for African American women

The worse outcomes for African American women with estrogen-receptor positive (ER+) breast cancer, when compared with European American patients, appears to be related to a reduced cellular sensitivity to tamoxifen.

Immune therapy tested for triple-negative breast cancer

Preliminary study results indicate that an experimental immune system drug is generally safe and well tolerated in women with metastatic, triple-negative breast cancer.

Disparities exist in treatment, survival among black, white men with early stage breast cancer

Disparities exist in treatment, survival among black, white men with early stage breast cancer

Researchers investigated the disparities between blacks and whites in receipt of treatment for early stage breast cancer.

Breast cancer and chemobrain: Stress of diagnosis can impair cognitive function before chemotherapy is started

Breast cancer and chemobrain: Stress of diagnosis can impair cognitive function before chemotherapy is started

Milder cognitive defects displayed by breast cancer patient even before the initiation of chemotherapy may be attributable to disease-related posttraumatic stress, new study data indicates.

Nipple preservation during mastectomy doesn't change recurrence rates

Nipple preservation during mastectomy doesn't change recurrence rates

Survival and recurrence rates show little difference in women who undergo full breast removal as opposed to retaining the nipple during the procedure.

One-third of women with breast cancer are concerned about genetic risk

For many women with breast cancer, there is concern about the genetic risk of developing other cancers themselves or of a loved one developing cancer.

With breast cancer treatment, you do get what you pay for

Higher costs for breast cancer treatments are linked to better outcomes, according to a recent study.

Study examines variability in measures of breast density

Study examines variability in measures of breast density

Lowest variability seen in Volpara and Quantra; higher variability for Cumulus ABD and CumulusV methods.

Factors Affecting Women's Election to Undergo Bilateral Mastectomy Identified

Factors Affecting Women's Election to Undergo Bilateral Mastectomy Identified

Physicians and cancer survivors influence women undergoing bilateral mastectomy as their treatment for breast cancer.

Breastfeeding linked with decreased breast cancer recurrence risk

Breastfeeding linked with decreased breast cancer recurrence risk

Women diagnosed with breast cancer who previously breastfed their babies had a 30% overall decreased risk of disease recurrence.

Gaps in information, support among women who gain weight during breast cancer treatment

Gaps in information, support among women who gain weight during breast cancer treatment

There may be gaps in information and support provision after diagnosis for breast cancer.

Risk of ovarian cancer may differ by type of BRCA1 or BRCA2 mutation

Researchers have identified mutations that were associated with significantly different risks of breast and ovarian cancers, which may have implications for risk assessment and cancer prevention decision making among carriers of these mutations.

Axillary lymph node evaluation performed frequently in DCIS

Axillary lymph node evaluation performed frequently in DCIS

Although not usually recommended for women with localized cancer undergoing breast-conserving surgery, axillary lymph node evaluation is performed frequently in women with ductal carcinoma in situ (DCIS) breast cancer.

Previvorship: Managing Cancer Risk Decisions in Unaffected BRCA-positive Women

Previvorship: Managing Cancer Risk Decisions in Unaffected BRCA-positive Women

Four major themes characterize the experience of cancer risk management for women who are positive for BRCA genetic mutations.

Exercise programs with higher intensity levels result in better outcomes for patients

Exercise programs with higher intensity levels result in better outcomes for patients

A supervised, moderate- to high-intensity exercise program is most effective for patients with breast cancer undergoing adjuvant chemotherapy.

Genetic variants combined to improve breast cancer

An analysis of the genetic data from more than 67,000 women has helped establish a polygenic risk score, derived from many genetic factors, which can be used to identify women with a greater breast cancer risk.

Symptoms of Poor Sleep Suggests Sleep Disorders in Breast Cancer Survivors

Symptoms of Poor Sleep Suggests Sleep Disorders in Breast Cancer Survivors

A large percentage of survivors of breast cancer have symptoms suggesting underlying sleep disorders that require referral.

Most women with early stage breast cancer avoid extensive lymph node removal

New research has found that in women with early stage breast cancer, surgeons no longer universally remove most of the lymph nodes in the underarm area when a biopsy of the nearby lymph nodes indicates cancer.

USPSTF: Mammography guidelines revisited

USPSTF: Mammography guidelines revisited

Women in their 40s should make an informed personal decision, say the new draft guidelines.

Teens with breast lumps may be able to avoid invasive biopsy

The use of breast ultrasound could eliminate the need for biopsy in many cases in adolescent girls, according to a recent study.

Biennial mammography optimal screening interval for average risk women

Biennial mammography optimal screening interval for average risk women

Biennial (once every two years) screening is preferable for women of age 50 through 74 that have an average risk of developing breast cancer.

Nighttime fasting may decrease breast cancer risk in women

Nighttime fasting may decrease breast cancer risk in women

An increase in overnight fasting decreases glucose levels and may lower the risk of breast cancer among women.

mHealth app assesses breast cancer risk and aids prevention

An evaluation of this mobile health app found easy to use for diverse, low-income women.

The switch that might tame the most aggressive of breast cancers

Researchers have learned more about breast cancer, including identification of a gene that drives the aggressive disease.

Most hospitalists not supportive of inpatient mammography

Most hospitalists not supportive of inpatient mammography

Most hospitalists would not order an inpatient mammography for breast cancer screening.

Breast cancer patients want, but may not get, genetic risk discussion

Breast cancer patients want, but may not get, genetic risk discussion

Although many patients with breast cancer are concerned about genetic risk for other cancer types, almost half don't have conversation with doctor about potential for future problems.

Low breast density in mammography worsens breast cancer prognosis

A low degree of mammographic breast density worsens the prognosis of breast cancer, according to a recent study.

Text message reminders boost breast cancer screening attendance

A text reminder can help increase breast cancer screening attendance, study data shows.

Specific mutated BRCA regions confer different risks of breast, ovarian cancers

Specific mutated BRCA regions confer different risks of breast, ovarian cancers

Specific BRCA mutations confer higher risks of breast cancer, while other BRCA mutations confer higher risks of ovarian cancer.

MRI can detect 90 percent of breast cancers

MRI can detect 90 percent of breast cancers

A recent study has determined that approximately 90 percent of breast cancers can be diagnosed via magnetic resonance imaging (MRI).

35 percent of patients with breast cancer worried about genetic risks to themselves, family members

35 percent of patients with breast cancer worried about genetic risks to themselves, family members

A third of women diagnosed with breast cancer are concerned about the genetic risk of a family member developing cancer.

Control of cell metabolism explains response to breast cancer drugs

A newly discovered mechanism that has helped researchers understand why some breast cancer tumors respond to specific chemotherapies and others do not.

Stress management improves long-term mood and quality of life in women with breast cancer

Stress management improves long-term mood and quality of life in women with breast cancer

Enabling patients to manage stress early in their breast cancer treatment can improve their mood and quality of life many years later.

Racial and ethnic differences extend to how surgeons and hospitals for breast cancer care are selected

Black and Hispanic women with breast cancer were less likely to use reputation as a factor ins selecting their surgeon or hospital for treatment, when compared with white women.

Hormone-blocking drug prevents ovarian failure and improves fertility in breast cancer patients

Breast cancer patients given the hormone-blocking drug goserelin during chemotherapy experience less ovarian failure and are more likely to have successful pregnancies, according to study results.

Diabetes may predispose individuals to advanced breast cancer

Diabetes may predispose individuals to advanced breast cancer

Women with diabetes may have an increased risk of being diagnosed with advanced breast cancer, according to new study results.

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