Nonadherence to Noncancer Medication Schedules Predicts Adherence to Adjuvant Hormone Therapy for Breast Cancer

Patients who do not adhere to their medication schedules for chronic conditions prior to a breast cancer diagnosis were twice as likely to skip oral adjuvant hormonal therapy.

Preoperative Breast MRI Affected by Patient Positioning

Preoperative Breast MRI Affected by Patient Positioning

Employing a prone position during preoperative breast magnetic resonance imaging might introduce error.

DECT Trial Results Show Trastuzumab Plus Anthracyclines Are Efficacious in HER2+ Breast Cancer

DECT Trial Results Show Trastuzumab Plus Anthracyclines Are Efficacious in HER2+ Breast Cancer

Results from the DECT trial indicate that a combination of epirubicin and trastuzumab improved outcomes in patients with HER2-positive breast cancer.

Patient Navigation Significantly Improves Cancer Screening Rates

Patient Navigation Significantly Improves Cancer Screening Rates

The addition of a patient navigation component to a population-based IT system boosted screening rates for breast cancer, cervical cancer, and colorectal cancer in patients at high risk for nonadherence.

Trastuzumab-related Cardiotoxicity Lower Among Taiwanese Patients

Trastuzumab-related Cardiotoxicity Lower Among Taiwanese Patients

Trastuzumab-related cardiotoxicity was far lower in Taiwanese women with breast cancer compared with previously published results, according to recent study data.

New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases

New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases

Researchers demonstrate how breast cancer cells invade bone marrow, where they escape chemotherapy and hormonal therapies that would otherwise eliminate the cancer cells.

Gene Expression Pattern in Surrounding Normal Tissue Linked to Breast Cancer Prognosis

A gene expression pattern in the noncancerous tissues surrounding estrogen receptor-positive breast cancer is associated with lower 10-year survival rates.

Patient Stress Level Influences Best Type of Couples' Therapy for Patients With Breast Cancer and Their Partners

Distressed patients with breast cancer benefit most from a couple-focused supportive group therapy, while less distressed patients benefit more from a structured, skills-based, couples-focused group therapy.

Healthy Lifestyle Could Reduce Risk of Developing Breast Cancer

Healthy Lifestyle Could Reduce Risk of Developing Breast Cancer

Following a healthy lifestyle could reduce the risk of developing breast cancer for women already at high risk for the disease due to genetic risk and family history.

Research Shows Potential for Breast Cancer Prevention in BRCA1-Driven Tumors

Research Shows Potential for Breast Cancer Prevention in BRCA1-Driven Tumors

The drug denosumab, which blocks a bone gene, may also prevent breast cancer caused by a BRCA1 mutation. This already approved drug could be available quickly, and would be the first drug for breast cancer prevention.

Exercise Cuts Cardiac Events in Non-Metastatic Breast Cancer

Exercise Cuts Cardiac Events in Non-Metastatic Breast Cancer

The incidence of cardiovascular events was down for patients with non-metastatic breast cancer that exercise.

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

Study Finds Racial Disparities in Breast and Ovarian Cancer Risk Management

Disparities in cancer risk management among BRCA carriers across a diverse sample of young black, Hispanic, and non-Hispanic white breast cancer survivors underscores that "the benefit from genetic testing comes from acting on the test results," not just the testing itself, a study presented at the ASCO 2016 Annual Meeting concluded.

Individual Surgeons Influence Likelihood of Mastectomy for Treatment of Localized Breast Cancer

Individual Surgeons Influence Likelihood of Mastectomy for Treatment of Localized Breast Cancer

A substantial and independent association between individual provider, the treatment center, and type of breast surgery among elderly women with breast cancer suggests the presence of physician and institutional biases. That is the conclusion of a Medicare claims database review presented at the 2016 ASCO Annual Meeting.

Long-Term Survival Results Show Axillary Lymph Node Dissection Should be Abandoned

Long-Term Survival Results Show Axillary Lymph Node Dissection Should be Abandoned

"Routine use of ALND should be abandoned." That's the conclusion based on 10-year survival data from the ACOSOG Z0011 randomized study comparing sentinel lymph node dissection alone to ALND in women with clinical T1-2 N0 M0 breast cancer and a positive sentinel node presented at the 2016 ASCO Annual Meeting.

Utidelone Plus Capecitabine Active in Patients Heavily Pretreated for Metastatic Breast Cancer

Utidelone Plus Capecitabine Active in Patients Heavily Pretreated for Metastatic Breast Cancer

The genetically engineered epothilone analog, utidelone, in combination with capecitabine significantly improved progression-free survival and objective response rates in patients with metastatic breast cancer who were heavily pretreated, compared with capecitabine alone, results of a phase 3 trial presented at the 2016 ASCO Annual Meeting have shown.

Tailored Dose-Dense Chemotherapy Improves Event-free Survival in High-Risk Breast Cancer

Tailored Dose-Dense Chemotherapy Improves Event-free Survival in High-Risk Breast Cancer

Tailored dose-dense chemotherapy significantly improved event-free survival and also showed efficacy in relapse-free and overall survival compared with standard adjuvant chemotherapy in patients with high-risk breast cancer, according to results of the phase 3 PANTHER study reported at the 2016 ASCO Annual Meeting.

Anthracycline-based Regimens Superior in Treating High-Risk, HER2-negative Breast Cancer

Anthracycline-based Regimens Superior in Treating High-Risk, HER2-negative Breast Cancer

Interim joint analysis of the ABC Trials showed invasive disease-free survival was significant for superiority of anthracycline/taxane-based chemotherapy regimens (TaxAC) relative to docetaxel plus cyclophosphamide, according to study results presented at the 2016 ASCO Annual Meeting.

Palbociclib Plus Fulvestrant Provides Significant Benefit in Hormone Receptor-Positive Metastatic Breast Cancer

Palbociclib Plus Fulvestrant Provides Significant Benefit in Hormone Receptor-Positive Metastatic Breast Cancer

ESR1 mutations detected in plasma circulating tumor DNA were identified in a high percentage of patients with hormone receptor-positive metastatic breast cancer, confirming an important role in endocrine resistance, according to an analysis of data from the phase 3 PALOMA-3 reported at the 2016 ASCO Annual Meeting.

ESR1 Mutations Predict Worse Outcome in HR-positive Metastatic Breast Cancer Treated with Aromatase Inhibitors

ESR1 Mutations Predict Worse Outcome in HR-positive Metastatic Breast Cancer Treated with Aromatase Inhibitors

The presence of circulating ESR1 somatic mutations at disease progression in patients with HR-positive metastatic breast cancer treated with first-line AIs represent a strong and independent poor prognostic value for overall survival but no predictive value, a study presented at the 2016 ASCO Annual Meeting has found.

Triple-Drug Therapy Produces Response in Triple-Negative Breast Cancer, Mouse Study Shows

Triple-Drug Therapy Produces Response in Triple-Negative Breast Cancer, Mouse Study Shows

A cocktail of 3 drugs shrank triple-negative breast cancer (TNBC) by killing off cancer cells and halting new tumor growth, a new study conducted in mice and lab-grown human cells has shown.

CDK4/6 Inhibitor Allows Sustained Dosing for Targeted Inhibition in 5 Solid Tumor Cancer Types

CDK4/6 Inhibitor Allows Sustained Dosing for Targeted Inhibition in 5 Solid Tumor Cancer Types

Abemaciclib, an investigational cancer therapeutic, showed durable clinical activity as a continuous single-agent therapy, according to results of a phase 1 trial with 5 tumor-specific cohorts.

SRC Kinase Inhibitor Could Be a New Treatment for Breast Cancer

SRC Kinase Inhibitor Could Be a New Treatment for Breast Cancer

Scientists discovered the compound eCF506. This compound was more effective than existing medicines at targeting breast cancer cells because it more selectively inhibited SRC tyrosine kinase.

Drug-Resistant Cancer May Be Combatted With New Generation mTOR Inhibitors

A potential cancer therapy with a unique strategy to block the mTOR molecule has been designed. This new mTOR-inhibiting compound reduced the size of tumors resistant to earlier-generation mTOR inhibitors.

Vitamin D and Androgen Receptor-Targeted Therapy Are Effective in Triple-Negative Breast Cancer

Vitamin D and androgen receptor-targeted therapy successfully reduced growth and induced death of cancerous cells in a cell culture model of triple-negative breast cancer.

Training Patients With Breast Cancer to Achieve Prolonged Breath Holds Could Improve Targeted Radiotherapy

Training Patients With Breast Cancer to Achieve Prolonged Breath Holds Could Improve Targeted Radiotherapy

Patients with breast cancer can be trained to achieve a breath hold lasting more than 5 minutes, allowing for targeted administration of radiotherapy with a single dose per daily session that can minimize damage to surrounding tissues.

Drug Candidate Successful in Targeting Cancer-Causing RNA

A new drug candidate reduced the growth of tumors in a mouse model of triple negative breast cancer (TNBC) by targeting the RNA, or expression, of a gene only expressed in the diseased cells.

Moderate Link for Automated and Clinical Breast Density Measures

Moderate Link for Automated and Clinical Breast Density Measures

Both automated and clinical assessments of breast density are associated with breast cancer risk.

No Clinical Benefit to Expanding Gene Panel Beyond Ovarian and Breast Cancer Genes in High-risk Women

Expanding a panel of tested genes beyond the known breast and ovarian cancer-specific genes in patients with breast and ovarian cancer did not confer any clinical benefit.

Adding Two Inhibitors Enhances Effectiveness of Tamoxifen in ER-positive Breast Cancer

Combining 2 existing chemotherapy drugs, a DNMT1 inhibitor and a histone deacetylase inhibitor, reduced the numbers of cancer stem cells and improved survival in a mouse model.

Higher CAM Use Associated With Decreased Chemo Initiation

Higher CAM Use Associated With Decreased Chemo Initiation

Researchers examined possible correlations between complementary and alternative medicine and delayed initiation of clinically indicated chemotherapy among patients with early-stage breast cancer.

BRCA1/2 Testing Recommendations Vary Between Black and White Patients

BRCA1/2 Testing Recommendations Vary Between Black and White Patients

Disparities in BRCA1/2 testing in black and white women is attributable to differences in physician recommendations, according to a recent study.

All Patients Need Monitoring for Heart Events After Trastuzumab Therapy for Breast Cancer

All Patients Need Monitoring for Heart Events After Trastuzumab Therapy for Breast Cancer

Patients undergoing treatment for breast cancer with trastuzumab-containing regimens need to be monitored for heart damage regardless of age.

Age Affects Outcomes After Mastectomy or Breast-conserving Therapy for Early Stage Breast Cancer

Age Affects Outcomes After Mastectomy or Breast-conserving Therapy for Early Stage Breast Cancer

For women younger than 45 years with early stage breast cancer that has not spread to the lymph nodes, opting for breast-conserving therapy with RT was associated with higher risk of local recurrence over 20 years compared with mastectomy and no RT.

Gene Alterations May Explain Treatment Resistance of Triple-negative Breast Cancer

Gene Alterations May Explain Treatment Resistance of Triple-negative Breast Cancer

Amplification of the JAK2 gene frequently occurs in triple-negative breast cancer (TNBC), suggesting that specific inhibitors of JAK2 should be investigated in TNBC.

Delaying Radiation Therapy for Women With Early Stage Breast Cancer Increased Risk of Recurrence

Delaying Radiation Therapy for Women With Early Stage Breast Cancer Increased Risk of Recurrence

Delayed radiation therapy (RT) after surgery significantly increased the risk of recurrent disease in women treated for very early breast cancer.

Risk for Fatal Cardiovascular Events Not Increased in Patients With Breast Cancer Taking Aromatase Inhibitors

Risk for Fatal Cardiovascular Events Not Increased in Patients With Breast Cancer Taking Aromatase Inhibitors

Risk of the most serious cardiovascular events, cardiac ischemia and stroke, were not increased in breast cancer patients taking aromatase inhibitors compared with tamoxifen users.

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

Disparities in the gut microbiome between healthy people and women with estrogen-driven breast cancer may indicate possible biomarkers based on the microbiome that could help to mitigate the risk of certain cancers.

New Drug Combination Before Surgery May Improve Outcomes for Advanced HER2+ Breast Cancer

New Drug Combination Before Surgery May Improve Outcomes for Advanced HER2+ Breast Cancer

Combining trastuzumab emtansine (T-DM1) and pertuzumab before surgery was more beneficial than the combination of paclitaxel plus trastuzumab for patients with HER2-positive invasive breast cancer.

A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer

A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer

[Breast Cancer: Basic and Clinical Research] The review examines the standard systemic and future treatment options in metastatic triple-negative breast cancer.

Including Information on Breast Reconstruction Options Help Women Make Better Treatment Decisions

Including Information on Breast Reconstruction Options Help Women Make Better Treatment Decisions

Comprehensive patient education that includes information on breast reconstruction, with photos, can help women with breast cancer make more informed decisions about their treatment options.

Low Fat Diet Helps Postmenopausal Women Avoid Deadly Breast Cancer

Low Fat Diet Helps Postmenopausal Women Avoid Deadly Breast Cancer

Postmenopausal women who stayed on a low fat diet for an extended time had a reduced risk of death from invasive breast cancers, according to clinical trial data.

Nipple-sparing Mastectomy Safe for Women With High Risk of Breast Cancer

Nipple-sparing Mastectomy Safe for Women With High Risk of Breast Cancer

Prophylactic nipple-sparing mastectomy is as effective at preventing breast cancer as more invasive surgeries, according to a multi-institution study.

BRCA1 Mutation May Reduce Women's Fertility

BRCA1 Mutation May Reduce Women's Fertility

The BRCA1 mutation may speed the aging of a woman's ovaries,according to a recent report.

Survival Is Better With SRS Than With WBRT for NSCLC or Breast Cancer Metastases to the Brain

Longer survival was achieved with stereotactic radiosurgery (SRS) alone than with whole-brain radiation therapy (WBRT) in patients with fewer than 4 brain metastases from NSCLC or breast cancer.

Anthracycline Chemotherapy Not Associated With Cognitive Decline

Anthracycline Chemotherapy Not Associated With Cognitive Decline

Anthracycline chemotherapy, such as doxorubicin and daunorubicin, is not associated with lasting cognitive decline among breast cancer survivors.

AI-only Users vs Tamoxifen Users Have Similar CVD Risk

The risk of the most serious cardiovascular events, including cardiac ischemia and stroke, was not higher for breast cancer survivors who received an aromatase inhibitor (AI) compared with tamoxifen users.

Total Weight Lost Is More Important Than Type of Diet in Reversing Obesity-Cancer Link

Total Weight Lost Is More Important Than Type of Diet in Reversing Obesity-Cancer Link

Significant weight loss through calorie restriction, but not moderate weight loss through a low-fat diet, was linked to reduced breast cancer growth in a preclinical study.

Breast Cancer Therapy and Cardiotoxicity Risk in Older Women

Breast Cancer Therapy and Cardiotoxicity Risk in Older Women

A study examined the relation between various forms of breast cancer therapies and risk of congestive heart failure.

Biosimilar Agent to Pegfilgrastim Equally Safe, Efficacious for Neutropenia Prevention

Biosimilar Agent to Pegfilgrastim Equally Safe, Efficacious for Neutropenia Prevention

A biosimilar agent to pegfilgrastim was therapeutically equivalent and comparable to the reference agent in terms of efficacy and safety in the prevention of chemotherapy-induced neutropenia in patients with early stage breast cancer receiving chemotherapy.

Home Visits From Promotora Increased Breast Cancer Screening Rates Among Latinas

Home Visits From Promotora Increased Breast Cancer Screening Rates Among Latinas

Latina women in the United States nearly doubled their rate of screening for breast cancer after visits from a health-promoting promotora.

Neratinib Not Superior to Trastuzumab for ERBB2+ Metastatic Breast Cancer

Neratinib Not Superior to Trastuzumab for ERBB2+ Metastatic Breast Cancer

Neratinib plus paclitaxel was not superior to trastuzumab plus paclitaxel with respect to progression-free survival as first-line treatment.

A stym therapy improves function and range of motion following mastectomy

A stym therapy improves function and range of motion following mastectomy

[Breast Cancer: Targets and Therapy] This research examines using Astym treatment to increase mobility after mastectomy.

Measurement Standard Developed for Breast Cancer MRI

Measurement Standard Developed for Breast Cancer MRI

The first widely useful standard for magnetic resonance imaging (MRI) of the breast has been developed by the NIST.

Acupuncture Improves Management of Hot Flashes, Quality of Life in Breast Cancer

Acupuncture Improves Management of Hot Flashes, Quality of Life in Breast Cancer

Women with breast cancer who used acupuncture plus enhanced self-care to manage their hot flashes were better able to manage their symptoms.

Mastectomy Increases Life Expectancy in Younger Women With Ovarian Cancer

Risk-reducing mastectomy (RRM) can increase life expectancy and be cost effective in women up to age 60 years with ovarian cancer as carriers of a BRCA mutation.

Arterial Calcification Seen on Mammography Linked to Risk of Heart Disease

Arterial Calcification Seen on Mammography Linked to Risk of Heart Disease

The amount of calcium in the arteries of the breast, readily visible on digital mammography, is linked to the level of calcium buildup in the coronary arteries.

Racial Disparities Observed in Trastuzumab Therapy for HER2-Positive Breast Cancer

Racial Disparities Observed in Trastuzumab Therapy for HER2-Positive Breast Cancer

For patients with stage I to III HER2-positive breast cancer, the monoclonal antibody trastuzumab is central to their adjuvant therapy.

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

German Study Confirms Accuracy of Multigene Test Predictions of Safe Omission of Chemotherapy for Breast Cancer

A multigene test can identify patients with early stage breast cancer who do not need chemotherapy and who will be alive 5 years after diagnosis.

Pill Improves Breast Imaging to Light Up Cancer

Pill Improves Breast Imaging to Light Up Cancer

Scientists are developing a pill that illuminates only cancerous tumors, improving on current methods that can identify tumors but cannot conclusively determine whether they are cancerous

Study Evaluates Population-based Breast Cancer Screening Methods

Study Evaluates Population-based Breast Cancer Screening Methods

Population-based screening for breast cancer with universal biennial mammography resulted in a substantial reduction in breast cancer deaths, while risk-based biennial mammography resulted in only a modest benefit.

Acupuncture Helps Manage Hot Flashes in Breast Cancer Patients

Acupuncture Helps Manage Hot Flashes in Breast Cancer Patients

Improvements seen in climacteric symptoms and quality of life measures when acupuncture was employed.

Increase in Genetic Risk of Breast Cancer Triggered by Alcohol Consumption

Increase in Genetic Risk of Breast Cancer Triggered by Alcohol Consumption

Researchers identified a cancer-causing gene triggered by alcohol use, providing a link between alcohol and breast cancer in cell-based research.

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

Use and clinical implications of a test commonly used to predict the aggressiveness of early stage ER-positive breast cancer is influenced by patient's race, insurance, and type of facility.

Prolonged Nightly Fasting May Reduce Breast Cancer Recurrence Risk

Prolonged Nightly Fasting May Reduce Breast Cancer Recurrence Risk

Prolonged nightly fasting may reduce the risk of recurrence for patients with breast cancer.

Risk Stratification and Treatment Options Differ for Male and Female Patients With Breast Cancer

Optimal risk stratification differs between male and female breast cancers. Outcomes for male patients with breast cancer were not significantly correlated with histologic grade, unlike for female patients.

Presurgical Treatment in HER2-positive Breast Cancer Achieves Significant Reduction in Disease

Treatment with lapatinib and trastuzumab before surgery and chemotherapy led to significant shrinkage or disappearance of the tumors in approximately 25% of women with HER2-positive breast cancer.

Tailored Vitamin D Supplementation Improves Normalization Rates

Tailored Vitamin D Supplementation Improves Normalization Rates

A tailored high-dose oral vitamin D supplementation safely allows a higher proportion of patients to achieve a normalized vitamin D level.

HER2 Peptide Vaccine Fails to Prevent Breast Cancer Recurrence

HER2 Peptide Vaccine Fails to Prevent Breast Cancer Recurrence

The HER2 peptide AE37 vaccine did not demonstrate a benefit in patients with breast cancer with any degree of HER2 expression.

Partial Breast Radiotherapy May Be Effective for Some Women With Early Breast Cancer

Partial breast radiotherapy was noninferior to whole breast radiotherapy in regard to local recurrence in women with low-risk early breast cancer.

How Insulin Levels Are Managed Affects Breast Density in Women With Diabetes

Diabetes treatments, such as diet or pills (eg, metformin), decrease mammographic density, whereas insulin may increase mammographic density.

Cell Growth Inhibitor Overcomes Therapy Resistance and Delays Tumor Recurrence in Breast Cancer

Cyclin D1/CDK4 inhibitor treatment overcame resistance to targeted therapy in transgenic mouse models, cell cultures, and human tissue samples of HER2-positive breast cancer.

Survival Improved for Premenopausal Breast Cancer Patients Through Dose-Dense Chemo

Dose-dense adjuvant chemotherapy (every 2 weeks) offers improved survival without increasing the risk of treatment-induced early menopause compared with the standard interval (every 3 weeks) chemotherapy for premenopausal women with breast cancer.

Newly Identified Gene Mutation Predominant in Chinese With a Family History of Breast Cancer

Germline mutations to the RECQL gene were identified in 0.5% of patients with familial breast cancer in a Chinese population.

Early MRI Screening May Reduce Breast Cancer Mortality Among HL Survivors

Early MRI Screening May Reduce Breast Cancer Mortality Among HL Survivors

Early MRI-based screening may reduce breast cancer mortality among women treated with radiation therapy for Hodgkin lymphoma.

Vitamin D Deficiency Increases Risk of Tumor Growth and Metastasis in Breast Cancer

Vitamin D Deficiency Increases Risk of Tumor Growth and Metastasis in Breast Cancer

Deficiency in vitamin D resulted in breast cancer tumors that grew faster and were more likely to metastasize, according to a recent study using mouse and cell culture models. The study also demonstrated a correlation between serum vitamin D levels and ID1.

Early Quality of Life Changes Predict Aromatase Inhibitor Therapy Discontinuation

Early Quality of Life Changes Predict Aromatase Inhibitor Therapy Discontinuation

Early changes in patient-reported outcomes during aromatase inhibitor (AI) therapy were associated with treatment discontinuation.

Most Patients Experience Posttraumatic Stress Disorder After a Breast Cancer Diagnosis

Symptoms of posttraumatic stress disorder (PTSD) develop in a majority of patients with breast cancer, and these symptoms persist for at least a year for most.

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

[Biomarkers in Cancer] This research examines the emerging role of genomic rearrangements in breast cancer, with a particular focus on fusion genes, and explores the therapeutic value of such rearrangements and their significance as predictive and prognostic biomarkers.

Breast Cancer Risk Higher in Latinas Who Consume Processed Meats

Eating processed meats such as bacon and sausage may increase the risk for breast cancer in Latinas, while the same association was not found in white women.

Significant Rise in Preventive Mastectomies for U.S. Women Over Past Decade

Significant Rise in Preventive Mastectomies for U.S. Women Over Past Decade

Patients with breast cancer increasingly opt to have the healthy breast removed, despite limited benefit.

Adding Palbociclib to Fulvestrant Improves Progression-free Survival in Select Women With Metastatic Breast Cancer

Progression-free survival was significantly and consistently improved when palbociclib was added to fulvestrant, compared with placebo and fulvestrant, for women with stage IV breast cancer that is hormone-receptor-positive and HER2-negative.

Outcomes After Breast Reconstruction Surgery Vary Depending on Abdominal Donor Site

In women undergoing postmastectomy breast reconstruction with their own tissue, a specific type of muscle-sparing abdominal tissue reduced complications and improved some aspects of quality of life.

Beta Blockers Halt Progression of Aggressive Breast Cancer Cell Line

Adrenaline acted on breast cancer cells via the cell surface beta2-adrenoceptor to promote disease growth and invasion, suggesting that beta-blockers might be helpful as adjuvant therapy for patients with aggressive breast cancer.

Targeted Radiation Holds Promise for Early Breast Cancer

Targeted Radiation Holds Promise for Early Breast Cancer

Limited radiotherapy effective after low-risk tumors are removed, but questions remain.

Study Evaluates Cardiac Safety of Paclitaxel Plus Trastuzumab, Pertuzumab

Study Evaluates Cardiac Safety of Paclitaxel Plus Trastuzumab, Pertuzumab

No significant changes in global longitudinal strain (GLS) or cardiac biomarkers occurred in HER2-positive breast cancer.

Single-dose Trastuzumab Kick Starts Immune Response in Some Breast Cancers

Women with the HER2-enriched type of HER2-positive breast cancer had the highest rate of immune response to treatment with trastuzumab, with a significant increase after just 1 dose of the drug.

Model Demonstrates Benefits of MRI Screening for Breast Cancer in Survivors of Childhood Hodgkin Lymphoma

Model Demonstrates Benefits of MRI Screening for Breast Cancer in Survivors of Childhood Hodgkin Lymphoma

Female survivors of childhood Hodgkin lymphoma (HL) who received chest radiation can reduce their risk of breast cancer through early screening.

Novel Hydrogel Scaffold Replicates Biologic Environment to Grow Human Breast Tissue

A new cell culture scaffold system supported human mammary tissue growth from patient-derived cells, allowing researchers to replicate human breast environment conditions to study breast development and the initiation and progression of breast cancer.

Breast Cancer Survivors Gain Short-term Benefits From Weight-loss Intervention

Breast Cancer Survivors Gain Short-term Benefits From Weight-loss Intervention

Modest weight loss can reduce the likelihood of comorbid conditions in breast cancer survivors.

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

Gene Test Identifies Patients With Breast cancer That Do Not Need Chemotherapy

An analysis of test results can help women who won't benefit from additional treatment avoid potential side effects.

Imaging Analysis Nearly Matches Genetic Tests in Determining Need for Chemotherapy in Breast Cancer

A new analysis method for magnetic resonance imaging (MRI) data appears to reliably determine whether patients would need hormonal treatment only or also need chemotherapy.

High Neutrophil to Lymphocyte Ratio Prognostic in Early Breast Cancer

High Neutrophil to Lymphocyte Ratio Prognostic in Early Breast Cancer

High neutrophil to lymphocyte ratio (NLR) is linked to worse prognosis in Caucasian patients with early breast cancer.

Tomosynthesis May be Primary Screening Modality in Breast Cancer Detection

Tomosynthesis May be Primary Screening Modality in Breast Cancer Detection

Ultrasound may have a better incremental breast cancer detection rate than tomosynthesis in mammography-negative dense breasts.

Breast and Colorectal Cancer Disparities Persist in African Americans

Disparities in some cancer mortality rates between African Americans and whites in the United States have decreased, but these differences remain in colorectal and breast cancers.

Metastasis Increases With Elimination of Cancer-promoting Component in Breast Cancer Tumors

Cancer metastasis is dynamically regulated by cancer-associated fibroblasts (CAFs), a cancer-promoting component in the tumor microenvironment. Eliminating the CAFs after 10 days dramatically increases the risk of the primary tumor metastasis to the lungs and bones in a mouse model.

Opting for Contralateral Prophylactic Mastectomy Linked With Improved QoL

Opting for Contralateral Prophylactic Mastectomy Linked With Improved QoL

Choice for contralateral prophylactic mastectomy (CPM) was associated with an improvement in breast satisfaction and psychosocial well-being.

Adding Palbociclib to Fulvestrant Improves PFS in HR+ Metastatic Breast Cancer

Adding Palbociclib to Fulvestrant Improves PFS in HR+ Metastatic Breast Cancer

The addition of palbociclib to fulvestrant was associated with significant and consistent improvement in progression-free survival.

Overexpression of Gene in the Brain Influences Breast Cancer Metastasis

A gene previously thought only to be expressed in the brain, GABAA receptor alpha3 (Gabra3), promotes breast cancer migration, invasion, and metastasis.

More Than One-quarter of Breast Cancer Survivors Experience Severe Fatigue

More Than One-quarter of Breast Cancer Survivors Experience Severe Fatigue

Approximately 1 in 4 survivors of breast cancer suffers from severe fatigue.

Genetic Testing for BRCA Gene Mutations Increasing Among Younger Women With Breast Cancer

Among women age 40 years or younger, rates of genetic testing for BRCA1 and BRCA2 mutations have increased, according to a recent study.

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