Higher frequency of BRCA mutations observed in black women

Higher frequency of BRCA mutations observed in black women

In a study reviewing black women under 50 with invasive breast cancer, 12 percent had BRCA1 or BRCA2 mutations.

Blood test detects the return of early-stage breast cancer

Blood test detects the return of early-stage breast cancer

Circulating tumor DNA analysis spots stray cells months before scans detect breast cancer recurrence.

New biomarker in breast and prostate cancer may help identify patients who will respond to taxanes

Researchers have pinpointed a novel genetic biomarker responsible for the progression of many breast and prostate cancers.

Researchers identify tumor microenvironment of metastasis (TMEM) that allows breast cancer to metastasize

Using high-resolution imaging, scientists have gained a greater understanding of how a doorway in the blood vessel wall allows cancer cells to metastasize.

Obesity may predispose breast tissue structure to cancer

Obesity may predispose breast tissue structure to cancer

Findings suggest obesity can trigger structural changes in extracellular matrix, rendering an individual more susceptible to breast cancer.

New contrast agent spotlights tiny tumors and micrometastases

Researchers have developed a magnetic resonance imaging (MRI) contrast agent with the capability to pinpoint much smaller aggressive breast cancer tumors and micrometastases.

Fertility concerns influence treatment decisions in younger patients with breast cancer

Fertility concerns influence treatment decisions in younger patients with breast cancer

Previous studies have shown that following a 5-year course of tamoxifen after breast cancer treatment can reduce recurrence.

Electroacupuncture may reduce hot flashes among breast cancer survivors

Electroacupuncture may reduce hot flashes among breast cancer survivors

Electroacupuncture may be more effective and safer than gabapentin for managing hot flashes among breast cancer survivors.

For patients with DCIS, risk of death higher for women under 35, black women

For patients with DCIS, risk of death higher for women under 35, black women

Women diagnosed with ductal carcinoma in situ have a 20-year breast cancer-specific death rate of 3.3%.

Adding regional nodal irradiation to whole-breast irradiation reduces breast cancer recurrence

Radiation to the lymph nodes as well as the standard treatment of whole-breast irradiation after breast-conserving surgery does not confer an overall survival benefit.

Health care barriers contribute to delays in follow-up screening for women with cancer

Health care barriers contribute to delays in follow-up screening for women with cancer

A better understanding of the association between barriers to care and clinical outcomes within patient navigation programs.

Overweight breast cancer survivors treated with tamoxifen may have higher risk for arm lymphedema

Overweight breast cancer survivors treated with tamoxifen may have higher risk for arm lymphedema

Breast cancer survivors with a body mass index (BMI) >25 who report the use of tamoxifen therapy may be at increased risk for arm lymphedema.

Molecular tinkering doubles cancer drug's efficacy

By surrounding molecules of paclitaxel with self-assembling spheres composed of amino acids, researchers doubled tumor exposure to the drug and reduced its effects on healthy tissue.

Profile of neratinib and its potential in the treatment of breast cancer

Profile of neratinib and its potential in the treatment of breast cancer

[Breast Cancer: Targets and Therapy] This research reviews the preclinical as well as clinical data on neratinib.

Music therapy may reduce anxiety in patients with breast cancer undergoing surgery

Music therapy may reduce anxiety in patients with breast cancer undergoing surgery

Including music therapy as a complementary approach with cancer surgery may help reduce preoperative anxiety.

Behavioral intervention boosts physical activity in breast cancer survivors

Behavioral intervention boosts physical activity in breast cancer survivors

A behavioral weight loss intervention can produce clinically meaningful weight loss in overweight/obese breast cancer survivors.

Alternative procedure to radical mastectomy investigated

Alternative procedure to radical mastectomy investigated

A revolutionary alternative to radical mastectomy has been developed that preserves the nipple, areola, and surrounding skin.

Regional node irradiation in breast cancer improves overall survival

The effect of irradiation of regional nodes in patients with stage I, II, or III breast cancer on overall survival is very limited, according to a study.

Screening breast, ovarian cancer gene mutations other than BRCA1/2 impact management

Screening breast, ovarian cancer gene mutations other than BRCA1/2 impact management

Multigene testing for hereditary breast and/or ovarian cancer that tests is more likely to inform clinical decision-making than testing for BRCA1/2 alone.

Studies find aromatase inhibitors (AIs) and bisphosphonates improve survival in postmenopausal breast cancer patients

Two new studies suggest that two different classes of drugs, aromatase inhibitors (AIs) and bisphosphonates, can each improve survival prospects for postmenopausal women with early breast cancer.

Melatonin may improve sleep, quality of life in patients with breast cancer

Melatonin may improve sleep, quality of life in patients with breast cancer

Melatonin may be a potential therapeutic agent for improve sleep and quality of life in patients with metastatic breast cancer.

Chemotherapy less likely to benefit older patients with breast cancer

Chemotherapy less likely to benefit older patients with breast cancer

Chemotherapy does not improve survival for older women with breast cancer.

Radiotherapy costs vary among Medicare patients with breast, lung, prostate cancers

Radiotherapy costs vary among Medicare patients with breast, lung, prostate cancers

Cost of radiotherapy among Medicare patients varied most widely because of year of diagnosis, location of treatment, clinic type, and provider.

Reducing body fat through exercise can improve risks of breast cancer in postmenopausal women

Postmenopausal women who exercised 300 minutes per week were better at reducing total fat, which could in turn lower their postmenopausal breast cancer risk.

Hypofractionated breast irradiation linked to lower toxicity

Hypofractionated breast irradiation linked to lower toxicity

Two studies show benefits for hypofractionated versus conventionally fractionated whole-breast irradiation.

Appropriate use of tomosynthesis mammography

Appropriate use of tomosynthesis mammography

With the availability of tomosynthesis mammography, should women at high risk for developing breast cancer still undergo annual MRI?

Dietary intervention primes triple-negative breast cancer cells for targeted therapy

Dietary intervention primes triple-negative breast cancer cells for targeted therapy

A diet that starves triple-negative breast cancer cells of an essential nutrient primes the cancer cells to be more easily killed by targeted treatment.

Research identifies factors in 'Angelina Jolie effect' on breast cancer screening

Research identifies factors in 'Angelina Jolie effect' on breast cancer screening

Research indicates that Angelina Jolie's announcement that she had tested positive for BRCA1 influenced some women's intentions to seek out similar genetic testing.

Shorter course of radiation for breast cancer offers patients important benefit

Shorter course of radiation for breast cancer offers patients important benefit

Shorter course of whole breast radiation therapy for early stage breast cancer results in less toxicity and improved quality of life.

Understanding the stress of Latina cancer patients

Understanding the stress of Latina cancer patients

Cultural differences in the Latino community result in unique stressors for these patients after a cancer diagnosis. This study identified some of those stressors.

Many Appalachian women miss benefits of aromatase inhibitors to prevent breast cancer recurrence

Many breast cancer survivors in Appalachia neglect taking critical follow-up treatment, even though their insurance would cover the cost, a study has found.

Pain after breast cancer surgery may be associated with underlying depression

Pain after breast cancer surgery may be associated with underlying depression

Depression may increase the intensity of postoperative acute pain in women with breast cancer.

Single-stage breast reconstruction no riskier

Single-stage breast reconstruction no riskier

Single-stage implant procedures after mastectomy may be a good option for selected patients.

Progesterone may improve breast cancer survival rates

Receptors that mediate activity of the female sex hormones (estrogen and progesterone) interact with DNA to control the growth of a large majority of breast cancers, research indicates.

Irradiation of regional nodes in breast cancer patients affects overall survival

Irradiation of regional nodes in breast cancer patients affects overall survival

Irradiation of regional nodes in patients with stage I-III breast cancer has a minimal effect on overall survival.

Comparison of zoledronic acid dosing schedules finds less frequent schedule noninferior

Comparison of zoledronic acid dosing schedules finds less frequent schedule noninferior

ASCO 2015: 12-week dosing schedule of zoledronic acid is noninferior to a more-frequent schedule of every 4 weeks.

MRI, near-infrared spectral tomography combination increases specificity in breast cancer imaging

MRI, near-infrared spectral tomography combination increases specificity in breast cancer imaging

Magnetic resonance imaging (MRI) and near-infrared spectral tomography (NIRST) is feasible and more accurate than MRI alone

No association between opioids, breast cancer recurrence

No association between opioids, breast cancer recurrence

There is no clinically relevant evidence of an association between opioid prescriptions and breast cancer recurrence.

In breast cancer survivors, lidocaine may relieve pain during intercourse

In breast cancer survivors, lidocaine may relieve pain during intercourse

Breast cancer survivors who experience pain or discomfort during sexual intercourse may benefit from applying liquid lidocaine to the vulvar area.

Generic meds may boost survival in some early breast cancers

Generic meds may boost survival in some early breast cancers

More evidence that two classes of generic drugs (aromatase inhibitors and bisphosphonates) reduce the risk of death in early breast cancer.

Aromatase inhibitors substantially reduce risk of death in ER-positive breast cancer

Aromatase inhibitors substantially reduce risk of death in ER-positive breast cancer

Aromatase inhibitors significantly decrease the risk of death in postmenopausal women with estrogen receptor-positive breast cancer.

More radiation may decrease breast cancer recurrence risk in some patients

More radiation may decrease breast cancer recurrence risk in some patients

Some women who undergo additional radiation along with whole-breast irradiation may be at a reduced risk of breast cancer recurrence.

Benefits of mammography may be statistically overestimated

Contrary to popular expectations, the rates of advanced breast cancer have not generally declined in a number of countries where mammography screening is employed.

State regulations associated with late-stage cancer diagnoses

State regulations associated with late-stage cancer diagnoses

State regulations of health insurance and practitioners are significantly associated with time receive breast or colorectal cancer diagnoses.

Breast cancer survivors gain more weight than those without cancer

Breast cancer survivors gain more weight than those without cancer

Survivors of breast cancer who also have a family history of breast cancer were found to experience more weight gain in a four-year period than were cancer-free women.

Leisure sitting time associated with increased risk of cancer in women

Leisure sitting time associated with increased risk of cancer in women

Researchers have found that spending more leisure time sitting was associated with an increased risk for developing cancer in women.

Protein removal may slow blood vessel, tumor growth

Scientists have discovered a new protein which triggers the growth of blood vessels in breast cancer tumors that have spread to the brain.

Latina women undergoing chemotherapy for breast cancer need more stress management tools

A recent study examined both attitudes and cultural perspectives of Latinas undergoing chemotherapy for breast cancer.

Reduced memory before breast cancer treatment associated with specific cytokine

Pretreatment cytokine levels are associated with reduced memory performance among newly diagnosed patients with post-menopausal breast cancer.

Tamoxifen with ovarian function suppression versus tamoxifen alone as an adjuvant treatment for premenopausal breast cancer: a meta-analysis of published randomized controlled trials

Tamoxifen with ovarian function suppression versus tamoxifen alone as an adjuvant treatment for premenopausal breast cancer: a meta-analysis of published randomized controlled trials

[OncoTargets and Therapy] This article examines possible survival benefits of ovarian function suppression (OFS) when combined with adjuvant tamoxifen treatment for breast cancer in premenopausal women.

Regular mammograms may cause widespread overdiagnosis

Regular mammograms may cause widespread overdiagnosis

No significant difference in breast cancer deaths seen in counties with higher screening and detection rates.

'Death-associated protein' promotes cancer growth in most aggressive breast cancers

Investigators have discovered that the death-associated protein kinase 1 (DAPK1) is actually essential for growth in breast and other cancers with mutations in the TP53 gene.

Stress hormones could undermine breast cancer therapy

The stress hormones often used to treat the side effects of chemotherapy could have the side effect of making effective cancer drugs fail sooner in some women with breast cancer, according to new research.

Selectively ordering breast biomarker tests could save millions in health care dollars

Selective use of biomarker testing for patients with breast cancer has the potential to save millions of dollars in health care spending without compromising care.

Obesity associated with increased breast cancer risk in postmenopausal women

Clinical trial data suggests that postmenopausal women of above-average weight have an increased risk of breast cancer.

Increasing percentages of patients undergoing breast-conserving therapy

The percentage of patients with early stage breast cancer undergoing breast-conserving therapy (BCT) increased from 54.3% in 1998 to 60.1% in 2011, according to a recent report. Notably, nonclinical factors including socioeconomic demographics, insurance, and the distance patients must travel to treatment facilities persist as key barriers to the treatment.

ALK1 protein may play a role in breast cancer metastasis

Breast cancer patients with high levels of the protein activin-like receptor kinase (ALK1) in the blood vessels of their tumors were more likely to develop metastatic disease, according to a new study. This makes inhibition of the ALK1 pathway a possible new target for the treatment of metastatic breast cancer.

Distinct triple-positive subtypes identified in breast cancer

CHICAGO, IL—Functional subtyping with a multigene classifier resulted in 1 in 5 tumors being reclassified compared with conventional immunohistochemistry/fluorescent in situ hybridization (IHC/FISH) analysis. This study was presented at the 2015 American Society for Clinical Oncology (ASCO) Annual Meeting.

10 percent urea cream superior to new ointment for hand-foot syndrome

10 percent urea cream superior to new ointment for hand-foot syndrome

10% urea cream is superior to a newly introduced ointment containing various antioxidants at preventing hand-foot syndrome.

Yoga and meditation can ease menopausal symptoms following breast cancer

Yoga and meditation can ease menopausal symptoms following breast cancer

Randomized trial shows beneficial effect for yoga combined with meditation in breast cancer survivors.

Racial differences in breast cancer survival

Racial differences in breast cancer survival

The links between demographic, treatment, and socioeconomic factors and breast cancer survival were examined in a recent study.

Partial versus entire breast radiation does not increase recurrence

Partial versus entire breast radiation does not increase recurrence

Women diagnosed with breast cancer and treated with a one-week regimen of partial breast radiation after tumor removal saw no increase in cancer recurrence or difference in cosmetic outcomes.

Lifestyle intervention trial produces posttreatment weight loss in patients with breast cancer

The presence of extra body fat causes increased risk of diabetes and heart disease, and also increases the chances for breast cancer recurrence.

Scientists identify key to preventing metastatic breast cancer

Scientists identify key to preventing metastatic breast cancer

The discovery of an enzyme that facilitates the spread of breast cancer may enable clinicians to prevent secondary cancer.

Embryo cryopreservation possible for women with breast cancer

Embryo cryopreservation possible for women with breast cancer

Embryo cryopreservation after aromatase inhibitor treatment and ovarian stimulation preserves fertility for patients with breast cancer, according to a study published online.

Smoking may have negative effect on breast cancer survival

Smoking may have negative effect on breast cancer survival

Premenopausal women with breast cancer are at increased risk of dying if they smoke.

Removing more breast tissue reduces the need for a second cancer surgery

Expanded surgical margins during a partial mastectomy could be beneficial for patients, preventing further surgery.

Majority of women with early-stage breast cancer undergoing imaging despite guidelines

Majority of women with early-stage breast cancer undergoing imaging despite guidelines

The majority of women with early-stage breast cancer undergo imaging for metastatic cancer despite guidelines.

Breast cancer false alarms have a negative impact on women's health

A false breast cancer diagnosis can have long-lasting psychological effects.

Breast-conserving therapy rates are slowly rising

Breast-conserving therapy rates are slowly rising

The number of patients that undergo breast-conserving therapy (BCT) has risen slowly in recent years, but many with early-stage disease still choose mastectomy.

Benefit of surgery for ductal carcinoma in-situ investigated

Breast surgery performed at or shortly after a diagnosis of low-grade ductal carcinoma in-situ (DCIS) was not found to significantly impact patients' survival rate.

Access to breast-conserving therapy still an issue for some patients

Access to breast-conserving therapy still an issue for some patients

Rates of breast-conserving therapy for early-stage breast cancer have increased.

Sleep quality impacts breast cancer survival

Sleep quality impacts breast cancer survival

Poor sleep and snoring before breast cancer diagnosis is tied to poor survival outcomes.

Misperceptions about impact of double mastectomy are common

Half of the women with breast cancer polled considered double mastectomy, but only a little more than a third knew the aggressive procedure doesn't up the chances of survival.

Attending breast cancer screening reduces risk of death from breast cancer by 40%

Attending breast cancer screening reduces risk of death from breast cancer by 40%

Women ages 50 to 69 years who attend mammography screening reduce their risk of dying from breast cancer by 40% compared with women who are not screened, according to the latest evidence.

Norwegian screening program reduces breast cancer-related death rates

Norwegian screening program reduces breast cancer-related death rates

A Norwegian breast cancer screening program has markedly reduced breast cancer mortality.

Male breast cancer added to list of obesity-associated cancers

Male breast cancer added to list of obesity-associated cancers

An increase in cases of male breast cancer to the growing list of cancers associated with rising obesity rates.

Obesity associated with increased postmenopausal invasive breast cancer risk

Obesity associated with increased postmenopausal invasive breast cancer risk

Obesity is associated with increased risk for invasive breast cancer in postmenopausal women.

Evidence for screening mammography for women in their 40s remains limited

Evidence for screening mammography for women in their 40s remains limited

A new research review indicates that breast screening in the 40s may not prevent breast cancer deaths, but the conclusion among researchers wasn't unanimous.

Prognosis for patients with breast cancer is not impeded by family history

A new study found that prognosis after treatment for women with breast cancer with a family history of the disease is no worse than it is for other women with breast cancer.

Surgery less likely if breast cancer diagnosed as an emergency

Surgery less likely if breast cancer diagnosed as an emergency

Breast cancer patients are much less likely to have potentially lifesaving surgery if diagnosed as an emergency rather than via urgent GP referral.

Increase in cancer screening may be result of ACA provision

Increase in cancer screening may be result of ACA provision

Affordable Care Act has removed financial barriers to preventive services, including breast and colorectal cancer screening.

ASCO: Palbociclib increases survival for HR+ metastatic breast cancer

ASCO: Palbociclib increases survival for HR+ metastatic breast cancer

Adding palbociclib to standard hormone therapy may be more beneficial than hormone therapy alone for HR+/HER2− breast cancer, according to a new study.

ASCO: Additional tissue removal reduces further breast cancer surgery

ASCO: Additional tissue removal reduces further breast cancer surgery

Removing extra tissue can halve the chances of requiring a second surgery in breast cancer.

Blood test detects breast cancer metastasis early

A blood test that involves examination of cell-free circulating DNA could be key to earlier detection of breast cancer metastases.

Breast surgery for low-grade ductal carcinoma may not improve survival

Breast surgery for low-grade ductal carcinoma may not improve survival

Breast surgery performed at or shortly after a diagnosis of low-grade ductal carcinoma in-situ (DCIS) experienced no difference in survival.

Cancer survivors have evolving information needs

Depending on the type of cancer faced, the needs of survivors can vary.

Enzalutamide May Represent Novel Therapeutic Option for Triple-Negative Breast Cancer

Enzalutamide May Represent Novel Therapeutic Option for Triple-Negative Breast Cancer

Enzalutamide may be a viable alternative therapy over cytotoxic chemotherapy for individuals with triple-negative breast cancer, according to a study presented at the 2015 American Society of Clinical Oncology annual meeting.

"Smarter" cancer screening advised for women with dense breasts

Not all women with dense breasts have a high enough breast cancer risk to justify additional imaging after a normal mammogram, according to a recent study.

Young Women with Breast Cancer on Ovarian Suppression Need Early Intervention to Mitigate Poor QOL

Young Women with Breast Cancer on Ovarian Suppression Need Early Intervention to Mitigate Poor QOL

Early intervention should be offered to young women with breast cancer on ovarian function suppression and tamoxifen, who experience poorer quality of life (QOL) in the early survivorship period, according to a study presented at the 2015 American Society of Clinical Oncology Annual Meeting.

Letrozole Significantly Reduces Late Invasive Events in HR+ Early Breast Cancer

Letrozole Significantly Reduces Late Invasive Events in HR+ Early Breast Cancer

Letrozole significantly reduced the rate of late invasive breast cancer events in postmenopausal women who had completed 4+ years of adjuvant endocrine therapy for HR+ breast cancer, the LATER trial concluded at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting.

Diagnostic Assay Improves Outcomes Prediction in Early Breast Cancer, Nixing Need for Chemo

Diagnostic Assay Improves Outcomes Prediction in Early Breast Cancer, Nixing Need for Chemo

Outcome prediction for postmenopausal patients with node-positive HR+ early breast cancer can be improved using a diagnostic assay, potentially negating the need for adjuvant chemotherapy, according to a study presented at ASCO 2015.

Breast cancer survivors can lose weight through modest lifestyle changes

Breast cancer survivors can lose weight through modest lifestyle changes

Female breast cancer survivors may be able to lose weight through modest lifestyle changes.

Men with high estrogen levels could be at greater risk of breast cancer

New research indicates that men with naturally high levels of the female hormone estrogen may have a greater risk of developing breast cancer.

A positive family history alone may not affect breast cancer outcomes

A positive family history alone may not affect breast cancer outcomes

No difference seen in distant disease-free intervals for those with versus those without a positive family history, say researchers.

Patients older than 60 years on hormone therapy for luminal A breast cancer may not need radiation

Women with luminal A subtype breast cancer, especially those older than 60 years, may not need radiation treatment if they are already taking hormone therapy.

False breast cancer alarm may still cause psychological strain

False breast cancer alarm may still cause psychological strain

A false breast cancer alarm may still result in severe psychological strain.

MRI shows potential to improve breast cancer prediction

Magnetic resonance imaging (MRI) can provide vital information for predicting the odds of breast cancer development.

Inconsistent Medicaid expansion would widen disparities in screenings for women's cancers

Low-income and women without insurance in states that are not expanding their Affordable Care Act (ACA) Medicaid coverage are less likely to receive breast and cervical cancer screenings.

Dense breasts do not always correlate to high risk of interval cancer

Dense breasts do not always correlate to high risk of interval cancer

Five-year risk plus breast density can best identify women at high risk for interval cancer.

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