Some breast cancer tumors hijack epigenetic machinery to evade drugs

A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, according to researchers.

High-fat diet tied to breast cancer subtypes

High-fat diet tied to breast cancer subtypes

High intake of saturated fat increases risk of HER2-negative, ER/PR-positive disease.

Faster genetic testing may transform breast cancer care

Faster and cheaper DNA sequencing techniques will likely improve care for patients with breast cancer but also create challenges for clinicians as they counsel patients on their treatment options.

Breast cancer prognoses distinguished by mechanical forces

The stiffening of breast tissue in breast-cancer development points to a new way to distinguish a type of breast cancer with a poor prognosis from a related but often less deadly type.

AACR: LY2835219 shows promise for metastatic breast cancer

AACR: LY2835219 shows promise for metastatic breast cancer

The novel cell cycle inhibitor selective for the cyclin-dependent kinases CDK4 and CDK6 (CDK4/6), LY2835219, shows promise for metastatic breast cancer, according to a study.

Big data identifies triple-negative breast, oropharyngeal, and lung cancers

Big data analytics has predicted if a patient is suffering from aggressive triple-negative breast cancer, slower-moving cancers, or noncancerous lesions with 95% accuracy.

Radiotherapy after mastectomy improves outcomes for patients with up to three positive lymph nodes

Women whose breast cancer has spread to just a few axial lymph nodes are less likely to have their disease recur or to die from it if they have radiotherapy after mastectomy.

Impact of fertility drugs on breast cancer risk examined

Impact of fertility drugs on breast cancer risk examined

Women with ever use of clomiphene have no increased breast cancer risk, although women undergoing multiple clomiphene cycles have an increased risk of invasive breast cancer.

Full-field digital mammography shows lower recall and biopsy rates

Full-field digital mammography shows lower recall and biopsy rates

Compared with screen-film mammography (SFM), full-field digital mammography is associated with reduced recall and biopsy rates, according to research.

Genetic testing selects patients with ER+ breast cancer for extended hormone therapy

Genetic testing selects patients with ER+ breast cancer for extended hormone therapy

Genetic analyses of results from postmenopausal women being treated for estrogen-responsive breast cancer have shown that some are more likely to have a late recurrence of their cancer and might benefit from additional years of hormone therapy.

Financial burden of breast cancer greater for minorities

Financial burden of breast cancer greater for minorities

There is a increased likelihood of financial decline and privations in minorities compared with whites dealing with breast cancer.

New approach reduces opioid painkiller use after breast reconstruction surgery

A new approach to breast reconstruction surgery aimed at helping patients' bodies get back to normal more quickly cut their postoperative painkiller use in half and reduced hospital stay, a new study found.

Next-gen sequencing to impact breast cancer care

Next-gen sequencing to impact breast cancer care

By utilizing NGS, breast cancer clinicians will know whether their patients carry high-risk mutations in genes, such as BRCA1 or BRCA2, before the start of treatment.

Screening does not shift breast cancer to earlier stages

Screening does not shift breast cancer to earlier stages

Screening for breast cancer appears to have a very limited effect on the number of serious cancer cases, but it also appears to detect cancer early in many more cases.

CBT/CBTH mitigates fatigue in patients with breast cancer undergoing radiotherapy

CBT/CBTH mitigates fatigue in patients with breast cancer undergoing radiotherapy

Cognitive behavioral therapy, alone or with hypnosis, can help patients with breast cancer undergoing radiotherapy to manage fatigue, often their most debilitating side effect.

ASCO guideline update for sentinel node biopsy in breast cancer

ASCO guideline update for sentinel node biopsy in breast cancer

The American Society of Clinical Oncology (ASCO) has updated its 2005 guideline for use of sentinel node biopsy in early breast cancer.

Vitamin D increases survival for breast cancer patients

Vitamin D increases survival for breast cancer patients

Breast cancer patients with high levels of vitamin D in their blood are twice as likely to survive the disease, according to a recent meta-analysis.

Epigenetic imprint of chemotherapy linked to inflammation in breast cancer survivors

Chemotherapy, one of the major treatments for breast cancer, can leave a long-lasting epigenetic imprint in the DNA of the blood cells of breast cancer patients, according to new research.

Breast reconstruction becoming more common after mastectomy

A new study finds that the majority of women who undergo mastectomy for breast cancer go on to get breast reconstruction, a practice that has increased dramatically over time.

Molecular subtyping of breast cancer can better identify women at high risk of recurrence

A method called molecular subtyping can help doctors better determine which of their breast cancer patients are at high risk of getting breast cancer again, according to a new study.

EBCC: Routine mammograms for most women 70 not beneficial

EBCC: Routine mammograms for most women 70+ not beneficial

More harm than good can result from mammogram breast cancer screenings for women aged 70 and older, and decision should be made case by case.

BRCAPRO model may underestimate BRCA1/2 mutation risk

BRCAPRO model may underestimate BRCA1/2 mutation risk

Use of the BRCAPRO model for assessment of the likelihood of having a germline BRCA1/BRCA2 mutation may underestimate the risk of mutations, according to a study

Post-mastectomy radiation beneficial after mastectomy

Post-mastectomy radiation beneficial after mastectomy

Reductions seen in locoregional recurrence, overall recurrence, and breast cancer mortality when radiotherapy is employed after mastectomy and axillary dissection.

Hypnosis therapy decreases fatigue in breast cancer patients

Hypnosis therapy decreases fatigue in breast cancer patients

Breast cancer patients receiving radiotherapy showed decreased fatigue as a result of cognitive behavioral therapy plus hypnosis, according to a new study.

Treatment priorities set for early breast tumors

A team of stakeholders has detailed research priorities necessary to address gaps in knowledge about early breast tumors in women.

Guideline update leaves out novel tests in breast cancer

Guideline update leaves out novel tests in breast cancer

Massimo Cristofanilli, MD, talks about why the updated ASCO/CAP guidelines should support the use of mRNA and DNA microarray assays.

Yoga increases QoL for breast cancer patients receiving radiotherapy

Yoga increases QoL for breast cancer patients receiving radiotherapy

For women with breast cancer, incorporating yoga into radiotherapy is associated with a lasting improvement in quality of life.

Breast cancer survival predicted by gene panel linked to powerful tumor suppressor

Breast cancer survival predicted by gene panel linked to powerful tumor suppressor

A panel of 55 genes, almost all of which are impacted by the loss of a particular protein, appears to predict if breast cancer will become invasive.

New target found for triple-negative breast cancer

A new study shows that targeting a particular nuclear protein may provide an effective approach for treating triple-negative breast cancer.

Possible genetic markers uncovered in breast cancer that spreads to the brain

Possible genetic markers uncovered in breast cancer that spreads to the brain

Possible genetic origins of breast cancer that spreads to the brain have been uncovered, according to a first-of-its-kind study.

Small noncoding RNAs could be warning signs of cancer

Small noncoding RNAs could be warning signs of cancer

Small noncoding RNAs can be used to predict if a person has breast cancer, concluded researchers who contributed to The Cancer Genome Atlas (TCGA) project.

Potential options to attack stem cells in triple-negative breast cancer

A protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells, according to new research.

Novel technique increases detection rate in screening mammography

Novel technique increases detection rate in screening mammography

Digital mammography screening with the new photon-counting technique offers high diagnostic performance, according to a new study.

Rise in breast reconstructions in U.S.

Rise in breast reconstructions in U.S.

Use of breast reconstruction in women undergoing mastectomy for breast cancer increased significantly, from 46% in 1998 to 63% in 2007.

New hormone receptor targets for breast cancer discovered

New hormone receptor targets for breast cancer discovered

Androgen and vitamin D receptors can be targeted in breast cancer, according to new research.

Yoga improves fatigue and reduces inflammatory markers in breast cancer survivors

Yoga improves fatigue and reduces inflammatory markers in breast cancer survivors

Improvements in fatigue, IL-6, TNF-a, and IL-1B seen in a clinical trial that measured the effects of yoga practice in women survivors of breast cancer.

Mammography benefits women in their 40s

Mammography benefits women in their 40s

Breast cancer was diagnosed at earlier stages in women age 40 to 49 years who underwent routine screening mammography, and their tumors were less likely to require chemotherapy.

Low recurrence breast cancer rates with negative margins

Low recurrence breast cancer rates with negative margins

Positive margins linked to two-fold increased risk of ipsilateral breast tumor recurrence, according to consensus guidelines.

Bilateral mastectomy reduces BRCA-related cancer mortality

Bilateral mastectomy reduces BRCA-related cancer mortality

Observational study supports removal of contralateral breast in women with hereditary breast cancer.

Positive long-term outcomes after adjuvant accelerated partial breast irradiation

Long-term outcomes of breast cancer patients receiving adjuvant accelerated partial breast irradiation after breast-conserving surgery show excellent tumor control with minimal late toxicity.

Mastectomy risk reduced by external beam radiation for invasive breast cancer

Standard external beam radiation therapy provided a higher breast preservation rate than brachytherapy in women 66 years and older with invasive breast cancer, according to new research.

New data contradicts current recommendations for managing breast biopsy abnormalities

Contrary to existing understanding, long-term follow-up of patients with two types of breast tissue abnormalities suggests that both types of abnormalities have the same potential to progress to breast cancer.

Brachytherapy raises future mastectomy risk compared with standard radiation in older women

When comparing treatments designed to enable long-term breast preservation for older women with invasive breast cancer, researchers found that those treated with brachytherapy were at higher risk for a later mastectomy.

Breast cancer drug proposed for bladder cancer patients

Researchers have found amplification of HER2—a known driver of some breast cancers—in a type of bladder cancer called micropapillary urothelial carcinoma (MPUC).

Smoking increases ER-positive breast cancer risk for women

Smoking increases ER-positive breast cancer risk for women

Younger women who smoke appear to be at increased risk for developing ER-positive breast cancer, according to research, but no association found for risk of triple-negative breast cancer.

Breast cancer spreads to the brain by disguising itself as neurons

Breast cancer spreads to the brain by disguising itself as neurons

Years can pass between the time a breast cancer patient goes into remission and a related brain tumor develops. During that time, the breast cancer cells somehow escape detection.

Running tops walking for breast cancer survival

Running tops walking for breast cancer survival

Researchers found a significantly reduced mortality risk for breast cancer survivors who run.

Key mechanisms discovered to inhibit triple-negative breast cancer

Critical complex mechanisms involved in the metastasis of deadly triple-negative breast cancers (TNBC) have been identified.

Subtypes of HER2-positive breast cancer with varying sensitivities identified

Research has not only shown that HER2-positive breast cancer can be classified into four different subtypes, but has also unmasked a subtype showing both a greater response to and increased benefit from chemotherapy and anti-HER2 therapy.

Breast cancer in young women after treatment for Hodgkin lymphoma

Girls treated for Hodgkin's lymphoma during adolescence acquire a considerable risk of developing breast cancer.

Yoga beneficial for breast cancer survivors

Yoga beneficial for breast cancer survivors

Twelve-week intervention linked to improved fatigue, vitality, lower levels of proinflammatory cytokines in participants.

Breast cancer stem cell discoveries explain metastasis

Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, according to an international collaboration of researchers.

CT and mammogram show consistent breast density readings

CT and mammogram show consistent breast density readings

Semiautomated computer-derived measurements are consistent with radiologist assessments, according to a study.

Adjuvant endocrine therapy and alopecia

Adjuvant endocrine therapy and alopecia

A patient on adjuvant endocrine therapy for breast cancer is complaining of hair loss. Could the alopecia be due to her endocrine therapy?

Risk-reduction surgery for ovarian cancer improves survival

Preventive surgery improves survival for women who are at greater risk of developing ovarian cancer, and it may be helpful for women at risk of developing breast cancer due to genetics.

Protein linked to spread of breast cancer to brain

Protein linked to spread of breast cancer to brain

A protein has been identified that may be a key culprit when breast cancer metastasizes to the brain.

Breast cancer survivors troubled most by postmastectomy pain

Women with breast cancer who undergo surgery rate persistent postmastectomy pain as the most troubling symptom.

New biomarkers linked to early diagnosis of breast cancer

New biomarkers linked to early diagnosis of breast cancer

Measuring the amount of certain protein fragments and microRNAs in a woman's blood and breast tissue might enable the early diagnosis of breast cancer or prediction of its metastasis.

Cell mechanism discovery is key to stopping breast cancer metastasis

A cellular mechanism has been discovered that drives breast cancer metastasis, and researchers have also discovered a therapy that blocks that mechanism.

Sugar uptake in breast cancer is a cancerous event

Aerobic glycolysis, which is glucose metabolism in the presence of oxygen, has been shown to be a cancerous event, rather than a consequence of the cancerous activity of malignant cells.

Radiotherapy is used less often in breast cancer patients with young children

Radiotherapy is used less often in breast cancer patients with young children

Radiotherapy after breast-conserving surgery has been shown to reduce the risk of breast cancer recurrence. But younger women are less likely to receive radiotherapy after breast-conserving surgery, according to a new study.

BMN 673 promising in BRCA cancers

BMN 673 promising in BRCA cancers

An investigational new PARP inhibitor, BMN 673, is showing early responses in patients with advanced, BRCA-related breast and ovarian cancers.

Patients still report some level of pain 1 year after breast cancer surgery

In a study that included more than 800 women who had undergone surgery for breast cancer, the majority reported some level of pain 12 months after surgery.

Trastuzumab benefit predicted by high levels of immune cells in breast cancer tumors

Women with HER2-positive breast cancer who had the highest levels of immune cells in their tumors gained the most benefit from presurgery treatment with chemotherapy and trastuzumab. These results were presented at the 2013 San Antonio Breast Cancer Symposium.

Surgery and radiation after chemotherapy not beneficial for patients with metastatic breast cancer

After a response to initial chemotherapy, treatment with radiotherapy and surgical removal of the breast tumor and nearby lymph nodes do not provide any additional benefit to patients with metastatic breast cancer.

Highly effective treatment options identified for HER2-positive breast cancer

Combining the chemotherapy drugs docetaxel and carboplatin with the HER2-targeted therapy trastuzumab was identified to be an ideal postsurgery treatment option for patients with HER2-positive breast cancer.

Exercise protects against aggressive breast cancer in black women

A nearly 20-year observational study involving more than 44,700 black women nationwide found that regular vigorous exercise offers significant protection against development of an aggressive subtype of breast cancer.

Mammography offers consistent benefits in reducing breast cancer mortality

Re-examination of data from four large studies of the benefits and harms of mammography screening shows that the benefits are more consistent across these studies than previously understood.

Deep sequencing of breast cancer tumors is predictive of outcomes after a single dose of therapy

Changes in the genetic composition of breast cancer tumors after brief exposure to either biologic therapy or chemotherapy can predict future clinical outcomes in patients, according to new research.

Radiotherapy can be avoided in older patients with breast cancer

Omission of radiotherapy is a reasonable option for women 65 years or older who receive hormone therapy after breast-conserving surgery for hormone receptor-positive, axillary node-negative breast cancer.

Models of drug-resistant breast cancer suggest better treatments

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research presented at the 2013 San Antonio Breast Cancer Symposium.

Staging is overused in younger, early-stage breast cancer patients

More than one-third of younger, early-stage breast cancer patients undergo unnecessary imaging procedures at the time of staging and diagnosis, according to research presented at the 2013 San Antonio Breast Cancer Symposium.

Review examines pros and cons of mammography

Review examines pros and cons of mammography

Among 1,000 U.S. women screened annually for 10 years, 0.3 to 3.2 will avoid breast cancer death due to mammography.

Exercise improves drug-associated joint pain in breast cancer survivors

Breast cancer survivors taking AIs, such as anastrozole, letrozole, and exemestane, experienced a reduction in joint pain if they exercised while on treatment. These results were presented at the 2013 San Antonio Breast Cancer Symposium.

Postoperative breast cancer pain common

Postoperative breast cancer pain common

Most women with unilateral non-metastasized breast cancer treated with breast conserving surgery or mastectomy with axillary surgery experience postoperative pain at 12 months, according to research.

PIK3CA gene mutations make some breast cancers resistant to treatment

Women with breast cancer characterized by high levels of the protein HER2 and hormone receptors gained much less benefit from presurgery treatment with chemotherapy and HER2-targeted therapies if their cancer had one or more mutations in the PIK3CA gene. These results were presented at the 2013 San Antonio Breast Cancer Symposium.

Dasatinib with letrozole delays disease progression for some metastatic breast cancer

Adding dasatinib to the standard antihormone therapy, letrozole, doubled the time before disease progressed for women with hormone receptor-positive, HER2-negative metastatic breast cancer. These results of a phase 2 clinical trial were presented at the 2013 San Antonio Breast Cancer Symposium.

Innovative clinical trial design is a new paradigm in breast cancer research

The first investigator results from an unprecedented nationwide effort to test promising new breast cancer drugs before the tumor is removed were presented during the 2013 San Antonio Breast Cancer Symposium.

Anastrozole may be a new option for breast cancer prevention

Breast cancer incidence among postmenopausal women at high risk for developing the disease was significantly reduced with the antihormone therapy anastrozole, according to the initial results of a double-blind, randomized, placebo-controlled trial presented at the 2013 San Antonio Breast Cancer Symposium.

Families do not understand the implications of genetic test results

Families do not understand the implications of genetic test results

Many relatives of patients who undergo testing for genetic links to breast and ovarian cancers misinterpret the results, and less than half of those who could benefit from genetic testing say they plan to undergo testing themselves, according to a recent study presented at the 2013 San Antonio Breast Cancer Symposium.

Ramucirumab combination therapy failed to delay progression of advanced breast cancer

Adding the antibody therapy ramucirumab to docetaxel therapy did not delay disease progression for patients with HER2-negative, advanced breast cancer. These results, from a placebo-controlled, randomized, phase 3 clinical trial, were presented at the 2013 San Antonio Breast Cancer Symposium.

Acupuncture aids breast cancer treatment outcomes

Acupuncture aids breast cancer treatment outcomes

No significant difference in outcomes seen for patients treated with real or sham acupuncture; both groups saw improvement.

New presurgery combination therapy promising for triple-negative breast cancer

I-SPY 2 has yielded positive results with the first drug to complete testing during the trial. Adding carboplatin and veliparib to standard presurgery chemotherapy improved outcomes for women with triple-negative breast cancer, according to results presented at the 2013 San Antonio Breast Cancer Symposium.

Chemoresistant breast cancer outcomes not improved by bisphosphonate treatment

Treatment with zoledronate, a bisphosphonate, did not improve outcomes for women with chemoresistant breast cancer, according to initial results of a phase 3 clinical trial presented at the 2013 San Antonio Breast Cancer Symposium.

Changing chemotherapy not beneficial for metastatic breast cancer with elevated CTCs

For women with metastatic breast cancer who had elevated amounts of CTCs in their blood after a first line of chemotherapy, switching immediately to a different chemotherapy did not improve overall survival or time to progression. These phase 3 clinical trial results were presented at the 2013 San Antonio Breast Cancer Symposium.

Breast cancer prognosis associated with oncometabolite accumulation

The metabolic profile of cancer cells can be used to develop therapies and identify biomarkers associated with cancer outcome. New research has discovered an association between the oncometabolite 2-HG levels, DNA methylation patterns, and breast cancer prognosis.

Biomarker linked to aggressive breast cancers and poor outcomes in African Americans

Increased levels of the protein HSET in African American women with breast cancer were associated with worse outcomes, according to results presented at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, in Atlanta.

Older breast cancer survivors should keep exercising

Older breast cancer survivors should follow an ongoing exercise program of resistance and impact training. Newly published research found that the bone benefit from 1 year of such training could be maintained, even with less exercise, up to a year later, which could help prevent bone fractures in the long run.

Molecular imaging tracer improves accuracy of treatment plans for brain metastases

Imaging with a molecular imaging tracer can help distinguish radiation-induced lesions from new tumor growth in patients who have been treated with radiation for brain metastases, according to new research.

3-D mammography increases cancer detection and reduces callback rates

Compared with traditional mammography, 3D mammography—known as digital breast tomosynthesis—found 22% more breast cancers and led to fewer callbacks in a large screening study, as researchers reported at the annual meeting of the Radiological Society of North America.

Breast cancer related to changes in breast density as women age

Breast cancer related to changes in breast density as women age

Automated breast density measurement is predictive of breast cancer risk in younger women, and that risk may be related to the rate at which breast density changes in some women as they age, according to research.

Supporting others brings healing to breast cancer survivors

A new study finds that survivors of hematopoietic stem cell transplant, an aggressive treatment for blood cancers, benefited from a two-part peer support process. The authors called this peer support process "expressive helping."

SABCS: Chemo combo aids triple-negative breast cancer

SABCS: Chemo combo aids triple-negative breast cancer

Two studies show increase in pathologic complete response with pre-op chemotherapy combinations.

SABCS: Drug decreases breast cancer risk in high-risk women

SABCS: Drug decreases breast cancer risk in high-risk women

Anastrozole reduces breast cancer risk by about half with few side effects, according to a study presented at the annual San Antonio Breast Cancer Symposium.

SABCS: Radiotherapy may be avoided in some breast cancers

SABCS: Radiotherapy may be avoided in some breast cancers

Radiotherapy has no benefit for some older women after surgery, and hormone treatment after surgery may provide a radiation alternative.

High cholesterol fuels breast cancer growth and spread

High cholesterol fuels breast cancer growth and spread

A by-product of cholesterol functions like the hormone estrogen to fuel the growth and spread of the most common types of breast cancers, according to researchers.

SABCS: Mammography benefit disparities reviewed

SABCS: Mammography benefit disparities reviewed

Apparent disparities between different reviews on the benefit of mammography screening on breast cancer mortality are mainly due to different denominators.

Less exercise leads to higher breast cancer mortality

Less exercise leads to higher breast cancer mortality

In addition to infrequent exercise, a larger breast cup size was also linked with increased risk of breast cancer mortality in female runners and walkers.

SABCS: Dual HER2 blockade in breast cancer examined

SABCS: Dual HER2 blockade in breast cancer examined

For human epidermal growth factor receptor 2 (HER2)-positive tumors, the combination of lapatinib and trastuzumab is better than either therapy alone, according to a study.

Potential cause found for deadly relapse of basal-like breast cancer

Researchers have discovered why some of the most aggressive and fatal breast cancer cells are resistant to chemotherapy, and they are developing ways to overcome this resistance.

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