Fifteen new breast cancer genetic risk 'hot-spots' revealed

Researchers compared tiny variations in the genetic make-up of more than 120,000 women of European ancestry, with and without breast cancer, and identified 15 new genetic variations linked to a higher risk of the disease.

Chemotherapy before breast cancer surgery increases likelihood of breast-preserving procedure

Patients with larger malignant tumors of the breast who undergo chemotherapy before breast cancer surgery are more likely to opt for a breast-preserving procedure, according to a new study.

Anesthetic technique could spare some women from chronic pain after breast cancer surgery

A regional anesthetic technique in combination with standard care could potentially spare a third of women undergoing a mastectomy chronic post-operative pain, according to study data.

Ultrasound lags behind MRI for supplemental breast cancer screening

Breast screening via ultrasound is unaffected by breast density, is not associated with ionizing radiation, and does not require IV contrast material, but acceptance of this modality has lagged.

Breast cancer more likely to be advanced stage disease at diagnosis in women with diabetes

Breast cancer more likely to be advanced stage disease at diagnosis in women with diabetes

Breast cancer in women with diabetes is more likely to be advanced stage at diagnosis.

Minority women less involved in breast cancer surgery decisions

Minority women less involved in breast cancer surgery decisions

Black and Hispanic women with breast cancer are less likely to select a surgeon or determine hospital based on reputation.

Inappropriate breast and prostate imaging of Medicare beneficiaries examined

An association of high rates of inappropriate imaging for prostate cancer and breast cancer found in a study of Medicare beneficiaries suggests that regional culture could contribute to inappropriate imaging.

US women's awareness of breast density varies

Disparities exist regarding the level of awareness and knowledge of breast density among US women, according to a study.

Disparities in adherence to breast cancer care linked to net worth

Household net worth can be linked to adherence to hormonal therapy among breast cancer patients and partially explains racial disparities in quality of care.

Newer breast implants could be safer for body

Newer breast implants could be safer for body

A newly developed surface for silicone breast implants could greatly increase the chance that they are properly assimilated by the body without rejection.

Text message reminders improve how women manage breast cancer screening

Text message reminders improve how women manage breast cancer screening

They found that women who received a reminder were 20% more likely to attend their breast cancer screening appointment.

Breast cancer metastasis may be tied to cell that regulates blood flow

Breast cancer metastasis may be tied to cell that regulates blood flow

Scientists believe that targeting blood vessel cells known as pericytes may offer a potential new therapeutic approach for breast and other cancers.

Family history of prostate cancer may indicate higher risk of breast cancer in women

A family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer, according to a new study.

Mental training program helps ease chemobrain in breast cancer

Mental training program helps ease chemobrain in breast cancer

A new program developed by UCLA researchers may ease post-treatment "chemo brain" in patients with breast cancer.

Magnetic resonance spectroscopy (MRS) shows precancerous breast changes in women with BRCA gene mutation

MRS that incorporates monitoring of biochemical changes in tissue could improve the management of women at risk of breast cancer, according to a new study.

Regional infrastructure tied to inappropriate breast, prostate cancer imaging

Regional infrastructure tied to inappropriate breast, prostate cancer imaging

Regional infrastructure could contribute to inappropriate imaging in patients at risk for prostate and breast cancer.

Therapeutic massage may ease fatigue in breast cancer

Therapeutic massage may ease fatigue in breast cancer

Researchers continue to examine the effects of massage therapy and how it may help to reduce fatigue in patients with breast cancer.

Education, not mandatory screening, best for women with dense breast tissue

Laws mandating notification of dense breasts may pose a risk of unnecessary procedures and false positives for women at low- and moderate-risk of breast cancer.

Sexual dysfunction in a breast cancer survivor: A case study

Sexual dysfunction in a breast cancer survivor: A case study

This case study examines a case of sex-related headaches in a breast cancer survivor after treatment for ductal carcinoma in situ (DCIS).

Goserelin reduces ovarian failure rate in breast cancer

Goserelin reduces ovarian failure rate in breast cancer

Use of the gonadotropin-releasing hormone agonist, goserelin, protects against ovarian failure, according to a study.

Mobile app helps to track breast cancer survivors' experiences

Mobile app helps to track breast cancer survivors' experiences

A new patient-centered mobile app entitled Share the Journey: Mind, Body and Wellness after Breast Cancer has launched.

History of prostate cancer in relatives may increase risk of breast cancer

History of prostate cancer in relatives may increase risk of breast cancer

Women with a family history of prostate cancer in first-degree relatives may have a higher risk of developing breast cancer.

Correlated spectroscopy pinpoints changes in BRCA1/2 carriers

Correlated spectroscopy pinpoints changes in BRCA1/2 carriers

Lipid and metabolite deregulation were seen in breast tissue of women carrying BRCA1/2 mutations.

Better informed women less likely to want to undergo mammography screening

Knowledge of the risk of over-detection and over-diagnosis associated with mammography screening can lower intentions to undergo breast screening, according to a new Lancet study.

Psychosocial challenges of pregnancy-associated breast cancer (PABC)

Psychosocial challenges of pregnancy-associated breast cancer (PABC)

Breast cancer during pregnancy presents additional psychosocial challenges as patients cope with a devastating diagnosis during a time of hope and promise for the future.

Breast cancer survivors may have increased risk of thyroid cancer

Breast cancer survivors may have increased risk of thyroid cancer

Female breast cancer survivors may be at an increased risk for developing thyroid cancer.

Inadequate pressure during manual breast examinations misses deep-tissue masses

Many physicians who tested their breast-examination skills on a new type of pressure-sensing breast model failed to detect masses deep in the breast because they were administering adequate pressure, a study has found.

Aluminum-containing deodorant safe for patients with breast cancer undergoing radiotherapy

Aluminum-containing deodorant safe for patients with breast cancer undergoing radiotherapy

Women undergoing radiotherapy for breast cancer can use deodorant without increasing risk of underarm skin reactions, pain, itching, or burning.

Major study links two new genetic variants to breast cancer

Major study links two new genetic variants to breast cancer

A worldwide study of the DNA of 100,000 women has discovered two new genetic variants associated with an increased risk of breast cancer.

New mechanism of acquired resistance to breast cancer drugs discovered

Researchers have discovered that ERBB4 (also known as HER4) is a driver protein in ERBB2-positive tumors that have developed resistance to first- or second-line treatments.

Crucial role of breast cancer tumor suppressor revealed

Cells that contain lower levels of protein profilin 1 in breast tumors have an increased capacity to metastasize and invade other tissues, according to research.

Women educated on overdiagnsosis are less likely to want mammogram

Women educated on overdiagnsosis are less likely to want mammogram

Risks and benefits of routine mammography continue to be debated, but educating women about the possibility of overdiagnosis from mammography screening may make some of them less likely to get the test.

New genetic anomalies linked to breast cancer in African American families

Newly discovered segments of DNA shared by African American family members who have breast cancer indicate there may still be undiscovered breast cancer genes that may be unique to African Americans.

Many patients with locally advanced breast cancer do not receive postmastectomy radiation

More than a third of women who should receive radiation subsequent to mastectomy are actually undergoing the recommended postmastectomy radiation therapy (PMRT), according to a new study.

Household net worth linked to hormonal therapy adherence among patients with breast cancer

Household net worth linked to hormonal therapy adherence among patients with breast cancer

Household net worth is a major factor in adherence to hormonal therapy among patients with breast cancer.

Epigenetic signatures differentiate triple negative breast cancers

Specific methylation patterns revealed in the primary biopsy breast cancer cells of breast cancer DNA methylome can indicate a better or worse prognosis.

Ultrasound helps determine which breast cancer patients need lymph nodes removed

Not all women with lymph node-positive breast cancer treated with chemotherapy before surgery need to have all underarm nodes removed, new research indicates.

California breast density law slow to have an impact

Half of primary care physicians are still unfamiliar with the California law mandating that clinicians notify women with dense breast tissue, and many do not feel comfortable answering breast density-related questions.

New model better predicts breast cancer risk in African American women

A new risk prediction model will allow for greater accuracy in predicting risk for breast cancer in African American women.

Women informed of over-detection risk less likely to want mammography

Women informed of over-detection risk less likely to want mammography

Women who are better informed about the risk of over-detection are less likely to have a breast cancer screening.

Some older patients with breast cancer can avoid postsurgery radiotherapy

Radiotherapy can be avoided by older women with breast cancer without a compromise to their safety, according to a recent study.

Smoking linked to breast and prostate cancer

Smoking linked to breast and prostate cancer

Smoking is associated with an increased risk of breast cancer, prostate cancer, and routine infections.

Eribulin effective in metastatic breast cancer

In treatment for metastatic breast cancer, eribulin is effective as a first-, second-, or third-line chemotherapy regimen.

Benefit of breast cancer prevention drug varies among at-risk women

Researchers examined the benefits and risks associated with taking drug tamoxifen for breast cancer prevention.

Factors identified for increased post-surgery weight gain among breast cancer survivors

Factors identified for increased post-surgery weight gain among breast cancer survivors

Average long-term weight gain among breast cancer survivors is small, but certain subgroups experience greater gain associated with adverse health.

Many patients with locally advanced breast cancer do not undergo recommended postmastectomy radiotherapy

Many patients with locally advanced breast cancer do not undergo recommended postmastectomy radiotherapy

Only 65% of patients with advanced breast cancer are receiving the postsurgical radiation therapy.

Ibrance now FDA-approved to treat advanced breast cancer

Ibrance now FDA-approved to treat advanced breast cancer

Ibrance (palbociclib) has been approved by the U.S. Food and Drug Administration (FDA) for postmenopausal women with ER, HER2-negative metastatic breast cancer.

Novel breast cancer risk prediction model is more accurate than current model

A new breast cancer risk model that combines histologic features of biopsied breast tissue from women with benign breast disease and individual patient demographic information more accurately classified breast cancer risk.

New imaging technique significantly improves detection of invasive breast cancers in dense breast tissue

A new breast imaging technique greatly increases the ability to detect invasive breast cancer in women with dense breast tissue, a number in which half of women of screening age are counted.

Potentially targetable signaling pathway generates chemotherapy-resistant cancer cells

Current research has identified a signaling pathway responsible for the generation of slowly proliferating cancer cells that are hard to eradicate via current treatments.

Poor metabolic health increases risk for postmenopausal breast cancer irrespective of BMI

Postmenopausal women who were metabolically unhealthy are at increased risk for breast cancer compared with their metabolically healthy counterparts, according to a recent study.

New sequencing technique reveals genetic clues to rare breast tumors

A recent study provides a comprehensive analysis of the molecular alterations at work in phyllodes tumors, a rare type of breast tumor.

FDA approval for novel breast cancer drug granted ahead of anticipated target date

FDA approval for novel breast cancer drug granted ahead of anticipated target date

The FDA granted accelerated approved for palbociclib (Ibrance) for the treatment of advanced breast cancer.

Many women with breast cancer have poor knowledge about their condition

Many women with breast cancer lack important knowledge about their illness, with minority patients less likely than white patients to know and report accurate information about their tumors' characteristics.

BMI and expression of estrogen receptor affect HER2 expression in luminal B breast cancer

Researchers continue to be fascinated and challenged by the multifactorial nature of breast cancer.

Maximum tolerated doses of gemcitabine

Maximum tolerated doses of gemcitabine

How much more toxicity and myelosuppression has been associated with gemcitabine (Gemzar) when it is infused over periods longer than 30 minutes?

Research promising for reducing risk of breast cancer spreading to the brain

New research seeks to better understand why breast cancer spreads to the brain, with the goal of developing a way to reduce the risk of this phenomenon.

Biopsies with DCIS diagnosis increase for women undergoing mammography

Biopsies with DCIS diagnosis increase for women undergoing mammography

Biopsy frequency went up after diagnostic, but not screening, mammographies.

Many breast cancer patients lack basic knowledge about their disease

Many breast cancer patients lack basic knowledge about their disease

Many women with breast cancer lack basic knowledge about their disease, and the problem is more pronounced among minority women.

Effectiveness of nanoparticle drugs was hindered by tumor microenvironment in triple-negative breast cancer

Nanoparticle drugs were considered to be a potential silver bullet against cancer, but they have not produced the anticipated improvement in overall survival rates.

Biological factors account for most of the variations in breast cancer survival rates

A study of approximately 375,000 U.S. women with invasive breast cancer showed differences in likelihood of diagnosis occurring at an early stage, and survival after stage I diagnosis, based on by race and ethnicity.

New model more accurately classifies breast cancer risk

New model more accurately classifies breast cancer risk

Histologic features of biopsied breast tissue from benign findings along with demographic data to more accurately determine risk.

Nutrition intervention leads to dietary behavior changes in Latina breast cancer survivors

Nutrition intervention leads to dietary behavior changes in Latina breast cancer survivors

An intervention aimed at an under-represented group of Latina breast cancer survivors helped encourage better eating habits and nutrition.

Nutrition education may help prevent breast cancer recurrence

Providing nutrition education to patients with breast cancer could be beneficial for patients and may help to prevent recurrence of their cancer, according to new research.

Mind body techniques added to aerobic exercise improve rehabilitation outcomes in breast cancer survivors

Mind body techniques added to aerobic exercise improve rehabilitation outcomes in breast cancer survivors

Researchers sought to determine the impact of aerobic exercise training and yoga on survivorship measures in breast cancer survivors.

Eribulin effective for earlier treatment of metastatic breast cancer

Eribulin effective for earlier treatment of metastatic breast cancer

Eribulin is active and well tolerated as first-, second-, or third-line therapy in patients with metastatic breast cancer.

Insulin resistance increases breast cancer risk

Insulin resistance increases breast cancer risk

Study of postmenopausal women suggests hormone levels matter more than excess weight, with regard to predicting breast cancer risk.

Combination therapy can reduce chance of recurrence from small HER2+ breast tumors

Women with stage 1 HER2-positive breast tumors who received a combination of lower-intensity chemotherapy and a targeted drug following surgery were unlikely to suffer cancer recurrence within 3 years of treatment.

Researchers map paths to cancer drug resistance

The researchers have mapped the steps used by cells of melanoma, breast cancer, and the blood cancer myelofibrosis to become resistant to drugs, allowing for better success in blocking these pathways and further enabling therapies.

Aerobic exercise reduces fatigue in women undergoing radiotherapy for breast cancer

Aerobic exercise reduces fatigue in women undergoing radiotherapy for breast cancer

Findings in a quasi-experimental study of Taiwanese women with early-stage breast cancer showed the potential for exercise to reduce fatigue in women undergoing radiotherapy.

Mindfulness-based intervention is helpful to younger breast cancer survivors

Mindfulness-based intervention is helpful to younger breast cancer survivors

Younger women with early stage breast cancer who had completed cancer treatment to a 6-week Mindful Awareness Practices (MAPS).

In breast cancer, febrile neutropenia-related admissions account for significant mortality

In breast cancer, febrile neutropenia-related admissions account for significant mortality

Febrile neutropenia-related hospitalizations still account for morbidity, and mortality among patients with breast cancer.

Breast cancer prognosis impacted by race and ethnicity

Breast cancer prognosis impacted by race and ethnicity

The odds of being early breast cancer development and survival chances vary greatly depending on race and ethnicity, according to a new study.

Women with atypical hyperplasia are at higher risk of breast cancer

A new study has better established the future risk of developing breast cancer for those with atypical hyperplasia of the breast.

Breast cancer data analyzed by race/ethnic groups to identify differences in diagnosis, prognosis

Breast cancer data analyzed by race/ethnic groups to identify differences in diagnosis, prognosis

Race and ethnicity may play a role in the timing of breast cancer diagnosis and the prognosis of the woman's disease.

Risk for leukemia after treatment for early stage breast cancer higher than reported

According to results of a new, retrospective study, the risk of developing leukemia after radiation therapy or chemotherapy for early stage breast cancer is double that previously reported.

Autologous breast reconstruction yields higher satisfaction rates

Research indicates that women who undergone mastectomy have greater satisfaction when breast reconstruction is performed using the patient's own tissues, rather than implants.

Trastuzumab improves long-term survival of HER2-positive breast cancer patients

Trastuzumab significantly improves the long-term survival of HER-2 positive breast cancer patients, according to a large national study.

Autologous breast reconstruction shows higher satisfaction rate

Autologous breast reconstruction shows higher satisfaction rate

For women undergoing breast reconstruction, autologous reconstruction leads to higher satisfaction than alloplastic reconstruction, but secondary correction is often required.

Targeting microRNA may benefit some patients with ovarian and breast cancer

Researchers believe they may have found a molecule-based approach to halting the destructive quality of the 3q26.2 amplicon, a frequent chromosomal aberrations seen in many cancers, including ovarian and breast cancers.

Older patients with breast cancer still undergo radiation despite its limited benefit

Women over 70 years with early stage breast cancer are very likely to receive radiation therapy, despite evidence of that it might not be the best form of treatment.

Intra-operative technology improves lumpectomy procedures for many breast cancer patients

Intra-operative technology improves lumpectomy procedures for many breast cancer patients

New intra-operative technology aids lumpectomy procedures by detecting microscopic amounts of cancer cells on tumor tissue.

Cancer risks associated with atypical hyperplasia of the breast discussed

Cancer risks associated with atypical hyperplasia of the breast discussed

Considerations for women with atypical hyperplasia include screening and chemoprevention, and more patient education is often needed.

Communication gaps between patients with breast cancer, caregivers, oncology care team

Communication gaps between patients with breast cancer, caregivers, oncology care team

Discussions on basic disease information between patients with metastatic breast cancer, caregivers, and oncologists.

Supplemental breast cancer screening with ultrasound may increase costs more than overall health in women with dense breasts

Supplemental ultrasound screening for all US women with dense breasts would substantially increase health care costs with little improvement in overall health.

Widely used osteoporosis drug may prevent breast, lung, and colon cancers

The most commonly used medications for osteoporosis worldwide, bisphosphonates, may also prevent certain kinds of lung, breast, and colon cancers, according to two recent studies.

Risk-based screening misses breast cancers in women in their 40s

A study of breast cancers detected with screening mammography found that strong family history and dense breast tissue were commonly absent in women ages 40 to 49 years at diagnosis of breast cancer.

Breast cancer outcomes in young women improving, but still better in white than in blacks

Breast cancer outcomes in young women improving, but still better in white than in blacks

Researchers conducted a study to determine whether there is a differential effect of race on outcomes for women with breast cancer.

Many breast cancer patients do not receive shorter radiation treatment

Although the use of a radiation treatment that is shorter in duration and less costly has increased among women with early stage breast cancer who underwent breast conserving surgery, most patients who meet guidelines to receive this treatment do not.

Genetic analyses identify more mutations and help plan treatment for breast cancer

Genetic analyses identify more mutations and help plan treatment for breast cancer

Three studies presented at the 2014 San Antonio Breast Cancer Symposium (SABCS): Cancer risk test detected 105% more mutations in cancer-causing genes than conventional BRCA testing alone; researchers at leading cancer research institutions validate use of companion diagnostic test to detect a DNA scar in tumor that is indicative of a dysfunctional DNA repair pathway; UK researchers evaluated the use of companion diagnostic assays to identify which patients would respond to carboplatin or docetaxel.

Updated results shows SC trastuzumab as safe and effective as IV formulation

Updated results shows SC trastuzumab as safe and effective as IV formulation

Researchers have found that subcutaneous trastuzumab has a similar safety profile and similar event-free survival rate with intravenous trastuzumab.

New breast cancer classification based on epigenetics

Two subgroups of breast tumors have been identified, based on epigenetic alterations.

Breast cancer treatment-related leukemia risk higher than thought

Breast cancer treatment-related leukemia risk higher than thought

Among early-stage breast cancer patients who undergo chemotherapy and/or radiation treatment, the risk for developing treatment-related leukemia, though low, is still double what experts had previously thought.

New device may ease mammography discomfort

Researchers have developed a new device that may help make mammography more comfortable for women.

3-D mammography improves cancer detection in dense breasts

Digital breast tomosynthesis has the potential to significantly increase the cancer detection rate of mammography screening in women that have dense breasts.

Mobile support system keeps up with a younger generation of breast cancer survivors

Mobile support system keeps up with a younger generation of breast cancer survivors

A new digital program using a Web site and social media aims to meet the unique support needs of women younger than 40 years with breast cancer.

Impact of adding bevacizumab to presurgery chemotherapy for triple-negative breast cancer varies

The addition of bevacizumab to standard presurgery chemotherapy showed greater benefit in those whose cancers were classified as basal-like by gene expression assay, compared with those whose cancers were nonbasal-like.

Fulvestrant improves survival over anastrozole for patients with advanced breast cancer

Fulvestrant did more to improve survival than anastrozole for patients with advanced, hormone receptor-positive breast cancer, according to data.

Breast cancer vaccine shows promise in small clinical trial

A breast cancer vaccine is safe in patients with metastatic breast cancer, as indicated by the results of an early clinical trial.

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