Aluminum-containing deodorant safe for patients with breast cancer undergoing radiotherapy

Aluminum-containing deodorant safe for patients with breast cancer undergoing radiotherapy

Women undergoing radiotherapy for breast cancer can use deodorant without increasing risk of underarm skin reactions, pain, itching, or burning.

Major study links two new genetic variants to breast cancer

A worldwide study of the DNA of 100,000 women has discovered two new genetic variants associated with an increased risk of breast cancer.

New mechanism of acquired resistance to breast cancer drugs discovered

Researchers have discovered that ERBB4 (also known as HER4) is a driver protein in ERBB2-positive tumors that have developed resistance to first- or second-line treatments.

Crucial role of breast cancer tumor suppressor revealed

Cells that contain lower levels of protein profilin 1 in breast tumors have an increased capacity to metastasize and invade other tissues, according to research.

Women educated on overdiagnsosis are less likely to want mammogram

Women educated on overdiagnsosis are less likely to want mammogram

Risks and benefits of routine mammography continue to be debated, but educating women about the possibility of overdiagnosis from mammography screening may make some of them less likely to get the test.

New genetic anomalies linked to breast cancer in African American families

Newly discovered segments of DNA shared by African American family members who have breast cancer indicate there may still be undiscovered breast cancer genes that may be unique to African Americans.

Many patients with locally advanced breast cancer do not receive postmastectomy radiation

More than a third of women who should receive radiation subsequent to mastectomy are actually undergoing the recommended postmastectomy radiation therapy (PMRT), according to a new study.

Household net worth linked to hormonal therapy adherence among patients with breast cancer

Household net worth linked to hormonal therapy adherence among patients with breast cancer

Household net worth is a major factor in adherence to hormonal therapy among patients with breast cancer.

Epigenetic signatures differentiate triple negative breast cancers

Specific methylation patterns revealed in the primary biopsy breast cancer cells of breast cancer DNA methylome can indicate a better or worse prognosis.

Ultrasound helps determine which breast cancer patients need lymph nodes removed

Not all women with lymph node-positive breast cancer treated with chemotherapy before surgery need to have all underarm nodes removed, new research indicates.

California breast density law slow to have an impact

Half of primary care physicians are still unfamiliar with the California law mandating that clinicians notify women with dense breast tissue, and many do not feel comfortable answering breast density-related questions.

New model better predicts breast cancer risk in African American women

A new risk prediction model will allow for greater accuracy in predicting risk for breast cancer in African American women.

Women informed of over-detection risk less likely to want mammography

Women informed of over-detection risk less likely to want mammography

Women who are better informed about the risk of over-detection are less likely to have a breast cancer screening.

Some older patients with breast cancer can avoid postsurgery radiotherapy

Radiotherapy can be avoided by older women with breast cancer without a compromise to their safety, according to a recent study.

Smoking linked to breast and prostate cancer

Smoking linked to breast and prostate cancer

Smoking is associated with an increased risk of breast cancer, prostate cancer, and routine infections.

Eribulin effective in metastatic breast cancer

In treatment for metastatic breast cancer, eribulin is effective as a first-, second-, or third-line chemotherapy regimen.

Benefit of breast cancer prevention drug varies among at-risk women

Researchers examined the benefits and risks associated with taking drug tamoxifen for breast cancer prevention.

Factors identified for increased post-surgery weight gain among breast cancer survivors

Factors identified for increased post-surgery weight gain among breast cancer survivors

Average long-term weight gain among breast cancer survivors is small, but certain subgroups experience greater gain associated with adverse health.

Many patients with locally advanced breast cancer do not undergo recommended postmastectomy radiotherapy

Many patients with locally advanced breast cancer do not undergo recommended postmastectomy radiotherapy

Only 65% of patients with advanced breast cancer are receiving the postsurgical radiation therapy.

Ibrance now FDA-approved to treat advanced breast cancer

Ibrance now FDA-approved to treat advanced breast cancer

Ibrance (palbociclib) has been approved by the U.S. Food and Drug Administration (FDA) for postmenopausal women with ER, HER2-negative metastatic breast cancer.

Novel breast cancer risk prediction model is more accurate than current model

A new breast cancer risk model that combines histologic features of biopsied breast tissue from women with benign breast disease and individual patient demographic information more accurately classified breast cancer risk.

New imaging technique significantly improves detection of invasive breast cancers in dense breast tissue

A new breast imaging technique greatly increases the ability to detect invasive breast cancer in women with dense breast tissue, a number in which half of women of screening age are counted.

Potentially targetable signaling pathway generates chemotherapy-resistant cancer cells

Current research has identified a signaling pathway responsible for the generation of slowly proliferating cancer cells that are hard to eradicate via current treatments.

Poor metabolic health increases risk for postmenopausal breast cancer irrespective of BMI

Postmenopausal women who were metabolically unhealthy are at increased risk for breast cancer compared with their metabolically healthy counterparts, according to a recent study.

New sequencing technique reveals genetic clues to rare breast tumors

A recent study provides a comprehensive analysis of the molecular alterations at work in phyllodes tumors, a rare type of breast tumor.

FDA approval for novel breast cancer drug granted ahead of anticipated target date

FDA approval for novel breast cancer drug granted ahead of anticipated target date

The FDA granted accelerated approved for palbociclib (Ibrance) for the treatment of advanced breast cancer.

Many women with breast cancer have poor knowledge about their condition

Many women with breast cancer lack important knowledge about their illness, with minority patients less likely than white patients to know and report accurate information about their tumors' characteristics.

BMI and expression of estrogen receptor affect HER2 expression in luminal B breast cancer

Researchers continue to be fascinated and challenged by the multifactorial nature of breast cancer.

Maximum tolerated doses of gemcitabine

Maximum tolerated doses of gemcitabine

How much more toxicity and myelosuppression has been associated with gemcitabine (Gemzar) when it is infused over periods longer than 30 minutes?

Research promising for reducing risk of breast cancer spreading to the brain

New research seeks to better understand why breast cancer spreads to the brain, with the goal of developing a way to reduce the risk of this phenomenon.

Biopsies with DCIS diagnosis increase for women undergoing mammography

Biopsies with DCIS diagnosis increase for women undergoing mammography

Biopsy frequency went up after diagnostic, but not screening, mammographies.

Many breast cancer patients lack basic knowledge about their disease

Many breast cancer patients lack basic knowledge about their disease

Many women with breast cancer lack basic knowledge about their disease, and the problem is more pronounced among minority women.

Effectiveness of nanoparticle drugs was hindered by tumor microenvironment in triple-negative breast cancer

Nanoparticle drugs were considered to be a potential silver bullet against cancer, but they have not produced the anticipated improvement in overall survival rates.

Biological factors account for most of the variations in breast cancer survival rates

A study of approximately 375,000 U.S. women with invasive breast cancer showed differences in likelihood of diagnosis occurring at an early stage, and survival after stage I diagnosis, based on by race and ethnicity.

New model more accurately classifies breast cancer risk

New model more accurately classifies breast cancer risk

Histologic features of biopsied breast tissue from benign findings along with demographic data to more accurately determine risk.

Nutrition intervention leads to dietary behavior changes in Latina breast cancer survivors

Nutrition intervention leads to dietary behavior changes in Latina breast cancer survivors

An intervention aimed at an under-represented group of Latina breast cancer survivors helped encourage better eating habits and nutrition.

Nutrition education may help prevent breast cancer recurrence

Providing nutrition education to patients with breast cancer could be beneficial for patients and may help to prevent recurrence of their cancer, according to new research.

Mind body techniques added to aerobic exercise improve rehabilitation outcomes in breast cancer survivors

Mind body techniques added to aerobic exercise improve rehabilitation outcomes in breast cancer survivors

Researchers sought to determine the impact of aerobic exercise training and yoga on survivorship measures in breast cancer survivors.

Eribulin effective for earlier treatment of metastatic breast cancer

Eribulin effective for earlier treatment of metastatic breast cancer

Eribulin is active and well tolerated as first-, second-, or third-line therapy in patients with metastatic breast cancer.

Insulin resistance increases breast cancer risk

Insulin resistance increases breast cancer risk

Study of postmenopausal women suggests hormone levels matter more than excess weight, with regard to predicting breast cancer risk.

Combination therapy can reduce chance of recurrence from small HER2+ breast tumors

Women with stage 1 HER2-positive breast tumors who received a combination of lower-intensity chemotherapy and a targeted drug following surgery were unlikely to suffer cancer recurrence within 3 years of treatment.

Researchers map paths to cancer drug resistance

The researchers have mapped the steps used by cells of melanoma, breast cancer, and the blood cancer myelofibrosis to become resistant to drugs, allowing for better success in blocking these pathways and further enabling therapies.

Aerobic exercise reduces fatigue in women undergoing radiotherapy for breast cancer

Aerobic exercise reduces fatigue in women undergoing radiotherapy for breast cancer

Findings in a quasi-experimental study of Taiwanese women with early-stage breast cancer showed the potential for exercise to reduce fatigue in women undergoing radiotherapy.

Mindfulness-based intervention is helpful to younger breast cancer survivors

Mindfulness-based intervention is helpful to younger breast cancer survivors

Younger women with early stage breast cancer who had completed cancer treatment to a 6-week Mindful Awareness Practices (MAPS).

In breast cancer, febrile neutropenia-related admissions account for significant mortality

In breast cancer, febrile neutropenia-related admissions account for significant mortality

Febrile neutropenia-related hospitalizations still account for morbidity, and mortality among patients with breast cancer.

Breast cancer prognosis impacted by race and ethnicity

Breast cancer prognosis impacted by race and ethnicity

The odds of being early breast cancer development and survival chances vary greatly depending on race and ethnicity, according to a new study.

Women with atypical hyperplasia are at higher risk of breast cancer

A new study has better established the future risk of developing breast cancer for those with atypical hyperplasia of the breast.

Breast cancer data analyzed by race/ethnic groups to identify differences in diagnosis, prognosis

Breast cancer data analyzed by race/ethnic groups to identify differences in diagnosis, prognosis

Race and ethnicity may play a role in the timing of breast cancer diagnosis and the prognosis of the woman's disease.

Risk for leukemia after treatment for early stage breast cancer higher than reported

According to results of a new, retrospective study, the risk of developing leukemia after radiation therapy or chemotherapy for early stage breast cancer is double that previously reported.

Autologous breast reconstruction yields higher satisfaction rates

Research indicates that women who undergone mastectomy have greater satisfaction when breast reconstruction is performed using the patient's own tissues, rather than implants.

Trastuzumab improves long-term survival of HER2-positive breast cancer patients

Trastuzumab significantly improves the long-term survival of HER-2 positive breast cancer patients, according to a large national study.

Autologous breast reconstruction shows higher satisfaction rate

Autologous breast reconstruction shows higher satisfaction rate

For women undergoing breast reconstruction, autologous reconstruction leads to higher satisfaction than alloplastic reconstruction, but secondary correction is often required.

Targeting microRNA may benefit some patients with ovarian and breast cancer

Researchers believe they may have found a molecule-based approach to halting the destructive quality of the 3q26.2 amplicon, a frequent chromosomal aberrations seen in many cancers, including ovarian and breast cancers.

Older patients with breast cancer still undergo radiation despite its limited benefit

Women over 70 years with early stage breast cancer are very likely to receive radiation therapy, despite evidence of that it might not be the best form of treatment.

Intra-operative technology improves lumpectomy procedures for many breast cancer patients

Intra-operative technology improves lumpectomy procedures for many breast cancer patients

New intra-operative technology aids lumpectomy procedures by detecting microscopic amounts of cancer cells on tumor tissue.

Cancer risks associated with atypical hyperplasia of the breast discussed

Cancer risks associated with atypical hyperplasia of the breast discussed

Considerations for women with atypical hyperplasia include screening and chemoprevention, and more patient education is often needed.

Communication gaps between patients with breast cancer, caregivers, oncology care team

Communication gaps between patients with breast cancer, caregivers, oncology care team

Discussions on basic disease information between patients with metastatic breast cancer, caregivers, and oncologists.

Supplemental breast cancer screening with ultrasound may increase costs more than overall health in women with dense breasts

Supplemental ultrasound screening for all US women with dense breasts would substantially increase health care costs with little improvement in overall health.

Widely used osteoporosis drug may prevent breast, lung, and colon cancers

The most commonly used medications for osteoporosis worldwide, bisphosphonates, may also prevent certain kinds of lung, breast, and colon cancers, according to two recent studies.

Risk-based screening misses breast cancers in women in their 40s

A study of breast cancers detected with screening mammography found that strong family history and dense breast tissue were commonly absent in women ages 40 to 49 years at diagnosis of breast cancer.

Breast cancer outcomes in young women improving, but still better in white than in blacks

Breast cancer outcomes in young women improving, but still better in white than in blacks

Researchers conducted a study to determine whether there is a differential effect of race on outcomes for women with breast cancer.

Many breast cancer patients do not receive shorter radiation treatment

Although the use of a radiation treatment that is shorter in duration and less costly has increased among women with early stage breast cancer who underwent breast conserving surgery, most patients who meet guidelines to receive this treatment do not.

Genetic analyses identify more mutations and help plan treatment for breast cancer

Genetic analyses identify more mutations and help plan treatment for breast cancer

Three studies presented at the 2014 San Antonio Breast Cancer Symposium (SABCS): Cancer risk test detected 105% more mutations in cancer-causing genes than conventional BRCA testing alone; researchers at leading cancer research institutions validate use of companion diagnostic test to detect a DNA scar in tumor that is indicative of a dysfunctional DNA repair pathway; UK researchers evaluated the use of companion diagnostic assays to identify which patients would respond to carboplatin or docetaxel.

Updated results shows SC trastuzumab as safe and effective as IV formulation

Updated results shows SC trastuzumab as safe and effective as IV formulation

Researchers have found that subcutaneous trastuzumab has a similar safety profile and similar event-free survival rate with intravenous trastuzumab.

New breast cancer classification based on epigenetics

Two subgroups of breast tumors have been identified, based on epigenetic alterations.

Breast cancer treatment-related leukemia risk higher than thought

Breast cancer treatment-related leukemia risk higher than thought

Among early-stage breast cancer patients who undergo chemotherapy and/or radiation treatment, the risk for developing treatment-related leukemia, though low, is still double what experts had previously thought.

New device may ease mammography discomfort

Researchers have developed a new device that may help make mammography more comfortable for women.

3-D mammography improves cancer detection in dense breasts

Digital breast tomosynthesis has the potential to significantly increase the cancer detection rate of mammography screening in women that have dense breasts.

Mobile support system keeps up with a younger generation of breast cancer survivors

Mobile support system keeps up with a younger generation of breast cancer survivors

A new digital program using a Web site and social media aims to meet the unique support needs of women younger than 40 years with breast cancer.

Impact of adding bevacizumab to presurgery chemotherapy for triple-negative breast cancer varies

The addition of bevacizumab to standard presurgery chemotherapy showed greater benefit in those whose cancers were classified as basal-like by gene expression assay, compared with those whose cancers were nonbasal-like.

Fulvestrant improves survival over anastrozole for patients with advanced breast cancer

Fulvestrant did more to improve survival than anastrozole for patients with advanced, hormone receptor-positive breast cancer, according to data.

Breast cancer vaccine shows promise in small clinical trial

A breast cancer vaccine is safe in patients with metastatic breast cancer, as indicated by the results of an early clinical trial.

Breast cancer has different biological characteristics and outcomes in men and women

Results from the largest series of male breast cancer cases ever studied shows improvement in male survival, but not equal to that seen in women with breast cancer.

Better tests and treatments for breast cancer may come from new insights into its spread

A study examining tumor cells from patients with breast cancer has provided compelling evidence so far that a specific trio of cells is required for the spread of breast cancer.

No higher risk of breast cancer seen for women with migraines

No higher risk of breast cancer seen for women with migraines

Since both conditions involve hormone levels, researchers suspected a possible connection.

Adding ultrasound to routine mammography improves cancer detection in dense breasts

Among women with denser breasts, an additional ultrasound can detect breast cancers not discovered by mammogram.

Nab-paclitaxel demonstrated superior activity vs paclitaxel in early breast cancer

Nab-paclitaxel demonstrated superior activity vs paclitaxel in early breast cancer

Nab-paclitaxel has demonstrated significant benefit for patients with early high-risk breast cancer when compared with conventional solvent-based paclitaxel, according to recent research.

Multigene test can predict risk of recurrence for women with ductal carcinoma in situ

A multigene test was validated as a predictor of risk of disease recurrence among women treated with breast-conserving surgery alone for ductal carcinoma in situ (DCIS), according to data from a large study.

Mental health inequalities in detecting breast cancer

Women with a mental illness are less likely to be screened for breast cancer, according to new research.

Lowering dietary fat intake reduces death rates in some women with breast cancer

Reducing dietary fat intake reduced death rates significantly in those with hormone-unrelated breast cancer, according to recent data.

SABCS: Novel breast cancer drugs show promise in early trials

SABCS: Novel breast cancer drugs show promise in early trials

Pictilisib and pembrolizumab may prolong survival for women with advanced breast cancer, according to data from preliminary studies.

Adding ovarian suppression to tamoxifen reduced recurrence for some premenopausal breast cancer

Among premenopausal women with early stage, HR-positive breast cancer, the addition of ovarian suppression to tamoxifen reduced breast cancer recurrence.

Tamoxifen found to lower breast cancer rates among high-risk women in trial

The International Breast Cancer Intervention Study-I (IBIS-I) trial found that tamoxifen significantly decreased the incidence of all breast cancers, according to data presented at the 2014 San Antonio Breast Cancer Symposium.

SABCS: Male breast cancer prognosis falls behind that for women

SABCS: Male breast cancer prognosis falls behind that for women

Although survival in male breast cancer has improved, treatment lags behind when compared to the cancer therapy women receive.

Pembrolizumab safe, and even effective in some patients, for triple-negative breast cancer

Pembrolizumab was well tolerated and yielded durable responses in patients with metastatic triple-negative breast cancer, according to recent trial data.

Capecitabine does not improve survival in elderly patients with early stage breast cancer

In elderly patients with moderate- to high-risk early stage breast cancer for whom standard chemotherapy is too toxic, capecitabine did not improve outcomes when tested as monotherapy, according to recent data.

Resistance exercise improves fatigue in patients with breast cancer receiving chemotherapy

Resistance exercise improves fatigue in patients with breast cancer receiving chemotherapy

Per a new study, resistant exercise decreased physical fatigue and maintained quality of life among patients with breast cancer receiving adjuvant chemotherapy.

Trastuzumab improves survival for HER2-positive breast cancer

Trastuzumab improves survival for HER2-positive breast cancer

Trastuzumab improved overall survival in early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer.

Vaccine targeting breast cancers produced robust immune response

A DNA vaccine targeting the breast cancer-associated antigen mammaglobin-A was proven safe and found to effectively elicit immune responses in women with metastatic breast cancer, according to a new study.

Patients with BRCA 1/2 mutations not at increased risk for anthracycline-induced cardiotoxicity

Patients with BRCA 1/2 mutations not at increased risk for anthracycline-induced cardiotoxicity

Breast cancer patients with BRCA 1/2 gene mutations do not have an increased risk of anthracycline-induced cardiac toxicity.

No association between migraine and breast cancer risk

No association between migraine and breast cancer risk

There is no associated between migraines and risk of breast cancer.

Dietary interventions can improve clinical outcomes for some women with breast cancer

Dietary interventions can improve clinical outcomes for some women with breast cancer

Reducing dietary intake of fat reduces death rates in some women with early stage breast cancer.

National trends in mastectomy for early stage breast cancer examined

An increasing number of of women eligible for breast conservation surgery (BCS) are opting instead for mastectomy, breast reconstruction, and bilateral mastectomy.

Many breast cancer patients overtreated with radiation therapy

Many breast cancer patients overtreated with radiation therapy

Two-thirds of breast-conserving surgical patients undergo six to seven weeks of radiation, but three weeks of higher-dose radiation could be more beneficial.

Inherited mutations typical in triple-negative breast cancer

Inherited mutations typical in triple-negative breast cancer

Deleterious mutations were identified in 14.6 percent of patients in a cohort unselected for family history.

Researchers suggest new follow-up model for breast cancer patients

The surveillance and follow-up of breast cancer survivors has the potential to improve, from the perspective of both patients and the health system.

Study confirms recommendations for genetic screening in patients with triple-negative breast cancer

Study confirms recommendations for genetic screening in patients with triple-negative breast cancer

A recent study recommends that patients with triple-negative breast cancer should undergo genetic testing for mutations in known breast cancer predisposition genes, including BRCA1 and BRCA2.

Smoking cessation prior to first child decreases risk of breast cancer

Smoking cessation prior to first child decreases risk of breast cancer

Many breast cancer cases in mothers can be averted if women do not smoke cigarettes prior to the birth of their first child.

Breast cancer vaccine shows promise in early testing

Breast cancer vaccine shows promise in early testing

An experimental breast cancer vaccine boosts immune response and appears to slow spread in those with advanced disease.

Counseling over the phone provides access to genetic testing for women in rural areas

Telephone counseling after genetic testing was found just as effective as in-person counseling in many respects, according to new study.

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