Brain Cancer

Spherical Shape of New Drug Holds Promise for Bypassing the Blood Brain Barrier and Treating Aggressive Brain Cancer

Spherical Shape of New Drug Holds Promise for Bypassing the Blood Brain Barrier and Treating Aggressive Brain Cancer

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An investigational drug with a novel spherical nucleic acid structure has the potential to cross the blood-brain barrier to treat glioblastoma multiforme.

Cognitively Engaging Activities Often Discontinued After Treatment of Primary Brain Tumors

Cognitively Engaging Activities Often Discontinued After Treatment of Primary Brain Tumors

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Survivors of primary brain tumors tend to freely discontinue cognitively engaging activities to compensate for diminishing cognitive function after treatment completion.

Research Shows Temozolomide Has Potential to Increase Depression

Research Shows Temozolomide Has Potential to Increase Depression

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Temozolomide, an antimitotic chemotherapy used to treat brain cancer, demonstrated the potential to increase depression in a mouse model.

Radiation Protocol Deviations Linked to Worse Outcomes in Pediatric Brain Malignancy

Radiation Protocol Deviations Linked to Worse Outcomes in Pediatric Brain Malignancy

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Deviation from radiation treatment protocol in young children being treated for brain neoplasms was associated with decreased overall survival.

High-Dose Vitamin C Infusions Increase Cancer Cell Sensitivity to Chemotherapy, Radiation

High-Dose Vitamin C Infusions Increase Cancer Cell Sensitivity to Chemotherapy, Radiation

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Regular infusions of high doses of vitamin C safely increased cancer cell sensitivity to treatment in patients with brain and lung cancers.

National Brain Tumor Society Launches Brain-Tumor Clinical Trial Finder

National Brain Tumor Society Launches Brain-Tumor Clinical Trial Finder

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NBTS launched a clinical trial finder specific to brain tumors to engage patients in research and clinical trials.

Temozolomide With Radiotherapy for Glioblastoma Provides Some Survival Benefit in Elderly

Temozolomide With Radiotherapy for Glioblastoma Provides Some Survival Benefit in Elderly

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The addition of temozolomide to short-course radiotherapy in elderly patients with glioblastoma was associated with some survival benefit compared with radiotherapy alone.

No Connection Found Between CMV Infection and Aggressive Brain Cancer

No Connection Found Between CMV Infection and Aggressive Brain Cancer

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A recent analysis of tumor tissue samples from patients with glioblastoma and glial cancer indicate no association between CMV infection and brain cancer.

Anti-malaria Drug Chloroquine May Help Combat Some Brain Tumors

Anti-malaria Drug Chloroquine May Help Combat Some Brain Tumors

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Adding the anti-malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize glioblastoma patients to targeted treatments that had previously stopped working.

Subtype of Glioblastoma Multiforme Responds to Antiangiogenic Chemotherapy

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Although previous clinical trials have demonstrated that antiangiogenetic chemotherapy is not effective in GBM, researchers conducted a retrospective of review of perfusion MR images to determine if a phenotypic subtype of GBM may respond to antiangiogenic chemotherapy.

Caregiver Mastery Linked to Patient Survival in Glioblastoma

Caregiver Mastery Linked to Patient Survival in Glioblastoma

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An analysis of data from caregivers and patients participating in a longitudinal study funded by the National Institutes of Health examines whether caregivers' anxiety, depressive symptoms, burden, and mastery influence survival for patients with newly diagnosed glioblastoma multiforme.

Medicaid Insurance Linked to Worse Outcomes for Patients With Glioblastoma Multiforme

Medicaid Insurance Linked to Worse Outcomes for Patients With Glioblastoma Multiforme

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Insurance status influences overall patient survival for some cancer types, but its impact on glioblastoma multiforme (GBM) survival is well documented. This research study explored the possible impact of insurance on GBM survival.

Postop RT Deferral Associated With Worse Survival in Children With Medulloblastoma

Postop RT Deferral Associated With Worse Survival in Children With Medulloblastoma

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Despite the use of adjuvant chemotherapy, deferral of postoperative radiotherapy is associated with worse survival in pediatric patients with medulloblastoma.

Dual Antigen Targeting by CAR T Cells Improves Immunotherapeutic Technique

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Chimeric antigen receptor (CAR) T cells may have improved therapeutic potential when they have 2 targets, according to preclinical findings using a mouse model.

High Blood Sugar Associated With Lower Risk of Meningioma

High Blood Sugar Associated With Lower Risk of Meningioma

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Benign brain tumors that have previously been associated with obesity and diabetes are surprisingly less likely to emerge in patients with high blood sugar, according to new research.

Extent of Resection Influences Length of Progression-Free Survival in Glioblastoma

Extent of Resection Influences Length of Progression-Free Survival in Glioblastoma

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Gross total resection to treat glioblastoma multiforme (GBM) showed progression-free survival benefits over subtotal resection and biopsy in a meta-analysis of 37 studies.

Personalized Medicine Approach Not Straightforward in Glioblastoma

Personalized Medicine Approach Not Straightforward in Glioblastoma

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The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers, attendees were told in a poster discussion session at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting.

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

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The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.

Eight Immune Genes Identified As Playing a Role in Glioblastoma

Eight Immune Genes Identified As Playing a Role in Glioblastoma

Discovery might eventually lead to better treatment for glioblastoma multiforme

Phase 1 Study Results Show CAR T-cell Therapy Promising in Solid Brain Tumors

Phase 1 Study Results Show CAR T-cell Therapy Promising in Solid Brain Tumors

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Glioblastoma tumors were successfully infiltrated by investigational CAR therapy with an acceptable safety profile.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

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The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

Altered Metabolism of Four Compounds Drives Glioblastoma Growth

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The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.

Novel Drug Combination Inhibits Growth of MYC-driven Medulloblastoma

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The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.

Novel Approach Harnesses Dendritic Cells to Treat Glioma

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A next-generation immunotherapy may offer hope for treating high-grade glioma, an aggressive form of brain cancer that is notoriously hard to treat.

New Therapy Holds Potential for Neuroblastoma Treatment

New Therapy Holds Potential for Neuroblastoma Treatment

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A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.

Radiotherapy/Histone Deacetylase Inhibitor Combination Safe, Effective in High-grade Gliomas

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Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.

Bevacizumab Plus Irinotecan Improves PFS in MGMT-positive Glioblastoma

Bevacizumab Plus Irinotecan Improves PFS in MGMT-positive Glioblastoma

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Bevacizumab plus irinotecan significantly improved the 6-month progression-free survival (PFS) rate and median progression-free survival.

Hypnosedation: An Alternative Sedation Method for Glioma Resection

Hypnosedation: An Alternative Sedation Method for Glioma Resection

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This technique, which does not use pharmaceutical sedatives, can ease the perioperative discomfort and anxiety experienced by some patients undergoing fully awake craniotomy to remove glioma.

Pan-glioma Analysis Reveals Unique Subtypes of This Brain Cancer

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Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.

Risk Factors of Suicidal Ideation in Patients With Brain Tumors

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A past history of psychiatric disorders has been linked to suicidal ideation in patients with brain tumors.

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