Brain Cancer

Caregiver Mastery Linked to Patient Survival in Glioblastoma

Caregiver Mastery Linked to Patient Survival in Glioblastoma

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An analysis of data from caregivers and patients participating in a longitudinal study funded by the National Institutes of Health examines whether caregivers' anxiety, depressive symptoms, burden, and mastery influence survival for patients with newly diagnosed glioblastoma multiforme.

Medicaid Insurance Linked to Worse Outcomes for Patients With Glioblastoma Multiforme

Medicaid Insurance Linked to Worse Outcomes for Patients With Glioblastoma Multiforme

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Insurance status influences overall patient survival for some cancer types, but its impact on glioblastoma multiforme (GBM) survival is well documented. This research study explored the possible impact of insurance on GBM survival.

Postop RT Deferral Associated With Worse Survival in Children With Medulloblastoma

Postop RT Deferral Associated With Worse Survival in Children With Medulloblastoma

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Despite the use of adjuvant chemotherapy, deferral of postoperative radiotherapy is associated with worse survival in pediatric patients with medulloblastoma.

Dual Antigen Targeting by CAR T Cells Improves Immunotherapeutic Technique

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Chimeric antigen receptor (CAR) T cells may have improved therapeutic potential when they have 2 targets, according to preclinical findings using a mouse model.

High Blood Sugar Associated With Lower Risk of Meningioma

High Blood Sugar Associated With Lower Risk of Meningioma

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Benign brain tumors that have previously been associated with obesity and diabetes are surprisingly less likely to emerge in patients with high blood sugar, according to new research.

Extent of Resection Influences Length of Progression-Free Survival in Glioblastoma

Extent of Resection Influences Length of Progression-Free Survival in Glioblastoma

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Gross total resection to treat glioblastoma multiforme (GBM) showed progression-free survival benefits over subtotal resection and biopsy in a meta-analysis of 37 studies.

Personalized Medicine Approach Not Straightforward in Glioblastoma

Personalized Medicine Approach Not Straightforward in Glioblastoma

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The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers, attendees were told in a poster discussion session at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting.

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

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The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.

Eight Immune Genes Identified As Playing a Role in Glioblastoma

Eight Immune Genes Identified As Playing a Role in Glioblastoma

Discovery might eventually lead to better treatment for glioblastoma multiforme

Phase 1 Study Results Show CAR T-cell Therapy Promising in Solid Brain Tumors

Phase 1 Study Results Show CAR T-cell Therapy Promising in Solid Brain Tumors

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Glioblastoma tumors were successfully infiltrated by investigational CAR therapy with an acceptable safety profile.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

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The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

Altered Metabolism of Four Compounds Drives Glioblastoma Growth

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The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.

Novel Drug Combination Inhibits Growth of MYC-driven Medulloblastoma

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The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.

Novel Approach Harnesses Dendritic Cells to Treat Glioma

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A next-generation immunotherapy may offer hope for treating high-grade glioma, an aggressive form of brain cancer that is notoriously hard to treat.

New Therapy Holds Potential for Neuroblastoma Treatment

New Therapy Holds Potential for Neuroblastoma Treatment

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A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.

Radiotherapy/Histone Deacetylase Inhibitor Combination Safe, Effective in High-grade Gliomas

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Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.

Bevacizumab Plus Irinotecan Improves PFS in MGMT-positive Glioblastoma

Bevacizumab Plus Irinotecan Improves PFS in MGMT-positive Glioblastoma

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Bevacizumab plus irinotecan significantly improved the 6-month progression-free survival (PFS) rate and median progression-free survival.

Hypnosedation: An Alternative Sedation Method for Glioma Resection

Hypnosedation: An Alternative Sedation Method for Glioma Resection

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This technique, which does not use pharmaceutical sedatives, can ease the perioperative discomfort and anxiety experienced by some patients undergoing fully awake craniotomy to remove glioma.

Pan-glioma Analysis Reveals Unique Subtypes of This Brain Cancer

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Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.

Risk Factors of Suicidal Ideation in Patients With Brain Tumors

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A past history of psychiatric disorders has been linked to suicidal ideation in patients with brain tumors.

Comprehensive Genetic Profiling Possible for Central Nervous System Tumors

Comprehensive Genetic Profiling Possible for Central Nervous System Tumors

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New genetic testing can assist brain cancer treatment planning.

Proton Beam Therapy Treats Childhood Brain Cancer as Effectively as Standard Radiation

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Treating medulloblastoma with proton beam therapy results in survival rates in line with other proton therapies, according to recent study data.

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Phase 2 trial data showed acceptable toxicity and similar survival as conventional radiotherapy for childhood medulloblastoma.

Valproic Acid, Levetiracetam Do Not Improve Survival in Newly Diagnosed GBM

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Valproic acid and levetiracetam do not improve survival outcomes in patients with newly diagnosed glioblastoma, according to a recently published study.

New Studies Reveal Long-Term Vision-related Health Concerns of Survivors of Childhood Retinoblastoma and Brain Cancer

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Two new studies investigate the impact of retinoblastoma on long-term health of survivors and the long-term psychological and socio-economic effects of blindness in survivors of brain tumors.

Type of Electromagnetic Field Therapy Improves Survival for Patients With Brain Tumor

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Progression-free and overall survival were prolonged with electromagnetic field and chemotherapy maintenance therapy in patients with a brain tumor.

Novel Test Offers Diagnostic and Disease Monitoring Potential for Rare Childhood Brain Cancer

A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor. It could also enable treatment monitoring without exposing patients to repeated doses of radiation.

Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors

Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors

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Brain tumor cells can self-organize, according to new research. Glioma cells build tumors by self-organizing into streams 10 to 20 cells wide that obey a mathematically predicted pattern for autonomous agents flowing together.

Action of Signaling Pathway Surprises Researchers Investigating Brain Tumor Development

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A signaling pathway present in most organisms suppresses the formation of specific types of brain tumor.

Adding Tumor-treating Fields to Maintenance Therapy May Prolong Survival in Glioblastoma

Adding Tumor-treating Fields to Maintenance Therapy May Prolong Survival in Glioblastoma

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Adding tumor-treating fields to maintenance temozolomide chemotherapy significantly prolonged progression-free survival.

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