Combination Regimen for Recurrent Glioblastoma Improves Progression-free Survival, But Not Overall Survival

SAN ANTONIO, TX—Bevacizumab treatment combined with lomustine in patients with progressive glioblastoma, despite prolonged progression-free survival, does not confer a survival advantage. These findings from the European Organisation for Research and Treatment of Cancer (EORTC) trial 26101 were presented at the 20th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology.

"The future challenge is to identify those patients deriving benefit from that treatment," said study coordinator Wolfgang Wick, MD, of the Uniklinik Heidelberg in Germany.

With an annual incidence of approximately 5 cases per 100,000 persons, gliomas are the most frequently occurring brain tumor in adults. Glioblastomas represent roughly 60% to 70% of all gliomas, and for this type of glioma there is no curative treatment.

"Standard first-line treatment consists of surgical resection followed by radiation and concomitant and adjuvant temozolomide therapy. For recurrence, there are treatment options, but we still have no standard treatment," pointed out Wick.

"Phase II data from the BELOB trial had indicated that the combination of bevacizumab and lomustine might produce an overall survival benefit compared with either monotherapy for patients with first progression of a glioblastoma."

EORTC trial 26101 was coordinated by the EORTC Brain Tumor Group and included 437 patients at 44 sites located in Austria, Belgium, France, Germany, Italy, Switzerland, The Netherlands, and the United Kingdom.

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