Spherical Shape of New Drug Holds Promise for Bypassing the Blood Brain Barrier and Treating Aggressive Brain Cancer
An investigational drug with a novel spherical nucleic acid structure has the potential to cross the blood-brain barrier to treat glioblastoma multiforme.
Survivors of primary brain tumors tend to freely discontinue cognitively engaging activities to compensate for diminishing cognitive function after treatment completion.
Temozolomide, an antimitotic chemotherapy used to treat brain cancer, demonstrated the potential to increase depression in a mouse model.
Deviation from radiation treatment protocol in young children being treated for brain neoplasms was associated with decreased overall survival.
Regular infusions of high doses of vitamin C safely increased cancer cell sensitivity to treatment in patients with brain and lung cancers.
NBTS launched a clinical trial finder specific to brain tumors to engage patients in research and clinical trials.
The addition of temozolomide to short-course radiotherapy in elderly patients with glioblastoma was associated with some survival benefit compared with radiotherapy alone.
A recent analysis of tumor tissue samples from patients with glioblastoma and glial cancer indicate no association between CMV infection and brain cancer.
Adding the anti-malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize glioblastoma patients to targeted treatments that had previously stopped working.
Although previous clinical trials have demonstrated that antiangiogenetic chemotherapy is not effective in GBM, researchers conducted a retrospective of review of perfusion MR images to determine if a phenotypic subtype of GBM may respond to antiangiogenic chemotherapy.
An analysis of data from caregivers and patients participating in a longitudinal study funded by the National Institutes of Health examines whether caregivers' anxiety, depressive symptoms, burden, and mastery influence survival for patients with newly diagnosed glioblastoma multiforme.
Insurance status influences overall patient survival for some cancer types, but its impact on glioblastoma multiforme (GBM) survival is well documented. This research study explored the possible impact of insurance on GBM survival.
Despite the use of adjuvant chemotherapy, deferral of postoperative radiotherapy is associated with worse survival in pediatric patients with medulloblastoma.
Chimeric antigen receptor (CAR) T cells may have improved therapeutic potential when they have 2 targets, according to preclinical findings using a mouse model.
Benign brain tumors that have previously been associated with obesity and diabetes are surprisingly less likely to emerge in patients with high blood sugar, according to new research.
Gross total resection to treat glioblastoma multiforme (GBM) showed progression-free survival benefits over subtotal resection and biopsy in a meta-analysis of 37 studies.
The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers, attendees were told in a poster discussion session at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting.
The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.
Discovery might eventually lead to better treatment for glioblastoma multiforme
Results from a recent clinical study show that distinct subtypes of glioblastoma tend to develop in different regions of the brain.
Glioblastoma tumors were successfully infiltrated by investigational CAR therapy with an acceptable safety profile.
The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.
The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.
The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.
A next-generation immunotherapy may offer hope for treating high-grade glioma, an aggressive form of brain cancer that is notoriously hard to treat.
A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.
Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.
Bevacizumab plus irinotecan significantly improved the 6-month progression-free survival (PFS) rate and median progression-free survival.
This technique, which does not use pharmaceutical sedatives, can ease the perioperative discomfort and anxiety experienced by some patients undergoing fully awake craniotomy to remove glioma.
Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.
A past history of psychiatric disorders has been linked to suicidal ideation in patients with brain tumors.
Chemotherapy for breast cancer can affect the body's ability to ward off common illnesses.
New genetic testing can assist brain cancer treatment planning.
Treating medulloblastoma with proton beam therapy results in survival rates in line with other proton therapies, according to recent study data.
Phase 2 trial data showed acceptable toxicity and similar survival as conventional radiotherapy for childhood medulloblastoma.
Valproic acid and levetiracetam do not improve survival outcomes in patients with newly diagnosed glioblastoma, according to a recently published study.
Excluding patients with renal insufficiency but good performance status from clinical trials due to concern of excessive hematologic toxicity or poor outcomes may not be necessary with appropriate dosing modifications.
New Studies Reveal Long-Term Vision-related Health Concerns of Survivors of Childhood Retinoblastoma and Brain Cancer
Two new studies investigate the impact of retinoblastoma on long-term health of survivors and the long-term psychological and socio-economic effects of blindness in survivors of brain tumors.
Progression-free and overall survival were prolonged with electromagnetic field and chemotherapy maintenance therapy in patients with a brain tumor.
A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor. It could also enable treatment monitoring without exposing patients to repeated doses of radiation.
Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors
Brain tumor cells can self-organize, according to new research. Glioma cells build tumors by self-organizing into streams 10 to 20 cells wide that obey a mathematically predicted pattern for autonomous agents flowing together.
Screening for and treatment of ductal carcinoma in situ (DCIS) is found to prevent subsequent invasive cancer.
A signaling pathway present in most organisms suppresses the formation of specific types of brain tumor.
Adding tumor-treating fields to maintenance temozolomide chemotherapy significantly prolonged progression-free survival.
Combination Regimen for Recurrent Glioblastoma Improves Progression-free Survival, But Not Overall Survival
Bevacizumab treatment combined with lomustine in patients with progressive glioblastoma, despite prolonged progression-free survival, does not confer a survival advantage.
[Clinical Medicine Insights: Oncology] This research examines hypoxia as a new therapeutic target for primary and secondary glioblastomas.
Scientists have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.
RNA test of blood platelets can detect, classify, and pinpoint the location of cancer by analyzing a sample equivalent to 1 drop of blood. Using this new method, researchers were able to identify cancer with 96% accuracy.
Liquid biopsy of cerebrospinal fluid has potential for prognosis, treatment, identification, and tracking of brain tumor genomic alterations both in real time and over time.
Researchers identified propentofylline as a drug that could help treat patients with the deadly brain cancer glioblastoma multiforme.
Incurable astrocytomas grow into healthy brain tissue like mycelium. Therefore, these tumors cannot be completely removed by surgery and invariably start growing again at some point despite intensive treatment.
A team has reported the first successful use of a targeted therapy drug to treat a patient with a debilitating, recurrent brain tumor.
A new laser-based microscope technology may help surgeons see the difference between tumor tissue and normal brain tissue in real-time.
Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center sought to assess the effects of treatment for brain tumors in children over 10 years of follow-up.
A new study finds that, while brain metastases share some genetic characteristics with the primary tumors from which they originated, they also carry unique genetic mutations, indicating that the evolutionary pathways of the metastatic and the primary tumors have diverged, which may change sensitivities to targeted therapy drugs.
Adult survivors of childhood brain tumors have lower working memory performance compared with healthy adults, according to research from Georgia State University and Emory University, in Atlanta.
Five new genetic variants associated with glioma have been identified in the biggest ever study of DNA in patients within this population.
It is feasible to treat seizures with a combination of non-oral benzodiazepines in the end-of-life phase of patients with gliomas.
For children with high-grade gliomas, the chances of survival are improved when surgery is successful in eliminating all visible cancer.
Researchers have discovered that determining a tumor's medulloblastoma subgroup can be achieved noninvasively, using magnetic resonance spectroscopy (MRS).
Ion channel blockers, drugs commonly used to treat cardiac, neurologic, and psychiatric disorders, might prove useful in cancer therapy, according to new research.
Targeted therapy for skin cancer is effective in patients with sonic hedgehog (SHH) subtype of medulloblastoma
A targeted therapy already used to treat advanced skin cancer has also been found to be effective when used to treat the most common subtype of adult medulloblastoma.
Effects of treatment-induced hearing loss on adult social attainment among adult survivors of childhood cancer.
Tumors can leverage glucose and acetate to resist targeted therapies directed at specific cellular molecules.
A tumor's DNA composition plays a key role in whether a glioma may transform into a more serious glioblastoma.
Outcomes for patients with low-grade gliomas have improved significantly in recent years, according to an analysis of clinical data collected from a US cancer registry over the past decade.
Clinicians testing dasatinib, approved for several blood cancers, were hoping to find that it would slow the growth of glioblastomas.
Majority of pediatric patients with relapsed neuroblastoma studied harbored mutations that promoted RAS-MAPK pathway signaling.
New research indicates that the IDH1 gene might be a prognostic marker for a rare form of brain cancer.
Preoperative navigated transcranial magnetic stimulation (nTMS) analysis of motor areas can improve the prognosis for patients with malignant brain tumors.
Radiosurgery and close monitoring is recommended to better preserve cognitive function in newly diagnosed brain metastases.
A combination approach utilizing three differing anticancer drug classes could hold the key to besting glioblastoma.
Depression in patients with brain cancer is easily overlooked by clinicians.
Gene-regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), research indicates.
Increasing the dose of radiotherapy given to children with an intracranial ependymoma can significantly improve their survival.
New research indicates that stem cells within tumors can help cancers resist treatment.
New evidence indicates that combining chemotherapy with radiation therapy may be the best option for people with a low-grade form of brain cancer.
Brain tumor patients who are uninsured or use Medicaid stay hospitalized longer and develop more medical complications than those with private insurance, according to a new study.
An innovative pretreatment can enhance the effectiveness of immunotherapy for glioblastoma, dramatically improving patient survival.
Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.
A new type of early phase clinical trial was recently introduced by the FDA, and is now being used to fast track potential drugs for the treatment of brain cancer.
A new study links a well-known cell communication pathway called Notch to pilocytic astrocytoma (PA), one of the more common brain tumors found in children.
Data clearly demonstrated stereotactic radiosurgery (SRS) alone offered benefits for younger patients with limited metastases.
Brain cancer is not increased by mobile phone use.
Research into the transfer of proteins within the cells of patients with autism has helped broaden our understanding of brain cancer.
A new study has identified three genes that combined enable a lethal form of brain cancer to recur and progress after radiation therapy.
A novel radio-guided surgery technique could quickly and effectively identify residual cancer cells during brain tumor surgery, reducing radiation exposure for both patients and surgeons.
The anti-cancer drug cisplatin is widely administered to treat brain cancer and other tumors.
A promising target for developing new therapies for children with high-risk neuroblastoma has been found.
Certain forms of birth control may increase the risk for developing a glioma, a rare brain cancer.
Researchers have found that bevacizumab-induced hypertension may be a predictive marker of improved outcomes in patients with recurrent glioblastoma who are treated with bevacizumab.
Scientists have developed a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.
A chemotherapy regimen of procarbazine, lomustine (CCNU), and vincristine (PCV) administered after radiation therapy improved both progression-free survival and overall survival in adults with low-grade gliomas.
Two engineering researchers have challenged a commonly held idea about tumor ablation.
Patients treated for central nervous system (CNS) cancer during childhood or adolescence can display altered self-perception later in adulthood.
Risk of brain cancer is three times higher after 25 years or more of mobile phone use.
Exposure to radiation during childhood increases a person's risk for developing meningioma before the age of 30.
A new drug breakthrough could extend the life of people living with glioblastoma, the most aggressive type of brain cancer.
Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.
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