Targeted therapy for skin cancer is effective in patients with sonic hedgehog (SHH) subtype of medulloblastoma
A targeted therapy already used to treat advanced skin cancer has also been found to be effective when used to treat the most common subtype of adult medulloblastoma.
Effects of treatment-induced hearing loss on adult social attainment among adult survivors of childhood cancer.
Tumors can leverage glucose and acetate to resist targeted therapies directed at specific cellular molecules.
A tumor's DNA composition plays a key role in whether a glioma may transform into a more serious glioblastoma.
Outcomes for patients with low-grade gliomas have improved significantly in recent years, according to an analysis of clinical data collected from a US cancer registry over the past decade.
Clinicians testing dasatinib, approved for several blood cancers, were hoping to find that it would slow the growth of glioblastomas.
Majority of pediatric patients with relapsed neuroblastoma studied harbored mutations that promoted RAS-MAPK pathway signaling.
New research indicates that the IDH1 gene might be a prognostic marker for a rare form of brain cancer.
Preoperative navigated transcranial magnetic stimulation (nTMS) analysis of motor areas can improve the prognosis for patients with malignant brain tumors.
Radiosurgery and close monitoring is recommended to better preserve cognitive function in newly diagnosed brain metastases.
A combination approach utilizing three differing anticancer drug classes could hold the key to besting glioblastoma.
Depression in patients with brain cancer is easily overlooked by clinicians.
Gene-regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), research indicates.
Increasing the dose of radiotherapy given to children with an intracranial ependymoma can significantly improve their survival.
New research indicates that stem cells within tumors can help cancers resist treatment.
New evidence indicates that combining chemotherapy with radiation therapy may be the best option for people with a low-grade form of brain cancer.
Brain tumor patients who are uninsured or use Medicaid stay hospitalized longer and develop more medical complications than those with private insurance, according to a new study.
An innovative pretreatment can enhance the effectiveness of immunotherapy for glioblastoma, dramatically improving patient survival.
Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.
A new type of early phase clinical trial was recently introduced by the FDA, and is now being used to fast track potential drugs for the treatment of brain cancer.
A new study links a well-known cell communication pathway called Notch to pilocytic astrocytoma (PA), one of the more common brain tumors found in children.
Data clearly demonstrated stereotactic radiosurgery (SRS) alone offered benefits for younger patients with limited metastases.
Brain cancer is not increased by mobile phone use.
Research into the transfer of proteins within the cells of patients with autism has helped broaden our understanding of brain cancer.
A new study has identified three genes that combined enable a lethal form of brain cancer to recur and progress after radiation therapy.
A novel radio-guided surgery technique could quickly and effectively identify residual cancer cells during brain tumor surgery, reducing radiation exposure for both patients and surgeons.
The anti-cancer drug cisplatin is widely administered to treat brain cancer and other tumors.
A promising target for developing new therapies for children with high-risk neuroblastoma has been found.
Certain forms of birth control may increase the risk for developing a glioma, a rare brain cancer.
Researchers have found that bevacizumab-induced hypertension may be a predictive marker of improved outcomes in patients with recurrent glioblastoma who are treated with bevacizumab.
Scientists have developed a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.
A chemotherapy regimen of procarbazine, lomustine (CCNU), and vincristine (PCV) administered after radiation therapy improved both progression-free survival and overall survival in adults with low-grade gliomas.
Two engineering researchers have challenged a commonly held idea about tumor ablation.
Patients treated for central nervous system (CNS) cancer during childhood or adolescence can display altered self-perception later in adulthood.
Risk of brain cancer is three times higher after 25 years or more of mobile phone use.
Exposure to radiation during childhood increases a person's risk for developing meningioma before the age of 30.
A new drug breakthrough could extend the life of people living with glioblastoma, the most aggressive type of brain cancer.
Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.
Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumor's epigenetic signature.
New research suggests that an antidepressant medication, repurposed, could target a novel molecular pathway that causes an aggressive form of medulloblastoma.
A blue-ribbon team of national experts stated that professional pessimism and out-of-date myths rather than current science may compromise the care of patients with brain cancer.
A triple therapy for glioblastoma, consisting of two types of immunotherapy and targeted radiation, has significantly prolonged the survival of mice with these brain cancers, according to a new report.
Dangerous brain tumors hijack the brain's existing blood supply throughout their progression, according to new research.
New research helps explain why brain tumors occur more often in males and frequently are more harmful than similar tumors in females. For example, glioblastomas, the most common malignant brain tumors, are diagnosed twice as often in males, who suffer greater cognitive impairments than females and do not survive as long.
New research shows the protein neurons use to stay alive and healthy is used by brain cancer cells to maintain longevity to grow and metastasize. The findings could lead to breakthroughs in treatments for brain cancer.
Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain's protective barrier, according to results of a study.
A blue-ribbon team of national experts on brain cancer said that professional pessimism and out-of-date myths rather than current science may compromise the care of patients with cancer that has metastasized to the brain.
Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression—this finding could ultimately lead to new ways to bring about the death of the tumor.
A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.
An exciting new study has characterized the cellular diversity in glioblastoma tumors from patients, which may pave the way for the development of new treatments.
Final results from a phase 2 study show that adding Prophage autologous cancer vaccine to the standard-of-care treatment for newly diagnosed GBM improves survival.
The hormone progesterone could become part of therapy against the most aggressive form of brain cancer.
A synthetic peptide carrier is a potential delivery vehicle for chemotherapy drugs for brain cancer and for other neurologic medications, according to new research.
Researchers have identified a genetic mutation in brain cancer tumor cells that plays a role in both the growth and the death of the cell.
Is there a difference in dosing (1 hour prior to radiotherapy vs bedtime) with temozolomide plus radiotherapy for glioblastoma multiforme?
US and Australian Researchers Form Alliance to Facilitate Development of Treatments for Childhood Cancers
Alliance of Australian and U.S. researchers and children's cancer advocates focused on developing drugs as potential treatments for neuroblastoma, the most common solid form of childhood cancer.
Stem cells derived from human body fat have been successfully used to deliver biologic treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives.
New mutations in pediatric brain tumors known as high-grade gliomas have been identified, and most often occur in the youngest patients.
The quest to improve survival of children with a high-risk brain tumor has led investigators to two drugs already used to treat adults with breast, pancreatic, lung, and other cancers.
The most common genetic alteration ever reported in the brain tumor ependymoma has been identified. Researchers also have evidence that the alteration drives tumor development.
Patients with malignant astrocytoma whose tumors carry the gene mutation IDH1 may benefit greatly from surgical removal of the largest possible amount of tumor.
First-of-its-kind research shows promise for developing a method to clearly identify cancerous tissue during surgery. These findings may potentially improve outcomes for those undergoing surgery to remove glioblastoma multiforme.
Years can pass between the time a breast cancer patient goes into remission and a related brain tumor develops. During that time, the breast cancer cells somehow escape detection.
A gene mutation associated with several types of cancer also may be responsible for a rare but debilitating brain tumor called papillary craniopharyngioma.
Researchers have also created an experimental vaccine to attack immune system targets related to cancer stem cells, the cells from which malignant brain tumors are believed to originate and regenerate.
Patients with recurrent GBM treated with an experimental vaccine made from the patient's own resected tumor tissue showed an improved survival compared with historical patients who received the standard of care alone, according to an analysis of a phase 2 trial of this vaccine.
A known genetic pathway is active in many difficult-to-treat pediatric brain tumors known as low-grade gliomas. This finding offers a potential new target for the treatment of these cancers.
A new approach selectively permeabilizes the blood-brain barrier at sites of brain metastases, even those 200 times smaller than currently detectable in the clinic.
Limiting the amount of radiation absorbed in the hippocampal portion of the brain during whole-brain radiotherapy (WBRT) for brain metastases preserves memory function in patients for up to 6 months after treatment.
Survival improved by stereotactic radiosurgery alone in adults under 50 years with limited brain metastases
Overall survival was improved for adults age 50 years and younger with brain cancer who were treated with stereotactic radiosurgery that was not combined with whole-brain radiotherapy.
A specific protein has been found in nearly 100% of high-grade meningiomas, which is the most common form of brain tumor. This finding suggests a new target for therapies for a cancer that does not respond to current chemotherapy.
A prominent protein activated by inflammation is the key instigator that converts glioblastoma multiforme cells to their most aggressive, untreatable form and promotes resistance to radiation therapy.
Cellular therapy and gene therapy have been successfully combined in a mouse model to develop a viable treatment strategy for breast cancer that has spread to a patient's brain.
About 15% of patients with glioblastoma could receive personalized treatment with drugs currently used in other cancers, based on new research that has identified 18 genes responsible for driving glioblastoma multiforme.
A large-scale analysis of the association between DNA viruses and human malignancies suggests that many of the most common cancers are not associated with DNA viruses
When 96 pilocytic astrocytomas were analyzed by whole-genome sequencing, all had MAPK-pathway alterations. This indicates that pilocytic astrocytoma is predominantly a single-pathway disease.
An oncolytic virus infected and killed both brain cancer stem cells and differentiated compartments of the common and deadly malignant brain tumor, glioblastoma multiforme (GBM), when combined with the immunosuppressant drug rapamycin.
An abnormal metabolic pathway drives the growth of cancer cells in a particular glioblastoma subtype, according to new research.
Attacking glioblastoma brain tumor cells with a modified poliovirus is showing encouraging early results in an ongoing study.
Genetic material secreted by bone marrow cells was used to reduce glioma tumor volume in a recent study.
The imaging technique of DTI allows neurosurgeons to visualize important pathways in the brain. This allows them to better adapt brain tumor surgeries and preserve language, visual function, and motor function while removing cancerous tissue.
Among patients undergoing surgery for a brain tumor, low T3 (triiodothyronine) syndrome has been found to be predictive of unfavorable clinical outcomes and depressive symptoms.
Low levels of the thyroid hormone triiodothyronine (T3) predict unfavorable outcomes after neurosurgery for the treatment of brain tumors.
Adipose tissue may provide a more efficient, less costly, and less invasive source of mesenchymal stem cells (MSCs) than bone marrow.
Combining the antiangiogenic bevacizumab with the kinase inhibitor dasatinib stopped glioblastoma metastasis after shrinking the tumors.
Fluorescence form 5-aminolevulinic acid (5-ALA) has been used to guide resection of recurrent GBM. Before surgery, the patient ingests 5-ALA, then the tumor cells fluoresce intraoperatively in response to certain wavelengths of light.
Large-scale genomic sequencing has revealed two DNA mutations that appear to drive about 15% of brain tumors known as meningiomas.
The forecast enables physicians to rapidly identify how well a tumor is responding to a particular therapy and allows a quick pivot to a new therapy in a critical time window if the current therapy is not effective.
ELTD1, a protein linked with angiogenesis, is the strongest candidate for a significant association with glioma out of nearly 200 possible markers.
Researchers have, for the first time, identified a new group of growth factor receptors that signal to brain tumors, which brings treatment of neurofibromatosis type 2 one step closer to a nonsurgical therapeutic option.
Patients with aggressive brain tumors can be effectively treated with smaller radiation fields to spare the rest of the brain and preserve cognition.
For patients receiving radiotherapy for glioblastoma, use of clinical target volume margins as small as 5 mm does not lead to an increase in marginal failures.
Imaging with 18F-FLT positron emission tomography provides tumor-specific details accurately and noninvasively in persons with gliomas.
Hemodynamic changes associated with pregnancy explain the growth of benign tumors in pregnant women. The study also identified some key characteristics associated with rapid growth of meningiomas in pregnant women.
A cell growth pathway that is unusually active in pediatric brain tumors known as gliomas has been identified. This same growth pathway was previously identified as a critical contributor to brain tumor formation and growth in neurofibromatosis-1.
Insurance coverage affects in-hospital mortality for brain tumor patients undergoing craniotomy.
The mTOR inhibitor dramatically reduced the volume of subependymal giant cell astrocytomas (SEGAs) in persons with tuberous sclerosis complex.
Persons with glioblastoma who undergo repeated resections can have improved survival, indicate the findings of a recent study.
A needs assessment tool can identify specific needs of caregivers of patients with a primary malignant brain tumor.
- Breakthrough supportive care: Overcoming cancer anorexia/cachexia
- Religiousness and spirituality have a significant impact on cancer patients' overall health and outcomes
- Even light drinking puts women at greater risk to develop cancer
- Study uses dog sledding to demonstrate benefits of adapted physical activities for children with cancer
- Cabozantinib granted Breakthrough Therapy Designation for kidney cancer
- Dietary intervention primes triple-negative breast cancer cells for targeted therapy
- Religiousness and spirituality have a significant impact on cancer patients' overall health and outcomes
- Lung cancer patients who stop smoking live longer
- Review examines strategies for hospital room surface cleanliness
- Appropriate use of tomosynthesis mammography
- Robotic inferior vena cava (IVC) thrombectomy successfully removes thrombus associated with kidney cancer
- Clinical scoring system suggests more precise colon cancer screening is possible
- Efficacy and safety of docetaxel for advanced non-small-cell lung cancer: A meta-analysis of Phase III randomized controlled trials
- Researchers identify tumor microenvironment of metastasis (TMEM) that allows breast cancer to metastasize
- Race and institutional factors play important roles in pharmacogenomics trial participation
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