Phase 1 Study Results Show CAR T-cell Therapy Promising in Solid Brain Tumors

Phase 1 Study Results Show CAR T-cell Therapy Promising in Solid Brain Tumors

Glioblastoma tumors were successfully infiltrated by investigational CAR therapy with an acceptable safety profile.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

Altered Metabolism of Four Compounds Drives Glioblastoma Growth

The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.

Novel Drug Combination Inhibits Growth of MYC-driven Medulloblastoma

The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.

Novel Approach Harnesses Dendritic Cells to Treat Glioma

A next-generation immunotherapy may offer hope for treating high-grade glioma, an aggressive form of brain cancer that is notoriously hard to treat.

New Therapy Holds Potential for Neuroblastoma Treatment

New Therapy Holds Potential for Neuroblastoma Treatment

A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.

Radiotherapy/Histone Deacetylase Inhibitor Combination Safe, Effective in High-grade Gliomas

Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.

Bevacizumab Plus Irinotecan Improves PFS in MGMT-positive Glioblastoma

Bevacizumab Plus Irinotecan Improves PFS in MGMT-positive Glioblastoma

Bevacizumab plus irinotecan significantly improved the 6-month progression-free survival (PFS) rate and median progression-free survival.

Hypnosedation: An Alternative Sedation Method for Glioma Resection

Hypnosedation: An Alternative Sedation Method for Glioma Resection

This technique, which does not use pharmaceutical sedatives, can ease the perioperative discomfort and anxiety experienced by some patients undergoing fully awake craniotomy to remove glioma.

Pan-glioma Analysis Reveals Unique Subtypes of This Brain Cancer

Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.

Risk Factors of Suicidal Ideation in Patients With Brain Tumors

A past history of psychiatric disorders has been linked to suicidal ideation in patients with brain tumors.

Vulnerability to Infection Increases for Breast Cancer Survivors Treated With Chemotherapy

Chemotherapy for breast cancer can affect the body's ability to ward off common illnesses.

Comprehensive Genetic Profiling Possible for Central Nervous System Tumors

Comprehensive Genetic Profiling Possible for Central Nervous System Tumors

New genetic testing can assist brain cancer treatment planning.

Proton Beam Therapy Treats Childhood Brain Cancer as Effectively as Standard Radiation

Treating medulloblastoma with proton beam therapy results in survival rates in line with other proton therapies, according to recent study data.

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Phase 2 trial data showed acceptable toxicity and similar survival as conventional radiotherapy for childhood medulloblastoma.

Valproic Acid, Levetiracetam Do Not Improve Survival in Newly Diagnosed GBM

Valproic acid and levetiracetam do not improve survival outcomes in patients with newly diagnosed glioblastoma, according to a recently published study.

No Need to Exclude Patients With Renal Insufficiency From Clinical Trials

Excluding patients with renal insufficiency but good performance status from clinical trials due to concern of excessive hematologic toxicity or poor outcomes may not be necessary with appropriate dosing modifications.

New Studies Reveal Long-Term Vision-related Health Concerns of Survivors of Childhood Retinoblastoma and Brain Cancer

Two new studies investigate the impact of retinoblastoma on long-term health of survivors and the long-term psychological and socio-economic effects of blindness in survivors of brain tumors.

Type of Electromagnetic Field Therapy Improves Survival for Patients With Brain Tumor

Progression-free and overall survival were prolonged with electromagnetic field and chemotherapy maintenance therapy in patients with a brain tumor.

Novel Test Offers Diagnostic and Disease Monitoring Potential for Rare Childhood Brain Cancer

A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor. It could also enable treatment monitoring without exposing patients to repeated doses of radiation.

Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors

Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors

Brain tumor cells can self-organize, according to new research. Glioma cells build tumors by self-organizing into streams 10 to 20 cells wide that obey a mathematically predicted pattern for autonomous agents flowing together.

Screen and Detection for Early Stage Breast Cancers May Prevent Invasive Disease

Screening for and treatment of ductal carcinoma in situ (DCIS) is found to prevent subsequent invasive cancer.

Action of Signaling Pathway Surprises Researchers Investigating Brain Tumor Development

A signaling pathway present in most organisms suppresses the formation of specific types of brain tumor.

Adding Tumor-treating Fields to Maintenance Therapy May Prolong Survival in Glioblastoma

Adding Tumor-treating Fields to Maintenance Therapy May Prolong Survival in Glioblastoma

Adding tumor-treating fields to maintenance temozolomide chemotherapy significantly prolonged progression-free survival.

Combination Regimen for Recurrent Glioblastoma Improves Progression-free Survival, But Not Overall Survival

Bevacizumab treatment combined with lomustine in patients with progressive glioblastoma, despite prolonged progression-free survival, does not confer a survival advantage.

Glioblastoma Stem Cells as a New Therapeutic Target for Glioblastoma

Glioblastoma Stem Cells as a New Therapeutic Target for Glioblastoma

[Clinical Medicine Insights: Oncology] This research examines hypoxia as a new therapeutic target for primary and secondary glioblastomas.

Peptide Reverses Temozolomide Resistance in Glioblastoma Cells

Scientists have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.

Blood Sample Offers a New Way of Detecting Cancer

Blood Sample Offers a New Way of Detecting Cancer

RNA test of blood platelets can detect, classify, and pinpoint the location of cancer by analyzing a sample equivalent to 1 drop of blood. Using this new method, researchers were able to identify cancer with 96% accuracy.

Liquid Biopsy of Cerebrospinal Fluid More Effective in Managing Brain Tumors

Liquid biopsy of cerebrospinal fluid has potential for prognosis, treatment, identification, and tracking of brain tumor genomic alterations both in real time and over time.

Existing Drug May Limit Recurrence and Metastasis of Glioblastoma Multiforme

Existing Drug May Limit Recurrence and Metastasis of Glioblastoma Multiforme

Researchers identified propentofylline as a drug that could help treat patients with the deadly brain cancer glioblastoma multiforme.

Network of Thread-like Branches Enables Brain Tumors to Avoid Effects of Treatment

Incurable astrocytomas grow into healthy brain tissue like mycelium. Therefore, these tumors cannot be completely removed by surgery and invariably start growing again at some point despite intensive treatment.

Targeted Treatment Produces Rapid Shrinkage of Recurrent BRAF-mutant Brain Tumor

Targeted Treatment Produces Rapid Shrinkage of Recurrent BRAF-mutant Brain Tumor

A team has reported the first successful use of a targeted therapy drug to treat a patient with a debilitating, recurrent brain tumor.

Laser-Based Tool Could Increase Accuracy and Safety of Brain Tumor Surgery

A new laser-based microscope technology may help surgeons see the difference between tumor tissue and normal brain tissue in real-time.

Predicting Seizure Incidence and Frequency in Survivors of Pediatric Brain Tumors

Predicting Seizure Incidence and Frequency in Survivors of Pediatric Brain Tumors

Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center sought to assess the effects of treatment for brain tumors in children over 10 years of follow-up.

Genetic Profiles of Brain Metastases Differ From Those of Primary Tumors

A new study finds that, while brain metastases share some genetic characteristics with the primary tumors from which they originated, they also carry unique genetic mutations, indicating that the evolutionary pathways of the metastatic and the primary tumors have diverged, which may change sensitivities to targeted therapy drugs.

Childhood Brain Tumors Affect Working Memory of Adult Survivors

Adult survivors of childhood brain tumors have lower working memory performance compared with healthy adults, according to research from Georgia State University and Emory University, in Atlanta.

Five New Genetic Variants Linked With Glioma Identified

Five New Genetic Variants Linked With Glioma Identified

Five new genetic variants associated with glioma have been identified in the biggest ever study of DNA in patients within this population.

Non-Oral Benzodiazepine Combination Feasible for Seizures in Patients With Gliomas

Non-Oral Benzodiazepine Combination Feasible for Seizures in Patients With Gliomas

It is feasible to treat seizures with a combination of non-oral benzodiazepines in the end-of-life phase of patients with gliomas.

Complete resection of high-grade gliomas improves survival in children, especially girls

Complete resection of high-grade gliomas improves survival in children, especially girls

For children with high-grade gliomas, the chances of survival are improved when surgery is successful in eliminating all visible cancer.

Imaging technique allows pediatric brain tumors to be classified noninvasively at diagnosis

Researchers have discovered that determining a tumor's medulloblastoma subgroup can be achieved noninvasively, using magnetic resonance spectroscopy (MRS).

Common class of channel blockers may find a role in cancer therapy

Ion channel blockers, drugs commonly used to treat cardiac, neurologic, and psychiatric disorders, might prove useful in cancer therapy, according to new research.

Targeted therapy for skin cancer is effective in patients with sonic hedgehog (SHH) subtype of medulloblastoma

A targeted therapy already used to treat advanced skin cancer has also been found to be effective when used to treat the most common subtype of adult medulloblastoma.

Treatment-induced hearing loss associated with outcomes in childhood CNS cancer survivors

Treatment-induced hearing loss associated with outcomes in childhood CNS cancer survivors

Effects of treatment-induced hearing loss on adult social attainment among adult survivors of childhood cancer.

Certain nutrients may fuel cancer therapy resistance

Certain nutrients may fuel cancer therapy resistance

Tumors can leverage glucose and acetate to resist targeted therapies directed at specific cellular molecules.

Low-grade brain tumor diagnosis redefined

A tumor's DNA composition plays a key role in whether a glioma may transform into a more serious glioblastoma.

Survival in adult patients with low-grade brain tumors has improved

Survival in adult patients with low-grade brain tumors has improved

Outcomes for patients with low-grade gliomas have improved significantly in recent years, according to an analysis of clinical data collected from a US cancer registry over the past decade.

Drug treatment may benefit only select group of patients with glioblastoma

Drug treatment may benefit only select group of patients with glioblastoma

Clinicians testing dasatinib, approved for several blood cancers, were hoping to find that it would slow the growth of glioblastomas.

Identifying mutations in relapsed pediatric neuroblastoma may lead to better treatment options

Identifying mutations in relapsed pediatric neuroblastoma may lead to better treatment options

Majority of pediatric patients with relapsed neuroblastoma studied harbored mutations that promoted RAS-MAPK pathway signaling.

IDH gene may serve as prognostic marker in anaplastic astrocytoma

New research indicates that the IDH1 gene might be a prognostic marker for a rare form of brain cancer.

Imaging technology maps brain tumor and key motor areas, improving postsurgical prognosis

Preoperative navigated transcranial magnetic stimulation (nTMS) analysis of motor areas can improve the prognosis for patients with malignant brain tumors.

Radiosurgery and Careful Monitoring Combo Recommended for Newly Diagnosed Brain Metastases

Radiosurgery and Careful Monitoring Combo Recommended for Newly Diagnosed Brain Metastases

Radiosurgery and close monitoring is recommended to better preserve cognitive function in newly diagnosed brain metastases.

New combination is a winning strategy against glioblastoma

A combination approach utilizing three differing anticancer drug classes could hold the key to besting glioblastoma.

Patients with brain tumor should be screened for depression

Patients with brain tumor should be screened for depression

Depression in patients with brain cancer is easily overlooked by clinicians.

Possible treatment identified for lethal pediatric brain cancer

Possible treatment identified for lethal pediatric brain cancer

Gene-regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), research indicates.

High radiotherapy dose improves prospects for children with brain cancer

Increasing the dose of radiotherapy given to children with an intracranial ependymoma can significantly improve their survival.

Stem cells lurking in tumors can resist treatment

New research indicates that stem cells within tumors can help cancers resist treatment.

Combination therapy found best for low-grade brain tumors

New evidence indicates that combining chemotherapy with radiation therapy may be the best option for people with a low-grade form of brain cancer.

Patients with brain tumors fare better with private insurance

Brain tumor patients who are uninsured or use Medicaid stay hospitalized longer and develop more medical complications than those with private insurance, according to a new study.

Tetanus primer significantly improves survival after immunotherapy for glioblastoma

Tetanus primer significantly improves survival after immunotherapy for glioblastoma

An innovative pretreatment can enhance the effectiveness of immunotherapy for glioblastoma, dramatically improving patient survival.

Gene regulatory path revealed as target for therapy of aggressive pediatric brain cancer

Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.

Revolutionary clinical trial fast tracks trials for patients with brain tumor

Revolutionary clinical trial fast tracks trials for patients with brain tumor

A new type of early phase clinical trial was recently introduced by the FDA, and is now being used to fast track potential drugs for the treatment of brain cancer.

Cell signaling pathway goes awry in common pediatric brain tumor

A new study links a well-known cell communication pathway called Notch to pilocytic astrocytoma (PA), one of the more common brain tumors found in children.

Single therapy offers improved survival in younger patients with limited brain metastases

Single therapy offers improved survival in younger patients with limited brain metastases

Data clearly demonstrated stereotactic radiosurgery (SRS) alone offered benefits for younger patients with limited metastases.

Increase in brain tumors is not attributed to mobile phone use

Increase in brain tumors is not attributed to mobile phone use

Brain cancer is not increased by mobile phone use.

What autism can teach us about brain cancer

Research into the transfer of proteins within the cells of patients with autism has helped broaden our understanding of brain cancer.

Three genes are tied to radiation resistance in recurrent glioblastoma tumors

A new study has identified three genes that combined enable a lethal form of brain cancer to recur and progress after radiation therapy.

Novel radioguided surgery technique could help pinpoint cancer tissue

A novel radio-guided surgery technique could quickly and effectively identify residual cancer cells during brain tumor surgery, reducing radiation exposure for both patients and surgeons.

Genetic variations associated with cisplatin-induced ototoxicity identified

Genetic variations associated with cisplatin-induced ototoxicity identified

The anti-cancer drug cisplatin is widely administered to treat brain cancer and other tumors.

Alternative DNA repair mechanism could provide better treatment for neuroblastoma in children

A promising target for developing new therapies for children with high-risk neuroblastoma has been found.

Oral contraceptives may increase risk for developing gliomas

Oral contraceptives may increase risk for developing gliomas

Certain forms of birth control may increase the risk for developing a glioma, a rare brain cancer.

Bevacizumab-induced hypertension is a marker for improved outcomes in recurrent glioblastoma

Bevacizumab-induced hypertension is a marker for improved outcomes in recurrent glioblastoma

Researchers have found that bevacizumab-induced hypertension may be a predictive marker of improved outcomes in patients with recurrent glioblastoma who are treated with bevacizumab.

Potential therapy found for incurable pediatric brain tumor

Scientists have developed a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.

Chemotherapy after radiation slows progression of low-grade gliomas

A chemotherapy regimen of procarbazine, lomustine (CCNU), and vincristine (PCV) administered after radiation therapy improved both progression-free survival and overall survival in adults with low-grade gliomas.

Collaboration yields new methods to treat tumors with antennas

Two engineering researchers have challenged a commonly held idea about tumor ablation.

Survivors of childhood central nervous system cancer show affected self-identity

Survivors of childhood central nervous system cancer show affected self-identity

Patients treated for central nervous system (CNS) cancer during childhood or adolescence can display altered self-perception later in adulthood.

Wireless phone may increase risk of gliomas

Wireless phone may increase risk of gliomas

Risk of brain cancer is three times higher after 25 years or more of mobile phone use.

Radiation exposure during childhood increases risk of meningioma

Radiation exposure during childhood increases risk of meningioma

Exposure to radiation during childhood increases a person's risk for developing meningioma before the age of 30.

Drug targeting glioblastoma to begin clinical trial

A new drug breakthrough could extend the life of people living with glioblastoma, the most aggressive type of brain cancer.

Targeting a unique receptor promising for glioblastoma multiforme

Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.

Finding keys to drug therapy resistance in glioblastoma

Finding keys to drug therapy resistance in glioblastoma

Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumor's epigenetic signature.

Repurposing antidepressant may target new medulloblastoma pathway

New research suggests that an antidepressant medication, repurposed, could target a novel molecular pathway that causes an aggressive form of medulloblastoma.

Brain mets: Time for a new approach

Brain mets: Time for a new approach

A blue-ribbon team of national experts stated that professional pessimism and out-of-date myths rather than current science may compromise the care of patients with brain cancer.

Triple therapy revs up immune system against a common brain tumor

A triple therapy for glioblastoma, consisting of two types of immunotherapy and targeted radiation, has significantly prolonged the survival of mice with these brain cancers, according to a new report.

Brain tumors hijack the brain's blood supply

Dangerous brain tumors hijack the brain's existing blood supply throughout their progression, according to new research.

A possible explanation for why brain tumors are more common, and more harmful, in males

A possible explanation for why brain tumors are more common, and more harmful, in males

New research helps explain why brain tumors occur more often in males and frequently are more harmful than similar tumors in females. For example, glioblastomas, the most common malignant brain tumors, are diagnosed twice as often in males, who suffer greater cognitive impairments than females and do not survive as long.

A Single Protein Could Unlock New Treatments For Brain Cancer

A Single Protein Could Unlock New Treatments For Brain Cancer

New research shows the protein neurons use to stay alive and healthy is used by brain cancer cells to maintain longevity to grow and metastasize. The findings could lead to breakthroughs in treatments for brain cancer.

Glioblastoma cell migration reveals a potential drug delivery route through the blood-brain barrier

Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain's protective barrier, according to results of a study.

Five myths may compromise care of patients with brain metastases

Five myths may compromise care of patients with brain metastases

A blue-ribbon team of national experts on brain cancer said that professional pessimism and out-of-date myths rather than current science may compromise the care of patients with cancer that has metastasized to the brain.

Glioblastoma cell investigation may lead to new cancer treatments

Glioblastoma cell investigation may lead to new cancer treatments

Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression—this finding could ultimately lead to new ways to bring about the death of the tumor.

Tool assists brain cancer surgery

Tool assists brain cancer surgery

A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.

Glioblastoma tumors exhibit more cellular diversity than previously thought

An exciting new study has characterized the cellular diversity in glioblastoma tumors from patients, which may pave the way for the development of new treatments.

Autologous cancer vaccine extends survival in patients with newly diagnosed GBM

Autologous cancer vaccine extends survival in patients with newly diagnosed GBM

Final results from a phase 2 study show that adding Prophage autologous cancer vaccine to the standard-of-care treatment for newly diagnosed GBM improves survival.

Progesterone could be added to brain cancer therapies

Progesterone could be added to brain cancer therapies

The hormone progesterone could become part of therapy against the most aggressive form of brain cancer.

Small-molecule drugs cross the blood-brain barrier

A synthetic peptide carrier is a potential delivery vehicle for chemotherapy drugs for brain cancer and for other neurologic medications, according to new research.

Newly identified brain cancer mutation may can aid drug development

Researchers have identified a genetic mutation in brain cancer tumor cells that plays a role in both the growth and the death of the cell.

Optimal dosing for TMZ: 1 hour prior to RT versus bedtime

Optimal dosing for TMZ: 1 hour prior to RT versus bedtime

Is there a difference in dosing (1 hour prior to radiotherapy vs bedtime) with temozolomide plus radiotherapy for glioblastoma multiforme?

US and Australian Researchers Form Alliance to Facilitate Development of Treatments for Childhood Cancers

US and Australian Researchers Form Alliance to Facilitate Development of Treatments for Childhood Cancers

Alliance of Australian and U.S. researchers and children's cancer advocates focused on developing drugs as potential treatments for neuroblastoma, the most common solid form of childhood cancer.

Human fat may be a Trojan horse in the fight against brain cancer

Stem cells derived from human body fat have been successfully used to deliver biologic treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives.

Gene sequencing discovers mutations tied to deadly brain tumors in young children

New mutations in pediatric brain tumors known as high-grade gliomas have been identified, and most often occur in the youngest patients.

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