Low-grade brain tumor diagnosis redefined

A tumor's DNA composition plays a key role in whether a glioma may transform into a more serious glioblastoma.

Survival in adult patients with low-grade brain tumors has improved

Survival in adult patients with low-grade brain tumors has improved

Outcomes for patients with low-grade gliomas have improved significantly in recent years, according to an analysis of clinical data collected from a US cancer registry over the past decade.

Drug treatment may benefit only select group of patients with glioblastoma

Drug treatment may benefit only select group of patients with glioblastoma

Clinicians testing dasatinib, approved for several blood cancers, were hoping to find that it would slow the growth of glioblastomas.

Identifying mutations in relapsed pediatric neuroblastoma may lead to better treatment options

Identifying mutations in relapsed pediatric neuroblastoma may lead to better treatment options

Majority of pediatric patients with relapsed neuroblastoma studied harbored mutations that promoted RAS-MAPK pathway signaling.

IDH gene may serve as prognostic marker in anaplastic astrocytoma

New research indicates that the IDH1 gene might be a prognostic marker for a rare form of brain cancer.

Imaging technology maps brain tumor and key motor areas, improving postsurgical prognosis

Preoperative navigated transcranial magnetic stimulation (nTMS) analysis of motor areas can improve the prognosis for patients with malignant brain tumors.

Radiosurgery and Careful Monitoring Combo Recommended for Newly Diagnosed Brain Metastases

Radiosurgery and Careful Monitoring Combo Recommended for Newly Diagnosed Brain Metastases

Radiosurgery and close monitoring is recommended to better preserve cognitive function in newly diagnosed brain metastases.

New combination is a winning strategy against glioblastoma

A combination approach utilizing three differing anticancer drug classes could hold the key to besting glioblastoma.

Patients with brain tumor should be screened for depression

Patients with brain tumor should be screened for depression

Depression in patients with brain cancer is easily overlooked by clinicians.

Possible treatment identified for lethal pediatric brain cancer

Possible treatment identified for lethal pediatric brain cancer

Gene-regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), research indicates.

High radiotherapy dose improves prospects for children with brain cancer

Increasing the dose of radiotherapy given to children with an intracranial ependymoma can significantly improve their survival.

Stem cells lurking in tumors can resist treatment

New research indicates that stem cells within tumors can help cancers resist treatment.

Combination therapy found best for low-grade brain tumors

New evidence indicates that combining chemotherapy with radiation therapy may be the best option for people with a low-grade form of brain cancer.

Patients with brain tumors fare better with private insurance

Brain tumor patients who are uninsured or use Medicaid stay hospitalized longer and develop more medical complications than those with private insurance, according to a new study.

Tetanus primer significantly improves survival after immunotherapy for glioblastoma

Tetanus primer significantly improves survival after immunotherapy for glioblastoma

An innovative pretreatment can enhance the effectiveness of immunotherapy for glioblastoma, dramatically improving patient survival.

Gene regulatory path revealed as target for therapy of aggressive pediatric brain cancer

Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.

Revolutionary clinical trial fast tracks trials for patients with brain tumor

Revolutionary clinical trial fast tracks trials for patients with brain tumor

A new type of early phase clinical trial was recently introduced by the FDA, and is now being used to fast track potential drugs for the treatment of brain cancer.

Cell signaling pathway goes awry in common pediatric brain tumor

A new study links a well-known cell communication pathway called Notch to pilocytic astrocytoma (PA), one of the more common brain tumors found in children.

Single therapy offers improved survival in younger patients with limited brain metastases

Single therapy offers improved survival in younger patients with limited brain metastases

Data clearly demonstrated stereotactic radiosurgery (SRS) alone offered benefits for younger patients with limited metastases.

Increase in brain tumors is not attributed to mobile phone use

Increase in brain tumors is not attributed to mobile phone use

Brain cancer is not increased by mobile phone use.

What autism can teach us about brain cancer

Research into the transfer of proteins within the cells of patients with autism has helped broaden our understanding of brain cancer.

Three genes are tied to radiation resistance in recurrent glioblastoma tumors

A new study has identified three genes that combined enable a lethal form of brain cancer to recur and progress after radiation therapy.

Novel radioguided surgery technique could help pinpoint cancer tissue

A novel radio-guided surgery technique could quickly and effectively identify residual cancer cells during brain tumor surgery, reducing radiation exposure for both patients and surgeons.

Genetic variations associated with cisplatin-induced ototoxicity identified

Genetic variations associated with cisplatin-induced ototoxicity identified

The anti-cancer drug cisplatin is widely administered to treat brain cancer and other tumors.

Alternative DNA repair mechanism could provide better treatment for neuroblastoma in children

A promising target for developing new therapies for children with high-risk neuroblastoma has been found.

Oral contraceptives may increase risk for developing gliomas

Oral contraceptives may increase risk for developing gliomas

Certain forms of birth control may increase the risk for developing a glioma, a rare brain cancer.

Bevacizumab-induced hypertension is a marker for improved outcomes in recurrent glioblastoma

Bevacizumab-induced hypertension is a marker for improved outcomes in recurrent glioblastoma

Researchers have found that bevacizumab-induced hypertension may be a predictive marker of improved outcomes in patients with recurrent glioblastoma who are treated with bevacizumab.

Potential therapy found for incurable pediatric brain tumor

Scientists have developed a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.

Chemotherapy after radiation slows progression of low-grade gliomas

A chemotherapy regimen of procarbazine, lomustine (CCNU), and vincristine (PCV) administered after radiation therapy improved both progression-free survival and overall survival in adults with low-grade gliomas.

Collaboration yields new methods to treat tumors with antennas

Two engineering researchers have challenged a commonly held idea about tumor ablation.

Survivors of childhood central nervous system cancer show affected self-identity

Survivors of childhood central nervous system cancer show affected self-identity

Patients treated for central nervous system (CNS) cancer during childhood or adolescence can display altered self-perception later in adulthood.

Wireless phone may increase risk of gliomas

Wireless phone may increase risk of gliomas

Risk of brain cancer is three times higher after 25 years or more of mobile phone use.

Radiation exposure during childhood increases risk of meningioma

Radiation exposure during childhood increases risk of meningioma

Exposure to radiation during childhood increases a person's risk for developing meningioma before the age of 30.

Drug targeting glioblastoma to begin clinical trial

A new drug breakthrough could extend the life of people living with glioblastoma, the most aggressive type of brain cancer.

Targeting a unique receptor promising for glioblastoma multiforme

Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.

Finding keys to drug therapy resistance in glioblastoma

Finding keys to drug therapy resistance in glioblastoma

Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumor's epigenetic signature.

Repurposing antidepressant may target new medulloblastoma pathway

New research suggests that an antidepressant medication, repurposed, could target a novel molecular pathway that causes an aggressive form of medulloblastoma.

Brain mets: Time for a new approach

Brain mets: Time for a new approach

A blue-ribbon team of national experts stated that professional pessimism and out-of-date myths rather than current science may compromise the care of patients with brain cancer.

Triple therapy revs up immune system against a common brain tumor

A triple therapy for glioblastoma, consisting of two types of immunotherapy and targeted radiation, has significantly prolonged the survival of mice with these brain cancers, according to a new report.

Brain tumors hijack the brain's blood supply

Dangerous brain tumors hijack the brain's existing blood supply throughout their progression, according to new research.

A possible explanation for why brain tumors are more common, and more harmful, in males

A possible explanation for why brain tumors are more common, and more harmful, in males

New research helps explain why brain tumors occur more often in males and frequently are more harmful than similar tumors in females. For example, glioblastomas, the most common malignant brain tumors, are diagnosed twice as often in males, who suffer greater cognitive impairments than females and do not survive as long.

A Single Protein Could Unlock New Treatments For Brain Cancer

A Single Protein Could Unlock New Treatments For Brain Cancer

New research shows the protein neurons use to stay alive and healthy is used by brain cancer cells to maintain longevity to grow and metastasize. The findings could lead to breakthroughs in treatments for brain cancer.

Glioblastoma cell migration reveals a potential drug delivery route through the blood-brain barrier

Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain's protective barrier, according to results of a study.

Five myths may compromise care of patients with brain metastases

Five myths may compromise care of patients with brain metastases

A blue-ribbon team of national experts on brain cancer said that professional pessimism and out-of-date myths rather than current science may compromise the care of patients with cancer that has metastasized to the brain.

Glioblastoma cell investigation may lead to new cancer treatments

Glioblastoma cell investigation may lead to new cancer treatments

Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression—this finding could ultimately lead to new ways to bring about the death of the tumor.

Tool assists brain cancer surgery

Tool assists brain cancer surgery

A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.

Glioblastoma tumors exhibit more cellular diversity than previously thought

An exciting new study has characterized the cellular diversity in glioblastoma tumors from patients, which may pave the way for the development of new treatments.

Autologous cancer vaccine extends survival in patients with newly diagnosed GBM

Autologous cancer vaccine extends survival in patients with newly diagnosed GBM

Final results from a phase 2 study show that adding Prophage autologous cancer vaccine to the standard-of-care treatment for newly diagnosed GBM improves survival.

Progesterone could be added to brain cancer therapies

Progesterone could be added to brain cancer therapies

The hormone progesterone could become part of therapy against the most aggressive form of brain cancer.

Small-molecule drugs cross the blood-brain barrier

A synthetic peptide carrier is a potential delivery vehicle for chemotherapy drugs for brain cancer and for other neurologic medications, according to new research.

Newly identified brain cancer mutation may can aid drug development

Researchers have identified a genetic mutation in brain cancer tumor cells that plays a role in both the growth and the death of the cell.

Optimal dosing for TMZ: 1 hour prior to RT versus bedtime

Optimal dosing for TMZ: 1 hour prior to RT versus bedtime

Is there a difference in dosing (1 hour prior to radiotherapy vs bedtime) with temozolomide plus radiotherapy for glioblastoma multiforme?

US and Australian Researchers Form Alliance to Facilitate Development of Treatments for Childhood Cancers

US and Australian Researchers Form Alliance to Facilitate Development of Treatments for Childhood Cancers

Alliance of Australian and U.S. researchers and children's cancer advocates focused on developing drugs as potential treatments for neuroblastoma, the most common solid form of childhood cancer.

Human fat may be a Trojan horse in the fight against brain cancer

Stem cells derived from human body fat have been successfully used to deliver biologic treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives.

Gene sequencing discovers mutations tied to deadly brain tumors in young children

New mutations in pediatric brain tumors known as high-grade gliomas have been identified, and most often occur in the youngest patients.

Adult cancer drug offers hope against aggressive pediatric brain tumor

The quest to improve survival of children with a high-risk brain tumor has led investigators to two drugs already used to treat adults with breast, pancreatic, lung, and other cancers.

Gene sequencing discovers common driver of childhood brain tumor ependymoma

Gene sequencing discovers common driver of childhood brain tumor ependymoma

The most common genetic alteration ever reported in the brain tumor ependymoma has been identified. Researchers also have evidence that the alteration drives tumor development.

Gene mutation defines brain tumors that benefit from aggressive surgery

Patients with malignant astrocytoma whose tumors carry the gene mutation IDH1 may benefit greatly from surgical removal of the largest possible amount of tumor.

Lightwaves improve brain tumor surgery

First-of-its-kind research shows promise for developing a method to clearly identify cancerous tissue during surgery. These findings may potentially improve outcomes for those undergoing surgery to remove glioblastoma multiforme.

Breast cancer spreads to the brain by disguising itself as neurons

Breast cancer spreads to the brain by disguising itself as neurons

Years can pass between the time a breast cancer patient goes into remission and a related brain tumor develops. During that time, the breast cancer cells somehow escape detection.

Targetable mutation identified in rare brain tumor

A gene mutation associated with several types of cancer also may be responsible for a rare but debilitating brain tumor called papillary craniopharyngioma.

Cancer stem cells targeted in malignant brain tumors

Researchers have also created an experimental vaccine to attack immune system targets related to cancer stem cells, the cells from which malignant brain tumors are believed to originate and regenerate.

Personalized vaccine for most lethal type of brain tumor shows promise

Personalized vaccine for most lethal type of brain tumor shows promise

Patients with recurrent GBM treated with an experimental vaccine made from the patient's own resected tumor tissue showed an improved survival compared with historical patients who received the standard of care alone, according to an analysis of a phase 2 trial of this vaccine.

Targeting the mTOR pathway could treat pediatric gliomas

A known genetic pathway is active in many difficult-to-treat pediatric brain tumors known as low-grade gliomas. This finding offers a potential new target for the treatment of these cancers.

New technique allows breast cancer drugs to cross the blood-brain barrier

A new approach selectively permeabilizes the blood-brain barrier at sites of brain metastases, even those 200 times smaller than currently detectable in the clinic.

Avoiding a specific brain region preserves memory during WBRT

Limiting the amount of radiation absorbed in the hippocampal portion of the brain during whole-brain radiotherapy (WBRT) for brain metastases preserves memory function in patients for up to 6 months after treatment.

Survival improved by stereotactic radiosurgery alone in adults under 50 years with limited brain metastases

Overall survival was improved for adults age 50 years and younger with brain cancer who were treated with stereotactic radiosurgery that was not combined with whole-brain radiotherapy.

Promising therapeutic target for meningioma brain tumors

A specific protein has been found in nearly 100% of high-grade meningiomas, which is the most common form of brain tumor. This finding suggests a new target for therapies for a cancer that does not respond to current chemotherapy.

Inflammatory protein converts glioblastoma cells into the most aggressive version

A prominent protein activated by inflammation is the key instigator that converts glioblastoma multiforme cells to their most aggressive, untreatable form and promotes resistance to radiation therapy.

New therapy strategy for breast cancer that has spread to the brain

Cellular therapy and gene therapy have been successfully combined in a mouse model to develop a viable treatment strategy for breast cancer that has spread to a patient's brain.

Genes that drive brain cancer revealed

About 15% of patients with glioblastoma could receive personalized treatment with drugs currently used in other cancers, based on new research that has identified 18 genes responsible for driving glioblastoma multiforme.

Percentage of cancers linked to viruses potentially overestimated

A large-scale analysis of the association between DNA viruses and human malignancies suggests that many of the most common cancers are not associated with DNA viruses

Brain tumors in children have a common cause

When 96 pilocytic astrocytomas were analyzed by whole-genome sequencing, all had MAPK-pathway alterations. This indicates that pilocytic astrocytoma is predominantly a single-pathway disease.

Virus plus rapamycin kills glioblastoma stem cells

An oncolytic virus infected and killed both brain cancer stem cells and differentiated compartments of the common and deadly malignant brain tumor, glioblastoma multiforme (GBM), when combined with the immunosuppressant drug rapamycin.

Aggressive brain cancer growth driven by metabolic enzyme

An abnormal metabolic pathway drives the growth of cancer cells in a particular glioblastoma subtype, according to new research.

Early poliovirus vaccine trial promising for recurrent glioblastoma

Attacking glioblastoma brain tumor cells with a modified poliovirus is showing encouraging early results in an ongoing study.

Bone marrow produces glioma treatment

Genetic material secreted by bone marrow cells was used to reduce glioma tumor volume in a recent study.

Personalized brain mapping technique preserves function after brain tumor surgery

The imaging technique of DTI allows neurosurgeons to visualize important pathways in the brain. This allows them to better adapt brain tumor surgeries and preserve language, visual function, and motor function while removing cancerous tissue.

Low T3 syndrome predicts unfavorable outcomes in surgical patients with brain tumor

Among patients undergoing surgery for a brain tumor, low T3 (triiodothyronine) syndrome has been found to be predictive of unfavorable clinical outcomes and depressive symptoms.

Poor thyroid function foretells worse outcome after brain-tumor surgery

Low levels of the thyroid hormone triiodothyronine (T3) predict unfavorable outcomes after neurosurgery for the treatment of brain tumors.

Stem cells from fat may aid glioblastoma treatment

Adipose tissue may provide a more efficient, less costly, and less invasive source of mesenchymal stem cells (MSCs) than bone marrow.

Dasatinib thwarts brain cancer metastasis after bevacizumab use

Combining the antiangiogenic bevacizumab with the kinase inhibitor dasatinib stopped glioblastoma metastasis after shrinking the tumors.

5-ALA fluorescence guide improves resection of glioblastoma multiforme

Fluorescence form 5-aminolevulinic acid (5-ALA) has been used to guide resection of recurrent GBM. Before surgery, the patient ingests 5-ALA, then the tumor cells fluoresce intraoperatively in response to certain wavelengths of light.

Genomic sequencing identifies mutant 'drivers' of meningioma brain tumors

Large-scale genomic sequencing has revealed two DNA mutations that appear to drive about 15% of brain tumors known as meningiomas.

Using a growth forecast to predict brain tumor response to treatment

The forecast enables physicians to rapidly identify how well a tumor is responding to a particular therapy and allows a quick pivot to a new therapy in a critical time window if the current therapy is not effective.

ELTD1 protein may be new biomarker for glioma

ELTD1, a protein linked with angiogenesis, is the strongest candidate for a significant association with glioma out of nearly 200 possible markers.

Understanding brain tumor growth opens the door for nonsurgical treatment

Researchers have, for the first time, identified a new group of growth factor receptors that signal to brain tumors, which brings treatment of neurofibromatosis type 2 one step closer to a nonsurgical therapeutic option.

Smaller radiation fields can spare brain when treating tumors

Patients with aggressive brain tumors can be effectively treated with smaller radiation fields to spare the rest of the brain and preserve cognition.

Smaller radiation fields OK for glioblastoma treatment

Smaller radiation fields OK for glioblastoma treatment

For patients receiving radiotherapy for glioblastoma, use of clinical target volume margins as small as 5 mm does not lead to an increase in marginal failures.

PET imaging helps guide glioma treatment

Imaging with 18F-FLT positron emission tomography provides tumor-specific details accurately and noninvasively in persons with gliomas.

Study findings reveal key characteristics of meningiomas during pregnancy

Hemodynamic changes associated with pregnancy explain the growth of benign tumors in pregnant women. The study also identified some key characteristics associated with rapid growth of meningiomas in pregnant women.

Clues to cause of pediatric gliomas revealed

A cell growth pathway that is unusually active in pediatric brain tumors known as gliomas has been identified. This same growth pathway was previously identified as a critical contributor to brain tumor formation and growth in neurofibromatosis-1.

Uninsured with brain tumors have higher post-op mortality

Uninsured with brain tumors have higher post-op mortality

Insurance coverage affects in-hospital mortality for brain tumor patients undergoing craniotomy.

Everolimus shrinks astrocytoma brain tumors

The mTOR inhibitor dramatically reduced the volume of subependymal giant cell astrocytomas (SEGAs) in persons with tuberous sclerosis complex.

Repeat glioblastoma surgeries may prolong life

Persons with glioblastoma who undergo repeated resections can have improved survival, indicate the findings of a recent study.

ONS Connections: Instrument can measure needs of caregivers of neuro-oncology patients

A needs assessment tool can identify specific needs of caregivers of patients with a primary malignant brain tumor.

Early surgery for low-grade gliomas better than waiting

A facility favoring early surgical resection of low-grade glioma had better overall survival rates than did a facility favoring watchful waiting.

Aggressive brain tumors can originate from a range of nervous system cells

Glioblastoma multiforme tumors can originate not only from the glial cells that make up the supportive tissue of the brain and from neural stem cells, but also from other types of differentiated cells in the nervous system, including cortical neurons.

FDA Update - September/October 2012

FDA Update - September/October 2012

News from the FDA on bosutinib (Bosulif), ziv-aflibercept (Zaltrap), and everolimus oral suspension tablets (Afinitor Disperz).

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