Long-Term Eltrombopag Increases Platelet Counts, Decreases Bleeding in ITP

Previous studies determined the effectiveness of 6 months of therapy with eltrombopag in patients with ITP. In this analysis, researchers extended 4 clinical trials to assess efficacy and safety of eltrombopag therapy for more than 6 months in patients with ITP.

New Class of Clinical Trial Enhances Research on Cancer Care Delivery

What is a CCDR clinical trial and how does it differ from clinical trials that test new drugs?

Nivolumab Provides Better Long-Term Efficacy Compared With Docetaxel in NSCLC

Two phase 3 studies reveal the clinical benefit, safety profile, and overall survival of nivolumab and docetaxel for patients with squamous and nonsquamous NSCLC.

High Rates of Adverse Events Lead to Earlier Dropouts in Phase 1 Cancer Trials

Phase 1 trials are used to determine the safety profiles of treatment regimens. In this retrospective review, investigators sought to understand the reasons participants in these studies drop out.

Invisible Burdens: The Complex Needs of Caregivers of Patients With Brain Cancer

Caregivers of patients with malignant brain tumors often bear additional burdens in their role, as these patients often experience cognition-related adverse effects as well as the effects of their cancer and its treatment.

Zika Virus Preferentially Targets Glioblastoma Stem Cells

Researchers have determined that, relative to differentiated tumor progeny or normal neuronal cells, ZIKV preferentially infects and kills GSCs.

Carfilzomib Improves Overall Survival in Relapsed/Refractory Multiple Myeloma

The first interim analysis of the ENDEAVOR trial reported superiority of carfilzomib in some outcomes; however, data on overall survival were not available. This second interim analysis reports on overall survival with carfilzomib for patients with relapsed/refractory multiple myeloma.

More Patients Enrolled in Cancer Trials Under ACA

Insurer approval rates rose from 85 percent before Affordable Care Act to 95 percent after the health care bill was enacted.

Rates at Some Milestones May Indicate Clinical Trial Results for Immunotherapeutics

An analysis of rates at certain milestones in clinical trials of treatments for mNSCLC suggests these rates reflect end point results for immunotherapies vs targeted and conventional therapies.

Savolitinib Active, Tolerable in Subset of Advanced Papillary Renal Cell Cancer

Results of a phase 2 clinical trial of savolitinib, a highly selective small molecule inhibitor of c-Met, found the agent was active and tolerable in patients with Met-driven advanced or metastatic papillary renal cell carcinoma (PRCC).

Clinical Trials May Benefit Oncology Patients

Research on the effects of research demonstrated that oncology-related clinical trials provide measurable benefits in terms

Older Patients Under-Represented in Cancer Drug Clinical Trials

Older adults are underrepresented in clinical trials of cancer drugs, according to study findings presented at the 2017 ASCO Annual Meeting.

Older Adults Under-Represented in Cancer Drug Clinical Trials

Patients aged 80 years and older had a cancer incidence of 16% in 2013 yet made up only 4% of cancer drug clinical trial participants during 2005-2015.

Cognitive Computing Expedites Matching Patients to Clinical Trials

IBM Watson for Clinical Trial Matching compares study enrollment criteria with patient data in electronic medical records.

Spherical Shape of New Drug Holds Promise for Bypassing the Blood Brain Barrier and Treating Aggressive Brain Cancer

An investigational drug with a novel spherical nucleic acid structure has the potential to cross the blood-brain barrier to treat glioblastoma multiforme.

IL-11 Plus Glucocorticoids Safe, Effective for ITP in Adults

Recent study results demonstrate that recombinant IL-11 with glucocorticoids is a safe and effective treatment for idiopathic thrombocytopenic purpura (ITP) in adults.

Cognitively Engaging Activities Often Discontinued After Treatment of Primary Brain Tumors

Survivors of primary brain tumors tend to freely discontinue cognitively engaging activities to compensate for diminishing cognitive function after treatment completion.

Research Shows Temozolomide Has Potential to Increase Depression

Temozolomide, an antimitotic chemotherapy used to treat brain cancer, demonstrated the potential to increase depression in a mouse model.

Durable Response Seen in Advanced HCC With Nivolumab

New data presented at the International Liver Congress 2017 suggest that nivolumab may produce long-term benefits in sorafenib-experienced patients with advanced HCC.

Radiation Protocol Deviations Linked to Worse Outcomes in Pediatric Brain Malignancy

Deviation from radiation treatment protocol in young children being treated for brain neoplasms was associated with decreased overall survival.

High-Dose Vitamin C Infusions Increase Cancer Cell Sensitivity to Chemotherapy, Radiation

Regular infusions of high doses of vitamin C safely increased cancer cell sensitivity to treatment in patients with brain and lung cancers.

Barriers in Routine Care Coverage for Cancer Clinical Trial Participants Still Exist

Despite the ACA mandate on coverage for clinical trial participants, many facilities involved in cancer research still coping with insurance denials for participants.

National Brain Tumor Society Launches Brain-Tumor Clinical Trial Finder

NBTS launched a clinical trial finder specific to brain tumors to engage patients in research and clinical trials.

CTCs Promising as Biomarker to Identify Lung Cancer Recurrence

Prospective pilot study demonstrates accuracy of circulating tumor cells as a biomarker indicating lung cancer recurrence.

Temozolomide With Radiotherapy for Glioblastoma Provides Some Survival Benefit in Elderly

The addition of temozolomide to short-course radiotherapy in elderly patients with glioblastoma was associated with some survival benefit compared with radiotherapy alone.

Characteristics of Clinical Trials and Barriers to Patient Enrollment Identified

Study identifies characteristics of clinical trials and barriers to patient accrual.

No Connection Found Between CMV Infection and Aggressive Brain Cancer

A recent analysis of tumor tissue samples from patients with glioblastoma and glial cancer indicate no association between CMV infection and brain cancer.

Women May Significantly Benefit from Entering OB/GYN Clinical Trials

The researchers hope the results will lead to an increase in clinicians offering trials to their patients and an increase in women volunteering to participate in trials.

VBPWPs Can Compliment Patient Management in Clinical Trials

Video Based Personal Webpages (VBPWP) Can Be Used as a Compliment to Clinical Trial Patient Management

Clinical Trial Enrollment of Adolescent and Young Adult Patients With Cancer: A Systematic Review of the Literature and Proposed Solutions

[Clinical Oncology in Adolescents and Young Adults] This research evaluates methods that have been utilized in the clinical trial enrollment for adolescent and young adults with cancer.

Anti-malaria Drug Chloroquine May Help Combat Some Brain Tumors

Adding the anti-malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize glioblastoma patients to targeted treatments that had previously stopped working.

Subtype of Glioblastoma Multiforme Responds to Antiangiogenic Chemotherapy

Although previous clinical trials have demonstrated that antiangiogenetic chemotherapy is not effective in GBM, researchers conducted a retrospective of review of perfusion MR images to determine if a phenotypic subtype of GBM may respond to antiangiogenic chemotherapy.

Video Tool to Increase Breast Cancer Clinical Trial Participation Among Black Women

A new tool may show promise for improving clinical trial participation among black women with breast cancer, according to a study presented at the 2016 San Antonio Breast Cancer Symposium (SABCS).

Combination of Gemcitabine and New CHK1 Inhibitor Is Effective in Soft Tissue Sarcomas

In a phase 1 clinical trial, the combination produces a significant and long-lasting response in patients with advanced disease including metastases to the peritoneum and lung.

Panobinostat, Bortezomib, Thalidomide Efficacious in Relapsed Myeloma

In this study, researchers sought to improve the safety of panobinostat plus bortezomib and dexamethasone for relapsed or relapsed and refractory multiple myeloma.

Caregiver Mastery Linked to Patient Survival in Glioblastoma

An analysis of data from caregivers and patients participating in a longitudinal study funded by the National Institutes of Health examines whether caregivers' anxiety, depressive symptoms, burden, and mastery influence survival for patients with newly diagnosed glioblastoma multiforme.

CDK4/6 Inhibitor Plus Aromatase Inhibitor Improves Progression-Free Survival in Metastatic Breast Cancer

Adding ribociclib to letrozole significantly improves progression-free survival for postmenopausal women with metastatic hormone receptor (HR)-positive breast cancer, compared with hormone therapy alone.

Cancer Patients Have Unrealistic Hopes When Entering Clinical Trials

Questionnaires completed by patients with cancer considering enrollment in early-stage clinical trials indicate they may have unrealistic expectations.

Affordable Care Act Tied to Increased Breast Cancer Care Access for Hispanics

Following the release of the Affordable Care Act (ACA) an increase in Hispanic women receiving breast cancer treatment and their related participation in clinical trials was observed.

Medicaid Insurance Linked to Worse Outcomes for Patients With Glioblastoma Multiforme

Insurance status influences overall patient survival for some cancer types, but its impact on glioblastoma multiforme (GBM) survival is well documented. This research study explored the possible impact of insurance on GBM survival.

Postop RT Deferral Associated With Worse Survival in Children With Medulloblastoma

Despite the use of adjuvant chemotherapy, deferral of postoperative radiotherapy is associated with worse survival in pediatric patients with medulloblastoma.

Dual Antigen Targeting by CAR T Cells Improves Immunotherapeutic Technique

Chimeric antigen receptor (CAR) T cells may have improved therapeutic potential when they have 2 targets, according to preclinical findings using a mouse model.

How Can We Have a Cancer Cure Moonshot if We're Short of Fuel?

Cancer research relies of patients with cancer to participate in clinical trials. However, many patients cite various fears and misconceptions — some supported by physicians - as reasons for why they decline to participate in clinical trials.

Increasing Numbers of Older Cancer Survivors Challenge Clinical Trial Participant Criteria

Improved cancer detection and advances in treatment mean larger numbers of older cancer patients are becoming survivors, combined with demographic trends. But older patients are underrepresented in clinical trials.

Poor Sleep Quality Negatively Impacts Some Adverse Effects in Patients With Advanced Cancer

Patients participating in early-phase clinical trials should be assessed for sleep quality, as poor sleep quality is associated with greater fatigue, symptom burden, and mood disturbance.

High Blood Sugar Associated With Lower Risk of Meningioma

Benign brain tumors that have previously been associated with obesity and diabetes are surprisingly less likely to emerge in patients with high blood sugar, according to new research.

Analysis Shows Better Integration Needed Between ClinicalTrials.gov and Drugs@FDA

Although Drugs@FDA may be useful for validating trial primary outcomes found on ClinicalTrials.gov, Drugs@FDA lacked information on secondary outcomes and adverse events, including deaths, according to an analysis of data from 100 trials available on both websites.

Extent of Resection Influences Length of Progression-Free Survival in Glioblastoma

Gross total resection to treat glioblastoma multiforme (GBM) showed progression-free survival benefits over subtotal resection and biopsy in a meta-analysis of 37 studies.

Novel Antibody-Drug Conjugate Bridges Patients With Relapsed ALL to Stem Cell Transplant

In a randomized phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with ALL whose disease had relapsed following standard therapies, qualified for stem cell transplants after treatment with the drug.

DECT Trial Results Show Trastuzumab Plus Anthracyclines Are Efficacious in HER2+ Breast Cancer

Results from the DECT trial indicate that a combination of epirubicin and trastuzumab improved outcomes in patients with HER2-positive breast cancer.

Outcomes in Clinical Trials Using Precision Medicine Demonstrate Effectiveness of Modality in Patients With Cancer

A meta-analysis of hundreds of cancer clinical trials revealed that therapeutic approaches using precision medicine had improved responses and longer disease remission, even in phase I trials.

Surrogate End Points Are Poor Predictors of Survival in Cancer Drug Approval

US FDA standards demand that surrogate end points used in clinical trials be "reasonably likely to predict" survival for accelerated approval, or be established proxies for survival for traditional approval; however, surrogate end points used frequently lack formal study.

Daratumumab in Combination With Standard-of-Care Treatment Significantly Improves Outcomes in Patients With Multiple Myeloma

Daratumumab in combination with the standard-of-care treatment regimen reduced risk of disease progression or death by 63% compared with the standard-of-care regimen alone in patients with multiple myeloma who had received at least 1 prior line of therapy.

Vaccine Enters Phase I Study for Safety and Effectiveness in Multiple Myeloma

A third clinical trial is beginning for phase I testing of SurVaxM, a cancer vaccine. This trial tests for safety and effectiveness of the vaccine in combination with lenalidomide as maintenance therapy for adults with multiple myeloma.

Prognostic Index Will Improve Clinical Practice Management of Patients With CLL and in Clinical Trials

An international consortium devised an international prognostic index for chronic lymphocytic leukemia (CLL-IPI) that combines genetic, biochemical, and clinical parameters into a prognostic model to enable more targeted management of patients with CLL.

Exercise is as Effective in Treating Metastatic Prostate Cancer as Medication

Physical exercise may have a direct effect on cancer that is as effective as drugs for treating patients with prostate cancer, even for those with advanced stages of the disease.

Potential Survival Advantage Observed for 177Lu-Dotatate in Midgut Neuroendocrine Tumors

NETTER-1 trial results of the somatostatin analogue peptide, 177Lu-DOTA0-Tyr3-octreotate (177Lu-Dotatate), suggest a potential survival benefit in patients with advanced midgut neuroendocrine tumors (NETs), attendees at the ASCO 2016 Annual Meeting were told.

Personalized Medicine Approach Not Straightforward in Glioblastoma

The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers, attendees were told in a poster discussion session at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting.

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.

Precision Medicine Linked to Better Outcomes in Early Trials

Patients whose treatment was based on the molecular characteristics of their particular tumor had significantly better outcomes compared with patients who did not.

Eight Immune Genes Identified As Playing a Role in Glioblastoma

Discovery might eventually lead to better treatment for glioblastoma multiforme

Many Americans Have Reservations About Clinical Trials

Only 40 percent of those polled had favorable view of these studies, but the number rose when they received more information.

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

Experimental Targeted Therapy Succeeds in Rare Pediatric Cancer

The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.

Tumor Regression Achieved With LOXO-101 in Phase 1 Study

Tumors of varied types of genetically defined cancer were significantly reduced by the drug LOXO-101, according to phase 1 study results.

Phase 1 Study Results Show CAR T-cell Therapy Promising in Solid Brain Tumors

Glioblastoma tumors were successfully infiltrated by investigational CAR therapy with an acceptable safety profile.

Research Unit Aims To Train Nurses to Provide Better Care to Clinical Trial Patients

A research unit created by oncology nurses trains nurses to provide high quality care to patients in oncology clinical trials.

Clinical Trial Infusion Nurse Orientation Improves Care for Patients in Investigational Studies

A clinical trial infusion nurse orientation improves training for nurses so they can better care for patients participating in investigational trials.

Antibody Therapy Reduces Numbers of Cancer Stem Cells in Patients With Multiple Myeloma

Cancer stem cells that drive tumor growth were halved by MEDI-551, an experimental antibody treatment for multiple myeloma, according to results of a small preliminary clinical trial.

Shortened Radiation Therapy Schedule No Worse Than Conventional Radiotherapy in Low-Risk Prostate Cancer

Treatment with a hypofractionated radiotherapy (HRT) schedule achieved similar efficacy as treatment with the longer, conventional RT (CRT) schedule in men with low-risk prostate cancer.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

Altered Metabolism of Four Compounds Drives Glioblastoma Growth

The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.

Novel Drug Combination Inhibits Growth of MYC-driven Medulloblastoma

The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.

Novel Approach Harnesses Dendritic Cells to Treat Glioma

A next-generation immunotherapy may offer hope for treating high-grade glioma, an aggressive form of brain cancer that is notoriously hard to treat.

New Therapy Holds Potential for Neuroblastoma Treatment

A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.

Radiotherapy/Histone Deacetylase Inhibitor Combination Safe, Effective in High-grade Gliomas

Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.

Social Media Has Unrealized Potential for Clinical Trial Communication and Recruitment

The social media platform Twitter could develop into a useful tool for communicating with the public about cancer clinical trials and for recruiting participants.

Bevacizumab Plus Irinotecan Improves PFS in MGMT-positive Glioblastoma

Bevacizumab plus irinotecan significantly improved the 6-month progression-free survival (PFS) rate and median progression-free survival.

Combination of Immune Checkpoint Blockers Shows Promise in Lung Cancer

Combination therapy with durvalumab and tremelimumab demonstrated antitumor activity in 23% of 102 patients with lung cancer in a phase 1b trial, and toxicity was manageable.

Hypnosedation: An Alternative Sedation Method for Glioma Resection

This technique, which does not use pharmaceutical sedatives, can ease the perioperative discomfort and anxiety experienced by some patients undergoing fully awake craniotomy to remove glioma.

Interferon Has Little Benefit for Patients With Small Amounts of Melanoma in the Lymph Nodes

No evidence that interferon is necessary or helpful in cases of melanoma with minimal metastasis to the lymph nodes, according to the final results of the Sunbelt Melanoma Trial.

Pan-glioma Analysis Reveals Unique Subtypes of This Brain Cancer

Detailed new information about diffuse glioma has come from an international collaborative study, raising hopes for improved clinical outcomes from a better understanding of the disease.

Risk Factors of Suicidal Ideation in Patients With Brain Tumors

A past history of psychiatric disorders has been linked to suicidal ideation in patients with brain tumors.

Comprehensive Genetic Profiling Possible for Central Nervous System Tumors

New genetic testing can assist brain cancer treatment planning.

Proton Beam Therapy Treats Childhood Brain Cancer as Effectively as Standard Radiation

Treating medulloblastoma with proton beam therapy results in survival rates in line with other proton therapies, according to recent study data.

Targeted Hormone-radiation Treatment Shows Promise in Midgut Neuroendocrine Tumors

Tumor growth may be substantially slowed by the novel therapy 177Lutetium-DOTATATE (Lutathera), according to early results from a phase III study of patients with previously treated, advanced midgut neuroendocrine tumors.

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Phase 2 trial data showed acceptable toxicity and similar survival as conventional radiotherapy for childhood medulloblastoma.

Optical Probes That Illuminate Solid Tumors in Surgery Move One Step Closer to Reality

Optical probes that make cancer cells glow and improve surgical tumor removal are in phase I and II clinical trials in humans. The probes could be commonplace in the next 5 to 10 years, hypothesize the researchers.

Mapping Tumor Position During Lung Function Improves Radiation Therapy for Lung Cancer

A new clinical trial aims to apply advanced image analysis techniques to 4D CT scans. Already a standard step in targeting lung cancer radiotherapy, the trial seeks to use the scans map areas of lung function without additional testing.

Valproic Acid, Levetiracetam Do Not Improve Survival in Newly Diagnosed GBM

Valproic acid and levetiracetam do not improve survival outcomes in patients with newly diagnosed glioblastoma, according to a recently published study.

Certain Characteristics of Clinical Trials May Predict Poor Accrual of Participants

Researchers identified characteristics that may lead to low patient accrual for a clinical trial.

No Need to Exclude Patients With Renal Insufficiency From Clinical Trials

Excluding patients with renal insufficiency but good performance status from clinical trials due to concern of excessive hematologic toxicity or poor outcomes may not be necessary with appropriate dosing modifications.

Mandatory Biopsy May Hinder Eligibility of Potential Participants in Cancer-related Clinical Trials

Mandatory tumor tissue specimens and associated analyses for clinical trial participation appear to be a significant barrier to clinical trial enrollment and may delay treatment.

New Studies Reveal Long-Term Vision-related Health Concerns of Survivors of Childhood Retinoblastoma and Brain Cancer

Two new studies investigate the impact of retinoblastoma on long-term health of survivors and the long-term psychological and socio-economic effects of blindness in survivors of brain tumors.

Type of Electromagnetic Field Therapy Improves Survival for Patients With Brain Tumor

Progression-free and overall survival were prolonged with electromagnetic field and chemotherapy maintenance therapy in patients with a brain tumor.

Novel Test Offers Diagnostic and Disease Monitoring Potential for Rare Childhood Brain Cancer

A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor. It could also enable treatment monitoring without exposing patients to repeated doses of radiation.

Pembrolizumab Increases Overall Survival for PD-L1-positive, Advanced Non-small Cell Lung Cancer

A recent study examined the efficacy of pembrolizumab for the treatment of previously treated, PD-L1-positive, advanced non-small-cell lung cancer.

Extra Biopsies in Clinical Trials Often Have No Impact on Drug Dose or Use in Cancer Treatments

Extra biopsies performed solely to study the pharmacodynamics of a new anticancer drug have no impact on subsequent drug development or on how physicians use these new drugs to treat future patients.

Glioma Cells Self-organize Into Streams of Cells That Follow a Mathematically Predicted Pattern to Build Brain Tumors

Brain tumor cells can self-organize, according to new research. Glioma cells build tumors by self-organizing into streams 10 to 20 cells wide that obey a mathematically predicted pattern for autonomous agents flowing together.

Patient Education Prior to Oncologist Visit Improves Knowledge and Attitude Toward Clinical Trials

Patient education on clinical trials prior to the first oncologic visit improves knowledge, attitudes, and preparation for decision making about clinical trials.

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