Bone Metastasis

New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases

New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases

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Researchers demonstrate how breast cancer cells invade bone marrow, where they escape chemotherapy and hormonal therapies that would otherwise eliminate the cancer cells.

Skeletal-related Events Linked With Worse Survival, Increased Costs

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Men with prostate cancer and bone metastases that have experienced at least one skeletal-related event (SRE) show worse survival, according to a recent study.

Tumor Location and Duration of Therapy Influence Palliative Effects of Radiation Therapy for Painful Bone Metastases

Tumor Location and Duration of Therapy Influence Palliative Effects of Radiation Therapy for Painful Bone Metastases

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In a review of the Dutch Bone Metastasis Study results, stratified for primary tumor location, palliative radiation therapy was found to reduce pain and improve quality of life for some patients.

Researchers Find Pathway to Cancer-Associated Muscle Weakness

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Cancer researchers have identified the molecular pathways that lead to cancer-associated muscle weakness. When they inhibited TGF-β, muscle function improved in mouse models of human cancers.

Process of metastasis to bone in breast cancer is identified

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A new study may have uncovered the key to the early detection of patients at risk of developing metastasis to bone.

New procedure tested to relieve pain from cancer that has spread to spine

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A new study is testing a new combination treatment that uses directly applied radiation to ease the pain from cancer that has spread to the spine.

HIV drug blocks bone metastases in prostate cancer

HIV drug blocks bone metastases in prostate cancer

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Although prostate cancer can be successfully treated in many men, if the disease metastasizes to the bone, it is eventually lethal.

Exercise improves quality of life for patients with bone metastases

Exercise improves quality of life for patients with bone metastases

Resistance training and aerobic exercise programs specifically designed to avoid injuring fragile areas of bone metastases are safe.

For patients with breast cancer, oral bisphosphonates may reduce risk for developing bone metastases

For patients with breast cancer, oral bisphosphonates may reduce risk for developing bone metastases

Oral bisphosphonates to treat osteoporosis may also slow skeletal metastases caused by breast cancer.

Monitoring the response of bone metastases to treatment with MRI and PET

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The European Journal of Cancer has released a position statement on recent developments in MRI and PET and how these techniques can be used to detect bone metastases.

Single-fraction radiation therapy (SFRT) as effective as multiple-fraction (MFRT) for palliating bone metastases

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Standardizing prescribing practices for single-fraction radiation therapy (SFRT) for palliation of bone metastases could lead to cost savings and improvement in patients' quality of life, according to a new study.

Standard of care for delivering bisphophonates

Standard of care for delivering bisphophonates

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What is the preferred delivery protocol for breast cancer adjuvant bisphosphonates?

Engineered Nanoparticles Prevent Bone Cancer, Strengthen Bones

Engineered Nanoparticles Prevent Bone Cancer, Strengthen Bones

Nanomedicine technologies were utilized to develop a drug-delivery system that precisely targets and attacks cancer cells in the bone. It also increases bone strength and volume to prevent bone cancer progression.

Less frequent zoledronic acid for bone metastases safe, effective

Less frequent zoledronic acid for bone metastases safe, effective

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In patients with breast cancer who had previously received monthly intravenous bisphosphonate therapy for bone metastases for a year or longer, maintenance zoledronic acid administered every 12 weeks was noninferior to every 4 weeks.

Model predicts therapy outcomes for prostate cancer with bone metastasis

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A new computational model that simulates bone metastasis of prostate cancer has the potential to rapidly assess experimental therapy outcomes and help develop personalized medicine for patients.

Dasatinib with letrozole delays disease progression for some metastatic breast cancer

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Adding dasatinib to the standard antihormone therapy, letrozole, doubled the time before disease progressed for women with hormone receptor-positive, HER2-negative metastatic breast cancer. These results of a phase 2 clinical trial were presented at the 2013 San Antonio Breast Cancer Symposium.

Oral drug may improve survival for patients with prostate cancer

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An investigational prostate cancer treatment slows the disease's progression and may increase survival, especially among men whose cancer has spread to the bones. This study adds long-term survival and safety data for the drug tasquinimod, a new candidate for treating advanced and recurrent prostate cancer.

Guidance to prevent fractures in cancer-associated bone disease

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The epidemiology and pathophysiology of cancer-associated bone disease was reviewed in a new paper published by an International Osteoporosis Foundation (IOF) Committee of Scientific Advisors Working Group.

RT for bone metastases in terminal cancer: More is not necessarily better

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Despite long-running evidence demonstrating that a single session of radiotherapy provides just as much pain relief to patients with terminal cancer as multiple treatments, the method has yet to be adopted into routine practice.

Using palliative radiotherapy to relieve bone metastasis pain

Using palliative radiotherapy to relieve bone metastasis pain

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Management of bone metastasis is an increasingly common challenge. Palliative radiotherapy is proving to effectively relieve pain and improve quality of life for patients.

Trastuzumab: not just for HER2-positive breast cancer anymore?

The monoclonal antibody trastuzumab (Herceptin) may be effective against HER2-negative breast cancers in addition to HER2-positive disease.

Emerging cancer drugs may promote bone tumors

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New evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone. The drugs block survival signals that many cancer cells rely on to stay alive; however, targeting the same protein that makes tumors vulnerable to death also overactivates osteoclasts.

Zytiga approved for metastatic prostate cancer

The FDA has expanded the indication for abiraterone acetate (Zytiga tablets) to combat metastatic castration-resistant prostate cancer.

Denosumab extended survival in lung cancer with bone metastases

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Denosumab improved overall survival in persons with lung cancer and bone metastases more effectively than did zoledronic acid.

Aspirin helps in some cancers

Aspirin helps in some cancers

Differences in the impact of aspirin in various forms of cancer are highlighted in two studies recently published in the oncology literature.

Denosumab Better for Breast Cancer With Bone Metastases

Denosumab Better for Breast Cancer With Bone Metastases

Denosumab better prevents skeletal complications, ups health-related QoL versus zoledronic acid.

The Happy Crappy

The Happy Crappy

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As a patient reveals a difficult past and a wished-for possibility, her nurse ponders the struggle to find the right words to say in a delicate situation.

New drugs change treatment landscape for advanced prostate cancer

Several newly approved drugs plus more in the pipeline present the real possibility of prolonging survival in men with advanced prostate cancer.

PET clarifies difficult breast cancer cases

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Positron emission tomography (PET) can help pinpoint a breast cancer diagnosis and predict prognosis in an aggressive form of the disease.

Denosumab shown to delay bone metastases in prostate cancer

A monoclonal antibody that disrupts the activation of osteoclasts increased bone-metastasis-free (BMF) survival in men with prostate cancer in a recent large trial.

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