Bone Marrow

Drug induces morphologic, molecular, and clinical remissions in myelofibrosis

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Imetelstat, a novel telomerase-inhibiting drug, has been found to induce morphologic, molecular, and clinical remissions in some patients with myelofibrosis, according to a new study. The results were presented at the 2013 ASH Annual Meeting, in New Orleans.

How a common chemo drug thwarts graft rejection in bone marrow transplants

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The chemotherapy drug cyclophosphamide prevents graft-versus-host (GVHD) disease in people who receive bone marrow transplants through an immune system cell that evades the toxic effects of cyclophosphamide.

Chemotherapy nerve damage stops regrowth of blood stem cells

Chemotherapy-induced nerve injury in the bone marrow is what impairs the regeneration of hematopoietic stem cells, leading to anemia.

Bone marrow produces glioma treatment

Genetic material secreted by bone marrow cells was used to reduce glioma tumor volume in a recent study.

Stem cells from fat may aid glioblastoma treatment

Adipose tissue may provide a more efficient, less costly, and less invasive source of mesenchymal stem cells (MSCs) than bone marrow.

DNA-repair problems destroy hardy leukemia cells

Leukemia stem cells that overcome drug therapy can be thwarted when deprived of RAD52, a protein key to DNA repair of these cancer cells.

Only a few gene mutations important in leukemia

Most of the hundreds of mutations found in acute myeloid leukemia (AML) genomes occur randomly as part of the aging process, unrelated to cancer.

HIV drug can prevent complications after stem-cell transplant

An HIV drug helped lower the risk of graft-versus-host disease in persons with blood cancer who had stem-cell transplants to rebuild bone marrow.

High rate of leukemia in elderly may be due to stem cell aging

Hematopoietic stem cells from healthy persons older than 65 years make fewer immunoprotective lymphocytes than do stem cells from healthy persons aged 20 to 35 years.

Myelodysplasia gene mutation can aid diagnosis

The recent discovery of gene mutations in a genomic study of myelodysplastic syndromes could enable diagnosis using only a blood test rather than a bone marrow biopsy.

CV drug shows promise as a leukemia treatment

A vasodilator that blocks the activity of a protein called Rho kinase (ROCK) may be effective against difficult-to-treat types of leukemia.

New technology offers alternative to painful bone marrow procedures

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The OnControl Bone Marrow System has been made available by Vidacare for use by clinicians to perform bone marrow aspiration and biopsy procedures.

Diagnosis of non-Hodgkin's lymphoma

The non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of tumours of the lymphoid system and a relatively complex group of disorders. Presentation can be variable with many patients developing extranodal disease. The disease accounts for 4% of all cancer in the UK.

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