Bone Cancer

Defects in DNA Imprinting Affect Development and Progression of Childhood Osteosarcoma

Defects in DNA Imprinting Affect Development and Progression of Childhood Osteosarcoma

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Osteosarcoma in children may be impacted by a defect in DNA imprinting that also occurs in their biological parents. These imprinting defects may be predictive of survival outcomes.

Potential treatment option discovered for children with Ewing's sarcoma

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Combining two anti-tumor agents appears to increase the sensitivity of cancer cells to these drugs and seems to lead to more effective Ewing's sarcoma treatment.

Patients with rare bone cancer still have low survival rates

Patients with rare bone cancer still have low survival rates

Mesenchymal chondrosarcoma remains classified among the more deadly cancer types.

Potential therapeutic strategy against a very aggressive children's bone cancer

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Inhibiting the protein Sirtuin1 could play a part in fighting Ewing sarcoma, a common bone cancer in adolescents and children.

Single genetic abnormality important in Ewing sarcoma

Single genetic abnormality important in Ewing sarcoma

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Better understanding of the two distinct processes at the heart of the genetic abnormality driving Ewing sarcoma development could lead to new, more effective therapies.

PRM-151 therapy well tolerated by patients with advanced myelofibrosis

PRM-151 therapy well tolerated by patients with advanced myelofibrosis

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The compound PRM-151 (PRM) has shown success in reducing progressive bone marrow fibrosis in patients with advanced myelofibrosis.

Ortho-oncology team achieves successful hip articulation by repurposing a shoulder surgical aid

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A shoulder surgical aid, known as the Spider Limb Positioner, was adapted successfully to conduct a left hip disarticulation on a patient with melanoma.

Calcium isotope analysis predicts myeloma progression

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Researchers believe that a staple of Earth science research can be used in biomedical settings to predict the course of disease.

First-of-its-kind study shows higher concentration of trace elements in bone cancer

First-of-its-kind study shows higher concentration of trace elements in bone cancer

Researchers investigating the distribution of trace elements in the tissue of bone tumors found that tumor tissue contains higher concentrations of trace elements, which could be a starting point in the development of targeted therapies for bone cancer.

New type of whole body scan could improve treatment of bone marrow cancer

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A new type of magnetic resonance imaging (MRI) scan, known as diffusion-weighted MRI, could improve care for myeloma and reduce reliance on bone marrow biopsies.

Bone Cancer (Fact Sheet)

This fact sheet reviews bone cancer, including its possible causes, frequency, symptoms, diagnosis, and treatment.

Biomarker predicts immune response after stem cell transplants

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A biomarker accessible in blood tests has been identified and validated. It could be used to predict which patients who have received stem cell transplants are at the highest risk for the potentially fatal immune response of graft-versus-host disease.

Patient's pain eased by therapy that heats and destroys bone tumors

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Treatment with magnetic resonance image-guided focused ultrasound (MRIgFU) ablation therapy significantly reduced pain in 67% of patients who received the treatment.

Burden of giant-cell tumor of the bone reduced by denosumab

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When patients with giant-cell tumor of the bone were treated with denosumab, which is a drug targeted against a protein that promotes bone destruction, the number of tumor giant cells decreased and new bone formation increased.

Ridding cells of EYA3 boosts chemotherapy response in Ewing sarcoma

Scientists have identified a protein that makes some children and teenagers afflicted with Ewing sarcoma more resistant to chemotherapy.

Protein may predict chemotherapy response in osteosarcoma

The expression of the P16 protein, which inhibits cell growth, may be useful for predicting how osteosarcoma will respond to chemotherapy.

Colorectal risk defined for childhood cancer survivors

Childhood cancer survivors may need earlier colorectal cancer screening, especially if abdominal radiation was part of their treatment.

Bisphosphonates reduce fractures, pain of multiple myeloma

Adding bisphosphonates to myeloma treatment decreases fractures of the vertebra and bone pain, affirm the results of a review of 20 trials.

FDA Update: May/June 2012

Drug Safety Communication on lenalidomide (Revlimid); FDA approval for pazopanib (Votrient)

Prostate cancer drug beneficial in bone metastasis

Very early data are promising for a drug treatment for castration-resistant prostate cancer, with the agent showing particular effectiveness against tumors that have metastasized to the bone.

Childhood cancer survivors more likely to have future GI problems

People who underwent cancer therapy as children have a heightened risk of developing gastrointestinal (GI) complications later in life, a new study shows.

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