Biomarkers

Prolactin Expression May Indicate Better Prognosis for Patients With TNBC

Prolactin Expression May Indicate Better Prognosis for Patients With TNBC

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Expression of this hormone receptor may indicate a less aggressive subtype of triple-negative breast cancer and better prognosis for patients with the disease.

Biomarkers Predict Response to TKI Therapy for Metastatic Renal Cell Carcinoma

Biomarkers Predict Response to TKI Therapy for Metastatic Renal Cell Carcinoma

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Presence of certain microRNAs (miRNAs) is predictive of response to TKIs and prognosis for patients with metastatic renal cell carcinoma (mRCC).

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

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Genetic biomarkers from tumor DNA circulating in the bloodstream could indicate the risk for recurrence of colorectal cancer and the efficacy of chemotherapy after surgery.

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

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Patients with kataegis, a recently discovered phenomenon in which multiple mutations cluster in a few hotspots in a genome, have less invasive tumors and better prognoses.

Fluid-Based Biomarkers Found Highly Predictive of Diagnosis and Prognosis in Prostate Cancer

Fluid-Based Biomarkers Found Highly Predictive of Diagnosis and Prognosis in Prostate Cancer

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Analysis of proteins identified in urine has led to the discovery of proteomic signatures for prostate cancer that have the potential to serve as highly accurate noninvasive biomarkers that can identify aggressive disease before surgery.

Outcomes in Clinical Trials Using Precision Medicine Demonstrate Effectiveness of Modality in Patients With Cancer

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A meta-analysis of hundreds of cancer clinical trials revealed that therapeutic approaches using precision medicine had improved responses and longer disease remission, even in phase I trials.

Biochemical Marker Is a Better Predictor of Adverse Effects in Patients with Non-small Cell Lung Cancer

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Albumin concentration with an established cutoff point is proven a better predictor of both chemotherapy toxicity and survival in patients with advanced lung cancer.

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

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The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.

Proteins May Be Biomarkers for Ominous Change in Basal Cell Carcinoma

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Aggressive basal cell skin cancers have higher levels of both EZH2 and Ki67, suggesting these proteins have potential to serve as biomarkers for when basal cell carcinoma has become dangerous.

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

Disparities in Gut Microbiome Could Lead to Biomarkers for Estrogen-driven Breast Cancer

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Disparities in the gut microbiome between healthy people and women with estrogen-driven breast cancer may indicate possible biomarkers based on the microbiome that could help to mitigate the risk of certain cancers.

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers

[Biomarkers in Cancer] This research examines the emerging role of genomic rearrangements in breast cancer, with a particular focus on fusion genes, and explores the therapeutic value of such rearrangements and their significance as predictive and prognostic biomarkers.

Biomarker Tests Hindered by Lack of Sufficient Evidence and Regulation

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Precision medicine aims to deliver the most appropriate treatment to individual patients; however, biomarker tests that are poorly validated or inappropriately applied could hinder administration of appropriate treatments, and in some cases motivate the use of harmful treatment.

Biomarker for Class 1 Uveal Melanoma Correlates with Metastatic Disease

Biomarker for Class 1 Uveal Melanoma Correlates with Metastatic Disease

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A new biomarker measurement might improve the accuracy of prognostic testing and precision medicine in uveal melanoma.

Metabolic Phenotyping of Blood Plasma Enables Lung Cancer Detection

Metabolic Phenotyping of Blood Plasma Enables Lung Cancer Detection

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Unique metabolic biomarkers specific to lung cancer were found through metabolic phenotyping of blood plasma by proton nuclear magnetic resonance (H-NMR), enabling diagnosis of both early-stage and late-stage disease.

Biomarker Indicates Potential Benefits of Treatment Options in Advanced Colorectal Cancer

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A recently developed biomarker test for patients with advanced colorectal cancer could help determine the best treatment options for each patient.

Researchers Identify Tumor Signature That Serves as a Biomarker of at Least 5 Types of Cancer

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A methylation signature was identified in 5 types of cancer, and it likely occurs in more. These findings may aid in developing a blood test to diagnose cancer at early stages, when it is most treatable.

Serum HPV Antibody Levels May Be a Biomarker for Recurrent HPV-associated Oropharyngeal Cancer

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Among patients treated for oropharyngeal cancers linked to human papillomavirus (HPV) infection, at least 1 HPV-infection antibody could help identify those patients at risk for a recurrence of the cancer.

New Guideline from ASCO Addresses Use of Biomarkers for Early Breast Cancer

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A new clinical practice guideline on the appropriate use of tests for breast tumor biomarkers was issued by ASCO.

Development of Microtubulin Inhibitor Is a Potential Lead to Novel Biologic Therapy

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Gatastatin, an inhibitor specific for γ-tubulin, known to be overexpressed in some cancer cells, has been identified and holds potential for the development of anticancer agents.

Inherited Genetic Markers Predictive of Survival Prognosis for Patients with Melanoma

Inherited Genetic Markers Predictive of Survival Prognosis for Patients with Melanoma

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Prognosis for patients with cutaneous melanoma may be predicted by an inherited genetic marker providing a personalized tool to gauge a person's survival and determine if closer monitoring is needed in the years following surgery.

Biomarker Is Diagnostic of Early Lung Cancer and Prognostic of Survival

Biomarker Is Diagnostic of Early Lung Cancer and Prognostic of Survival

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Researchers identified a biomarker that detects the most common type of lung cancer in its earliest stage. The discovery could one day change how long lung cancer patients live.

TARC Confirmed as Biomarker of Response to PET, Brentuximab Vedotin in Hodgkin Lymphoma

TARC Confirmed as Biomarker of Response to PET, Brentuximab Vedotin in Hodgkin Lymphoma

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TARC levels correlated with PET-normalization in certain patients with Hodgkin lymphoma treated with brentuximab vedotin, a study indicates.

Protein Biomarker Assays for Diagnosing Thyroid Cancer May Show Inaccurate Readings

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To test thyroid malignancy, many biomarkers are tested separately to confirm cancer. However, new research shows that the tests used to measure 2 major biomarkers in the diagnosis of thyroid cancer may be inaccurate.

Precision Medicine Trial in Cancer Prevention Identifies Chemoprevention Strategy

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A team of scientists has reported that the genetic biomarker LOH is able to predict which patients with premalignant mouth lesions are at highest risk of developing oral cancer. The findings present a new tool that could be used to identify patients most likely to benefit from chemoprevention.

Breast Cancer Marker CK5 Also Marks Cisplatin-Resistant Ovarian Cancer

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The protein cytokeratin 5 (CK5), known to be a marker of poor prognosis in patients with breast cancer, also marks ovarian cancers likely to be resistant to the common chemotherapy cisplatin.

MACC1 gene is independent prognostic biomarker for survival in patients with Klatskin tumor

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Bile duct cancer is rare and usually detected too late; therefore, often only extensive liver surgery or, in rare cases, liver transplantation can help. Using the oncogene MACC1 as a biomarker, physicians now have a tool to help them decide if which surgical option is best for patients with one type of bile duct cancer.

Novel Prediagnostic Biomarker Identified for Non-Small Cell Lung Cancer

Novel Prediagnostic Biomarker Identified for Non-Small Cell Lung Cancer

Diacetylspermine was identified as serum biomarker, according to a new study published online.

Researchers discover a potential biomarker for AML relapse after stem cell transplant

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Targeting exhausted immune cells may change the prognosis for patients with AML relapse after a stem cell transplant, according to a recent study.

Finding biomarkers for early lung cancer diagnosis

Finding biomarkers for early lung cancer diagnosis

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Lung cancer diagnoses are often made only when the disease is already at an advanced stage and hard to treat. Researchers may be changing that by identifying biomarkers that could be the basis of early tests for lung cancer.

Novel diagnostic tool for ethnically diverse patients with non-small cell lung cancer

Novel diagnostic tool for ethnically diverse patients with non-small cell lung cancer

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A panel of five serum microRNAs has been identified as a potential biomarker to diagnose early stage non-small cell lung cancer.

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