Biological-Based Therapy

Early promise with new drug for cancers caused by viruses

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Specialized fat molecules, called sphingolipids, play a key role in the survival of aggressive lymphomas caused by viruses, according to new research.

Biological Therapies for Cancer (Fact Sheet)

This fact sheet provides an overview of how the immune system functions and examines biological therapies, including monoclonal antibodies, cytokines, therapeutic vaccines, cancer-killing viruses, gene therapy, and adoptive T-cell transfer as well as side effects.

Non-small cell lung cancer: Molecular targets and 
emerging options for care

Non-small cell lung cancer: Molecular targets and 
emerging options for care

This activity from myCME offers a review of groundbreaking molecular research and novel treatment options for patients with NSCLC.

Radiation effects could be gauged by small molecules in the blood

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Molecules in the bloodstream that might accurately gauge the likelihood of radiation illness after exposure to ionizing radiation have been identified. This animal study shows that X-rays or gamma rays alter the levels of certain molecules called microRNA (miRNA) in the blood in a predictable way.

Ibrutinib appears safe, effective against chronic lymphocytic leukemia

Ibrutinib, which targets the Bruton's tyrosine kinase to combat chronic lymphocytic leukemia, showed promising results in two phase II studies.

Nanoparticles show potential in photothermal therapy for colorectal cancer

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Electrically-conductive polymers, commonly used in solar energy applications, have been modified so that infrared light causes them to generate heat that can be used to kill colorectal cancer cells.

Abnormal gene that launches rare childhood leukemia is identified

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A fusion gene that is responsible for 30% of a rare subtype of childhood leukemia with an extremely poor prognosis has been identified. This finding offers the first evidence of a mistake that gives rise to a significant percentage of acute megakaryoblastic leukemia cases in children.

Individualized molecular portraits can match patients to clinical trials

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French researchers are taking advantage of the progress in genetic and molecular profiling to analyze the make-up of the tumors of individual cancer patients and then using the information to assign patients to particular treatments and phase I clinical trials.

Advanced melanoma controlled with chemotherapy/ immunotherapy combo

A combination of chemotherapy and immunotherapy appears to be a labor-intensive but feasible treatment for persons with metastatic melanoma.

Vaccine for existing HPV infection may thwart cervical cancer

A therapeutic vaccine for women who are already harboring human papillomavirus (HPV) appeared to fight cervical cancer in a small, phase 1 study.

Melanoma cells stay active by staying in the dark about drug damage

Melanoma cells are able to build up tolerance to chemotherapy by means of a genetic pathway that inhibits their detection of DNA damage.

Potential targets to treat squamous cell lung cancer

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Many potential targets for squamous cell lung cancer (SCLC) have been identified by The Cancer Genome Atlas (TCGA). The study involved a team of researchers from throughout the United States, plus the British Columbia Cancer Agency in Vancouver, British Columbia, Canada.

Injectable trastuzumab quicker than IV version

Subcutaneous delivery of trastuzumab (Herceptin) appears to be as safe and effective as the much more time-consuming intravenous system.

FDA Update - July/August 2012

News about pertuzumab injection (Perjeta); ondansetron (Zofran); carfilzomib (Kyprolis); Therascreen KRAS RGQ PCR Kit; Prostate Health Index (phi); and Prepopik

Interleukin-9 could inhibit melanoma

Mice without the genes responsible for the development of the T helper 17 (TH17) cell demonstrated significant resistance to melanoma tumor growth.

Bringing radiotherapy into the personalized medicine revolution

Bringing radiotherapy into the personalized medicine revolution

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Researchers are investigating the use of genomics to achieve better cure rates with less morbidity in patients undergoing radiation treatment.

Abscopal effect strengthens combination therapy in a melanoma patient

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Combination therapy may be a promising treatment approach for patients with advanced melanoma who experience the abscopal effect.

Imatinib helpful after interferon fails in CML treatment

A long-term study indicated that imatinib is the treatment of choice for people with chronic myeloid leukemia who do not respond to interferon.

Virus can target tumors without causing collateral damage

A recent trial indicates that a viral therapy delivered intravenously can consistently infect and spread within tumors without harming normal tissue in humans.

Alternative therapies are popular among breast cancer patients

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Women recovering from breast cancer choose biological-based therapies, according to findings published in Nursing Research (2010 Jan-Feb;59(1):58-66).

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