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BIDIL
CHF and arrhythmias
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Drug Name:

BIDIL Rx

Generic Name and Formulations:
Isosorbide dinitrate 20mg, hydralazine HCl 37.5mg; scored tabs.

Company:
Arbor Pharmaceuticals, LLC

Therapeutic Use:

Indications for BIDIL:

Heart failure (HF) in black patients, as adjunct to standard treatment, to improve survival, prolong time to hospitalization for HF, and improve patient-reported functional status.

Limitations Of use:

Not established in NYHA Class IV HF.

Adult:

Initially 1 tab 3 times daily, may reduce to ½ tab 3 times daily if not tolerated; titrate as tolerated after 3–5 days. Max 2 tabs 3 times daily.

Children:

Not established.

Contraindications:

Allergy to organic nitrates. Concomitant PDE5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil), or riociguat.

Warnings/Precautions:

Correct volume/salt depletion prior to initiation. Hypotension. Hypertrophic cardiomyopathy. Discontinue if syncope occurs. Give pyridoxine if peripheral neuritis occurs. Hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Severe hypotension with PDE5 inhibitors or riociguat.

Pharmacological Class:

Vasodilators (nitrate + direct-acting).

Adverse Reactions:

Headache (usually transient), dizziness, asthenia, nausea, vomiting, hypotension, sinusitis, tachycardia, paresthesia, amblyopia; SLE.

How Supplied:

Tabs—180

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