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AYGESTIN
Endometriosis
Menopause and HRT
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Drug Name:

AYGESTIN Rx

Generic Name and Formulations:
Norethindrone acetate 5mg; scored tabs.

Company:
Teva Pharmaceuticals

Therapeutic Use:

Indications for AYGESTIN:

Endometriosis.

Adult:

Initially 5mg daily for 2 weeks, then increase by 2.5mg/day every 2 weeks up to 15mg/day maintenance dose. Continue for 6–9 months unless breakthrough bleeding is intolerable.

Children:

Not applicable.

Contraindications:

Thromboembolic disorders. Hepatic dysfunction. Undiagnosed vaginal bleeding. Breast or genital carcinoma. Missed abortion. Pregnancy (Cat.X).

Warnings/Precautions:

Cardiac or renal dysfunction. Depression. Include Pap smear in pretreatment exam. Conditions aggravated by fluid retention. Discontinue if jaundice, visual disturbances, migraine, or thrombotic disorders occur. Nursing mothers.

Interactions:

Rifampin may increase metabolism.

Pharmacological Class:

Progestin.

Adverse Reactions:

Menstrual and cervical changes, edema, jaundice, rash, depression, mastodynia, decreased glucose tolerance, weight changes, thromboembolic disease, breakthrough bleeding, melasma, chloasma.

How Supplied:

Tabs—50

Indications for AYGESTIN:

Secondary amenorrhea, abnormal uterine bleeding due to hormonal imbalance without organic pathology.

Adult:

2.5–10mg daily for 5–10 days during 2nd half of theoretical menstrual cycle after estrogens if needed.

Children:

Not applicable.

Contraindications:

Thromboembolic disorders. Hepatic dysfunction. Undiagnosed vaginal bleeding. Breast or genital carcinoma. Missed abortion. Pregnancy (Cat.X).

Warnings/Precautions:

Cardiac or renal dysfunction. Depression. Include Pap smear in pretreatment exam. Conditions aggravated by fluid retention. Discontinue if jaundice, visual disturbances, migraine, or thrombotic disorders occur. Nursing mothers.

Interactions:

Rifampin may increase metabolism.

Pharmacological Class:

Progestin.

Adverse Reactions:

Menstrual and cervical changes, edema, jaundice, rash, depression, mastodynia, decreased glucose tolerance, weight changes, thromboembolic disease, breakthrough bleeding, melasma, chloasma.

How Supplied:

Tabs—50

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