Treatment with single-agent carfilzomib achieved durable responses in patients with relapsed/refractory multiple myeloma whose disease had relapsed after they received all available therapies (including bortezomib and immunomodulatory agents), suggesting that this agent has the potential to offer substantial clinical benefit. The data was presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

Bosutinib has therapeutic potential in the treatment of patients with Philadelphia chromosome-positive (Ph+) chronic-phase (CP) chronic myeloid leukemia (CML) with resistance to—or, particularly, intolerance to—other second-generation tyrosine kinase inhibitor (TKI) therapies, results of an open-label, phase 1/2 study presented at the 52nd American Society of Hematology Annual Meeting and Exposition has found.

Patients with pulmonary embolism (PE) are initially treated in the hospital with low molecular weight heparin (LMWH). Using Hestia criteria, however, they may be selected and safely treated as outpatients, results of a clinical study presented at the 52nd American Society of Hematology Annual Meeting and Exposition have found.

Both dasatinib (DAS) and imatinib (IM) are highly effective and generally well tolerated in patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP), results of an open-label phase 2 study presented at the 52nd American Society of Hematology Annual Meeting and Exposition have found.

Consolidation with yttrium-90 ibritumomab tiuxetan following dose-dense cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab (CHOP-R) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL) converted partial remissions (PR) to complete remissions (CR) and maintained durable responses with acceptable toxicity, according to a study presented at the 52nd American Society of Hematology Annual Meeting and Exposition..

Updated results from the phase 3b MAXIMA study provides additional support for utilizing rituximab maintenance every 2 months for 2 years following rituximab-containing induction therapy for patients with newly diagnosed or previously treated follicular lymphoma (FL). The data was presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

A study by Ronald Sobecks, MD, and colleagues at the Cleveland Clinic in Cleveland, Ohio, has been found that using IV busulfan (Bu) instead of oral Bu reduces variability in drug exposure and potentially improves safety. The study was presented at the 52nd American Society of Hematology Meeting and Exposition.

Hyperglycemia occurring during front-line treatment with nilotinib was usually mild, transient, manageable, and did not lead to treatment discontinuation in patients with chronic-phase chronic myeloid leukemia (CML-CP) with or without preexisting type 2 diabetes, according to a study presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

In patients with relapsed follicular lymphoma (FL), the addition of weekly bortezomib (Vc) to rituximab (R) was associated with statistically significant improvements in progression-free survival (PFS), response rate, and time to next anti-lymphoma treatment, results of a randomized phase 3 trial presented at the 52nd American Society of Hematology Annual Meeting and Exposition have found.

Bendamustine plus rituximab (B-R) demonstrated a superior progression-free survival benefit in patients with relapsed follicular, indolent, or mantle cell lymphomas when compared with fludarabine plus rituximab (F-R), final results of a randomized phase 3 study presented at the 52nd American Society of Hematology Annual Meeting and Exposition have confirmed.

Continuous lenalidomide treatment (MPR-R: melphalan, prednisone, and lenalidomide induction followed by lenalidomide maintenance) achieved a higher overall response rate (ORR) as well as better quality and more rapid responses than melphalan and prednisone (MP) in transplant-ineligible patients with newly diagnosed multiple myeloma. The data was presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

The combination of 5-azacitidine and vorinostat is safe and active in patients with newly diagnosed myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) ineligible for clinical trials because of poor performance status or the presence of other comorbidities, results of an ongoing study presented at the 52nd American Society of Hematology Annual Meeting and Exposition have found.

Alireza Eghtedar, MD, of the University of Texas in Houston, Texas, and colleagues conducted a study to evaluate the activity of INCB018424 in patients with advanced hematologic cancers and recently presented their findings at the 52nd American Society of Hematology Meeting and Exposition.

Hubert Serve of the Goethe University of Frankfurt in Frankfurt, Germany, and colleagues conducted a multicenter, randomized, placebo-controlled, double-blind, phase 2 trial in elderly (>60 years) AML patients to evaluate the effect of sorafenib in combination with standard chemotherapy and as a maintenance therapy for up to 1 year. The findings from this study were presented at the 52nd American Society of Hematology Meeting and Exposition.

Intravenous iron should be used for the treatment of patients with cancer-related anemia; those treated have better hematopoietic response and less need for transfusion, with no difference in mortality or adverse events, according to a study presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

Imatinib should be included in initial therapy of adult patients with Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL), final results of the largest single study of patients with Ph+ ALL have found. The study was presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

In patients with polycythemia vera (PV) and essential thrombocythemia (ET) refractory or intolerant to hydroxyurea, use of the JAK1/JAK2 inhibitor, INCB018424, results in rapid and durable clinical benefits, including normalization of hematologic parameters, resolution of splenomegaly, and alleviation of symptoms, long-term follow-up data from an ongoing open-label phase 2 study have found. The data was presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

Patients with myelodysplastic syndrome (MDS) previously treated with intensive regimens had responses to decitabine similar to those who were treatment-naïve, suggesting this population should be considered for this hypomethylating therapy, results of a retrospective analysis have found. The data was presented at the 52nd American Society of Hematology Annual Meeting and Exposition.

A high combined percentage of newly diagnosed patients with Philadelphia chromosome-positive (Ph+) chronic phase (CP) chronic myeloid leukemia (CML) treated with bosutinib or imatinib achieve major molecular response (MMR), complete cytogenetic response (CCyR), and complete hematologic response (CHR), with a relatively low incidence of generally manageable grade 3 events, results of a randomized, open label, phase 3 study presented at the 52nd American Society of Hematology Annual Meeting and Exposition have found.

Dasatinib continues to demonstrate superior efficacy compared with imatinib as initial treatment for patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP), results of an 18-month follow-up of the phase 3 DASISION comparative trial have shown. The data was presented at the 52nd American Society of Hematology Annual Meeting and Exposition.