Anti-Cancer Activity

Some breast cancer tumors hijack epigenetic machinery to evade drugs

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A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, according to researchers.

How diabetes drugs may work against cancer

How diabetes drugs may work against cancer

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Scientists have identified a major mitochondrial pathway that allows cancer cells to survive in a low-glucose environment.

Unexpected cell-hijack method revealed in pancreatic cancer

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Pancreatic stellate cells, which normally aid tissue repair, unwittingly help pancreatic cancer grow and spread in a method of cell hijack only seen before in brain and breast cancer, according to new research. The research also revealed that the process can be blocked, thereby preventing the growth and spread of the tumor.

Promising new approach discovered to treat leukemia

Promising new approach discovered to treat leukemia

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A group of researchers discovered a promising new approach to treating leukemia by disarming a gene that is responsible for tumor progression.

Grape seed promising against colon cancer

Grape seed promising against colon cancer

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Grape seed can aid the effectiveness of chemotherapy in killing colon cancer cells as well as reducing chemotherapy side effects, according to new research.

Drug-resistant tumors made vulnerable with cyclophosphamide

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The drug cyclophosphamide may make recurrent tumors vulnerable again after they have developed resistance to cancer drugs that work by recruiting antibodies from the body's own immune system.

How do cancer cells thrive in low-oxygen tumors?

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A new study has identified the molecular pathway that enables cancer cells to grow in areas of a tumor where oxygen levels are low, a condition called hypoxia.

Early promise with new drug for cancers caused by viruses

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Specialized fat molecules, called sphingolipids, play a key role in the survival of aggressive lymphomas caused by viruses, according to new research.

BMH-21 demonstrates potential in shutting down common cancer process

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A previously known but little-studied chemical compound targets and shuts down a common cancer process, according to recent research. In studies of laboratory-grown human tumor cell lines, the drug disrupted tumor cell division and prevented growth of advanced cancer cells.

Drug-antibody pair has promising activity in non-Hodgkin lymphoma

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A toxin linked to a targeted monoclonal antibody has shown compelling antitumor activity in patients with non-Hodgkin lymphomas (NHLs) who were no longer responding to treatment, according to a new report.

Intestinal bacteria reinforce chemotherapy

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The intestinal flora stimulates an person's immune responses to combat cancer during chemotherapy, according to newly published research.

Less exercise leads to higher breast cancer mortality

Less exercise leads to higher breast cancer mortality

In addition to infrequent exercise, a larger breast cup size was also linked with increased risk of breast cancer mortality in female runners and walkers.

Imaging studies may predict tumor response to antiangiogenic drugs

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Advanced imaging techniques may be able to distinguish which patients' tumors will respond to treatment with antiangiogenic drugs and which will not.

Resistance mechanism of colorectal cancer to bevacizumab detailed

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When colorectal cancer is targeted by the drug bevacizumab, tumors may switch dependence from VEGF-A (targeted by the drug) to related growth factors that include VEGF-C, VEGF-D, and placental growth factor.

Genetic details of leukemia resistance

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Two gene alterations pair up to promote the growth of leukemia cells and their escape from anticancer drugs, according to new research.

Nontoxic diet-and-oxygen combo prolonged survival in advanced cancer

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A regimen of ketogenic diet and hyperbaric oxygen therapy produced significant anticancer effects in a mouse model of systemic metastatic cancer.

Antibody therapy helps immune system fight tumors

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Regulatory T (Treg) cells that infiltrate tumors express proteins that can serve as targets for therapeutic antibodies, suggesting that treatments aimed at these immune cells could be a promising approach in cancer treatment.

Diet can thwart prostate 
cancer progression

Diet can thwart prostate 
cancer progression

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Men with early-stage prostate cancer may be able to inhibit tumor growth and progression by following a high-fiber diet.

Copper depletion therapy keeps high-risk triple-negative breast cancer at bay

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An anticopper drug compound that disables the ability of bone marrow cells to set up a "home" in organs to receive and nurture migrating cancer tumor cells has shown surprising benefit in high-risk triple-negative breast cancer.

Common genetic alteration in head and neck cancers may not be key to effective treatment

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Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, recently published data indicates that deregulation of this pathway does not necessarily signify that the tumor is dependent on it for survival and progression.

Stress can fuel prostate cancer

Behavioral stress can accelerate the development of prostate cancer and weaken the effectiveness of drugs designed to fight the disease.

Gold nanoparticles kill lymphoma without chemotherapy

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Lymphoma can be starved to death by depriving it of what appears to be a favorite food: HDL cholesterol. A new nanoparticle appears to the cancerous lymphoma cell like a preferred meal of natural HDL.

Aggressiveness of recurrent tumors driven by changes in immune system

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The traditional view is that recurrent tumors are resistant to therapy because they acquired additional genetic mutations that make them more aggressive and impervious to drugs. However, these research findings alter that view.

Sickle cells target both tumor and vasculature

Usually associated with potentially life-threatening diseases, sickle cells may actually be helpful in the fight against cancer.

Pomalidomide extends survival in multiple myeloma

A new immunomodulatory drug under FDA review significantly increased survival in persons with multiple myeloma, including older patients.

Zytiga approved for metastatic prostate cancer

The FDA has expanded the indication for abiraterone acetate (Zytiga tablets) to combat metastatic castration-resistant prostate cancer.

Study drug makes marrow transplant possible in relapsed leukemia

The final data from a phase II study confirmed the high degree of activity of quizartinib in persons with acute myeloid leukemia.

Ibrutinib appears safe, effective against chronic lymphocytic leukemia

Ibrutinib, which targets the Bruton's tyrosine kinase to combat chronic lymphocytic leukemia, showed promising results in two phase II studies.

Eribulin may be useful earlier in breast cancer

A drug used for metastatic breast cancer after several previous treatments may improve survival when administered earlier in the disease course.

Statin use may improve survival in inflammatory breast cancer

Persons with inflammatory breast cancer who were using statins at time of diagnosis had better progression-free survival than did nonusers.

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