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AMPYRA
Multiple sclerosis
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Drug Name:

AMPYRA Rx

Generic Name and Formulations:
Dalfampridine 10mg; ext-rel tabs.

Company:
Acorda Therapeutics

Therapeutic Use:

Indications for AMPYRA:

To improve walking in patients with multiple sclerosis (demonstrated by an increase in walking speed).

Adult:

Swallow whole. ≥18yrs: max 10mg every 12hrs.

Children:

<18yrs: not established.

Contraindications:

History of seizures. Moderate to severe renal impairment (CrCl ≤50mL/min). Previous allergies to 4-aminopyridine.

Warnings/Precautions:

Assess renal function before initiation; monitor at least annually. Mild renal impairment (CrCl 51–80mL/min): increased risk of seizures. Discontinue if signs/symptoms of anaphylaxis occurs. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

Interactions:

Discontinue other forms of 4-aminopyridine prior to initiating. Concomitant OCT2 inhibitors (eg, cimetidine) may potentiate the risk of seizures.

Pharmacological Class:

Potassium channel blocker.

Adverse Reactions:

UTI, insomnia, dizziness, headache, nausea, asthenia, back pain, balance disorder, MS relapse, paresthesia, nasopharyngitis, constipation, dyspepsia, throat pain; seizures (possible at higher doses), severe allergic reactions.

How Supplied:

Tabs—60

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