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Amiloride
Edema
Hypertension
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Drug Name:

Amiloride Rx

Generic Name and Formulations:
Amiloride HCl 5mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Amiloride:

Adjunct in edema where normokalemia is important.

Adult:

Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring. After initial diuresis, reassess therapy; may be given intermittently for maintenance.

Children:

Not recommended.

Contraindications:

Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy.

Warnings/Precautions:

Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test.

Pharmacological Class:

Diuretic (K+ sparing).

Adverse Reactions:

Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence.

Note:

Formerly known under the brand name Midamor.

How Supplied:

Contact supplier.

Indications for Amiloride:

Adjunct in hypertension.

Adult:

Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring.

Children:

Not recommended.

Contraindications:

Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy.

Warnings/Precautions:

Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test.

Pharmacological Class:

Diuretic (K+ sparing).

Adverse Reactions:

Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence.

Note:

Formerly known under the brand name Midamor.

How Supplied:

Contact supplier.

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