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Alprazolam INTENSOL
Anxiety/OCD
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Drug Name:

Alprazolam INTENSOL CIV

Generic Name and Formulations:
Alprazolam 1mg; per 1mL; concentrated soln.

Company:
Roxane Laboratories, Inc.

Therapeutic Use:

Indications for Alprazolam INTENSOL:

Anxiety.

Adult:

Mix with liquid or semi-solid food. Adjust at intervals of at least 3–4 days. ≥18yrs: initially 0.25–0.5mg 3 times daily; max 4mg daily in divided doses. Elderly, debilitated, or advanced liver disease: initially 0.25mg 2–3 times daily.

Children:

<18yrs: not recommended.

Contraindications:

Acute narrow angle glaucoma. Concomitant itraconazole, ketoconazole.

Warnings/Precautions:

Not for use in untreated open-angle glaucoma. Reevaluate periodically. Change dose gradually. Withdrawal symptoms on abrupt cessation or dose reduction. Suicidal ideation. Psychosis. Mania. Renal, cardiovascular, hepatic, pulmonary dysfunction (monitor). Obesity. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics, anticonvulsants, other CNS depressants. Potentiated by CYP3A inhibitors; reduce alprazolam dose; caution with cimetidine, nefazodone, fluvoxamine; caution with weaker CYP3A inhibitors (eg, fluoxetine, propoxyphene, oral contraceptives). Antagonized by CYP3A inducers (eg, carbamazepine). May increase levels of imipramine, desipramine.

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

CNS depression; impaired memory, coordination, or attention; dysarthria, ataxia, arthralgia, dyspnea, paradoxical excitement, increased salivation, withdrawal seizures, tremors, decreased libido, sexual dysfunction.

How Supplied:

Soln—30mL (w. dropper)

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