Aggressive Cancer

Genetic landscape can impact treatment for children with rare, aggressive cancer

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Precision medicine may help doctors determine the best treatment options for children with rare, aggressive, and advanced cancer. Information from a patient's entire genome helped personalize treatment options for children with cancer, according to a new study.

Researchers develop a more efficient process for identifying personalized bladder cancer treatment

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Researchers developed a way to personalize treatments for aggressive bladder cancer. Taking bladder tumors from individual patients, identifying actionable mutations, and grafting the tumors into mice, researchers were able to simultaneously test multiple therapies in the tumor models.

Organ transplant recipients more likely to develop aggressive melanoma

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Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant, and are three times more likely to die of the dangerous skin cancer, new research suggests.

Molecule that provides cellular energy found key to aggressive thyroid cancer

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Cancer researchers have identified a molecule linked to the survival of anaplastic thyroid carcinoma (ATC), a lethal tumor with no current effective therapies.

Gene regulatory path revealed as target for therapy of aggressive pediatric brain cancer

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Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.

Eribulin effective in metastatic breast cancer

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In treatment for metastatic breast cancer, eribulin is effective as a first-, second-, or third-line chemotherapy regimen.

New study suggests why pancreatic cancer is so aggressive

New study suggests why pancreatic cancer is so aggressive

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New study helps explain why pancreatic cancer is so lethal, with less than one-third of patients surviving even early stage disease.

Study findings show improved survival in aggressive acute myeloid leukemia (AML)

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Survival rates for patients who relapse in their battle with acute myeloid leukemia may benefit from therapies that combine an existing agent, cytarabine, with a newer compound, vosaroxin.

Radiation exposure linked to aggressive thyroid cancers

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For the first time, researchers have found that exposure to radioactive iodine is associated with more aggressive forms of thyroid cancer, according to a careful study of over a thousand individuals.

TCGA study of thyroid genome finds markers of aggressive tumors

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A new comprehensive analysis of thyroid cancer from The Cancer Genome Atlas (TCGA) Research Network has identified markers of aggressive tumors, which could allow for improved targeted therapy.

Prostate cancer treatment controversy continues as study finds watchful waiting not enough for some men

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An active controversy among oncologists concerns watchful waiting versus more active treatment for prostate cancer.

Patient and tumor characteristics in melanoma examined for clues to aggressive form of disease

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Researchers in Australia examined patient and tumor characteristics of melanomas for higher mitotic rates (a marker of tumor cell growth) in an effort to increase early detection.

Some aggressive cancers may respond to anti-inflammatory drugs

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New research raises the prospect that some cancer patients with aggressive tumors may benefit from a class of anti-inflammatory drugs currently used to treat rheumatoid arthritis.

A new target for aggressive bladder cancer found

A new target for aggressive bladder cancer found

An international team of scientists have discovered a faulty process in certain bladder cancers that could point to new ways to treat patients with an aggressive form of the disease.

Liquid biopsy tracks lung cancer

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Scientists have shown how a lung cancer patient's blood sample could be used to monitor and predict their response to treatment, which may pave the way for personalized medicine for the disease.

Vitamin D deficiency may have ties to aggressive prostate cancer

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Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in men who underwent their first prostate biopsy because of abnormal PSA test and/or DRE results.

Chronic inflammation may be linked to aggressive prostate cancer

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The presence of chronic inflammation in benign prostate tissue was associated with high-grade, or aggressive, prostate cancer.

Lack of vitamin D may increase risk of aggressive prostate cancer

Lack of vitamin D may increase risk of aggressive prostate cancer

Severe vitamin D deficiency linked with higher grade and stage of prostate tumors, according to research.

Fast and effective mechanism combats ovarian tumors

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A new type of strategy has been proposed to tackle an aggressive subtype of ovarian cancer by using a nanoscale drug-delivery system designed to target specific cancer cells.

Genetic mutation in prostate cancer linked to later aggressive cancer

Genetic mutation in prostate cancer linked to later aggressive cancer

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A new study examined how a genetic mutation in untreated patients is linked to aggressive prostate cancer later in life.

Potential cause found for deadly relapse of basal-like breast cancer

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Researchers have discovered why some of the most aggressive and fatal breast cancer cells are resistant to chemotherapy, and they are developing ways to overcome this resistance.

Multivitamins with minerals may protect older women with breast cancer

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Findings from a study involving thousands of postmenopausal women suggest that women who develop invasive breast cancer may benefit from taking supplements that contain both multivitamins and minerals.

Tricyclic antidepressants may be effective against an aggressive lung cancer

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A little-used class of antidepressants appears potentially effective in combating a particularly deadly form of lung cancer, according to a new study.

Three-gene panel shows whether low-risk prostate cancer will stay that way

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Researchers have identified a gene signature that is expected to help predict which low-risk prostate tumors will become lethal.

Inflammatory protein converts glioblastoma cells into the most aggressive version

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A prominent protein activated by inflammation is the key instigator that converts glioblastoma multiforme cells to their most aggressive, untreatable form and promotes resistance to radiation therapy.

Pre-chemotherapy treatment delays return of aggressive lymphoma

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In a small study, most patients given low doses of azacitidine prior to standard chemotherapy for diffuse large B-cell lymphoma (DLBCL) remained cancer-free for up to 28 months.

Prostate cancer grade usually does not progress over time

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The proportion of men with advanced-stage prostate tumors at diagnosis has dropped dramatically since the widespread implementation of PSA screening, but the proportion of men with aggressive cancers at diagnosis has not changed substantially.

BH3 mimetics improved tamoxifen therapy in breast cancer

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The addition of BH3 mimetics to standard tamoxifen treatment improved the effectiveness of hormone therapy in luminal B cancers, an aggressive subtype of ER-positive breast cancer.

Active surveillance of prostate cancer may be risky in African Americans

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African American men with very-low-risk prostate cancer, and who meet criteria for active surveillance, but undergo immediate surgery are much more likely than men of other races to actually have aggressive disease.

Genetic variants that predict aggressive prostate cancers identified

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A method has been developed to identify aggressive prostate cancers that require immediate therapy.

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