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AGGRENOX
Thromboembolic disorders
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Drug Name:

AGGRENOX Rx

Generic Name and Formulations:
Dipyridamole 200mg (extended-release), aspirin 25mg (immediate-release); caps.

Company:
Boehringer Ingelheim Pharmaceuticals

Therapeutic Use:

Indications for AGGRENOX:

To reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.

Adult:

Swallow whole. 1 cap twice daily, one in the morning and one in the evening. Alternative regimen in case of intolerable headaches: switch to 1 cap at bedtime and low-dose aspirin in AM; return to usual regimen as soon as possible, usually within 1 week.

Children:

Not recommended.

Contraindications:

NSAID allergy. Patients with the syndrome of asthma, rhinitis, and nasal polyps. Viral infection in children/teens (risk of Reye syndrome).

Warnings/Precautions:

Not interchangeable with individual components of aspirin and dipyridamole. Increased risk of bleeding, including GI bleed. History of active peptic ulcer, severe hepatic or renal dysfunction; avoid. Coronary artery disease. Pre-existing hypotension. Chronic, heavy alcohol use. Pregnancy (Cat.D); avoid during 3rd trimester and during labor & delivery. Nursing mothers.

Interactions:

Increased risk of bleeding with anticoagulants, antiplatelets, heparin, anagrelide, fibrinolytic therapy, alcohol, chronic NSAID use. Potentiates adenosine, acetazolamide, methotrexate, oral hypoglycemics. May antagonize ACE inhibitors, β-blockers, diuretics, cholinesterase inhibitors, uricosurics. May increase risk of renal dysfunction with NSAIDs. Monitor phenytoin, valproic acid, other anticonvulsants.

Pharmacological Class:

Combination antiplatelet.

Adverse Reactions:

Headache, dyspepsia, abdominal pain, nausea, diarrhea; bleeding risk, increased liver enzymes, hepatic failure.

Metabolism:

Hepatic. 99% protein bound.

Elimination:

Fecal, renal.

Generic Availability:

YES

How Supplied:

Caps—60

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