Advanced Cancer

Progression-Free, Overall Survival in Liposarcoma Improved With Eribulin vs Dacarbazine

Progression-Free, Overall Survival in Liposarcoma Improved With Eribulin vs Dacarbazine

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Comparison study shows significantly improved overall survival and progression-free survival in patients with advanced LPS treated with eribulin vs dacarbazine.

Cabazitaxel in Prostate Cancer: Reduced Dose Noninferior to Standard Dose

Cabazitaxel in Prostate Cancer: Reduced Dose Noninferior to Standard Dose

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A smaller dose of cabazitaxel (C20) is noninferior to a larger dose (C25) in the post-docetaxel treatment of mCRPC.

Combination Better At Easing Agitated Delirium in Advanced Cancer Patients

Combination Better At Easing Agitated Delirium in Advanced Cancer Patients

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Lorazepam plus haloperidol is more effective than haloperidol alone at reducing agitation, study finds.

Updated ASTRO Guideline Bolsters Safety, Efficacy of Palliative RT for Bone Metastases

Updated ASTRO Guideline Bolsters Safety, Efficacy of Palliative RT for Bone Metastases

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Palliative radiotherapy for bone metastases is safe, effective — but controversy persists for single-fraction treatment.

Walking Improves Quality of Life in Patients with Advanced Cancer

Walking Improves Quality of Life in Patients with Advanced Cancer

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Simply walking for 30 minutes 3 times a week has significant impact on symptom severity and ability to cope, as well as quality of life, for patients with advanced cancer.

No Association Between Vasectomy and Prostate Cancer Risk

No Association Between Vasectomy and Prostate Cancer Risk

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There is no association between vasectomy and the risk of overall, high-grade, or advanced-stage prostate cancer or prostate cancer-related mortality.

Patients Undergoing Multiple Systemic Therapies for Metastatic Prostate Cancer Expect a Cure

Patients Undergoing Multiple Systemic Therapies for Metastatic Prostate Cancer Expect a Cure

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Treatment expectations of individuals with metastatic prostate cancer and their health care providers often do not match.

Considerable Shifts in NSCLC Treatment With Modest Gains in Survival

Considerable Shifts in NSCLC Treatment With Modest Gains in Survival

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Investigators report on trends in treatment of advanced-stage NSCLC from 2000 to 2011, including impact on survival and total Medicare spending.

Osimertinib New Standard of Care for T790M+ Advanced NSCLC

Osimertinib New Standard of Care for T790M+ Advanced NSCLC

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A study presented at the World Conference on Lung Cancer compared progression-free survival after treatment with osimertinib with that of platinum therapy plus pemetrexed in a select group of patients with T790M-positive advanced NSCLC.

Half of Patients With Advanced Cancer Believe They Will Be Cured

Half of Patients With Advanced Cancer Believe They Will Be Cured

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Nearly half of patients with advanced cancer around the world believe they will be cured, with the perception of curability significantly differing by education, performance status, and country of origin.

Methylnaltrexone Linked to Improved Survival in Advanced Cancer

Methylnaltrexone Linked to Improved Survival in Advanced Cancer

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Treatment with methylnaltrexone was associated with improved overall survival in patients with advanced cancer.

Use, Outcomes of Urine Drug Tests Among Patients With Advanced Cancer

Use, Outcomes of Urine Drug Tests Among Patients With Advanced Cancer

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Despite the infrequency of urine drug test ordering, greater than half of all urine drug tests results were abnormal among outpatients with advanced cancer.

Increasing Weight Associated With Disease Progression in Multiple Myeloma

Increasing Weight Associated With Disease Progression in Multiple Myeloma

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Increasing body mass index (BMI) allows growth and progression of disease in patients with multiple myeloma, a recently published study has shown.

Advanced Cancer Patients Often Unaware That They Are More Optimistic About Their Prognosis Than Their Oncologists

Advanced Cancer Patients Often Unaware That They Are More Optimistic About Their Prognosis Than Their Oncologists

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Most patients with advanced cancer report far more optimistic expectations for survival prognosis than their oncologists because patients misunderstand their oncologists' clinical judgment.

Trastuzumab Biosimilar Comparable the Monoclonal Antibody for Advanced HER2+ Breast Cancer

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MYL-1401O is comparable in efficacy and safety to the anti-HER2 monoclonal antibody trastuzumab as frontline therapy in breast cancer.

Web Application Improves Follow-up in Patients With Advanced Lung Cancer

Web Application Improves Follow-up in Patients With Advanced Lung Cancer

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A Web application called Moovcare that guides follow-up improved survival for patients with advanced lung cancer after receiving initial therapy.

Poor Sleep Quality Negatively Impacts Some Adverse Effects in Patients With Advanced Cancer

Poor Sleep Quality Negatively Impacts Some Adverse Effects in Patients With Advanced Cancer

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Patients participating in early-phase clinical trials should be assessed for sleep quality, as poor sleep quality is associated with greater fatigue, symptom burden, and mood disturbance.

Improving Tools for Managing Pain and Monitoring Sedation Among Patients With Cancer

Improving Tools for Managing Pain and Monitoring Sedation Among Patients With Cancer

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Managing pain with opioids and keeping a close eye on adverse effects is an important part of cancer care. But there is room for improvement in pain management tools, and nurses play a key role in their evolution.

Nivolumab Maintains Baseline HRQoL in Advanced Melanoma

Nivolumab Maintains Baseline HRQoL in Advanced Melanoma

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In addition to improving overall survival compared with dacarbazine in patients with advanced melanoma, nivolumab maintains baseline levels of health-related quality of life to ultimately confer long-term quality of survival benefit.

Chemotherapy Boosts Effectiveness of Immunotherapy in the Treatment of Ovarian Cancer

Chemotherapy Boosts Effectiveness of Immunotherapy in the Treatment of Ovarian Cancer

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Immunotherapy for advanced ovarian cancer more effectively treats tumors when administered immediately after chemotherapy. Sequential chemoimmunotherapy could improve disease control in stage IIIC/IV tubo-ovarian HGSC.

Utidelone Plus Capecitabine Active in Patients Heavily Pretreated for Metastatic Breast Cancer

Utidelone Plus Capecitabine Active in Patients Heavily Pretreated for Metastatic Breast Cancer

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The genetically engineered epothilone analog, utidelone, in combination with capecitabine significantly improved progression-free survival and objective response rates in patients with metastatic breast cancer who were heavily pretreated, compared with capecitabine alone, results of a phase 3 trial presented at the 2016 ASCO Annual Meeting have shown.

Biomarker Indicates Which Patients With Colorectal Cancer Will Respond to Cetuximab

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A blood-based test pinpoints which patients with metastatic colorectal cancer will benefit from treatment with cetuximab.

A Protein Could Predict the Response to Immunotherapy in Metastatic Melanoma

A Protein Could Predict the Response to Immunotherapy in Metastatic Melanoma

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The Bim protein might predict which patients could be successfully treated with immunotherapy for metastatic melanoma.

Study Identifies Factors Associated With Depression, Anxiety in Family Caregivers

Study Identifies Factors Associated With Depression, Anxiety in Family Caregivers

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A recent study examined depression and anxiety among family caregivers of patients with incurable cancer and sought to identify factors linked to these symptoms.

Initiating Palliative Care in the Emergency Department

Initiating Palliative Care in the Emergency Department

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Despite the benefits of early palliative care intervention, palliative care is less frequently employed at the emergency department. Researchers sought to evaluate patient outcomes related to ED palliative care.

Wine Does Not Improve Appetite in Patients With Advanced Cancer

Wine Does Not Improve Appetite in Patients With Advanced Cancer

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White wine does not improve appetite or weight in patients with advanced cancer, a recent study has shown.

Biomarker Indicates Potential Benefits of Treatment Options in Advanced Colorectal Cancer

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A recently developed biomarker test for patients with advanced colorectal cancer could help determine the best treatment options for each patient.

Exercise Does Not Improve Functioning With Advanced Breast Cancer

Exercise Does Not Improve Functioning With Advanced Breast Cancer

An exercise intervention did not improve physical functioning for women living with advanced breast cancer, according to a study.

Exercise Intervention Fails to Improve Physical Functioning in Advanced Breast Cancer

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Moderate exercise intervention did not appear to improve physical functioning in women with advanced breast cancer to a significant degree, according to study data.

Treatment Goals Separate From Life Goals Among Patients With Advanced Cancer

Treatment Goals Separate From Life Goals Among Patients With Advanced Cancer

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Patients with advanced cancer view life goals as distinct from and less important than treatment goals, according to a recent study.

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