Acute Myeloid Leukemia Risk Factors ID'd in Texas Adults

Share this article:
Acute Myeloid Leukemia Risk Factors ID'd in Texas Adults
Acute Myeloid Leukemia Risk Factors ID'd in Texas Adults

(HealthDay News) -- Solvent exposure, smoking, and obesity are significant risk factors for de novo acute myeloid leukemia (AML) in Texas, according to a study published online Feb. 1 in Cancer.

To investigate associations between lifestyle characteristics and AML risk, Sara S. Strom, Ph.D., of the University of Texas M.D. Anderson Cancer Center in Houston, and colleagues used questionnaires to collect demographic and occupational characteristics on 638 adults with de novo AML and 636 matched controls.

The researchers found that AML risk was significantly increased among men exposed to low or moderate/high levels of occupational solvents (odds ratio [OR], 2.87 and 4.13, respectively), or men who were heavy smokers (≥30 pack-years; OR, 1.86). For women, there was a significantly increased risk of AML with exposure to low or moderate/high levels of solvent (OR, 2.73 and 3.90, respectively), or for those who were obese (OR 1.62). Obesity correlated with a significantly increased risk of AML with recurrent cytogenetic abnormalities (RCA) (OR, 3.15). Solvent exposure at low or moderate/high levels correlated with a significantly increased risk of AML-RCA or AML with multilineage dysplasia (low level OR, 4.11 and 2.54, respectively, and moderate/high level OR, 5.13 and 3.02, respectively). There was a joint effect of smoking and solvent exposure, with the highest risk seen for smokers who were exposed to solvents (OR, 4.51).

"These findings highlight the need for multicenter collaborations to identify the epidemiologic and genetic risk factors associated with AML development to better understand the complexity of AML etiology and the underlying heterogeneity of the disease," the authors write.

Abstract
Full Text (subscription or payment may be required)

This article originally appeared here.
Share this article:
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in Daily Oncology News

Chest radiation may be useful for combatting advanced lung cancers

Chest radiation may be useful for combatting advanced ...

The addition of chest radiation reduces recurrence rate and, improves survival when added to chemo in extensive stage small-cell lung cancer.

Market changes needed as patients take on greater care costs

Market changes needed as patients take on greater ...

As consumers take on more costs of care, access to data for informed decisions is deemed crucial.

For black men with prostate cancer, watchful waiting may be unwise

For black men with prostate cancer, watchful waiting ...

For men with early-stage prostate cancer, watching waiting is not always the best course of action, especially for black patients.